Open Close
General Information
Symbol
Dmel\dpy
Species
D. melanogaster
Name
dumpy
Annotation Symbol
CG33196
Feature Type
FlyBase ID
FBgn0053196
Gene Model Status
Stock Availability
Gene Snapshot
dumpy (dpy) encodes an extracellular protein involved in epidermal-cuticle attachment, aposition of wing surfaces and trachea development. [Date last reviewed: 2019-09-26]
Also Known As

dp, SP460

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:4,477,462..4,614,300 [-]
Recombination map

2-12

RefSeq locus
NT_033779 REGION:4477462..4614300
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
MUCINS -
Mucin/mucin-like proteins are heavily O-glycosylated proteins characterized by proline, threonine and serine tandem repeats. Mucins form extracellular matrix networks or act as mucosal secretion lubricants. (Adapted from FBrf0205867.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
dp: dumpy
thumb
dpo: dumpy-oblique
From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 65.
thumb
dpov: dumpy-oblique vortex
Edith Wallace, unpublished.
dp alleles have variable effects on wing length and shape and on the thoracic cuticle. Presence of wing phenotype indicated by o = oblique in the allelic designation and of thoracic phenotype by v = vortex or cm = comma. The wing effect is an oblique truncation affecting the margins of the first and second posterior cells in weak alleles and reducing wings to approximately half normal length in extreme genotypes, where the truncation is more nearly perpendicular to the long axis of wing. Margins remain intact; angle between veins L2 and L5 increased, and intercrossvein distance decreased. Phenotype resembles rudimentary. Thoracic phenotype comprises five types of hypodermal irregularities: first vortices, second vortices, commas, pre-episternal pits, and posterior invagination; all five have the form of pits, eruptions, or raised pits of the cuticle (Metcalfe, 1970, Genetics 65: 627-54). First vortices are hypodermal pits or eruptions located posterolaterally on the scutum; they disrupt the acrostichal rows, resulting in surrounding whorls of microchaete. Second vortices are located anterolaterally on the scutum and resemble first vortices morphologically. Commas are comma-shaped depressions at the anterior margin of the scutum. The pre-episternal pit is in the pre-episternal plate immediately anterior to the sternopleural chaetae, which sometimes exhibit disturbed orientation (Metcalf, 1969, DIS 44: 91). The posterior invagination occurs between the laterotergite plate and the metanotum (Metcalf, 1969); different alleles exhibit different combinations of these traits. Musculature attached to disturbed regions of the cuticle often degenerates (Metcalfe, 1970). Some alleles show reduced body size and small weak legs (dph, dpobw females, dpolv/dpov). Phenotypic expression enhanced by increased temperature during development; wing and thorax effects show dominance when heterozygotes exposed to increased temperatures at 12-16 and 8-10 hr of pupal life, respectively (Blanc and Child, 1940, Physiol. Zool. 13: 65-72). Normal larvae fed 6-azauracil produce adults with oblique phenocopies; 6-azauracil feeding suppresses dp (Rizki and Rizki, 1965, Science 150: 222-23), su(r) enhances the oblique phenotype (Stroman, 1974, Hereditas 78: 157-68). The four genotypes studied [dpo2, dpovN, dpv2, and dpv; e(dpv)] show increased orotate phosphoribosyl transferase activity during third larval instar and enhanced incorportion of labeled glucose into chitin (Blass and Hunt, 1980, Mol. Gen. Genet. 178: 437-42). Many alleles are lethal when homozygous; they are identified by l in the allelic designation. Lethal stages vary among alleles, e.g., dpolv is embryonic lethal; dplv1, and dplvI die at the egg-larval boundary; dplm homozygotes die primarily at larval ecdysis between the first and second larval instar with some death at hatching and at ecdysis of second-instar larvae; dpobm homozygotes die mostly at hatching but a few die during first and second larval instars (Metcalfe, 1971, Genet. Res. 17: 173-83). In Me/+ heterozygotes, many dp alleles show a dominant oblique effect when heterozygous for dp+ and dp; dpv is an exception (Carlson, 1959). dpv homozygotes normal; show thoracic phenotype only if third chromosomes homozygous for e(dpv).
Gene Model and Products
Number of Transcripts
16
Number of Unique Polypeptides
16

