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Gene Dmel\CG33523

General Information
Symbol	Dmel\CG33523	Species	D. melanogaster
Name		Annotation symbol	CG33523
Feature type	protein_coding_gene	FlyBase ID	FBgn0053523
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	CG10977
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64F5-65A1	Sequence location	3L:5,917,155..5,923,220 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG33523 (FBgn0053523). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: structural molecule activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 19 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; intersegmental nerve; mesothoracic tergum. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Cellular retinaldehyde-binding/triple function, C-terminal; Major sperm protein; PapD-like; Phosphatidylinositol transfer protein-like, N-terminal; Vesicle-associated membrane protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult male reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult ovary, larval/adult carcass. Gene sequence location is 3L:5917155..5923220.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon
FB2012_01	Sequence features HFA09814 BKN29603
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64F5-65A1   Limits computationally determined from genome sequence between P{PZ}vn10567 and P{PZ}loj04026
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG33523 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	3' UTR contains an ORF that is conserved among close Drosophila species (potential peptide 155 aa in length; possible stop-codon suppression).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG33523-RA FBtr0091478  NM_001014566   1508   234 CG33523-RB FBtr0091476  NM_001014568   1360   206 CG33523-RC FBtr0091477  NM_001014567   1656   240 CG33523-RD FBtr0091475  NM_001014569   2381   498 CG33523-RE FBtr0306383     2479   285
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG33523-PA   FBpp0090957   25.8   234   9.29     NP_001014566   AAF50728 CG33523-PB   FBpp0090955   22.7   206   9.30     NP_001014568   AAN12234 CG33523-PC   FBpp0090956   26.4   240   9.06     NP_001014567   AAN12233 CG33523-PD   FBpp0090954   56.4   498   7.74     NP_001014569   AAN12232 CG33523-PE   FBpp0297475   32.9   285   5.74
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Major sperm protein (IPR000535) Cellular retinaldehyde-binding/triple function, C-terminal (IPR001251) PapD-like (IPR008962) Vesicle-associated membrane protein (IPR016763) Phosphatidylinositol transfer protein-like, N-terminal (IPR011074)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141326   AA392554   AA802887   AA820871   AA941761   AE014296 AAF50728   AE014296 AAN12232   AE014296 AAN12233   AE014296 AAN12234   AI113398   AI296546   AI297317   AI944738   AI947002   AQ073002   AQ073088   AQ073089   AX094239   BE976421   BE978386   BE978651   BF494505   BF499806   BF506345   BG638418   BG638459   BI172243   BI242627   BI352182   BI354933   BP542078   BP542968   BT001314 AAN71069   BT001406 AAN71161   BT001638 AAN71393   BT010032 AAQ22501   BT120195   CO154545   CO190445   CO191056   CO193418   CO193893   CO299405   CO301236   CO313563   CO313660   CO317466   CO321922   CO330465   CO331015   CO331021   CO331357   CO343767   CO344267   CZ468421   CZ469651   CZ469948   CZ480941   EC059724   EC065294   EC079828   EC089537   EC200436   EC205109   EC216414   EC228747   EC229925   EC230012   EC237214   EC239537   EC250807   EC256281   EC260649   EC262835   EY198851   GH755508   GH758278   GH760683   GH761083   GH770676   GH771203   GH777364   GH777524   GH787505   GH787891   GH788292   GH790495   GH794488   GH794679   GH795030   GH797572   GH797720   GH798219   GH801037   GH802318   GH803006   GH804340   GH810661   GH814035   GH820459   GH823213   GH825422   GH828127   GH832451   GH837187   GH839266   GH840655   GH844499   GH845036   GH848110   GH848653   GH856042   GH868376   GH876056   GH876411   GH883853   GH884737   GH884852   GH887224   GH887984   GH889012   GH893598   GH893983   GH896134   GH898291   GH900329   GH903651   GH923304   GH930370   GH939468   GH939524   GH940424   GH940572
