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Gene Dmel\sav

General Information
Symbol	Dmel\sav	Species	D. melanogaster
Name	salvador	Annotation symbol	CG33193
Feature type	protein_coding_gene	FlyBase ID	FBgn0053193
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	shar-pei
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	94D10-94D10	Sequence location	3R:18,884,331..18,886,991 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene salvador is referred to in FlyBase by the symbol Dmel\sav (CG33193, FBgn0053193). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; sensory organ development; cell proliferation; renal tubule development; response to ionizing radiation; stem cell differentiation; stem cell proliferation; programmed cell death; negative regulation of biological process; regulation of apoptosis; regulation of neurogenesis; neuron differentiation; response to stimulus. 30 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R8 of pale ommatidium; eye; trichogen cell; photoreceptor cell R8 of yellow ommatidium; mesothoracic tergum; wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: SARAH; WW/Rsp5/WWP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628053_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of sav. Gene sequence location is 3R:18884331..18886991.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Poon et al., 2011, Dev. Cell 21(5): 896--906 Sequence features BKN27562 HFA14682 HFA14681
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94D10-94D10   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3- (Tapon and Hariharan, 1999)
Left of (cM)	hh P{lacW}crbj1B5 (Kango-Singh et al., 2002)
Right of (cM)	klg P{SUPor-P}CG5346KG05850 P{lacW}howE7-3-4 (Kango-Singh et al., 2002)
Notes	Located on the right arm of chromosome 3 (Tapon and Hariharan, 1999)
Gene Model & Products
Please see the GBrowse view of Dmel\sav for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sav-RA FBtr0084356  NM_176544   2200   608 sav-RB FBtr0303509  NM_001202340   2185   603
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sav-PA   FBpp0083749   68.1   608   9.92     NP_788721   AAF56090 sav-PB   FBpp0292543   67.5   603   9.90     NP_001189269   ADV37360
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WW/Rsp5/WWP (IPR001202) SARAH (IPR011524)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56090   AE014297 ADV37360   AI403760   AI404092   AI543516   AW944627   AX260190   AY069854 AAL39999   AY131211 AAM97280   BF498672   BI355383   BI367071   CO323764   EV594580   EV596535   EV597286   GH750679   GH754211   GH757021   GH759044   GH761268   GH761276   GH772028   GH773636   GH774247   GH774879   GH775658   GH780889   GH781327   GH790353   GH794826   GH795509   GH796267   GH796807   GH799125   GH800078   GH803161   GH803499   GH803729   GH807576   GH807705   GH807878   GH808881   GH809104   GH810211   GH811013   GH815941   GH816615   GH818028   GH818656   GH821803   GH821851   GH823051   GH823632   GH823798   GH826114   GH826747   GH831054   GH835300   GH837757   GH840302   GH842084   GH842629   GH843500   GH845748   GH846411   GH846421   GH847224   GH847645   GH847741   GH848624   GH848774   GH849127   GH849536   GH850397   GH851555   GH854389   GH856610   GH858763   GH859465   GH863866   GH864400   GH865445   GH866241   GH866464   GH866861   GH869417   GH872122   GH873756   GH874302   GH880714   GH881538   GH882459   GH884829   GH888407   GH891537   GH892258   GH892412   GH895078   GH896013   GH897009   GH900151   GH901385   GH901733   GH905108   GH907501   GH908183   GH908872   GH909575   GH919389   GH920653   GH923137   GH925661   GH928543   GH928850   GH930425   GH935856   GH939296   GH939935   GH939946   GH940687   GH940748   GH941005   GH942609   GH944613
