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Gene Dmel\btsz

General Information
Symbol	Dmel\btsz	Species	D. melanogaster
Name	bitesize	Annotation symbol	CG33555
Feature type	protein_coding_gene	FlyBase ID	FBgn0053555
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	l(3)10418, CG7343
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88D4-88D5	Sequence location	3R:10,629,814..10,679,626 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bitesize is referred to in FlyBase by the symbol Dmel\btsz (CG33555, FBgn0053555). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transporter activity. There is experimental evidence that it is involved in the biological process: morphogenesis of embryonic epithelium; establishment of planar polarity of embryonic epithelium; positive regulation of cell size; apical junction assembly; gastrulation involving germ band extension; actin filament organization; positive regulation of multicellular organism growth. 33 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; mesothoracic tergum; tormogen cell; wing; ommatidium. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Synaptotagmin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea. Gene sequence location is 3R:10629814..10679626.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transgenic Constructs P{GD12208}
FB2012_01	Sequence features BKN32184 HFA14982 HFA15320 BKN33637 HFA16231
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88D4-88D5   Limits computationally determined from genome sequence between P{EP}CG33967EP666 and P{lacW}Hsc70-4L3929
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88D5-88D6   (determined by in situ hybridisation)   (Spradling et al., 1999) 88D5-88D6   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\btsz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) btsz-RB FBtr0091530  NM_001014625   7361   1102 btsz-RC FBtr0091531  NM_001014624   8603   2645 btsz-RD FBtr0091532  NM_001014623   5591   1517 btsz-RE FBtr0113468  NM_001104324   3022   708 btsz-RF FBtr0273198  NM_001144583   2698   600 btsz-RH FBtr0273200  NM_001144584   5015   1137 btsz-RI FBtr0306612     12383   3734
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein btsz-PB   FBpp0099987   121.5   1102   9.28     NP_001014625   AAX52953 btsz-PC   FBpp0099988   285.8   2645   5.28     NP_001014624   AAX52954 btsz-PD   FBpp0099989   164.9   1517   5.50     NP_001014623   AAX52955 btsz-PE   FBpp0112379   80.2   708   10.01     NP_001097794   ABW08676 btsz-PF   FBpp0271706   67.7   600   10.32     NP_001138055   ACL83513 btsz-PH   FBpp0271708   125.5   1137   9.40     NP_001138056   ACL83514 btsz-PI   FBpp0297567   405.1   3734   5.78
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium-dependent membrane targeting (IPR000008) Synaptotagmin (IPR001565) C2 calcium/lipid-binding domain, CaLB (IPR008973) C2 membrane targeting protein (IPR018029)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699078   AE014297 AAX52953   AE014297 AAX52954   AE014297 AAX52955   AE014297 ABW08676   AE014297 ACL83513   AE014297 ACL83514   AI113358   AI259248   AI387616   AQ026231   AQ073020   AY118748 AAM50608   AY229969 AAP04480   AY229970 AAP04481   AY229971 AAP04482   BI616850   BI627125   BT024249   BT025937   CK131412   CK661856   CL525886   CO177333   CO187427   CO190481   CO266465   CO268582   CO274373   CO313466   CO324597   CO326887   CO338971   CO342239   CO344248   CO344616   CZ469483   CZ471364   CZ476509   EC058008   EC065949   EC080492   EC083026   EC194506   EC202703   EC221937   EC223263   EC223626   EC235282   EC243012   EC243945   EC256279   EC259179   EC259681   EC260157   EL879208   EL879562   EL884368   EL884481
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q6XK18 Q6XK19 Q6XK20 Q8MSJ8 B7Z0K2 Q59DX2 B7Z0K1 A8JR10 Q59DW9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0053555    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0053555 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0053555 expression level Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr    3816 embryo 04-06hr    2151 embryo 06-08hr    1727 embryo 08-10hr    1674 embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr    1725 white prepupae 24hr    1958 pupae 2d postWPP    1554 pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (287) embryo 02-04hr  (3816) embryo 04-06hr  (2151) embryo 06-08hr  (1727) embryo 08-10hr  (1674) embryo 10-12hr  (1352) embryo 12-14hr  (1350) embryo 14-16hr  (1241) embryo 16-18hr  (1050) embryo 18-20hr  (995) embryo 20-22hr  (707) embryo 22-24hr  (761) larva L1  (753) larva L2  (848) larva L3 12hr old  (639) larva L3 puffstage 1-2  (466) larva L3 puffstage 3-6  (838) larva L3 puffstage 7-9  (928) white prepupae new  (1153) white prepupae 12hr  (1725) white prepupae 24hr  (1958) pupae 2d postWPP  (1554) pupae 3d postWPP  (1094) pupae 4d postWPP  (635) adult male 01day  (911) adult male 05day  (691) adult male 30day  (665) adult female 01day  (774) adult female 05day  (439) adult female 30day  (465) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr  (3816) embryo 04-06hr  (2151) embryo 06-08hr  (1727) embryo 08-10hr  (1674) embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr  (1725) white prepupae 24hr  (1958) pupae 2d postWPP  (1554) pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr    3816 embryo 04-06hr    2151 embryo 06-08hr    1727 embryo 08-10hr    1674 embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr    1725 white prepupae 24hr    1958 pupae 2d postWPP    1554 pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr    3816 embryo 04-06hr    2151 embryo 06-08hr    1727 embryo 08-10hr    1674 embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr    1725 white prepupae 24hr    1958 pupae 2d postWPP    1554 pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0053555 expression level Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr    3816 embryo 04-06hr    2151 embryo 06-08hr    1727 embryo 08-10hr    1674 embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr    1725 white prepupae 24hr    1958 pupae 2d postWPP    1554 pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (287) embryo 02-04hr  (3816) embryo 04-06hr  (2151) embryo 06-08hr  (1727) embryo 08-10hr  (1674) embryo 10-12hr  (1352) embryo 12-14hr  (1350) embryo 14-16hr  (1241) embryo 16-18hr  (1050) embryo 18-20hr  (995) embryo 20-22hr  (707) embryo 22-24hr  (761) larva L1  (753) larva L2  (848) larva L3 12hr old  (639) larva L3 puffstage 1-2  (466) larva L3 puffstage 3-6  (838) larva L3 puffstage 7-9  (928) white prepupae new  (1153) white prepupae 12hr  (1725) white prepupae 24hr  (1958) pupae 2d postWPP  (1554) pupae 3d postWPP  (1094) pupae 4d postWPP  (635) adult male 01day  (911) adult male 05day  (691) adult male 30day  (665) adult female 01day  (774) adult female 05day  (439) adult female 30day  (465) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr  (3816) embryo 04-06hr  2151 embryo 06-08hr  1727 embryo 08-10hr  1674 embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr  1725 white prepupae 24hr  1958 pupae 2d postWPP  1554 pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr    3816 embryo 04-06hr    2151 embryo 06-08hr    1727 embryo 08-10hr    1674 embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr    1725 white prepupae 24hr    1958 pupae 2d postWPP    1554 pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    287 embryo 02-04hr    3816 embryo 04-06hr    2151 embryo 06-08hr    1727 embryo 08-10hr    1674 embryo 10-12hr    1352 embryo 12-14hr    1350 embryo 14-16hr    1241 embryo 16-18hr    1050 embryo 18-20hr    995 embryo 20-22hr    707 embryo 22-24hr    761 larva L1    753 larva L2    848 larva L3 12hr old    639 larva L3 puffstage 1-2    466 larva L3 puffstage 3-6    838 larva L3 puffstage 7-9    928 white prepupae new    1153 white prepupae 12hr    1725 white prepupae 24hr    1958 pupae 2d postWPP    1554 pupae 3d postWPP    1094 pupae 4d postWPP    635 adult male 01day    911 adult male 05day    691 adult male 30day    665 adult female 01day    774 adult female 05day    439 adult female 30day    465 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0053555    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0053555 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7343-RA;CG31306-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for btsz Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal btszJ5-2 lethal | germline clone btszJ5-2 lethal | recessive btsz10418 semi-lethal btsz10418 semi-lethal | larval stage | recessive btszJ5-2 semi-lethal | recessive btsz10418 viable btsz10418 btszEY03603 viable, with Scer\GAL4[-]: btszEP3567 viable, with Scer\GAL4pnr-MD237 btszGD10224 btszGD12208 Sterility Allele fertile btsz10418 btszEY03603 semi-fertile | recessive btszunspecified Other Phenotypes Allele body color defective | recessive btszunspecified decreased cell number | adult stage | recessive btszJ5-2 decreased cell size | adult stage | recessive btszJ5-2 small body | adult stage | recessive btszJ5-2 visible, with Scer\GAL4pnr-MD237 btszGD10224 Phenotype manifest in Allele eye btszunspecified macrochaeta btszunspecified mesothoracic tergum, with Scer\GAL4pnr-MD237 btszGD10224 ommatidium btszunspecified tormogen cell, with Scer\GAL4pnr-MD237 btszGD10224 wing btszunspecified
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of btsz Class Mutagen Stocks Known lesion btszK13-4 P-element activity 2 Yes btsz10418 P-element activity 1 Yes btszd00072 P-element activity 1 -- btszd08989 P-element activity 1 -- btszDG09205 1 -- btsze02796 1 -- btszEP3567 P-element activity 1 Yes btszEY02982 1 -- btszEY03603 P-element activity 1 -- btszf02808 1 -- btszJ5-2 P-element activity 1 Yes btszNP5412 1 -- btsz5-HA-2183 0 -- btszc04745 piggyBac transposase 0 -- btszEY15736 0 -- btszunspecified 0 --