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8I0D5 Q8I934 Q8I935 Q8IGR6 Q8IHC4 Q9VRR4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0053523    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0053523 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0053523 expression level Developmental Stage   Expression Level embryo 00-02hr    2812 embryo 02-04hr    1436 embryo 04-06hr    979 embryo 06-08hr    1419 embryo 08-10hr    1710 embryo 10-12hr    2558 embryo 12-14hr    2225 embryo 14-16hr    3861 embryo 16-18hr    2262 embryo 18-20hr    1681 embryo 20-22hr    1798 embryo 22-24hr    1973 larva L1    1710 larva L2    1957 larva L3 12hr old    1450 larva L3 puffstage 1-2    1818 larva L3 puffstage 3-6    1826 larva L3 puffstage 7-9    2369 white prepupae new    3003 white prepupae 12hr    3915 white prepupae 24hr    3148 pupae 2d postWPP    3716 pupae 3d postWPP    2771 pupae 4d postWPP    3604 adult male 01day    4731 adult male 05day    5910 adult male 30day    6630 adult female 01day    2658 adult female 05day    2643 adult female 30day    2723 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2812) embryo 02-04hr  (1436) embryo 04-06hr  (979) embryo 06-08hr  (1419) embryo 08-10hr  (1710) embryo 10-12hr  (2558) embryo 12-14hr  (2225) embryo 14-16hr  (3861) embryo 16-18hr  (2262) embryo 18-20hr  (1681) embryo 20-22hr  (1798) embryo 22-24hr  (1973) larva L1  (1710) larva L2  (1957) larva L3 12hr old  (1450) larva L3 puffstage 1-2  (1818) larva L3 puffstage 3-6  (1826) larva L3 puffstage 7-9  (2369) white prepupae new  (3003) white prepupae 12hr  (3915) white prepupae 24hr  (3148) pupae 2d postWPP  (3716) pupae 3d postWPP  (2771) pupae 4d postWPP  (3604) adult male 01day  (4731) adult male 05day  (5910) adult male 30day  (6630) adult female 01day  (2658) adult female 05day  (2643) adult female 30day  (2723) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2812) embryo 02-04hr  1436 embryo 04-06hr    979 embryo 06-08hr  1419 embryo 08-10hr  (1710) embryo 10-12hr  (2558) embryo 12-14hr  (2225) embryo 14-16hr  (3861) embryo 16-18hr  (2262) embryo 18-20hr  (1681) embryo 20-22hr  (1798) embryo 22-24hr  (1973) larva L1  (1710) larva L2  (1957) larva L3 12hr old  1450 larva L3 puffstage 1-2  (1818) larva L3 puffstage 3-6  (1826) larva L3 puffstage 7-9  (2369) white prepupae new  (3003) white prepupae 12hr  (3915) white prepupae 24hr  (3148) pupae 2d postWPP  (3716) pupae 3d postWPP  (2771) pupae 4d postWPP  (3604) adult male 01day  (4731) adult male 05day  (5910) adult male 30day  (6630) adult female 01day  (2658) adult female 05day  (2643) adult female 30day  (2723) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2812 embryo 02-04hr    1436 embryo 04-06hr    979 embryo 06-08hr    1419 embryo 08-10hr    1710 embryo 10-12hr    2558 embryo 12-14hr    2225 embryo 14-16hr    3861 embryo 16-18hr    2262 embryo 18-20hr    1681 embryo 20-22hr    1798 embryo 22-24hr    1973 larva L1    1710 larva L2    1957 larva L3 12hr old    1450 larva L3 puffstage 1-2    1818 larva L3 puffstage 3-6    1826 larva L3 puffstage 7-9    2369 white prepupae new    3003 white prepupae 12hr    3915 white prepupae 24hr    3148 pupae 2d postWPP    3716 pupae 3d postWPP    2771 pupae 