Please see the GBrowse view of Dmel\dpy or the JBrowse view of Dmel\dpy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0332355
59206
19560
FBtr0305141
47440
15638
FBtr0305142
48068
15105
FBtr0305145
26263
8579
FBtr0332343
68745
22743
FBtr0332344
62656
20710
FBtr0332345
71382
22949
FBtr0332346
69016
22830
FBtr0332347
56449
18641
FBtr0332348
69435
22300
FBtr0332349
67506
21657
FBtr0332350
63747
20404
FBtr0332351
56567
18014
FBtr0332352
47000
14825
FBtr0332353
54801
18095
FBtr0332354
50529
15998
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0304632
2082.0
19560
4.77
FBpp0293671
1662.7
15638
4.68
FBpp0293672
1606.4
15105
4.65
FBpp0293675
915.9
8579
5.21
FBpp0304620
2421.1
22743
4.89
FBpp0304621
2204.3
20710
4.89
FBpp0304622
2443.4
22949
4.91
FBpp0304623
2430.9
22830
4.91
FBpp0304624
1986.2
18641
5.40
FBpp0304625
2373.9
22300
4.88
FBpp0304626
2306.1
21657
4.87
FBpp0304627
2176.1
20404
4.97
FBpp0304628
1915.8
18014
4.70
FBpp0304629
1576.3
14825
4.63
FBpp0304630
1927.0
18095
5.35
FBpp0304631
1702.8
15998
5.16
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dpy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097
(assigned by InterPro )
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence model
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dpy in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 309 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dpy
Transgenic constructs containing regulatory region of dpy
Deletions and Duplications ( 57 )
Disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
thorax & microchaeta
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (45)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
3 of 15
Yes
Yes
3 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (39)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
3 of 15
Yes
Yes
3 of 15
Yes
Yes
3 of 15
Yes
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
 
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (34)
3 of 13
Yes
Yes
3 of 13
Yes
Yes
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
2 of 12
Yes
Yes
2 of 12
Yes
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (34)
2 of 15
Yes
Yes
2 of 15
Yes
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (35)
5 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
1 of 9
Yes
Yes
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
1 of 12
Yes
Yes
1 of 12
Yes
Yes
1 of 12
Yes
No
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190000 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150000 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0000 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0005 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G000C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (15)
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    enhanceable
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map

    2-12

    Cytogenetic map
    Sequence location
    2L:4,477,462..4,614,300 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    24F4-25A1
    Limits computationally determined from genome sequence between P{lacW}Tps1k08903&P{EP}morgueEP1184 and P{lacW}l(2)k10004k10004&P{EP}CG3036EP963
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    24F-25A
    (determined by in situ hybridisation)
    Maps in or near 25A3--25A4.
    Experimentally Determined Recombination Data
    Left of (cM)
    Notes
    Stocks and Reagents
    Stocks (402)
    Genomic Clones (53)
    cDNA Clones (88)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: dpy dp

    Source for database merge of

    Source for merge of: dp CG15637

    Source for merge of: dp BcDNA:SD02173

    Additional comments

    Renamed from 'dp' to 'dpy' to minimise confusion with the 'Dp' (' DP transcription factor') gene symbol, from which it differed only by case.

    Source for merge of dp BcDNA:SD02173 was a shared cDNA ( date:030728 ).

    One, two, or three of the phenotypic attributes of dp (o, l, or v) may be expressed in an allele, and alleles are classified according to which attributes they exhibit; the information is generally included in the superscript designation; the order olv is roughly in accord with map order. As a rule, the heteroallelic combination of any two alleles exhibits only phenotypic features common to the two alleles <up>e.g., dpo/dpv is normal, and dpov1/dplv1 exhibits thoracic but not wing abnormalities (Carlson, 1959)</up>. Partial complementations between some pairs of olv and l or lv alleles are exceptions to this rule (Carlson, 1959; Grace, 1980).

    Other Comments

    dp is essential for the integrity of the inner layer of the apical extracellular matrix and its link to the the apical surface of the epidermis in the embryo.

    New annotation (CR33195) in release 3 of the genome annotation.

    The dp gene encodes the longest transcript and protein in the Release 3 Genome Annotation.

    The dp gene is extraordinarily large and encodes a 70kb cDNA which codes for a 2.5 MDa extracellular matrix protein.

