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Gene Dmel\Ste:CG33247

General Information
Symbol	Dmel\Ste:CG33247	Species	D. melanogaster
Name	Ste:CG33247	Annotation symbol	CG33247
Feature type	protein_coding_gene	FlyBase ID	FBgn0053247
Gene Model Status	Current	Stock availability	None publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	12D3-12D3	Sequence location	X:13,940,805..13,941,528 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ste:CG33247 is referred to in FlyBase by the symbol Dmel\Ste:CG33247 (CG33247, FBgn0053247). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein kinase regulator activity. Based on sequence similarity, it is predicted to be involved in the biological process: spermatogenesis; regulation of protein kinase activity. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Casein kinase II, regulatory subunit; Casein kinase II, regulatory subunit, alpha-helical; Casein kinase II, regulatory subunit, beta-sheet. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages. CAVEAT: These RNA-Seq temporal profiles depend upon RNA-Seq reads that are uniquely placed in the genome. For this reason, genes such as histones, Stellates and many classes of RNA genes that are present in multiple exact or near exact copies in the genome, expression levels may be reported as much lower than their true values. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Ste:CG33247. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Ste:CG33247. Gene sequence location is X:13940805..13941528.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12D3-12D3   Limits computationally determined from genome sequence between P{EP}EP1595EP1595 and P{EP}l(1)G0007EP764 12D3
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ste:CG33247 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Represents one of the multicopy Ste genes.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ste:CG33247-RB FBtr0300096  NM_206698   607   172
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ste:CG33247-PB   FBpp0289373   19.5   172   7.88     NP_996421   AAS65327
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Casein kinase II, regulatory subunit (IPR000704) Casein kinase II, regulatory subunit, alpha-helical (IPR016149) Casein kinase II, regulatory subunit, beta-sheet (IPR016150)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAS65327   AY118877
UniProtKB/Swiss-Prot	Q7KV23
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053247 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32605-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Ste:CG33247 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ste:CG33247 Class Mutagen Stocks Known lesion Ste:CG33247KK116026 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK116026} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
protein kinase regulator activity inferred from sequence or structural similarity with InterPro:IPR000704 AND inferred from sequence or structural similarity with UniProtKB:P13862 (FlyBase Genome Annotators, 2004)
Biological Process
CV term Evidence References
regulation of protein kinase activity inferred from sequence or structural similarity with UniProtKB:P13862 (FlyBase Genome Annotators, 2004) spermatogenesis inferred from sequence or structural similarity with UniProtKB:P15021 (assigned by UniProtKB) (UniProtKB Project Members, 2005.7.5)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity with UniProtKB:P15021 (assigned by UniProtKB) (UniProtKB Project Members, 2005.7.5) nucleus inferred from sequence or structural similarity with UniProtKB:P15021 (assigned by UniProtKB) (UniProtKB Project Members, 2005.7.5) protein kinase CK2 complex inferred from sequence or structural similarity with InterPro:IPR000704 AND inferred from sequence or structural similarity with UniProtKB:P13862 (FlyBase Genome Annotators, 2004)
Sequence Ontology: Class of Gene
	member_gene_array   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ste:CG33247 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0053247 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768904
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR22M24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM31840
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053247 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768904
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Member gene of	Ste
Additional comments	Annotation CG32605 split into 12 annotations, each representing a member of the Ste cluster, in release 3.2 of the genome annotation. The 12 annotations are: Ste:CG33236, Ste:CG33237, Ste:CG33238, Ste:CG33239, Ste:CG33240, Ste:CG33241, Ste:CG33242, Ste:CG33243, Ste:CG33244, Ste:CG33245, Ste:CG33246 and Ste:CG33247. (FlyBase Genome Annotators, 2004)
Other Comments
	New annotation (CG32605) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206698 RefSeq (Proteins) • NP_996421 DDBJ / EMBL / GenBank • AAS65327 Entrez Gene - A searchable database of RefSeq genes. • 2768904 UniProtKB/Swiss-Prot • Q7KV23
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Casein kinase II, regulatory subunit (IPR000704) Casein kinase II, regulatory subunit, alpha-helical (IPR016149) Casein kinase II, regulatory subunit, beta-sheet (IPR016150)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0053247 DRSC - Results from RNAi screens. • FBgn0053247 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053247 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32605-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053247 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768904 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768904 modMine - Data generated by the modENCODE project. • FBgn0053247
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG32605   CG33247 (Keleman et al., 2009.8.5) Ste:CG33247 (UniProtKB Project Members, 2005.7.5)
Name Synonym	Ste:CG33247
Secondary FlyBase IDs
	FBgn0052605
References ( 8 )
Research paper	Kogan et al., 2012, PLoS ONE 7(5): e37738 Expansion and evolution of the X-linked testis specific multigene families in the melanogaster species subgroup. [FBrf0219650] Olenkina et al., 2012, Biokhimiya 77(11): 1285--1293 Mapping of cis-Regulatory Sites in the Promoter of Testis-Specific Stellate Genes of Drosophila melanogaster. [FBrf0220225] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
FlyBase analysis	FlyBase Genome Annotators, 2004, Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. [FBrf0166453] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
Protein sequence record	UniProtKB Project Members, 2005.7.5, UniProtKB: Q7KV23 Stellate protein CG33247. [FBrf0198874]