4d postWPP    3604 adult male 01day    4731 adult male 05day    5910 adult male 30day    6630 adult female 01day    2658 adult female 05day    2643 adult female 30day    2723 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2812 embryo 02-04hr    1436 embryo 04-06hr    979 embryo 06-08hr    1419 embryo 08-10hr    1710 embryo 10-12hr    2558 embryo 12-14hr    2225 embryo 14-16hr    3861 embryo 16-18hr    2262 embryo 18-20hr    1681 embryo 20-22hr    1798 embryo 22-24hr    1973 larva L1    1710 larva L2    1957 larva L3 12hr old    1450 larva L3 puffstage 1-2    1818 larva L3 puffstage 3-6    1826 larva L3 puffstage 7-9    2369 white prepupae new    3003 white prepupae 12hr    3915 white prepupae 24hr    3148 pupae 2d postWPP    3716 pupae 3d postWPP    2771 pupae 4d postWPP    3604 adult male 01day    4731 adult male 05day    5910 adult male 30day    6630 adult female 01day    2658 adult female 05day    2643 adult female 30day    2723 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0053523 expression level Developmental Stage   Expression Level embryo 00-02hr    2812 embryo 02-04hr    1436 embryo 04-06hr    979 embryo 06-08hr    1419 embryo 08-10hr    1710 embryo 10-12hr    2558 embryo 12-14hr    2225 embryo 14-16hr    3861 embryo 16-18hr    2262 embryo 18-20hr    1681 embryo 20-22hr    1798 embryo 22-24hr    1973 larva L1    1710 larva L2    1957 larva L3 12hr old    1450 larva L3 puffstage 1-2    1818 larva L3 puffstage 3-6    1826 larva L3 puffstage 7-9    2369 white prepupae new    3003 white prepupae 12hr    3915 white prepupae 24hr    3148 pupae 2d postWPP    3716 pupae 3d postWPP    2771 pupae 4d postWPP    3604 adult male 01day    4731 adult male 05day    5910 adult male 30day    6630 adult female 01day    2658 adult female 05day    2643 adult female 30day    2723 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2812) embryo 02-04hr  (1436) embryo 04-06hr  (979) embryo 06-08hr  (1419) embryo 08-10hr  (1710) embryo 10-12hr  (2558) embryo 12-14hr  (2225) embryo 14-16hr  (3861) embryo 16-18hr  (2262) embryo 18-20hr  (1681) embryo 20-22hr  (1798) embryo 22-24hr  (1973) larva L1  (1710) larva L2  (1957) larva L3 12hr old  (1450) larva L3 puffstage 1-2  (1818) larva L3 puffstage 3-6  (1826) larva L3 puffstage 7-9  (2369) white prepupae new  (3003) white prepupae 12hr  (3915) white prepupae 24hr  (3148) pupae 2d postWPP  (3716) pupae 3d postWPP  (2771) pupae 4d postWPP  (3604) adult male 01day  (4731) adult male 05day  (5910) adult male 30day  (6630) adult female 01day  (2658) adult female 05day  (2643) adult female 30day  (2723) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2812) embryo 02-04hr  1436 embryo 04-06hr    979 embryo 06-08hr  1419 embryo 08-10hr  1710 embryo 10-12hr  (2558) embryo 12-14hr  2225 embryo 14-16hr  (3861) embryo 16-18hr  2262 embryo 18-20hr  1681 embryo 20-22hr  1798 embryo 22-24hr  1973 larva L1  1710 larva L2  1957 larva L3 12hr old  1450 larva L3 puffstage 1-2  1818 larva L3 puffstage 3-6  1826 larva L3 puffstage 7-9  2369 white prepupae new  (3003) white prepupae 12hr  (3915) white prepupae 24hr  (3148) pupae 2d postWPP  (3716) pupae 3d postWPP  (2771) pupae 4d postWPP  (3604) adult male 01day  (4731) adult male 05day  (5910) adult male 30day  (6630) adult female 01day  (2658) adult female 05day  (2643) adult female 30day  (2723) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2812 embryo 02-04hr    1436 embryo 04-06hr    979 embryo 06-08hr    1419 embryo 08-10hr    1710 embryo 10-12hr    2558 embryo 12-14hr    2225 embryo 14-16hr    3861 embryo 16-18hr    2262 embryo 18-20hr    1681 embryo 20-22hr    1798 embryo 22-24hr    1973 larva L1    1710 larva L2    1957 larva L3 12hr old    1450 larva