scaffold protein - restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis - physically interacts with Warts - the stability of Salvador (Sav), which is believed to promote Hippo/Warts association, is crucially dependent on its binding partner Hippo
Gene model reviewed during 5.48
None of the polypeptides share 100% sequence identity.
Interacts with Wts via its WW domains. Interacts (via FBM motif) with Mer (via FERM domain). Interacts with Kibra. Interacts with Hpo (via SARAH domain). Interacts with jub.
Phosphorylated by Hpo.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sav using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sav in GBrowse 2
Located on the right arm of chromosome 3
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG13831, CG13832 merged as CG33193 in release 3 of the genome annotation.
Source for merge of CG13831 CG13832 was a shared cDNA ( date:010720 ).
Source for merge of sav anon-WO0172774.152 was sequence comparison ( date:051113 ).
dsRNA has been made from templates generated with primers directed against this gene.
sav is required for the proper termination of cell proliferation during imaginal disc development.
Identification: Isolated as a mutation that causes overgrowth in homozygous clones in the eye.
The gene is called "shar-pei" because of the mutant folded cuticle phenotype in the head, which resembles the folded skin of Shar-pei dogs.