Gene Dmel\dp
| General Information | ||||
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| Symbol | Dmel\dp | Species | D. melanogaster | |
| Name | dumpy | Annotation symbol | CG33196 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0053196 | |
| Created / Updated | 2004-08-10/2004-08-10 | |||
| Genomic Location | ||||
| Chromosome (arm) | 2L | Recombination map | 2-13.0 | |
| Cytogenetic map | 24F4-25A1 | Sequence location | 2L:4,479,471..4,591,963 [-] | |
| Map ( GBrowse ) |
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Summary Information
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Automatically generated summary
See sections below for more information | The gene dumpy is referred to in FlyBase by the symbol dp (CG33196, FBgn0053196). It has the cytological map location 24F4-25A1. Its sequence location is 2L:4479471..4591963. Its molecular function is described as: electron carrier activity; endonuclease activity; zinc ion binding; 4 iron, 4 sulfur cluster binding; calcium ion binding; serine-type endopeptidase inhibitor activity. It is involved in the biological processes: chitin-based embryonic cuticle biosynthetic process; chitin-based cuticle attachment to epithelium; apposition of dorsal and ventral imaginal disc-derived wing surfaces; open tracheal system development. 268 alleles are reported. The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: adult segment; organ system; embryonic/larval tracheal system; adult mesothoracic segment; adult; thoracic segment; tracheal system; peripheral nervous system; nervous system; adult tracheal system; lateral trunk posterior branch. It has one annotated transcript and one annotated polypeptide. | |||
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | dp: dumpy
dp alleles have variable effects on wing length and
shape and on the thoracic cuticle. Presence of wing phenotype
indicated by o = oblique in the allelic designation and of
thoracic phenotype by v = vortex or cm = comma. The wing
effect is an oblique truncation affecting the margins of the
first and second posterior cells in weak alleles and reducing
wings to approximately half normal length in extreme genotypes, where the truncation is more nearly perpendicular to
the long axis of wing. Margins remain intact; angle between
veins L2 and L5 increased, and intercrossvein distance
decreased. Phenotype resembles rudimentary. Thoracic phenotype comprises five types of hypodermal irregularities: first
vortices, second vortices, commas, pre-episternal pits, and
posterior invagination; all five have the form of pits, eruptions, or raised pits of the cuticle (Metcalfe, 1970, Genetics
65: 627-54). First vortices are hypodermal pits or eruptions
located posterolaterally on the scutum; they disrupt the
acrostichal rows, resulting in surrounding whorls of microchaete. Second vortices are located anterolaterally on the
scutum and resemble first vortices morphologically. Commas
are comma-shaped depressions at the anterior margin of the
scutum. The pre-episternal pit is in the pre-episternal plate
immediately anterior to the sternopleural chaetae, which sometimes exhibit disturbed orientation (Metcalf, 1969, DIS
44: 91). The posterior invagination occurs between the
laterotergite plate and the metanotum (Metcalf, 1969); different alleles exhibit different combinations of these traits.
Musculature attached to disturbed regions of the cuticle often
degenerates (Metcalfe, 1970). Some alleles show reduced body
size and small weak legs (dph, dpobw females, dpolv/dpov).
Phenotypic expression enhanced by increased temperature during
development; wing and thorax effects show dominance when
heterozygotes exposed to increased temperatures at 12-16 and
8-10 hr of pupal life, respectively (Blanc and Child, 1940,
Physiol. Zool. 13: 65-72). Normal larvae fed 6-azauracil
produce adults with oblique phenocopies; 6-azauracil feeding
suppresses dp (Rizki and Rizki, 1965, Science 150: 222-23),
su(r) enhances the oblique phenotype (Stroman, 1974, Hereditas
78: 157-68). The four genotypes studied [dpo2, dpovN, dpv2,
and dpv; e(dpv)] show increased orotate phosphoribosyl
transferase activity during third larval instar and enhanced
incorportion of labeled glucose into chitin (Blass and Hunt,
1980, Mol. Gen. Genet. 178: 437-42). Many alleles are lethal
when homozygous; they are identified by l in the allelic
designation. Lethal stages vary among alleles, e.g., dpolv is
embryonic lethal; dplv1, and dplvI die at the egg-larval boundary; dplm homozygotes die primarily at larval ecdysis between
the first and second larval instar with some death at hatching
and at ecdysis of second-instar larvae; dpobm homozygotes die
mostly at hatching but a few die during first and second larval instars (Metcalfe, 1971, Genet. Res. 17: 173-83).
In Me/+ heterozygotes, many dp alleles show a dominant
oblique effect when heterozygous for dp+ and dp; dpv is an
exception (Carlson, 1959). dpv homozygotes normal; show
thoracic phenotype only if third chromosomes homozygous for
e(dpv).
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 24F4-25A1
Limits computationally determined from genome sequence between P{lacW}Tps1k08903&P{EP}morgueEP1184 and P{lacW}l(2)k10004k10004&P{EP}CG3036EP963
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| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 25A1-25A2 24F-25A (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | ||||
| Location | 2-13.0 2-13 | |||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | ||||
Gene Model & Products
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Please see the
GBrowse view of
Dmel\dp
for information on other features
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| Comments on Gene Model | ||||
Transcript Data
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| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0290006
69439
22971 | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | ||||
| Comments | ||||
| External Data | ||||
| Crossreferences | ||||
Polypeptide Data
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| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0288445
2446.0
22971
4.91
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| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | ||||
| Comments | ||||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Aspartic acid and asparagine hydroxylation site (IPR000152)
EGF-like, type 3 (IPR000742)
Endoglin/CD105 antigen (IPR001507)
EGF-like calcium-binding (IPR001881)
Follistatin-like, N-terminal (IPR003645)
YLP motif (IPR004019)
EGF-like (IPR006209)
EGF (IPR006210)
Zinc finger, C2H2-type (IPR007087)
Concanavalin A-like lectin/glucanase (IPR008985)
EGF-like region, conserved site (IPR013032)
EGF calcium-binding (IPR013091)
Proteinase inhibitor I7, squash (IPR000737)
Iron-sulphur cluster loop (IPR003651)
Cysteine-rich repeat (IPR006150)
PDB
- Protein Data Bank. An information portal to biological macromolecular structures
• | |||
Sequences Consistent with the Gene Model
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| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | |||
| UniProtKB/Swiss-Prot | ||||
| UniProtKB/TrEMBL | ||||
| Maps to | ||||
| Does NOT map to | ||||
| Identified with | ||||
Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References | ||||
External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
• | |||
| Crossreferences | ||||
Expression Data
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| FlyBase-Curated Data | ||||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | |||
Summary of Transcript Expression
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Stage Tissue/Position
Reference
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| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | ||||
Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | ||||
Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele
Other Phenotypes Allele
Sterility Allele Phenotype manifest in Allele
adult thorax & adult epidermis
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Stage(s)
9-10
Stage(s)
11-12
Stage(s)
13-16