UniProtKB/Swiss-Prot	Q9VCR6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0053193    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0053193 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0053193 expression level Developmental Stage   Expression Level embryo 00-02hr    4099 embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr    1855 embryo 08-10hr    1714 embryo 10-12hr    1995 embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6    1584 larva L3 puffstage 7-9    1762 white prepupae new    2205 white prepupae 12hr    1720 white prepupae 24hr    1921 pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day    1984 adult female 05day    2265 adult female 30day    2566 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4099) embryo 02-04hr  (985) embryo 04-06hr  (1299) embryo 06-08hr  (1855) embryo 08-10hr  (1714) embryo 10-12hr  (1995) embryo 12-14hr  (1136) embryo 14-16hr  (1176) embryo 16-18hr  (704) embryo 18-20hr  (747) embryo 20-22hr  (468) embryo 22-24hr  (434) larva L1  (759) larva L2  (671) larva L3 12hr old  (860) larva L3 puffstage 1-2  (1085) larva L3 puffstage 3-6  (1584) larva L3 puffstage 7-9  (1762) white prepupae new  (2205) white prepupae 12hr  (1720) white prepupae 24hr  (1921) pupae 2d postWPP  (1319) pupae 3d postWPP  (886) pupae 4d postWPP  (919) adult male 01day  (903) adult male 05day  (1004) adult male 30day  (1106) adult female 01day  (1984) adult female 05day  (2265) adult female 30day  (2566) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4099) embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr  (1855) embryo 08-10hr  (1714) embryo 10-12hr  (1995) embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6  (1584) larva L3 puffstage 7-9  (1762) white prepupae new  (2205) white prepupae 12hr  (1720) white prepupae 24hr  (1921) pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day  (1984) adult female 05day  (2265) adult female 30day  (2566) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4099 embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr    1855 embryo 08-10hr    1714 embryo 10-12hr    1995 embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6    1584 larva L3 puffstage 7-9    1762 white prepupae new    2205 white prepupae 12hr    1720 white prepupae 24hr    1921 pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day    1984 adult female 05day    2265 adult female 30day    2566 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4099 embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr    1855 embryo 08-10hr    1714 embryo 10-12hr    1995 embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6    1584 larva L3 puffstage 7-9    1762 white prepupae new    2205 white prepupae 12hr    1720 white prepupae 24hr    1921 pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day    1984 adult female 05day    2265 adult female 30day    2566 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0053193 expression level Developmental Stage   Expression Level embryo 00-02hr    4099 embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr    1855 embryo 08-10hr    1714 embryo 10-12hr    1995 embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6    1584 larva L3 puffstage 7-9    1762 white prepupae new    2205 white prepupae 12hr    1720 white prepupae 24hr    1921 pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day    1984 adult female 05day    2265 adult female 30day    2566 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4099) embryo 02-04hr  (985) embryo 04-06hr  (1299) embryo 06-08hr  (1855) embryo 08-10hr  (1714) embryo 10-12hr  (1995) embryo 12-14hr  (1136) embryo 14-16hr  (1176) embryo 16-18hr  (704) embryo 18-20hr  (747) embryo 20-22hr  (468) embryo 22-24hr  (434) larva L1  (759) larva L2  (671) larva L3 12hr old  (860) larva L3 puffstage 1-2  (1085) larva L3 puffstage 3-6  (1584) larva L3 puffstage 7-9  (1762) white prepupae new  (2205) white prepupae 12hr  (1720) white prepupae 24hr  (1921) pupae 2d postWPP  (1319) pupae 3d postWPP  (886) pupae 4d postWPP  (919) adult male 01day  (903) adult male 05day  (1004) adult male 30day  (1106) adult female 01day  (1984) adult female 05day  (2265) adult female 30day  (2566) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4099) embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr  1855 embryo 08-10hr  1714 embryo 10-12hr  1995 embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6  1584 larva L3 puffstage 7-9  1762 white prepupae new  2205 white prepupae 12hr  1720 white prepupae 24hr  1921 pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day  1984 adult female 05day  2265 adult female 30day  (2566) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4099 embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr    1855 