L3 puffstage 1-2    1818 larva L3 puffstage 3-6    1826 larva L3 puffstage 7-9    2369 white prepupae new    3003 white prepupae 12hr    3915 white prepupae 24hr    3148 pupae 2d postWPP    3716 pupae 3d postWPP    2771 pupae 4d postWPP    3604 adult male 01day    4731 adult male 05day    5910 adult male 30day    6630 adult female 01day    2658 adult female 05day    2643 adult female 30day    2723 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2812 embryo 02-04hr    1436 embryo 04-06hr    979 embryo 06-08hr    1419 embryo 08-10hr    1710 embryo 10-12hr    2558 embryo 12-14hr    2225 embryo 14-16hr    3861 embryo 16-18hr    2262 embryo 18-20hr    1681 embryo 20-22hr    1798 embryo 22-24hr    1973 larva L1    1710 larva L2    1957 larva L3 12hr old    1450 larva L3 puffstage 1-2    1818 larva L3 puffstage 3-6    1826 larva L3 puffstage 7-9    2369 white prepupae new    3003 white prepupae 12hr    3915 white prepupae 24hr    3148 pupae 2d postWPP    3716 pupae 3d postWPP    2771 pupae 4d postWPP    3604 adult male 01day    4731 adult male 05day    5910 adult male 30day    6630 adult female 01day    2658 adult female 05day    2643 adult female 30day    2723 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0053523    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0053523 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult male reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult ovary, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053523 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10977-RA;CG32410-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CG33523GD2326 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CG33523GD2326 viable CG33523e03176 CG33523EY01207 viable, with Scer\GAL4pnr-MD237 CG33523GD10886 Sterility Allele fertile CG33523e03176 CG33523EY01207 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 CG33523GD2326 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 CG33523EP3539 visible, with Scer\GAL4pnr-MD237 CG33523GD2326 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 CG33523EP3539 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CG33523GD2326 ganglion mother cell | larval stage, with Scer\GAL41407 CG33523GD2326 intersegmental nerve, with Scer\GAL4elav-C155 CG33523EP3539 mesothoracic tergum, with Scer\GAL4pnr-MD237 CG33523GD2326 trichogen cell, with Scer\GAL4pnr-MD237 CG33523GD2326
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of CG33523 Class Mutagen Stocks Known lesion CG33523e03176 piggyBac transposase 2 -- CG33523c03097 piggyBac transposase 1 -- CG33523c04974 piggyBac transposase 1 -- CG33523c05404 piggyBac transposase 1 -- CG33523d00629 1 -- CG33523d03649 1 -- CG33523EY01207 1 -- CG33523G4280 P-element activity 1 -- CG33523NP4600 1 -- CG33523d01677 0 -- CG33523d03153 0 -- CG33523d08784 0 -- CG33523EP3539 P-element activity 0 Yes CG33523EP3647 P-element activity 0 -- CG33523EP3648 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG33523 Class Mutagen Stocks Known lesion CG33523GD2326 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes CG33523JF01856 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG33523GD10886 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG33523KK109603 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel7210 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2326} NA P{GD10886} NA P{KK109603} NA P{TRiP.JF01856} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG33523EP3539 NA P{EP}CG33523EP3647 NA P{EP}CG33523EP3648 NA P{EP}CG33523G4280 NA P{EPgy2}CG33523EY01207 NA P{XP}CG33523d00629 NA P{XP}CG33523d01677 NA P{XP}CG33523d03153 NA P{XP}CG33523d03649 NA P{XP}CG33523d08784 NA miscellaneous insertions PBac{PB}CG33523c03097 NA PBac{PB}CG33523c04974 NA PBac{PB}CG33523c05404 NA PBac{RB}CG33523e03176 NA insertion of enhancer trap binary system P{GawB}CG33523NP4600 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
