Tra1, TRRAP, dTra1, l(2)41Ah, dTRRAP
Homologue of the yeast Tra1 and human TRRAP proteins - a key component of both the SAGA and Tip60 (NuA4) chromatin-modifying complexes - required for Mastermind function during wing development
Gene model reviewed during 6.02
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Gene model reviewed during 6.04
None of the polypeptides share 100% sequence identity.
Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1 (PubMed:15528408). Probable component of some SAGA complex (PubMed:12697829). Interacts with Spt3, Gcn5, Ada3 and Ada2b (PubMed:12697829).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nipped-A using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Nipped-A in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Release 4.1 annotation CG33554 (which corresponds to Nipped-A) contains sequences corresponding to both release 3.2 annotation CG2905 and release 2 annotation CG10549.
Source for merge of Tra1 CG2905 CG10549 was sequence comparison ( date:030120 ).
Complementation map circular, with the majority of mutants falling into a single complementation group that is complemented by only three of the thirty alleles.
dsRNA has been made from templates generated with primers directed against this gene.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
CG10549 was eliminated in release 3 of the genome annotation, January 2003.