embryo 08-10hr    1714 embryo 10-12hr    1995 embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6    1584 larva L3 puffstage 7-9    1762 white prepupae new    2205 white prepupae 12hr    1720 white prepupae 24hr    1921 pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day    1984 adult female 05day    2265 adult female 30day    2566 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4099 embryo 02-04hr    985 embryo 04-06hr    1299 embryo 06-08hr    1855 embryo 08-10hr    1714 embryo 10-12hr    1995 embryo 12-14hr    1136 embryo 14-16hr    1176 embryo 16-18hr    704 embryo 18-20hr    747 embryo 20-22hr    468 embryo 22-24hr    434 larva L1    759 larva L2    671 larva L3 12hr old    860 larva L3 puffstage 1-2    1085 larva L3 puffstage 3-6    1584 larva L3 puffstage 7-9    1762 white prepupae new    2205 white prepupae 12hr    1720 white prepupae 24hr    1921 pupae 2d postWPP    1319 pupae 3d postWPP    886 pupae 4d postWPP    919 adult male 01day    903 adult male 05day    1004 adult male 30day    1106 adult female 01day    1984 adult female 05day    2265 adult female 30day    2566 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0053193    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0053193 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0053193 expression level Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0053193 expression level Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    70.975 Larval Midgut    124.7 Larval Hindgut    132.9 Larval Malpighian Tubules    113.3 Larval Fat Body    147.1 Larval Salivary Gland    193.6 Larval Trachea    111.2 Larval Carcass    164.775 Adult Head    47.1 Adult Eye    65.425 Adult Brain    39.9 Adult Thoracic-Abdominal Ganglion    41 Adult Crop    95.8 Adult Midgut    75.4 Adult Hindgut    75.6 Adult Malpighian Tubules    84.7 Adult Fat Body    55.9 Adult Salivary Gland    66.1 Adult Heart    61.55 Adult VirginFemale Spermatheca    73.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    205.1 Adult Testis    87.1 Adult Male Accessory Gland    81 Adult Carcass    64.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    47.1   NA  Eye    65.425   NA  Brain    39.9   70.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    41   NA  Crop    95.8   124.7  Midgut    75.4   132.9  Hindgut    75.6   113.3  Malpighian Tubules    84.7   147.1  Fat Body    55.9   193.6  Salivary Gland    66.1   NA  Heart    61.55   111.2  Trachea    NA   NA  VirginFemale Spermatheca    73.3   NA  InseminatedFemale Spermatheca    78.1   NA  Ovary    205.1   NA  Testis    87.1   NA  Male Accessory Gland    81   164.775  Carcass    64.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053193 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33193-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3R)hh) sav1 sav2 sav3 sav4 lethal (with sav1) sav2 sav4 lethal (with sav2) sav1 sav3 sav4 lethal (with sav3) sav2 sav4 lethal (with sav4) sav1 sav2 sav3 lethal | larval stage (with Df(3R)EB6) sav1 lethal | larval stage (with sav1) sav3 lethal | larval stage (with sav3) sav1 lethal | larval stage | recessive savshrp-1 savshrp-2 savshrp-3 savshrp-4 savshrp-5 savshrp-6 lethal | pupal stage, with Scer\GAL4pnr-MD237 savGD8128 lethal | recessive sav1 sav2 sav3 sav4 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 savGD8128 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 savGD8128 cell polarity defective | somatic clone sav3 increased cell number | somatic clone sav1 sav2 sav3 sav4 large body | somatic clone savshrp-1 savshrp-2 savshrp-3 savshrp-4 savshrp-5 savshrp-6 neuroanatomy defective sav3 small body, with Scer\GAL4da.G32 savScer\UAS.T:Ivir\HA1 stress response defective | somatic clone sav3 visible, with Scer\GAL4pnr-MD237 savGD8128 visible | recessive savshrp-3 visible | somatic clone sav1X1 sav3 savSH13 savshrp-1 savshrp-3 Phenotype manifest in Allele adult head | somatic clone savshrp-1 savshrp-2 savshrp-3 savshrp-4 savshrp-5 savshrp-6 adult Malpighian tubule | somatic clone sav3 adult thorax | somatic clone savshrp-3 cell cycle | somatic clone sav3 chaeta | supernumerary, with Scer\GAL4pnr-MD237 savGD8128 dorsal multidendritic neuron ddaC | somatic clone & dendritic tree sav3 eye savshrp-3 eye | somatic clone sav1 sav2 sav3 sav4 