structural molecule activity inferred from electronic annotation with InterPro:IPR000535 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG33523 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64128 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0053523 DroID - A comprehensive database of gene and protein interactions. • FBgn0053523 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38668
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24005 Dere\GG15302 Dgri\GH14689 Dmoj\GI13304 Dper\GL21079 Dpse\GA28323 Dsec\GM14735 Dvir\GJ12072 Dwil\GK16664 Dyak\GE21523
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014296-PA Aedes aegypti (mosquito) AGAP005556-PA Anopheles gambiae (mosquito) XP_393236.2 Apis mellifera (honey bee) XP_001944841.1 Acyrthosiphon pisum (pea aphid) At2g18180.1 Arabidopsis thaliana (wall cress) At4g34580.1 Arabidopsis thaliana (wall cress) 22348 Batrachochytrium dendrobatidis (chytrid fungus) 23580 Batrachochytrium dendrobatidis (chytrid fungus) 210728 Branchiostoma floridae (lancelet) BGIBMGA011898-PA Bombyx mori (silk worm) CN12118 Caenorhabditis brenneri (small nematode) CBP30133 Caenorhabditis briggsae (nematode) CE39202 Caenorhabditis elegans (worm) ENSCAFP00000017492 Canis familiaris (dog) JA05416 Caenorhabditis japonica (nematode) ENSCPOP00000006827 Cavia porcellus (guinea pig) RP47783 Caenorhabditis remanei (nematode) 229022 Daphnia pulex (daphnia) ENSDARP00000090483 Danio rerio (zebra fish) ENSECAP00000016632 Equus caballus (horse) ENSGACP00000005106 Gymnopilus aculeatus (mushroom) ENSGALP00000026692 Gallus gallus (chicken) ENSP00000369860 Homo sapiens (human) ISCW007391-PA Ixodes scapularis (deer tick) 237580 Lottia gigantea (owl limpet) 29638 Monocosta brevicollis (choanoflagellate) ENSMODP00000021552 Monodelphis domestica (gray opossum) ENSMMUP00000023459 Macaca mulatta (rhesus monkey) ENSMUSP00000004715 Mus musculus (house mouse) 241034 Nematostella vectensis (starlet anemone) ENSOANP00000004135 Ornithorynchus anatinus (platypus) ENSORLP00000022329 Oryzias latipes (japanese killifish) PHUM003988-PA Pediculus humanus (human body louse) ENSPPYP00000022529 Pongo pygmaeus (orangutan) ENSPTRP00000037146 Pan troglodytes (chimpanzee) ENSRNOP00000004533 Rattus norvegicus (norway rat) 56337 Trichoplax adhaerens (metazoa) XP_973987.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016962 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023418 Takifugu rubripes (pufferfish Takifugu) 3716.m00136 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000021985 Xenopus tropicalis (frog) YALI0D04488g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15005 NV16909 LH20990 ISCW012683 ISCW011418 ISCW007391 FBgn0238780 FBgn0238779 FBgn0218666 FBgn0218665 FBgn0199324 FBgn0199323 FBgn0185611 FBgn0185610 FBgn0185609 FBgn0169655 FBgn0169656 FBgn0249685 JGI_V11_229022 FBgn0076893 FBgn0158674 FBgn0158664 FBgn0136061 FBgn0136060 FBgn0052407 FBgn0122165 FBgn0122164 FBgn0107554 FBgn0107552 FBgn0100999 FBgn0100998 CPIJ008520 CPIJ008519 BGIBMGA011898 ACYPI006174 GB18553 AGAP005556 AAEL014296 PHUM537350 GLEAN_02960
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	25838 y1 v1; P{TRiP.JF01856}attP2 18128 w1118; PBac{RB}CG33523e03176 27948 y1 w*; P{EP}CG33523G4280
Harvard	- P{XP}CG33523d00629 - P{XP}CG33523d03649 - PBac{PB}CG33523c03097 - PBac{PB}CG33523c04974 - PBac{PB}CG33523c05404 - PBac{RB}CG33523e03176
VDRC	v37237 w1118; P{GD2326}v37237 v37238 w1118; P{GD2326}v37238 v44377 w1118; P{GD2326}v44377
	More stocks available...
