FlyBase Gene Report: Dmel\Kdm4B

General Information

Symbol

Dmel\Kdm4B

Species

D. melanogaster

Name

Lysine demethylase 4B

Annotation Symbol

CG33182

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053182

Gene Model Status

Current

Stock Availability

18 publicly available

Enzyme Name (EC)

[histone H3]-trimethyl-L-lysine(9) demethylase (1.14.11.66)

[histone H3]-trimethyl-L-lysine(36) demethylase (1.14.11.69)

Gene Summary

Lysine (K)-specific demethylase 4B (Kdm4B) encodes a histone demethylase that removes methyl groups from histone 3 lysines 9 and 36. It participates in DNA repair and transcription regulation. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Histone demethylase 4B

Key Links

Genomic Location

Cytogenetic map

49F4-49F7

Sequence location

2R:13,176,553..13,198,337 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13176553..13198337

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables histone H3K36me2/H3K36me3 demethylase activity

inferred from direct assay

(Lin et al., 2008)

inferred from mutant phenotype

(Lloret-Llinares et al., 2008)

enables histone H3K9me2/H3K9me3 demethylase activity

inferred from mutant phenotype

(Lloret-Llinares et al., 2008)

inferred from direct assay

(Lin et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables histone H3K36 demethylase activity

inferred from biological aspect of ancestor with PANTHER:PTN000075207

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:O75164

(Gene Ontology Curators, 2002-)

enables histone H3K9 demethylase activity

inferred from biological aspect of ancestor with PANTHER:PTN000075207

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in circadian behavior

inferred from mutant phenotype

(Shalaby et al., 2018)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred from biological aspect of ancestor with PANTHER:PTN000075014

(GO Reference Genome Project, 2011-)

involved_in negative regulation of DNA-templated transcription

inferred from sequence or structural similarity with UniProtKB:O75164

(Gene Ontology Curators, 2002-)

involved_in regulation of gene expression

inferred from biological aspect of ancestor with PANTHER:PTN000075014

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Shalaby et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in chromatin

inferred from biological aspect of ancestor with PANTHER:PTN000075014

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000075014

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:O75164

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

JMJC FAMILY HISTONE DEMETHYLASES

Protein Family (UniProt)

Belongs to the JHDM3 histone demethylase family. (Q9V6L0)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

histone H3K36me2/H3K36me3 demethylase activity

N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2 (1.14.11.69)

RHEA 60236: histone H3K9me2/H3K9me3 demethylase activity

N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2 (1.14.11.66)

RHEA 60200:

Summaries

Gene Snapshot

Gene Group (FlyBase)

JMJC FAMILY HISTONE DEMETHYLASES -: The Jumonji C (JmjC) domain-containing demethlyases catalyze histone lysine or arginine demethylation through an oxidative reaction that requires iron Fe(II) and α-ketoglutarate as cofactors. (Adapted from FBrf0195283).

Protein Function (UniProtKB)

Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).

(UniProt, Q9V6L0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Kdm4B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V6L0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Complex/atypical overlap: Shares UTR sequences with 2 downstream genes; one isoform shares portion of CDS with downstream gene; for some isoforms internal coding exons correspond to UTR exons of other gene.

Genes with CDS overlap: minor isoform of Kdm4B appears to share coding sequence with seq (terminal coding exon of Kdm4B and initial coding exon of seq). Other Kdm4B isoforms are highly conserved; seq orthologs not found outside Drosophila.

Gene model reviewed during 5.47

Exons of Kdm4B, seq and CG17724 overlap.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.43

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Kdm4B-RA

FBtr0087770

NM_176164

2184

590

Kdm4B-RB

FBtr0302052

NM_001169666

2225

590

Kdm4B-RC

FBtr0302053

NM_001169667

2585

590

Kdm4B-RD

FBtr0302054

NM_001169668

2667

590

Kdm4B-RE

FBtr0310498

NM_001274013

5718

717

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Kdm4B-PA

FBpp0086883

66.4

590

7.51

FBpp0291262

66.4

590

7.51

FBpp0291263

66.4

590

7.51

FBpp0291264

66.4

590

7.51

FBpp0302636

80.4

717

8.07

A0A0B4KFJ8

NP_001260942

AGB93475

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

590 aa isoforms: Kdm4B-PA, Kdm4B-PB, Kdm4B-PC, Kdm4B-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Kdm4B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.40

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Shalaby et al., 2017)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Kdm4B in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Kdm4B

View exonic expression by tissue for Dmel\Kdm4B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318918/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053182

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053182

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053182

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33182

Flygut - An atlas of the Drosophila adult midgut

FBgn0053182

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Kdm4B

Transgenic constructs containing regulatory region of Kdm4B

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority live | male

Kdm4B^KO

viable

Kdm4B^EY10737

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Kdm4B^GD16017

viable, with Scer\GAL4^Mef2.PR

Kdm4B^GD16017

viable, with Scer\GAL4^tin.CΔ4

Kdm4B^GD16017

Sterility

Allele

fertile

Kdm4B^EY10737

Other Phenotypes

Allele

radiation sensitive | dominant

Kdm4B⁰³⁵³¹

suppressor of variegation, with In(1)w^m4

Kdm4B^KO

suppressor of variegation, with T(2;3)Sb^V

Kdm4B^KO

Phenotype manifest in

Allele

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Pxn.PS

Kdm4B^EY10737

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\KDM4A

9 of 14

Yes

Hsap\KDM4C

9 of 14

Yes

8 of 14

6 of 14

6 of 14

6 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Kdm4a

8 of 14

Yes

7 of 14

7 of 14

6 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (18)

Mmus\Kdm4a

8 of 14

Yes

Mmus\Kdm4c

8 of 14

Yes

7 of 14

7 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (10)