savSH13 savshrp-1 sav1X1 eye disc | cell autonomous | somatic clone savshrp-1 eye disc | somatic clone sav3 savshrp-4 savshrp-5 eye photoreceptor cell | somatic clone sav3 haltere | somatic clone sav3 savshrp-3 mesothoracic tergum, with Scer\GAL4pnr-MD237 savGD8128 mesothoracic tergum | somatic clone sav3 ommatidial precursor cluster | somatic clone savshrp-1 photoreceptor cell R8 of pale ommatidium savshrp-1 photoreceptor cell R8 of yellow ommatidium savshrp-1 pigment cell | ectopic | somatic clone sav1 sav3 pigment cell | somatic clone | supernumerary savshrp-4 trichogen cell, with Scer\GAL4pnr-MD237 savGD8128 wing, with Scer\GAL4Bx-MS1096 savScer\UAS.T:Ivir\HA1 wing disc | somatic clone savshrp-3 savshrp-4
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of sav Class Mutagen Stocks Known lesion sav1 0 Yes sav1X1 0 -- sav2 hypomorphic allele - genetic evidence 0 Yes sav3 loss of function allele 0 Yes sav4 0 Yes savSH13 ethyl methanesulfonate 0 -- savSH8 ethyl methanesulfonate 0 -- savshrp-1 loss of function allele ethyl methanesulfonate 0 Yes savshrp-2 loss of function allele ethyl methanesulfonate 0 Yes savshrp-3 loss of function allele ethyl methanesulfonate 0 Yes savshrp-4 loss of function allele ethyl methanesulfonate 0 Yes savshrp-5 loss of function allele ethyl methanesulfonate 0 Yes savshrp-6 loss of function allele ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sav Class Mutagen Stocks Known lesion savGD16019 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes savGD8128 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes savHMS00760 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes savJF02840 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes savKK107562 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes savAct5C.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes savAct5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes savC1.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes savC2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes savGMR.PT in vitro construct - regulatory fusion 0 Yes savScer\UAS.cEa in vitro construct - regulatory fusion 0 Yes savScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes savshrp6.Act5C.T:Zzzz\FLAG in vitro construct - deletion 0 Yes savWW.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes savΔC1.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes savΔC2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes savΔC3.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6193 (Ryder, 2004.4.26) Df(3R)hh (Tapon et al., 2002, Kango-Singh et al., 2002) Df(3R)M95A (Kango-Singh et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8128} NA P{GD16019} NA P{KK107562} NA P{TRiP.HMS00760} NA P{TRiP.JF02840} NA P{UAS-sav.C1.FLAG} NA P{UAS-sav.C2.FLAG} NA P{UAS-sav.E} NA P{UAS-sav.FLAG} NA P{UAS-sav.WW.FLAG} NA P{UAS-sav.ΔC1.FLAG} NA P{UAS-sav.ΔC2.FLAG} NA P{UAS-sav.ΔC3.FLAG} NA characterization construct P{GMR-sav.T} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with hpo (Polesello et al., 2006) inferred from physical interaction with kibra (Yu et al., 2010) inferred from physical interaction with Mer (Yu et al., 2010)
Biological Process
CV term Evidence References
imaginal disc development inferred from mutant phenotype (Kango-Singh et al., 2002) induction of apoptosis inferred from mutant phenotype (Tapon et al., 2002) Malpighian tubule development inferred from mutant phenotype (Zeng et al., 2010) negative regulation of cell proliferation inferred from mutant phenotype (Kango-Singh et al., 2002) R8 cell fate specification inferred from mutant phenotype (Mikeladze-Dvali et al., 2005) regulation of cell cycle inferred from mutant phenotype (Tapon et al., 2002) regulation of dendrite morphogenesis inferred from genetic interaction with wts (Emoto et al., 2006) regulation of multicellular organism growth inferred from mutant phenotype (Polesello et al., 2006) response to ionizing radiation inferred from mutant phenotype (Colombani et al., 2006) retinal cell programmed cell death inferred from genetic interaction with W AND inferred from mutant phenotype (Tapon et al., 2002) stem cell differentiation inferred from mutant phenotype (Zeng et al., 2010) stem cell proliferation inferred from mutant