Genomic Clones ( 2 )
	BACR01O19 BACR11A21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 116 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT14559 GH09028 LP10490 RE40017
Other clones	DPiM_GH09028 DPiM_LP10490 MIP15655
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03153 AT08788 GM06520 GM18224 GM28940 LD12801 LP11587 RE14555
Other clones	60772 107467 107689 163655 192558 193931 194408 214351.20 214537.18 272609 523862 bs04g10 bs33h10 bs50d09 bs78b01 bs81c05 CK01.1B.G6 CK01.5A.A12 CK01.59C.E3 CK01.62C.G12 CK01.124B.B2 CK01608 EC35761 EC36961 EK048218 EK050558 EK175407 EK180506 EK186811 EK233431 EK233658 EK268262 EK295332 EK297233 EK297260 EK299357 EN04329 EP18010 EP18947 FGC008H02 FGC017H09 LD24790 LD25942 RP003018382 RP003036045 RP003038142 RP003067162 RP003076778 RP003090787 RP003112025 RP003147323 RP003210280 RP003212218 RP003218207 RP003229112 RP003231603 RP003252299 RP003277857 RP003290389 RP003333387 RP003337930 RP003349059 RP003351094 RP003356421 RP003366006 RP003382087 RP003412328 RP003436431 RP003445032 RP003446644 RP003451220 RP003473039 RP003477793 RP003488967 RP003491497 RP003492329 RP003516767 RP003519017 RP003532968 RP003536131 RP003546760 RP003553495 RP003555890 RP003556628 RP003585253 RP003585954 RP003591934 RP003600812 RP003605415 RP003615277 RP003617716 RP003627800 RP003627893 RP003647471 RP003647747 RP003653469 RP003660475 RP003660677 RP003663081 RP003665116 RP003668131
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053523 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38668 318017
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG10977 BcDNA:GH09028 (FlyBase Genome Annotators, 2005, FlyBase, 1996-)
Additional comments	Source for merge of CG10977 BcDNA:GH09028 was a shared cDNA (date:030728). (FlyBase Genome Annotators, 2005, FlyBase, 1996-) Annotation CG10727 split into CG32407 and CG32410 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Area matching Drosophila ESTS AA802887 and AA820871. These ESTs have sequence similarity to C. elegans protein B0336.11. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001014566 NM_001014567 NM_001014568 NM_001014569 RefSeq (Proteins) • NP_001014566 NP_001014567 NP_001014568 NP_001014569 DDBJ / EMBL / GenBank • AA802887 AA820871 AAF50728 AAF50728.2 AAN12232 AAN12232.1 AAN12233 AAN12233.1 AAN12234 AAN12234.1 AAN71069 AAN71161 AAN71393 AAQ22501 AI113398 AI296546 AI944738 AI947002 AQ073002 AQ073088 AQ073089 AX094239 BF499806 BI242627 BT001314 BT001406 BT001638 BT010032 CZ468421 CZ469651 CZ469948 CZ480941 Entrez Gene - A searchable database of RefSeq genes. • 38668 UniProtKB/TrEMBL • Q8I0D5 Q8I934 Q8I935 Q8IGR6 Q8IHC4 Q9VRR4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Major sperm protein (IPR000535) Cellular retinaldehyde-binding/triple function, C-terminal (IPR001251) PapD-like (IPR008962) Vesicle-associated membrane protein (IPR016763) Phosphatidylinositol transfer protein-like, N-terminal (IPR011074)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64128 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0053523 DroID - A comprehensive database of gene and protein interactions. • FBgn0053523 DRSC - Results from RNAi screens. • FBgn0053523 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053523 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10977-RA;CG32410-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053523 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38668 