Gene Dmel\Nmdar2

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ionotropic glutamate receptor (IPR001320)

NMDA receptor (IPR001508)

Extracellular ligand-binding receptor (IPR001828)

Extracellular solute-binding protein, family 3 (IPR001638)

Glutamate receptor, L-glutamate/glycine-binding (IPR019594)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval central nervous system | ubiquitous

(Volkner et al., 2000)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | punctate & ubiquitous

neuron | subset of adult brain

(Chen et al., 2012)

dorsal anterior lateral neuron of the protocerebrum

(Chen et al., 2012)

ring neuron R4m

adult brain | faint & ubiquitous

calyx of adult mushroom body

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

Additional Descriptive Data

Nmdar1 protein is expressed throughout the adult brain but more strongly in some cells. Staining is punctate which suggests synaptic localisation. Cells more strongly stained include four pairs of dorsal posterior medial DPM4 neurons (where it co-localises with Nmdar1 protein) and one pair of dorsal anterior lateral DAL2 neurons.

Marker for

Subcellular Localization (GO Cellular Component)

CV term

References

integral to membrane

inferred from direct assay

ionotropic glutamate receptor complex

inferred from physical interaction with Nmdar1

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		28
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		(28)
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		28
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		28
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		28
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		28
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		28
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		22
central nervous system, pupae P8		28
head, virgin 1-day female		18
head, virgin 4-day female		17
head, virgin 20-day female		7
head, mated 1-day female		19
head, mated 4-day female		12
head, mated 20-day female		7
head, mated 1-day male		26
head, mated 4-day male		19
head, mated 20-day male		14
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		1
fat body, pupae P8		5
carcass, larvae L3 wandering		3
carcass, 1-day adult		1
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		1
embryo 12-14hr		1
embryo 14-16hr		3
embryo 16-18hr		5
embryo 18-20hr		7
embryo 20-22hr		8
embryo 22-24hr		10
larva L1		8
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		3
pupae 3d postWPP		4
pupae 4d postWPP		3
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		2
embryonic GM2		1
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(Graveley et al., 2011)

mE1_20_mRNA_expression_cluster_13

External Data & Images

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0053513

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG14794-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Nmdar2^GD3192

viable, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Nmdar2^GD1621

viable, with Scer\GAL4^pnr-MD237

Nmdar2^GD1621

Other Phenotypes

Allele

memory defective, with Scer\GAL4^ey-OK107

Nmdar2^{dsRNA.Scer\UAS.cWa}

memory defective, with Scer\GAL4^Feb170

neuroanatomy defective | larval stage, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

touch sensitivity defective, with Scer\GAL4^109(2)80

Nmdar2^GD3192

touch sensitivity defective, with Scer\GAL4^1003.3

Nmdar2^GD3192

touch sensitivity defective | larval stage, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

Phenotype manifest in

Allele

dorsal multidendritic neuron ddaA | larval stage, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

sensory dendrite | larval stage, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of Nmdar2	Class	Mutagen	Stocks	Known lesion
Nmdar2^MB09441			1	--
Nmdar2^MI03069			1	--

Alleles Carried on Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Nmdar2	Mutagen	Stocks	Known lesion
Nmdar2^GD3192	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Nmdar2^GD1621	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Nmdar2^HMS02012	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Nmdar2^HMS02176	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Nmdar2^JF02044	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Nmdar2^{dsRNA.Scer\UAS.cWa}	in vitro construct - regulatory fusion in vitro construct - RNAi	0	Yes
Nmdar2^GD3191	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Nmdar2^NIG.14794R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Nmdar2^Scer\UAS.cWa	in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(1)Exel8196

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap binary system

Mi{ET1}Nmdar2^MB09441

miscellaneous insertions

Mi{MIC}Nmdar2^MI03069

Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )

Terms Based on Experimental Evidence ( 7 terms )

Molecular Function

CV term

References

contributes_to
N-methyl-D-aspartate selective glutamate receptor activity

inferred from direct assay

Biological Process

CV term

ionotropic glutamate receptor signaling pathway

References

inferred from direct assay

long-term memory

inferred from genetic interaction with Nmdar1

(Chen et al., 2012)

inferred from mutant phenotype

medium-term memory

inferred from mutant phenotype

sensory perception of touch

inferred from mutant phenotype

(Tsubouchi et al., 2012)

Cellular Component

CV term

References

integral to membrane

inferred from direct assay

ionotropic glutamate receptor complex

inferred from physical interaction with Nmdar1

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

extracellular-glutamate-gated ion channel activity

References

inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR001508, InterPro:IPR019594

(FlyBase Curators et al., 2004-)

N-methyl-D-aspartate selective glutamate receptor activity

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000, EDGP Project Members, 1994-)

Biological Process

CV term

(FlyBase Curators et al., 2004-)