    9 alleles of dp have been isolated in a genetic screen for autosomal mutations that produce blisters in somatic wing clones.

    Phenotypic variation of the genetic components underlying oviposition behaviour is analysed using the complete diallel mating design.

    Recombination between alleles belonging to the same or different phenotypic classes allows construction of genetic map with clusters of discontinuously distributed alleles; o and olv alleles found in several clusters, other phenotypic classes confined to a single cluster.

    dp alleles have variable effects on wing length and shape and on the thoracic cuticle. Presence of wing phenotype indicated by o = oblique in the allelic designation and of thoracic phenotype by v = vortex or cm = comma. The wing effect is an oblique truncation affecting the margins of the first and second posterior cells in weak alleles and reducing wings to approximately half normal length in extreme genotypes, where the truncation is more nearly perpendicular to the long axis of wing. Margins remain intact; angle between veins L2 and L5 increased and intercrossvein distance decreased. Phenotype resembles rudimentary. Thoracic phenotype comprises five types of hypodermal irregularities: first vortices, second vortices, commas, pre-episternal pits and posterior invagination; all five have the form of pits, eruptions, or raised pits of the cuticle (Metcalfe, 1970). First vortices are hypodermal pits or eruptions located posterolaterally on the scutum; they disrupt the acrostichal rows, resulting in surrounding whorls of microchaete. Second vortices are located anterolaterally on the scutum and resemble first vortices morphologically. Commas are comma-shaped depressions at the anterior margin of the scutum. The pre-episternal pit is in the pre-episternal plate immediately anterior to the sternopleural chaetae, which sometimes exhibit disturbed orientation (Metcalf, 1969). The posterior invagination occurs between the laterotergite plate and the metanotum (Metcalf, 1969); different alleles exhibit different combinations of these traits. Musculature attached to disturbed regions of the cuticle often degenerates (Metcalfe, 1970). Some alleles show reduced body size and small weak legs (dpovh, dpobw females, dpolv/dpov1). Phenotypic expression enhanced by increased temperature during development; wing and thorax effects show dominance when heterozygotes exposed to increased temperatures at 12-16 and 8-10 hr of pupal life, respectively (Blanc and Child, 1940). Normal larvae fed 6-azauracil produce adults with oblique phenocopies; 6-azauracil feeding suppresses dp (Rizki and Rizki, 1965), su(r) enhances the oblique phenotype (Stroman, 1974). The four genotypes studied <up>dpo2, dpovN, dpv2 and dpv; e(dpv)</up> show increased orotate phosphoribosyl transferase activity during third larval instar and enhanced incorporation of labeled glucose into chitin (Blass and Hunt, 1980). Many alleles are lethal when homozygous; they are identified by l in the allelic designation. Lethal stages vary among alleles, e.g., dpolv is embryonic lethal; dplv1 and dplvI die at the egg-larval boundary; dplm homozygotes die primarily at larval ecdysis between the first and second larval instar with some death at hatching and at ecdysis of second-instar larvae; dpobm homozygotes die mostly at hatching but a few die during first and second larval instars (Metcalfe, 1971). In Me/+ heterozygotes, many dp alleles show a dominant oblique effect when heterozygous for dp+ and dp; dpv is an exception (Carlson, 1959). dpv homozygotes normal; show thoracic phenotype only if third chromosomes homozygous for e(dpv).

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 116 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    PDB - An information portal to biological macromolecular structures
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (31)
    Reported As
    Symbol Synonym
    BcDNA:SD02173
    CG31724
    CG31725
    CG31726
    CG31727
    CG31964
    CG31965
    CG31966
    CG31967
    CG31968
    CG33000
    CG33086
    CR33195
    Q8IQ18_DROME
    l(2)24Fd
    olvD
    Secondary FlyBase IDs
    • FBgn0000488
    • FBgn0029129
    • FBgn0031612
    • FBgn0051724
    • FBgn0051725
    • FBgn0051726
    • FBgn0051727
    • FBgn0051964
    • FBgn0051965
    • FBgn0051966
    • FBgn0051967
    • FBgn0051968
    • FBgn0053000
    • FBgn0053195
    • FBgn0062896
    • FBgn0063623
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (255)