318017 InParanoid A subset of ortholog calls from InParanoid. • AAEL014296-PA Aedes aegypti (mosquito) AGAP005556-PA Anopheles gambiae (mosquito) XP_393236.2 Apis mellifera (honey bee) XP_001944841.1 Acyrthosiphon pisum (pea aphid) At2g18180.1 Arabidopsis thaliana (wall cress) At4g34580.1 Arabidopsis thaliana (wall cress) 22348 Batrachochytrium dendrobatidis (chytrid fungus) 23580 Batrachochytrium dendrobatidis (chytrid fungus) 210728 Branchiostoma floridae (lancelet) BGIBMGA011898-PA Bombyx mori (silk worm) CN12118 Caenorhabditis brenneri (small nematode) CBP30133 Caenorhabditis briggsae (nematode) CE39202 Caenorhabditis elegans (worm) ENSCAFP00000017492 Canis familiaris (dog) JA05416 Caenorhabditis japonica (nematode) ENSCPOP00000006827 Cavia porcellus (guinea pig) RP47783 Caenorhabditis remanei (nematode) 229022 Daphnia pulex (daphnia) ENSDARP00000090483 Danio rerio (zebra fish) ENSECAP00000016632 Equus caballus (horse) ENSGACP00000005106 Gymnopilus aculeatus (mushroom) ENSGALP00000026692 Gallus gallus (chicken) ENSP00000369860 Homo sapiens (human) ISCW007391-PA Ixodes scapularis (deer tick) 237580 Lottia gigantea (owl limpet) 29638 Monocosta brevicollis (choanoflagellate) ENSMODP00000021552 Monodelphis domestica (gray opossum) ENSMMUP00000023459 Macaca mulatta (rhesus monkey) ENSMUSP00000004715 Mus musculus (house mouse) 241034 Nematostella vectensis (starlet anemone) ENSOANP00000004135 Ornithorynchus anatinus (platypus) ENSORLP00000022329 Oryzias latipes (japanese killifish) PHUM003988-PA Pediculus humanus (human body louse) ENSPPYP00000022529 Pongo pygmaeus (orangutan) ENSPTRP00000037146 Pan troglodytes (chimpanzee) ENSRNOP00000004533 Rattus norvegicus (norway rat) 56337 Trichoplax adhaerens (metazoa) XP_973987.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016962 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023418 Takifugu rubripes (pufferfish Takifugu) 3716.m00136 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000021985 Xenopus tropicalis (frog) YALI0D04488g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38668 modMine - Data generated by the modENCODE project. • FBgn0053523 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15005 NV16909 LH20990 ISCW012683 ISCW011418 ISCW007391 FBgn0238780 FBgn0238779 FBgn0218666 FBgn0218665 FBgn0199324 FBgn0199323 FBgn0185611 FBgn0185610 FBgn0185609 FBgn0169655 FBgn0169656 FBgn0249685 JGI_V11_229022 FBgn0076893 FBgn0158674 FBgn0158664 FBgn0136061 FBgn0136060 FBgn0052407 FBgn0122165 FBgn0122164 FBgn0107554 FBgn0107552 FBgn0100999 FBgn0100998 CPIJ008520 CPIJ008519 BGIBMGA011898 ACYPI006174 GB18553 AGAP005556 AAEL014296 PHUM537350 GLEAN_02960
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BcDNA:GH09028   CG10727   CG10977 (Oliver, 2001.8.16, Giot et al., 2003, ) CG32410   CG33523 (Arancio et al., 2010, Gan et al., 2010, Dorus et al., 2006, Perkins et al., 1.15.2009, Chai et al., 2008, Jordan et al., 2007, Wasbrough et al., 2010, Keleman et al., 2009.8.5)
Name Synonym	MSP protein (Kraut et al., 2001, Kraut et al., 2001)
Secondary FlyBase IDs
	FBgn0035650 FBgn0035651 FBgn0052410 FBgn0064970 FBpp0076741 FBpp0076742 FBpp0076743 FBpp0076744 FBtr0077033 FBtr0077034 FBtr0077035 FBtr0077036
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 6 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 )
Recent research papers ( 2 )
	Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Show all research papers ...