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Gene Dmel\Ddr

General Information
Symbol	Dmel\Ddr	Species	D. melanogaster
Name	Discoidin domain receptor	Annotation symbol	CG33531
Feature type	protein_coding_gene	FlyBase ID	FBgn0053531
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	CG9490, CG9488, CG13985
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26C1-26C2	Sequence location	2L:6,253,123..6,323,466 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Discoidin domain receptor is referred to in FlyBase by the symbol Dmel\Ddr (CG33531, FBgn0053531). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane receptor protein tyrosine kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: transmembrane receptor protein tyrosine kinase signaling pathway. 16 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Coagulation factor 5/8 C-terminal type domain; Galactose-binding domain-like; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 2L:6253123..6323466.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Ddr[MI05645] Ddr[MI05632]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26C1-26C2   Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ddr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Gene merge based on protein alignment (BLASTX) data and FBrf0149572
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ddr-RC FBtr0340168     4390   1064 Ddr-RD FBtr0340169     1690   380 Ddr-RE FBtr0340170     4800   1064
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ddr-PC   FBpp0309153   117.7   1064   6.77       Ddr-PD   FBpp0309154   42.1   380   8.26       Ddr-PE   FBpp0309155   117.7   1064   6.77
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase-like domain (IPR011009) Protein kinase, catalytic domain (IPR000719) Galactose-binding domain-like (IPR008979) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245) Coagulation factor 5/8 C-terminal type domain (IPR000421)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name BT025126   BT128907   CO312725   EC052013   EC053057   EC054493   EC054998   EC202483   EL873064   EL873065   EL873240   EL873326   EL878654   EL878655   EL878830   EL878922   FL502808   FL502874
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q59DZ7 E1JHA2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    11 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053531 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11573-RA;CG9488-RA;CG9490-RA;Stencil:2L:6265031:6273206:GENSCAN
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable DdrEU173 viable, with Scer\GAL4pnr-MD237 DdrGD13382 DdrGD15146 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 DdrGD15146 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 DdrGD15146 trichogen cell, with Scer\GAL4pnr-MD237 DdrGD15146
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of Ddr Class Mutagen Stocks Known lesion Ddr5-HA-1712 1 -- DdrEU173 1 -- Ddrf05621b 1 -- Ddrf08070 1 -- DdrKG03464 1 -- DdrMB00544 1 -- DdrMB11489 1 -- DdrMI02079 1 -- DdrMI03300 1 -- DdrMI04117 1 -- DdrMI05632 1 -- DdrMI05645 1 -- DdrNP0725 1 -- DdrMB00529 0 -- Ddrunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ddr Class Mutagen Stocks Known lesion DdrGD7334 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes DdrGD13382 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DdrGD15146 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6016 (Ryder, 2004.4.26) Df(2L)Exel9038 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7334} NA P{GD13382} NA P{GD15146} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}DdrMI02079 NA Mi{MIC}DdrMI03300 NA Mi{MIC}DdrMI04117 NA Mi{MIC}DdrMI05632 NA Mi{MIC}DdrMI05645 NA P{RS5}Ddr5-HA-1712 NA P{SUPor-P}DdrKG03464 NA PBac{WH}Ddrf05621b NA PBac{WH}Ddrf08070 NA insertion of enhancer trap binary system Mi{ET1}DdrMB00529 No Mi{ET1}DdrMB00544 No Mi{ET1}DdrMB11489 No P{GawB}DdrNP0725 No insertion of mobile activating element P{EP}DdrEU173 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity non-traceable author statement (Morrison et al., 2000) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity with human DDR2 (FlyBase, 1992-)
Biological Process
CV term Evidence References
cell adhesion inferred from electronic annotation with InterPro:IPR000421 (FlyBase Curators et al., 2004-) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) transmembrane receptor protein tyrosine kinase signaling pathway inferred from sequence or structural similarity with human DDR2 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with human DDR2 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ddr allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77927 DroID - A comprehensive database of gene and protein interactions. • FBgn0053531 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3346209
Orthologs
OrthoDB Orthologs (68) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6M6632 Dipteran inclusive ortholog search EOG6H1B3V Insect inclusive ortholog search EOG6XD2KZ Arthropod inclusive ortholog search EOG66T1GC Metazoa inclusive ortholog search EOG6PS5HK
Orthologs in Drosophila Species (EOG6M6632)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ddr     Drosophila simulans   Dsim\GD23398 Y   Drosophila sechellia   Dsec\GM18617     Drosophila erecta   Dere\GG10400     Drosophila yakuba   Dyak\GE13758     Drosophila ananassae   Dana\GF14513     Drosophila pseudoobscura pseudoobscura   Dpse\GA28018 Y   Drosophila persimilis   Dper\GL25514 Y   Drosophila willistoni   Dwil\GK14750 Y   Drosophila virilis   Dvir\GJ12739     Drosophila mojavensis   Dmoj\GI11477 Y   Drosophila grimshawi   Dgri\GH10734 Y
Orthologs in non-Drosophila Dipterans (EOG6H1B3V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002640 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008742 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008741 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011076 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011077 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011079 Y