References

ion transport

inferred from electronic annotation with InterPro:IPR001508

Cellular Component

CV term

outer membrane-bounded periplasmic space

References

inferred from electronic annotation with InterPro:IPR001638

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Nmdar2 allele

Gene

References

External Data

y¹ v¹; P{TRiP.JF02044}attP2

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0053513

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

31107

Orthologs

OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG676KJH

Dipteran inclusive ortholog search

EOG67M25W

Insect inclusive ortholog search

EOG65MM16

Arthropod inclusive ortholog search

EOG61RN8T

Metazoa inclusive ortholog search

EOG65BD77

Orthologs in Drosophila Species (EOG676KJH)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13251

Drosophila persimilis

Dper\GL14372

Drosophila willistoni

Dwil\GK18818

Drosophila willistoni

Dwil\GK14575

Drosophila virilis

Dvir\GJ15548

Drosophila mojavensis

Dmoj\GI16039

Drosophila grimshawi

Dgri\GH17573

Orthologs in non-Drosophila Dipterans (EOG67M25W)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013695

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008090

Anopheles gambiae

Malaria mosquito

Agam\AGAP012429

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013901

Orthologs in non-Dipteran Insects (EOG65MM16)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB48097

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012232

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH21723

Atta cephalotes

Leafcutter ant

Acep\ACEP27859

Atta cephalotes

Leafcutter ant

Acep\ACEP20494

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO17356

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL17854

Linepithema humile

Argentine ant

Lhum\LH15719

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB21237

Solenopsis invicta

Red fire ant

Sinv\SINV10327

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008628

Bombyx mori

Silkmoth

Bmor\BGIBMGA011691

Pediculus humanus

Human body louse

Phum\PHUM390530

Pediculus humanus

Human body louse

Phum\PHUM390520

Tribolium castaneum

Red flour beetle

Tcas\TC003802

Orthologs in non-Insect Arthropods (EOG61RN8T)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_105549

Daphnia pulex

Water flea

Dpux\YWHAQ

Ixodes scapularis

Deer tick

Isca\ISCW005598

Orthologs in non-Arthropod Metazoa (EOG65BD77)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\T01C3.10

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13251

Drosophila persimilis

Dper\GL14372

Drosophila willistoni

Dwil\GK14575

Drosophila virilis

Dvir\GJ15548

Drosophila mojavensis

Dmoj\GI16039

Drosophila grimshawi

Dgri\GH17573

Stocks & Reagents

Stocks Listed in FlyBase ( 8 )

Bloomington

29884

Mi{ET1}Nmdar2^MB09441 w¹¹¹⁸

26019

36432

y¹ Mi{MIC}Nmdar2^MI03069 w^*

40846

y¹ sc^* v¹; P{TRiP.HMS02012}attP2

40928

y¹ sc^* v¹; P{TRiP.HMS02176}attP40

VDRC

v12189

w¹¹¹⁸; P{GD3192}v12189

v3196

w¹¹¹⁸; P{GD1621}v3196/TM3

v12187

w¹¹¹⁸; P{GD3192}v12187/CyO

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 15 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

DRSC - Results from RNAi screens.

•

FBgn0053513

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

31107

Antibody Information

monoclonal

polyclonal

(FlyBase Genome Annotators, 2005)

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: Nmdar2 EG:80H7.7

(Volkner et al., 2000)

Source for database merge of

Source for merge of: Nmdar2 CG14794

Additional comments

Annotations CG14793 and CG14794 merged as CG33513 (which corresponds to Nmdar2) in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

Entrez Gene - A searchable database of RefSeq genes.

•

31107

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ionotropic glutamate receptor (IPR001320)

NMDA receptor (IPR001508)

Extracellular ligand-binding receptor (IPR001828)

Extracellular solute-binding protein, family 3 (IPR001638)

Glutamate receptor, L-glutamate/glycine-binding (IPR019594)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0053513

DRSC - Results from RNAi screens.

•

FBgn0053513

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0053513

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG14794-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0053513

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

31107

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

•

/hjmuller/nmda1.htm

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

31107

modMine - Data generated by the modENCODE project.

•

FBgn0053513

Synonyms & Secondary IDs ( 17 )

Reported As

Symbol Synonym

79G8T

(Louis et al., 1997)

anon-sts34

CG14793

(Benos, 2000.12.13, Tsubouchi et al., 2012)

CG14794

CG33513

(Lee et al., 2009, Perkins et al., 1.15.2009, Benton et al., 2009, Croset et al., 2010, Ni et al., 2010.12.1)

CT34603

(Littleton and Ganetzky, 2000)

DmelNmdar2

(Croset et al., 2010)

dnmdar-II

(Volkner et al., 2000)

dNR2

(Xia et al., 2005, Glanzman, 2005, Xia et al., 2007, Chen et al., 2012, Tamura et al., 2010, Wu et al., 2007, Larkin et al., 2010)

DrNR2

(Fu et al., 2001)

EG:80H7.7

(Chiang et al., 2002, Benos et al., 2001, Madueno et al., 1995, )

ESTS:79G8T

Nmdar2

(Wu et al., 2007, Benton et al., 2009, Singh et al., 2010, Tsubouchi et al., 2012, Croset et al., 2010, Tsubouchi et al., 2012, Japanese National Institute of Genetics, 2012.5.21)

NMDAR2

(Malik et al., 2008)

NR2

(Zachepilo et al., 2008)

Name Synonym

dNR2