phenotype (Zeng et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apoptotic process non-traceable author statement (Tapon, 2002.7.12) negative regulation of organ growth traceable author statement (Hafen and Stocker, 2003) regulation of cell cycle non-traceable author statement (Tapon, 2002.7.12) regulation of cell proliferation traceable author statement (Lee and Orr-Weaver, 2003) regulation of imaginal disc growth traceable author statement (Lee and Orr-Weaver, 2003) signal transduction inferred from electronic annotation with InterPro:IPR011524 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sav allele Gene References sav3 hpo (Wu et al., 2003) W (Tapon et al., 2002) sav4 hpo (Wu et al., 2003) savGMR.PT wts (Harvey et al., 2003, Pantalacci, 2003) unspecified p53 (Colombani et al., 2006) Rassf (Polesello et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 76064 DroID - A comprehensive database of gene and protein interactions. • FBgn0053193 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 252554
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18269 Dere\GG12465 Dmoj\GI10759 Dper\GL27353 Dpse\GA27046 Dsec\GM23596 Dsim\GD18409 Dvir\GJ14361 Dwil\GK13578 Dyak\GE23988
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011983-PA Aedes aegypti (mosquito) AGAP004628-PA Anopheles gambiae (mosquito) XP_624790.1 Apis mellifera (honey bee) XP_001948529.1 Acyrthosiphon pisum (pea aphid) 117824 Branchiostoma floridae (lancelet) 125826 Branchiostoma floridae (lancelet) ENSBTAP00000002017 Bos taurus (bovine) CN17888 Caenorhabditis brenneri (small nematode) CBP21063 Caenorhabditis briggsae (nematode) CE39400 Caenorhabditis elegans (worm) ENSCAFP00000021364 Canis familiaris (dog) ENSCINP00000012865 Ciona intestinalis (sea squirt) JA05602 Caenorhabditis japonica (nematode) CPIJ006349 Culex pipens (mosquito) RP20358 Caenorhabditis remanei (nematode) ENSDARP00000025090 Danio rerio (zebra fish) ENSGACP00000015693 Gymnopilus aculeatus (mushroom) ENSGALP00000020137 Gallus gallus (chicken) 182144 Hypsipyla robusta (cedar shoot borer) ENSP00000324729 Homo sapiens (human) ENSMODP00000016401 Monodelphis domestica (gray opossum) ENSMMUP00000032920 Macaca mulatta (rhesus monkey) ENSMUSP00000021467 Mus musculus (house mouse) XP_001602119.1 Nasonia vitripennis (wasp) ENSORLP00000011283 Oryzias latipes (japanese killifish) PP24992 Pristionchus pacificus (nematode) ENSPPYP00000006597 Pongo pygmaeus (orangutan) ENSPTRP00000010732 Pan troglodytes (chimpanzee) ENSRNOP00000007314 Rattus norvegicus (norway rat) XP_971039.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022535 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021996 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057723 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11343 LH23100 FBgn0241130 FBgn0215586 FBgn0201574 FBgn0189934 FBgn0178461 JGI_V11_16039 FBgn0248417 FBgn0164934 FBgn0133522 FBgn0125660 FBgn0119179 FBgn0104753 FBgn0095287 CPIJ006349 BGIBMGA004937 ACYPI008384 GB13186 AGAP004628 AAEL011983 PB21412 PHUM105930 GLEAN_09195
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	28006 y1 v1; P{TRiP.JF02840}attP2 32965 y1 sc* v1; P{TRiP.HMS00760}attP2
VDRC	v101323 P{KK107562}VIE-260B v24801 w1118; P{GD8128}v24801/TM3 v24802 w1118; P{GD8128}v24802/CyO v46445 w1118; P{GD16019}v46445/CyO v46446 w1118; P{GD16019}v46446/CyO
Genomic Clones ( 2 )
	BACR01K08 BACR17P04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 119 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10307
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13124 GH23265 GH23684 GM30584 RE52745
Other clones	Dmel_neb_002233_0908_3545 Dmel_neb_002397_0575_3555 Dmel_neb_009228_0890_0548 EK191405 RP003023598 RP003043527 RP003046033 RP003047667 RP003051081 RP003054191 RP003063708 RP003067929 RP003077523 RP003089268 RP003089439 RP003089595 RP003093277 RP003095078 RP003095658 RP003109238 RP003112977 RP003129688 RP003133379 RP003134297 RP003137128 RP003152665 RP003154417 RP003157282 RP003161286 RP003168212 RP003175936 RP003182630 RP003184994 RP003195131 RP003198076 RP003200512 RP003204792 RP003208636 RP003219800 RP003220992 RP003246925 RP003247775 RP003248880 RP003260493 RP003263947 RP003264386 RP003270545 RP003283200 RP003288225 RP003289235 RP003290676 RP003294498 