FB2021_06, released December 14, 2021

Gene: Dmel\Dop2R

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General Information
Symbol
Dmel\Dop2R
Species
D. melanogaster
Name
Dopamine 2-like receptor
Annotation Symbol
CG33517
Feature Type
protein_coding_gene
FlyBase ID
FBgn0053517
Gene Model Status
Current
Stock Availability
22 publicly available
Gene Summary
Dopamine 2-like receptor (Dop2R) encodes a G protein-coupled receptor that is activated by dopamine. Postulated Dop2R-mediated functions include regulation of: aggression, cardiac function, feeding, levels of juvenile hormone and 20-hydroxyecdysone, lifespan, locomotor activity, nocturnal activity, olfactory associative learning, response to stress, sleep and sucrose acceptance. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

D2R, DD2R

Key Links
Genomic Location
Cytogenetic map
19A4-19A4
Sequence location
Recombination map
1-64
RefSeq locus
NC_004354 REGION:20004680..20062706
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go
inferred from direct assay
(assigned by UniProt )
(Hearn et al., 2002)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go
inferred from biological aspect of ancestor with PANTHER:PTN000664816
(assigned by GO_Central )
(Gaudet et al., 2011)
enables G protein-coupled amine receptor activity
inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573
(Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in anesthesia-resistant memory
inferred from mutant phenotype
(Scholz-Kornehl and Schwärzel, 2016)
involved_in dopamine receptor signaling pathway
inferred from direct assay
(assigned by UniProt )
(Hearn et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001205212
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573
(Brody and Cravchik, 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
non-traceable author statement
(assigned by UniProt )
(Hearn et al., 2002)
inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573
(Brody and Cravchik, 2000)
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (Q8IS44)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Dopamine 2-like receptor (Dop2R) encodes a G protein-coupled receptor that is activated by dopamine. Postulated Dop2R-mediated functions include regulation of: aggression, cardiac function, feeding, levels of juvenile hormone and 20-hydroxyecdysone, lifespan, locomotor activity, nocturnal activity, olfactory associative learning, response to stress, sleep and sucrose acceptance. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
DOPAMINE RECEPTORS -
Dopamine GPCRs are Class A GPCRs. Dopamine is a neurotransmitter involved in a variety of behavioural and physiological functions such as memory, arousal and mating behaviour. (Adapted from PMID:17088868 and FBrf0219823).
Protein Function (UniProtKB)
Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
(UniProt, Q8IS44)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\Dop2R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dop2R-RB
FBtr0070034
NM_001014759
4359
466
Dop2R-RF
FBtr0343167
NM_001014757
5461
760
Dop2R-RG
FBtr0343168
NM_001298548
5756
897
Dop2R-RH
FBtr0343169
NM_001014758
5896
905
Dop2R-RI
FBtr0343170
NM_001014760
5893
904
Dop2R-RJ
FBtr0343171
NM_001031909
5596
805
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Dop2R-PB
FBpp0099563
51.0
466
9.59
NP_001014759
AAF45375
Dop2R-PF
FBpp0309861
80.2
760
4.76
NP_001014757
AAX52463
Dop2R-PG
FBpp0309862
94.2
897
5.03
NP_001285477
AHN59947
Dop2R-PH
FBpp0309863
95.1
905
5.03
NP_001014758
AAX52464
Dop2R-PI
FBpp0309864
95.0
904
5.03
NP_001014760
AAX52462
Dop2R-PJ
FBpp0309865
85.2
805
5.06
NP_001027080
AAZ52487
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop2R using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval ventral nerve cord | restricted
(Draper et al., 2007)
larval thoracic segment | dorsal | restricted | ventral
(Draper et al., 2007)
larval abdominal segment | dorsal | restricted
(Draper et al., 2007)
embryonic/larval brain | restricted
(Draper et al., 2007)
embryonic/larval posterior midgut | restricted
(Draper et al., 2007)
embryonic/larval anterior midgut | restricted
(Draper et al., 2007)
embryonic/larval anterior Malpighian tubule | restricted
(Draper et al., 2007)
adult stage
adult ventral nerve cord | restricted
(Draper et al., 2007)
adult deutocerebrum | restricted
(Draper et al., 2007)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

In the dorsal aspect of the larval VNC, D2R is expressed in a series of 11 paired neurons, one in each of the three thoracic segments and 8 abdominal segments, and are often in close proximity to dopaminergic cells. In the ventral aspect of the ventral nerve cord, one pair of D2R positive cells are found in each of the larval thoracic segments. In adults, D2R is expressed in three pairs of dorsal neurons within each thoracic segment of the ventral ganglion, and in a U-shaped cluster of cells in the abdominal neuromere.

