FB2021_02, released April 13, 2021

Gene: Dmel\CG33129

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General Information
Symbol
Dmel\CG33129
Species
D. melanogaster
Name
Annotation Symbol
CG33129
Feature Type
protein_coding_gene
FlyBase ID
FBgn0053129
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
32C1-32C1
Sequence location
2L:10,964,905..10,970,275 [-]
Recombination map
2-44
RefSeq locus
NT_033779 REGION:10964905..10970275
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2003-04-10 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in response to hyperoxia
inferred from mutant phenotype
(Zhao et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN000335433
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN000335433
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CG33129 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG33129-RA
FBtr0080170
NM_176010
1504
237
CG33129-RB
FBtr0080171
NM_176011
1533
237
CG33129-RC
FBtr0080172
NM_176012
1473
237
CG33129-RE
FBtr0080169
NM_176009
2652
677
CG33129-RF
FBtr0340550
NM_001298891
2815
677
CG33129-RG
FBtr0340551
NM_001298892
1782
237
CG33129-RH
FBtr0340552
NM_001298893
1661
237
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG33129-PA
FBpp0079759
25.8
237
10.33
NP_788024
AAN10768
CG33129-PB
FBpp0079760
25.8
237
10.33
NP_788025
AAN10769
CG33129-PC
FBpp0079761
25.8
237
10.33
NP_788026
AAF53036
CG33129-PE
FBpp0079758
75.7
677
9.92
NP_788023
AAF53037
CG33129-PF
FBpp0309448
75.7
677
9.92
NP_001285820
AHN54334
CG33129-PG
FBpp0309449
25.8
237
10.33
NP_001285821
AHN54335
CG33129-PH
FBpp0309450
25.8
237
10.33
NP_001285822
AHN54336
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

677 aa isoforms: CG33129-PE, CG33129-PF
237 aa isoforms: CG33129-PA, CG33129-PB, CG33129-PC, CG33129-PG, CG33129-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG33129 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG33129 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG33129
Transgenic constructs containing regulatory region of CG33129
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7049
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TMEM214
13 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tmem214
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Tmem214
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\tmem214
3 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\tmem214
13 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (3)
Atha\AT1G70770
3 of 9
Yes
Yes
Atha\AT1G23170
2 of 9
No
Yes
Atha\AT3G11880
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904IW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001872
Drosophila simulans
Dsim\GD22209
Drosophila sechellia
Dsec\GM11259
Drosophila erecta
Dere\GG10340
Drosophila yakuba
Dyak\GE13143
Drosophila ananassae
Dana\GF14050
Drosophila pseudoobscura pseudoobscura
Dpse\GA17304
Drosophila persimilis
Dper\GL19022
Drosophila willistoni
Dwil\GK18367
Drosophila virilis
Dvir\GJ16168
Drosophila mojavensis
Dmoj\GI17132
Drosophila grimshawi
Dgri\GH11685
Drosophila grimshawi
Dgri\GH11686
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502N2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024014
Glossina morsitans
Tsetse fly
Gmor\GMOY002629
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03942
Mayetiola destructor
Hessian fly
Mdes\Mdes011326
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000944
Anopheles darlingi
American malaria mosquito
Adar\ADAC009780
Anopheles gambiae
Malaria mosquito
Agam\AGAP009823
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000883
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DIO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001842
Danaus plexippus
Monarch butterfly
Dple\DPOGS209131-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008143
Apis florea
Little honeybee
Aflo\2907755108
Apis mellifera
Western honey bee
Amel\LOC726030
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25352
Bombus terrestris
Buff-tailed bumblebee
Bter\15207311
Linepithema humile
Argentine ant
Lhum\LH15747
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000487
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011515
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_13025
Tribolium castaneum
Red flour beetle
Tcas\TC009435
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03706
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08PC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000551
Ixodes scapularis
Black-legged tick
Isca\ISCW020051
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72027.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g00040
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_242020
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0WVG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmem214_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmem214
Ciona intestinalis
Vase tunicate
Cint\LOC100186389
Gallus gallus
Domestic chicken
Ggal\TMEM214
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TMEM214; transmembrane protein 214
    13 of 15
    615301
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        RNA-protein
        Physical Interaction
        Assay
        References
        CG33129 - egl
        anti tag coimmunoprecipitation, full identification by DNA sequencing, quantitative reverse transcription pcr
        (Vazquez-Pianzola et al., 2017)
        protein-protein
        Physical Interaction
        Assay
        References
        CG33129 - CG2064
        experimental knowledge based
        (Guruharsha et al., 2011)
        CG33129 - Ugt36D1
        experimental knowledge based
        (Guruharsha et al., 2011)
        CG33129 - p38a
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Belozerov et al., 2012)
        CG33129 - p38c
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Belozerov et al., 2012)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-44
        Cytogenetic map
        32C1-32C1
        Sequence location
        2L:10,964,905..10,970,275 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        32C1-32C1
        Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-44

        (FlyBase, 2016)

        2-37.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (16)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (299)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: CG6087 CG6089

        (FlyBase Genome Annotators, 2002-2003)
        Additional comments

        Annotations CG6087 and CG6089 merged as CG33129 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Other Comments

        Host gene for maternally inherited stable intronic sequence RNA (sisRNA).

        (Tay and Pek, 2017)

        Candidate stable intronic sequence RNA (sisRNA) identified within 5'UTR of this gene.

        (Pek et al., 2015)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 60 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (3)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (58)