RP003298940 RP003300915 RP003307834 RP003313055 RP003314893 RP003321277 RP003328947 RP003374081 RP003375462 RP003380773 RP003384448 RP003414985 RP003424295 RP003427256 RP003436727 RP003442396 RP003445097 RP003459372 RP003476836 RP003476988 RP003500144 RP003525132 RP003538259 RP003538287 RP003552734 RP003556314 RP003556622 RP003569200 RP003571660 RP003578352 RP003578665 RP003587789 RP003599827 RP003600279 RP003605973 RP003613419 RP003615929 RP003619729 RP003622497 RP003622581 RP003626412 RP003627033 RP003633467 RP003636192 RP003641438 RP003645249 RP003648132 RP003648509 RP003652558 RP003657391 RP003660645 RP003665974 RP003668913 RP003669689 RP003673746 RP003674857 RP003675983 RP003676876 RP003681516 RP003682361 RP004239103
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053193 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 252554
Antibody Information
Other Information
Discoverer
Etymology
	The gene is called "shar-pei" because of the mutant folded cuticle phenotype in the head, which resembles the folded skin of Shar-pei dogs. (Kango-Singh et al., 2002)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG13831 CG13832 (FlyBase, 1996-) Source for merge of: salvador CG13831 (Tapon, 2002.7.12) Source for merge of: sav anon-WO0172774.152 (FlyBase, 1996-)
Additional comments	Annotations CG13831, CG13832 merged as CG33193 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of sav anon-WO0172774.152 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of CG13831 CG13832 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	sav acts cell autonomously in class IV neurons. (Emoto et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Polesello et al., 2006) sav is required for the proper termination of cell proliferation during imaginal disc development. (Kango-Singh et al., 2002) sav promotes both cell cycle exit and apoptosis. (Tapon et al., 2002) Identification: Isolated as a mutation that causes overgrowth in homozygous clones in the eye. (Tapon and Hariharan, 1999) Mutations in sav abolish developmentally controlled programmed cell death in homozygous clones in the eye. (Tapon and Hariharan, 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176544 NM_001202340 RefSeq (Proteins) • NP_788721 NP_001189269 DDBJ / EMBL / GenBank • AAF56090 AAL39999 AAM97280 ADV37360 AI543516 AW944627 AX260190 AY069854 AY131211 Entrez Gene - A searchable database of RefSeq genes. • 252554 UniProtKB/Swiss-Prot • Q9VCR6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WW/Rsp5/WWP (IPR001202) SARAH (IPR011524)
Linkouts
	BioGRID - A database of protein and genetic interactions • 76064 DroID - A comprehensive database of gene and protein interactions. • FBgn0053193 DRSC - Results from RNAi screens. • FBgn0053193 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053193 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33193-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053193 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 101151 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 252554 InParanoid A subset of ortholog calls from InParanoid. • AAEL011983-PA Aedes aegypti (mosquito) AGAP004628-PA Anopheles gambiae (mosquito) XP_624790.1 Apis mellifera (honey bee) XP_001948529.1 Acyrthosiphon pisum (pea aphid) 117824 Branchiostoma floridae (lancelet) 125826 Branchiostoma floridae (lancelet) ENSBTAP00000002017 Bos taurus (bovine) CN17888 Caenorhabditis brenneri (small nematode) CBP21063 Caenorhabditis briggsae (nematode) CE39400 Caenorhabditis elegans (worm) ENSCAFP00000021364 Canis familiaris (dog) ENSCINP00000012865 Ciona intestinalis (sea squirt) JA05602 Caenorhabditis japonica (nematode) CPIJ006349 Culex pipens (mosquito) RP20358 Caenorhabditis remanei (nematode) ENSDARP00000025090 Danio rerio (zebra fish) ENSGACP00000015693 Gymnopilus aculeatus (mushroom) ENSGALP00000020137 Gallus gallus (chicken) 182144 Hypsipyla robusta (cedar shoot borer) ENSP00000324729 Homo sapiens (human) ENSMODP00000016401 Monodelphis domestica (gray opossum) ENSMMUP00000032920 Macaca mulatta (rhesus monkey) ENSMUSP00000021467 Mus musculus (house mouse) XP_001602119.1 Nasonia vitripennis (wasp) ENSORLP00000011283 Oryzias latipes (japanese killifish) PP24992 Pristionchus pacificus (nematode) ENSPPYP00000006597 Pongo pygmaeus (orangutan) ENSPTRP00000010732 Pan troglodytes (chimpanzee) ENSRNOP00000007314 Rattus norvegicus (norway rat) XP_971039.