Gene model reviewed during 5.51
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop2R using the Feature Mapper tool.
In the dorsal aspect of the larval VNC, D2R is expressed in a series of 11 paired neurons, one in each of the three thoracic segments and 8 abdominal segments, and are often in close proximity to dopaminergic cells. In the ventral aspect of the ventral nerve cord, one pair of D2R positive cells are found in each of the larval thoracic segments. In adults, D2R is expressed in three pairs of dorsal neurons within each thoracic segment of the ventral ganglion, and in a U-shaped cluster of cells in the abdominal neuromere.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Dop2R in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG9569 and CG17004 merged as CG33517 (which corresponds to D2R) in release 4.1 of the genome annotation.
Source for identity of DD2R CG17004 was sequence comparison ( date:021108 ).
Source for merge of D2R anon-WO0170980.130 anon-WO0170980.131 anon-WO0170980.31 anon-WO0170980.32 was sequence comparison ( date:051113 ).
Dop2R is required for support of consolidated anesthesia-resistant memory.
Pharmacologic assessment of D2R reveals that among the biogenic amines, dopamine is the most potent agonist. Stimulation of D2R with dopamine triggers pertussis toxin sensitive Gi/o mediated signaling. The D2 selective agonist, bromocriptine, stimulates D2R with a nanomolar EC50.
Pharmacologic assessment of the D2R reveals that among the endogenous biogenic amines, dopamine is the most potent agonist. Stimulation of D2R with dopamine triggers pertussis toxin sensitive Gi/o mediated signaling. The D2 selective agonist, bromocriptine stimulates the D2R with nanomolar EC50.