Orthologs in non-Dipteran Insects (EOG6XD2KZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42408 Y Apis mellifera Western honey bee  Amel\GB44276 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016185 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017868 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18853 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18845 Y Atta cephalotes Leafcutter ant  Acep\ACEP25142 Y Atta cephalotes Leafcutter ant  Acep\ACEP25135 Y Atta cephalotes Leafcutter ant  Acep\ACEP25133 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18940 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18935 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18934 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16056 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16063 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16064 Y Linepithema humile Argentine ant  Lhum\LH23968 Y Linepithema humile Argentine ant  Lhum\LH13875 Y Linepithema humile Argentine ant  Lhum\LH23969 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22734 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22733 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22728 Y Solenopsis invicta Red fire ant  Sinv\SINV23773 Y Solenopsis invicta Red fire ant  Sinv\SINV23802 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI29477 Y Pediculus humanus Human body louse  Phum\PHUM500220 Y Pediculus humanus Human body louse  Phum\PHUM542980 Y Pediculus humanus Human body louse  Phum\PHUM618770 Y Tribolium castaneum Red flour beetle  Tcas\TC001549 Y Tribolium castaneum Red flour beetle  Tcas\TC001551 Y Tribolium castaneum Red flour beetle  Tcas\TC000265 Y
Orthologs in non-Insect Arthropods (EOG66T1GC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_332239 Y Ixodes scapularis Deer tick  Isca\ISCW022772 Y
Orthologs in non-Arthropod Metazoa (EOG6PS5HK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ddr-1 Y Caenorhabditis elegans Nematode  Cele\ddr-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026731gn Y Danio rerio Zebrafish  Drer\CABZ01009712.1 Y Danio rerio Zebrafish  Drer\ddr2l Y Danio rerio Zebrafish  Drer\ddr2a Y Danio rerio Zebrafish  Drer\ddr2b Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000004752 Y Xenopus tropicalis Western clawed frog  Xtro\ddr1 Y Xenopus tropicalis Western clawed frog  Xtro\ddr2 Y Gallus gallus Domestic chicken  Ggal\DDR2 Y Gallus gallus Domestic chicken  Ggal\GTF2H4 Y Mus musculus House mouse  Mmus\Ddr2 Y Mus musculus House mouse  Mmus\Ddr1 Y Rattus norvegicus Norway rat  Rnor\Ddr1 Y Rattus norvegicus Norway rat  Rnor\Ddr2 Y Homo sapiens Human  Hsap\DDR2 Y Homo sapiens Human  Hsap\DDR1 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\DDR2     Hsap\DDR1
AAA Orthologs (6) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23398 Drosophila pseudoobscura pseudoobscura Dpse\GA28018 Drosophila persimilis Dper\GL25514 Drosophila willistoni Dwil\GK14750 Drosophila mojavensis Dmoj\GI11477 Drosophila grimshawi Dgri\GH10734
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	29214 w1118; Mi{ET1}DdrMB11489 37144 y1 w*; Mi{MIC}DdrMI02079 37178 y1 w*; Mi{MIC}DdrMI03300 43876 y1 w*; Mi{MIC}DdrMI05645 44150 y1 w*; Mi{MIC}DdrMI05632
Harvard	- PBac{WH}Ddrf08070
Kyoto	125360 w1118; P{RS5}Ddr5-HA-1712 103728 w*; P{GawB}DdrNP0725 / CyO
VDRC	v51719 w1118; P{GD7334}v51719 v52126 w1118; P{GD7334}v52126 v23316 w1118; P{GD13382}v23316 v29720 w1118; P{GD15146}v29720
	More stocks available...
Genomic Clones ( 2 )
	BACR05J04 BACR23K01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP08577
Other clones	MIP05449
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG4-chr2L.11.020.pred.a EC052013 EC053057 EC054493 EC054998 EK229753 IP04867 IP05067 IP05167 IP08477 IP08677 IP08777
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053531 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3346209
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ddr CG9488 CG13985 CG11573 CG9490 (Edwards, 2003.2.11)
Source for database merge of	Source for merge of: CG9488 CG13985 CG11573 CG9490 (Edwards, 2003.2.11)
Additional comments	Annotations CG9488, CG13985, CG11573 and CG9490 merged as CG33531 (which corresponds to Ddr) in release 4.1 of the genome annotation. (FlyBase Genome Annotators, 2005)
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, chromosome abnormalities are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AAF52360.1 AAF52361.1 AAF52362.1 AAF52363.1 AAF52364.2 AAX52658 ACZ94186 Entrez Gene - A searchable database of RefSeq genes. • 3346209 UniProtKB/TrEMBL • E1JHA2 Q59DZ7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase-like domain (IPR011009) Protein kinase, catalytic domain (IPR000719) Galactose-binding domain-like (IPR008979) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245) Coagulation factor 5/8 C-terminal type domain (IPR000421)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77927 DroID - A comprehensive database of gene and protein interactions. • FBgn0053531 DRSC - Results from RNAi screens. • FBgn0053531 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053531 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11573-RA;CG9488-RA;CG9490-RA;Stencil:2L:6265031:6273206:GENSCAN FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053531 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3346209 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3346209 modMine - Data generated by the modENCODE project. • FBgn0053531
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG9488 (Bettencourt-Dias et al., 2004, Anholt and Mackay, 2001, ) CG9490 (Anholt and Mackay, 2001, Giot et al., 2003, Lee et al., 2002, Wheeler et al., 2004) CG11573 (Anholt and Mackay, 2001, ) CG13985 (Giot et al., 2003, Tuxworth et al., 2011) CG33531 (Holloway et al., 2008) CT33540 (Morrison et al., 2000) DDR (Morrison et al., 2000) Ddr (Holloway et al., 2008, Kazemi-Esfarjani, 2010.6.21, Wheeler et al., 2004)
Name Synonym	Discoidin domain receptor (Edwards, 2003.2.11)
Secondary FlyBase IDs
	FBgn0031793 FBgn0031794 FBgn0031795 FBgn0031796 FBgn0031797
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Tuxworth et al., 2011, Hum. Mol. Genet. 20(10): 2037--2047 The Batten disease gene CLN3 is required for the response to oxidative stress. [FBrf0213533] Show all research papers ...