Xtro\gtf3c5

5 of 13

Yes

Xtro\kdm4b

5 of 13

Yes

4 of 13

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (17)

Drer\kdm4aa

9 of 14

Yes

Drer\kdm4ab

9 of 14

Yes

7 of 14

6 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\jmjd-2

9 of 14

Yes

Cele\lin-49

1 of 14

Cele\phf-14

1 of 14

Cele\rbr-2

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP011180

11 of 12

Yes

4 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\AT2G38950

2 of 13

Yes

Atha\AT5G46910

2 of 13

Yes

Atha\JMJ14

2 of 13

Yes

Atha\JMJ18

2 of 13

Yes

Atha\MEE27

2 of 13

Yes

Atha\PKDM7D

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\RPH1

8 of 13

Yes

Scer\GIS1

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\jmj3

3 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Kdm4B. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

10 of 13

3 of 13

3 of 13

1 of 13

1 of 13

rno

1 of 13

seq

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Kdm4B^KO

model of alcohol use disorder

CEA

(Pinzón et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Kdm4B^KK102089

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Park et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KDM4A; lysine demethylase 4A

9 of 14

609764

KDM4C; lysine demethylase 4C

9 of 14

605469

KDM4B; lysine demethylase 4B

8 of 14

609765

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 65; MRD65

autosomal dominant intellectual developmental disorder 65

KDM4D; lysine demethylase 4D

6 of 14

609766

KDM4E; lysine demethylase 4E

6 of 14

616581

KDM4F; lysine demethylase 4F

6 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Kdm4B - stau

anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization

(Laver et al., 2013)

protein-protein

Physical Interaction

Assay

References

Kdm4B - His3

enzymatic study, western blot

(Lin et al., 2008)

Kdm4B - bur

anti bait coimmunoprecipitation, Identification by mass spectrometry, pull down, anti tag western blot, anti tag coimmunoprecipitation

(Takakura et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Kdm4B

(Schneiderman et al., 2010)

smo

enhanceable

Kdm4B

(Shalaby et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0053182

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

49F4-49F7

Sequence location

2R:13,176,553..13,198,337 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F4-49F7

; Limits computationally determined from genome sequence between P{EP}EP873^EP873 and P{EP}CG33182^EP728&P{lacW}Aats-val^k14804

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

76243

w^*; TI{TI}Kdm4B^KO

62409

y¹ v¹; P{TRiP.HMJ23832}attP40/CyO

58616

y¹ w^*; Mi{MIC}Kdm4B^MI12566

20208

y¹ w^67c23; P{EPgy2}Kdm4B^EY10737

Kyoto

103764

w^*; P{GawB}Kdm4B^NP0792 / CyO

104142

w^*; P{GawB}Kdm4B^NP2264 / SM1

112848

w^*; P{GawB}Kdm4B^NP2264 / CyO

NIG-Fly

4037R-2

P{NIG.4037R}2

4037R-4

P{NIG.4037R}4

HMJ23832

y¹ v¹; P{TRiP.HMJ23832}attP40/CyO

VDRC

v110158

P{KK102089}VIE-260B

v46444

w¹¹¹⁸; P{GD16017}v46444

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (102)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD47433

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0053182

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0053182

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Shalaby et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by Kdm4B and CG17724.

(FlyBase Genome Annotators, 2012)

Annotation CG4037 split into CG33182, CG32904 (seq) and CG17724 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Kdm4B CG33182

(Lin et al., 2008)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG33182

(Shalaby et al., 2017, Holowatyj et al., 2015, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Curtis et al., 2011, Ni et al., 2011.7.19, Lorbeck et al., 2010, Ni et al., 2010.12.1, Schneiderman et al., 2010, Keleman et al., 2009.8.5, Lin et al., 2008, Lloret-Llinares et al., 2008, Stofanko et al., 2008, Klose et al., 2006)

CG4037

KDM4B

(Bernués et al., 2022, Chaouch and Lasko, 2021, Shimaji et al., 2019, Shalaby et al., 2018, Pinzón et al., 2017, Shalaby et al., 2017, Greer and Shi, 2012, Kwon et al., 2010)

Kdm4B

(Berry et al., 2024, Chvilicek et al., 2024, Marzullo et al., 2023, Takakura et al., 2023, Mika and Benton, 2021, Vidaurre and Chen, 2021, Hall et al., 2019, Meltzer et al., 2019, Michalak et al., 2019, Tsurumi et al., 2019, Song et al., 2018, Holowatyj et al., 2015, Tsurumi et al., 2013, FlyBase Genome Annotators, 2012, Gan et al., 2010)

Kdm4b

(Gulati et al., 2020)

dJMJD2(2)

(Lloret-Llinares et al., 2008)

dKDM4B

(Lin et al., 2008)

dKdm4B

(Palomera-Sanchez et al., 2010)

kdm4b

(Park et al., 2019)

Name Synonyms

CG33182

Histone demethylase 4B

(Laver et al., 2013)

Lysine (K)-specific demethylase 4B

Lysine demethylase 4B

(Shafer, 2025)

Secondary FlyBase IDs

FBgn0033804

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

318918

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V6L0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V6L0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V6L0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318918/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053182

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053182

FlyMine - An integrated database for Drosophila genomics

FBgn0053182

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33182

MARRVEL_MODEL - MARRVEL (model organism gene)

318918

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0053182

DroID - A comprehensive database of gene and protein interactions.

FBgn0053182

DRSC - Results frm RNAi screens

FBgn0053182

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053182

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0053182

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33182

Flygut - An atlas of the Drosophila adult midgut

FBgn0053182

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015663

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (70)

The following external sites may use different assemblies or annotations than FlyBase.

0.40

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