(Draper et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dop2R in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dop2R
Transgenic constructs containing regulatory region of Dop2R
Aberrations (Deficiencies and Duplications) ( 2 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal feeding behavior, with Scer\GAL4elav-C155
abnormal feeding behavior, with Scer\GAL4l.Trh.PK
abnormal locomotor behavior, with Scer\GAL4Act5C.PI
abnormal locomotor behavior, with Scer\GAL4elav-C155
abnormal memory | adult stage
abnormal memory | adult stage, with Scer\GAL417d
abnormal memory | adult stage, with Scer\GAL4elav.PU
abnormal memory | adult stage, with Scer\GAL4GH146
abnormal memory | adult stage, with Scer\GAL4GH298
abnormal memory | adult stage, with Scer\GAL4Mef2.247
abnormal memory | adult stage, with Scer\GAL4NP1131
abnormal memory | adult stage, with Scer\GAL4NP1227
abnormal memory | adult stage, with Scer\GAL4NP2426
abnormal memory | adult stage, with Scer\GAL4NP2631
abnormal memory | adult stage, with Scer\GAL4ple.PF
abnormal memory | adult stage (with Df(1)BSC587)
abnormal memory | adult stage (with Dop2RΔ1)
abnormal memory | adult stage (with Dop2RΔ2)
abnormal sleep | adult stage
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DRD2
9 of 15
Yes
Yes
6  
Hsap\DRD3
7 of 15
No
Yes
Hsap\DRD4
4 of 15
No
Yes
Hsap\OR5T1
1 of 15
No
Yes
Hsap\OR13F1
1 of 15
No
Yes
Hsap\OR56A1
1 of 15
No
Yes
Hsap\OR56A4
1 of 15
No
Yes
Hsap\OR56A5
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Drd2
9 of 15
Yes
Yes
Mmus\Drd3
7 of 15
No
Yes
Mmus\Drd4
4 of 15
No
Yes
Mmus\Olfr150
1 of 15
No
Yes
Mmus\Olfr275
1 of 15
No
Yes
Mmus\Olfr683
1 of 15
No
Yes
Mmus\Olfr684
1 of 15
No
Yes
Mmus\Olfr919
1 of 15
No
Yes
Mmus\Olfr1101
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (9)
Rnor\Drd2
6 of 13
Yes
Yes
Rnor\Drd3
5 of 13
No
Yes
Rnor\Drd4
4 of 13
No
Yes
Rnor\LOC500460
1 of 13
No
Yes
Rnor\Olr192
1 of 13
No
Yes
Rnor\Olr533
1 of 13
No
Yes
Rnor\Olr841
1 of 13
No
Yes
Rnor\Olr1257
1 of 13
No
Yes
Rnor\Olr1320
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\drd2
4 of 12
Yes
Yes
Danio rerio (Zebrafish) (7)
Drer\drd2b
9 of 15
Yes
Yes
Drer\drd4-rs
8 of 15
No
Yes
Drer\drd2a
7 of 15
No
Yes
Drer\drd3
7 of 15
No
Yes
Drer\drd2l
6 of 15
No
Yes
Drer\drd4a
4 of 15
No
Yes
Drer\drd4b
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\dop-3
8 of 15
Yes
Yes
Cele\dop-2
5 of 15
No
Yes
Cele\dop-5
2 of 15
No
Yes
Cele\dop-6
2 of 15
No
Yes
Cele\dop-4
1 of 15
No
No
Cele\ser-1
1 of 15
No
No
Cele\ser-2
1 of 15
No
No
Cele\ser-6
1 of 15
No
No
Cele\tyra-2
1 of 15
No
No
Cele\tyra-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904EJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008407
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013471
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006504
Drosophila simulans
Dsim\GD27412
Drosophila sechellia
Dsec\GM22697
Drosophila erecta
Dere\GG18014
Drosophila yakuba
Dyak\GE17345
Drosophila ananassae
Dana\GF20457
Drosophila pseudoobscura pseudoobscura
Dpse\GA14269
Drosophila persimilis
Dper\GL12926
Drosophila willistoni
Dwil\GK16340
Drosophila virilis
Dvir\GJ19479
Drosophila mojavensis
Dmoj\GI14816
Drosophila grimshawi
Dgri\GH24329
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150775 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020402
Glossina morsitans
Tsetse fly
Gmor\GMOY004240
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05298
Mayetiola destructor
Hessian fly
Mdes\Mdes002444
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRDOP3_2
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRDOP3_1
Anopheles darlingi
American malaria mosquito
Adar\ADAC010554
Anopheles gambiae
Malaria mosquito
Agam\GPRDOP3
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015294
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0C8Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008272
Bombyx mori
Silkmoth
Bmor\BGIBMGA008273
Danaus plexippus
Monarch butterfly
Dple\DPOGS208004-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205883-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017818
Apis florea
Little honeybee
Aflo\4524631348
Apis mellifera
Western honey bee
Amel\GB42577
Apis mellifera
Western honey bee
Amel\GB54408
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21538
Bombus terrestris
Buff-tailed bumblebee
Bter\15206845
Linepithema humile
Argentine ant
Lhum\LH17279
Linepithema humile
Argentine ant
Lhum\LH17278
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00044f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG023476
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00789
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06043
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00786