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022535 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021996 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057723 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/salvadr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 252554 modMine - Data generated by the modENCODE project. • FBgn0053193 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11343 LH23100 FBgn0241130 FBgn0215586 FBgn0201574 FBgn0189934 FBgn0178461 JGI_V11_16039 FBgn0248417 FBgn0164934 FBgn0133522 FBgn0125660 FBgn0119179 FBgn0104753 FBgn0095287 CPIJ006349 BGIBMGA004937 ACYPI008384 GB13186 AGAP004628 AAEL011983 PB21412 PHUM105930 GLEAN_09195
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-WO0172774.152   CG13831 (Kango-Singh et al., 2002, ) CG13832   CG33193 (Giot et al., 2003, Keleman et al., 2009.8.5, Perkins et al., 2009, Formstecher et al., 2005, Ni et al., 2010.12.1) Salvador/Shar-pei (Vidal and Cagan, 2006) sav (Polesello et al., 2006, Tyler et al., 2007, Pantalacci, 2003, Mikeladze-Dvali et al., 2005, Edgar, 2006, Colombani et al., 2006, Bennett and Harvey, 2006, Yu et al., 2008, Fernández et al., 2011, Ohsawa et al., 2011, Firth and Baker, 2005, Sun et al., 2008, Menut et al., 2007, Emoto et al., 2006, Wei et al., 2007, Zhang et al., 2008, Tyler and Baker, 2007, Polesello and Tapon, 2007, Parrish et al., 2007, Dutta and Baehrecke, 2008, Hamaratoglu et al., 2006, Rhiner et al., 2009, Cho et al., 2006, Parrish et al., 2009, Das Thakur et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Baumgartner et al., 2010, Milton et al., 2010, Wasbrough et al., 2010) Sav (Jukam and Desplan, 2007, Polesello and Tapon, 2007, Dong et al., 2007, Polesello et al., 2006, Jukam and Claude, 2008, Hariharan, 2006, Oh and Irvine, 2008, Oh and Irvine, 2009, Zhang et al., 2009, Formstecher et al., 2005, Yu et al., 2010, Yu et al., 2010, Ribeiro et al., 2010, Zeng et al., 2010) shar-pei (Hay and Guo, 2003, Kango-Singh et al., 2003)
Name Synonym	salvador (Tapon et al., 2002, Bennett and Harvey, 2006, Bateman and McNeill, 2005, Xu and Bergmann, 2008, Sun et al., 2008, Menut et al., 2007, Rhiner et al., 2009, Zhang et al., 2009, Cho et al., 2006, Parrish et al., 2009, Milton et al., 2010) Salvador (Colombani et al., 2006, Jukam and Desplan, 2007, Silva et al., 2006, Yu et al., 2008, Polesello et al., 2006, Deng et al., 2008, Hariharan, 2006, Emoto et al., 2006, Polesello and Tapon, 2007, Dutta and Baehrecke, 2008, Das Thakur et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Yu et al., 2010, Ribeiro et al., 2010) salvador/shar-pei (Bergmann and Lane, 2003)
Secondary FlyBase IDs
	FBgn0026180 FBgn0039046 FBgn0039047 FBgn0046446
References ( 104 )
Generate a list of	All references relating to this gene ( 104 )
List References by type	Research paper  ( 47 ) Supplementary material  ( 9 ) Review  ( 18 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 15 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Patent  ( 1 ) Automatic genome annotation  ( 1 ) Conference report  ( 2 )
Recent research papers ( 12 )
	Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Napoletano et al., 2011, EMBO J. 30(5): 945--958 Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. [FBrf0213147] Nicolay et al., 2011, Genes Dev. 25(4): 323--335 Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. [FBrf0214348] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Das Thakur et al., 2010, Curr. Biol. 20(7): 657--662 Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. [FBrf0210592] Grzeschik et al., 2010, Curr. Biol. 20(7): 573--581 Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. [FBrf0210559] Milton et al., 2010, Development 137(5): 735--743 Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. [FBrf0209966] Ribeiro et al., 2010, Mol. Cell 39(4): 521--534 Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling. [FBrf0211636] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Yu et al., 2010, Dev. Cell 18(2): 288--299 Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded. [FBrf0210017] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...