flavoprotein monooxygenase - large, multidomain protein expressed in axons - interacts with the neuronal Plexin A - enzymatic function required for Semaphorin 1a/PlexA-mediated repulsive axon guidance
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Shares 5' UTR with nested gene (one isoform in each case).
Gene model reviewed during 5.49
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.42
Gene model reviewed during 6.02
Interacts with plexA.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mical using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mical in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mical has a cell-autonomous role in dendrite pruning and is specifically required for dendrite severing of class I and IV dendritic arborization neurons, but is dispensable for neuronal apoptosis in other apoptotic dendritic arborization neurons during early metamorphosis.
Gene is named "milchstrasse" (German for "milky way") based on the resemblance of bouton accumulations (marked with a fluorescent protein) to star clusters or galaxies at the neuromuscular junctions of mutant larvae.