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01149
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06045
Tribolium castaneum
Red flour beetle
Tcas\TC032795
Pediculus humanus
Human body louse
Phum\PHUM286710
Cimex lectularius
Bed bug
Clec\CLEC025324
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007415
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15682
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0C6T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006339
Ixodes scapularis
Black-legged tick
Isca\ISCW008917
Ixodes scapularis
Black-legged tick
Isca\ISCW015254
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74412.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g05910
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g05930
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_56664
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06VI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1b_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1aL_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht1F
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adra1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh2_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009149gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1aL_4
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018919
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019975
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020513
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004433
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013284
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004781
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003264
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024198
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008896
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002943
Ciona intestinalis
Vase tunicate
Cint\LOC100176265
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014975
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015953
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026029
Gallus gallus
Domestic chicken
Ggal\HTR1A
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023521
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008949
Gallus gallus
Domestic chicken
Ggal\HTR1D
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009640
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000024171
Gallus gallus
Domestic chicken
Ggal\HTR2A
Gallus gallus
Domestic chicken
Ggal\HTR1F
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000469
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003050
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007794
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000019018
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006362
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004066
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015974
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006540
Gallus gallus
Domestic chicken
Ggal\HTR2C
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003270
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015117
Gallus gallus
Domestic chicken
Ggal\HTR1E
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001416
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010778
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001383
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005085
Gallus gallus
Domestic chicken
Ggal\HTR1B
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004930
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013994
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013995
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012040
Gallus gallus
Domestic chicken
Ggal\Gga.320
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008365
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012894
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026998
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015608
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000016013
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (17)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Oct-TyrR
3 of 10
Dop1R2
2 of 10
DopEcR
2 of 10
Octβ1R
2 of 10
Octβ3R
2 of 10
TyrRII
2 of 10
TyrR
2 of 10
5-HT2B
1 of 10
CG12290
1 of 10
CG13579
1 of 10
Dop1R1
1 of 10
mAChR-A
1 of 10
mAChR-B
1 of 10
mAChR-C
1 of 10
Oamb
1 of 10
Octα2R
1 of 10
Octβ2R
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Dop2RGD732
    model of  alcohol use disorder
    CEA
    (Petruccelli et al., 2018)
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DRD2; dopamine receptor D2
    9 of 15
    126450
         
        DRD3; dopamine receptor D3
        7 of 15
        126451
        DRD4; dopamine receptor D4
        4 of 15
        126452
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Dop2R
        suppressible
        Gad1
        (Zhou et al., 2019)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-64
        Cytogenetic map
        19A4-19A4
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        19A4-19A4
        Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-64

        (FlyBase, 2016)

        1-63.5

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (22)
        Genomic Clones (39)
        cDNA Clones (17)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Zhou et al., 2019, Gruntenko et al., 2012, Draper et al., 2007)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: DD2R CG17004

        (FlyBase, 1996-)

        Source for identity of: Dop2R D2R

        (FlyBase, 2009-)
        Source for database merge of

        Source for merge of: D2R CG9569

        (Hearn et al., 2002)

        Source for merge of: D2R anon-WO0170980.130 anon-WO0170980.131 anon-WO0170980.31 anon-WO0170980.32

        (FlyBase, 1996-)
        Additional comments

        Annotations CG9569 and CG17004 merged as CG33517 (which corresponds to D2R) in release 4.1 of the genome annotation.

        (FlyBase Genome Annotators, 2005)

        Source for identity of DD2R CG17004 was sequence comparison ( date:021108 ).

        (FlyBase, 1996-)

        Source for merge of D2R anon-WO0170980.130 anon-WO0170980.131 anon-WO0170980.31 anon-WO0170980.32 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Other Comments

        Dop2R is required for support of consolidated anesthesia-resistant memory.

        (Scholz-Kornehl and Schwärzel, 2016)

        Pharmacologic assessment of D2R reveals that among the biogenic amines, dopamine is the most potent agonist. Stimulation of D2R with dopamine triggers pertussis toxin sensitive Gi/o mediated signaling. The D2 selective agonist, bromocriptine, stimulates D2R with a nanomolar EC50.

        (Hearn et al., 2002)

        Pharmacologic assessment of the D2R reveals that among the endogenous biogenic amines, dopamine is the most potent agonist. Stimulation of D2R with dopamine triggers pertussis toxin sensitive Gi/o mediated signaling. The D2 selective agonist, bromocriptine stimulates the D2R with nanomolar EC50.

        (Ren et al., 2002)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 64 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (21)
        Reported As
        Symbol Synonym
        CG17004
        (Aradska et al., 2015, Hauser et al., 2006, Srivastava et al., 2005, Brody and Cravchik, 2000)
        CG33517
        (Kondo et al., 2020, Scholz-Kornehl and Schwärzel, 2016, Meadows, 2014.12.12, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009.1.15)
        CG9569
        (Srivastava et al., 2005, Bryson-Richardson et al., 2004, Brody and Cravchik, 2000)
        D2R
        (Demakova et al., 2020, Guven-Ozkan et al., 2020, Kondo et al., 2020, Li et al., 2019, Stern et al., 2019, Al-Ramahi et al., 2018, Landayan et al., 2018, Xie et al., 2018, Liu et al., 2017, Crocker et al., 2016, Scholz-Kornehl and Schwärzel, 2016, Zhang et al., 2016, Kong et al., 2015, Yang et al., 2015, Ashwal-Fluss et al., 2014, Sytnikova et al., 2014, Argue and Neckameyer, 2013, Argue and Neckameyer, 2013, Chen et al., 2012, Inagaki et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Liu et al., 2012, Marella et al., 2012, Neckameyer and Bhatt, 2012, Bang et al., 2011, Bellen et al., 2011, Seugnet et al., 2011, Shang et al., 2011, Seugnet et al., 2009)
        DD2R
        (Mazzotta et al., 2020, Zhou et al., 2019, Qi and Lee, 2014, Alekseyenko et al., 2013, Wiemerslage et al., 2013, Gruntenko et al., 2012, Bogomolova et al., 2011, Karpova et al., 2011, Rauschenbach et al., 2011, Bogomolova et al., 2010, Bogomolova et al., 2010, Chintapalli et al., 2007, Draper et al., 2007, Yuan and Lee, 2007, Hearn, 2002.9.17, Hearn et al., 2002, Ren et al., 2002)
        DmDOP3
        (Qi et al., 2017)
        Dop2R
        (Liu et al., 2021, Sareen et al., 2021, Scaplen and Petruccelli, 2021, Xie et al., 2021, Jakšić et al., 2020, Kondo et al., 2020, Naz et al., 2020, Petruccelli et al., 2020, Scaplen et al., 2020, Brunet Avalos et al., 2019, Deng et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Shih et al., 2019, Croset et al., 2018, Zhang et al., 2018, Branco et al., 2017, Pimentel et al., 2016, Zhang et al., 2016, Gene Disruption Project members, 2015-, Vernes, 2014, Sepp et al., 2008)
        anon-WO0170980.130
        anon-WO0170980.131
        anon-WO0170980.31
        anon-WO0170980.32
        d2r
        (Naganos et al., 2016)
        dD2R
        (Pavlowsky et al., 2018, Lee et al., 2013)
        Name Synonyms
        D2 autoreceptor
        (Privman Champaloux et al., 2021)
        D2-like receptor
        (Rauschenbach et al., 2011)
        D2 receptor
        (Neckameyer and Bhatt, 2012)
        D2-like receptor
        (Srivastava et al., 2005)
        Dopamine 2-like Receptor
        (Sepp et al., 2008)
        Dopamine 2-like receptor
        (Hearn, 2002.9.17)
        dopamine 2-like receptor
        (Draper et al., 2007)
        dopamine D2 receptor
        (Lee et al., 2013)
        Secondary FlyBase IDs
        • FBgn0031083
        • FBgn0031084
        • FBgn0046542
        • FBgn0046543
        • FBgn0046600
        • FBgn0046601
        • FBgn0062410
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (128)