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of btsz Class Mutagen Stocks Known lesion btszGD10224 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes btsz1.gl.Scer\UAS in vitro construct - regulatory fusion 1 Yes btsz2.gl.Scer\UAS.T:PV\Pym in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes btsz2.gl.Scer\UAS in vitro construct - regulatory fusion 1 Yes btsz3.Scer\UAS in vitro construct - regulatory fusion 1 Yes btszBLR.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion 1 Yes btszKK112184 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btsz2.gl.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes btsz2.Δ3'UTR.gl.Scer\UAS in vitro construct - regulatory fusion 0 Yes btsz3.Δ3'UTR.Scer\UAS in vitro construct - regulatory fusion 0 Yes btsz3.ΔC2.Scer\UAS in vitro construct - regulatory fusion in vitro construct 0 Yes btsz3.ΔCT.Scer\UAS in vitro construct - regulatory fusion 0 Yes btszC2.gl.Scer\UAS in vitro construct - regulatory fusion 0 Yes btszC2AB.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes btszCT.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes btszGD12208 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes btszΔC2AB.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6275 (Ryder, 2004.4.26) Df(3R)Exel8160 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10224} NA P{GUS-btsz.1} NA P{GUS-btsz.2} NA P{GUS-btsz.2myc} NA P{GUS-btsz.2poly} NA P{GUS-btsz.2Δ3'UTR} NA P{GUS-btsz.3ΔC2} NA P{KK112184} NA P{UAS-btsz.3} NA P{UAS-btsz.3Δ3'UTR} NA P{UAS-btsz.3ΔC2} NA P{UAS-btsz.3ΔCT} NA P{UAS-btsz.CT} NA P{UAS-btsz.ΔC2AB-HA} NA P{UAS-C2AB-HA} NA P{UAS-GFP.BLR} NA characterization construct P{GD12208} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}btsz10418 No insertion of mobile activating element P{EP}btszEP3567 NA P{EPgy2}btszEY02982 NA P{EPgy2}btszEY03603 NA P{EPgy2}btszEY15736 NA P{XP}btszd00072 NA P{XP}btszd08989 NA miscellaneous insertions P{RS5}btsz5-HA-2183 NA P{wHy}btszDG09205 NA PBac{PB}btszc04745 NA PBac{RB}btsze02796 NA PBac{WH}btszf02808 NA insertion of enhancer trap binary system P{GawB}btszNP5412 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Pilot et al., 2006) apical junction assembly inferred from mutant phenotype (Pilot et al., 2006) establishment of planar polarity of embryonic epithelium inferred from mutant phenotype (Pilot et al., 2006) gastrulation involving germ band extension inferred from mutant phenotype (Pilot et al., 2006) morphogenesis of embryonic epithelium inferred from mutant phenotype (Pilot et al., 2006) positive regulation of cell size inferred from mutant phenotype (Serano and Rubin, 2003) positive regulation of multicellular organism growth inferred from mutant phenotype (Serano and Rubin, 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
transporter activity inferred from sequence or structural similarity with UniProtKB:Q96C24 (FlyBase, 1992-)
Biological Process
CV term Evidence References
synaptic vesicle transport inferred from sequence or structural similarity with UniProtKB:Q96C24 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
membrane inferred from sequence or structural similarity with UniProtKB:Q96C24 (FlyBase, 1992-) synaptic vesicle inferred from electronic annotation with InterPro:IPR001565 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions btsz allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77885 DroID - A comprehensive database of gene and protein interactions. • FBgn0053555 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3346167
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18128 Dere\GG21056 Dgri\GH14085 Dmoj\GI10617 Dper\GL23667 Dpse\GA26691 Dsec\GM25825 Dsim\GD20399 Dvir\GJ22970 Dwil\GK13835 Dyak\GE26427
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP005288-PA Anopheles gambiae (mosquito) XP_001947972.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000030362 Bos taurus (bovine) CPIJ001093 Culex pipens (mosquito) ENSCPOP00000006310 Cavia porcellus (guinea pig) 94612 Daphnia pulex (daphnia) 191179 Hypsipyla robusta (cedar shoot borer) ISCW022158-PA Ixodes scapularis (deer tick) XP_001607636.1 Nasonia vitripennis (wasp) ENSORLP00000018896 Oryzias latipes (japanese killifish) PHUM011326-PA Pediculus humanus (human body louse) XP_975183.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14150 LH24512 ISCW022158 FBgn0243451 FBgn0215843 FBgn0210072 FBgn0191871 FBgn0180681 JGI_V11_94612 FBgn0248064 FBgn0161257 FBgn0133381 FBgn0121561 FBgn0113239 FBgn0095146 CPIJ001094 BGIBMGA012483 ACYPI001625 GB13617 AGAP005288 AAEL003283 PB24723 PHUM597310 GLEAN_01061
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	8658 w1118; P{UAS-btsz.3}3 8660 w1118; P{GUS-btsz.2}2 8661 w1118; P{GUS-btsz.1}2 8659 w1118; P{UAS-GFP.BLR}3 8662 w1118; P{GUS-btsz.2poly}2
Harvard	- P{XP}btszd00072 - P{XP}btszd08989 - PBac{RB}btsze02796 - PBac{WH}btszf02808
VDRC	v102608 P{KK112184}VIE-260B v40236 w1118; P{GD10224}v40236/TM3 v40237 w1118; P{GD10224}v40237/TM3
	More stocks available...
Genomic Clones ( 3 )
	BACR08H11 BACR18C01 BACR48E23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 42 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06647 IP13955 IP15871
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18184 HL07423 LP21618 RH46948 RH68341
Other clones	12491 35597 59322 63804 66510 107241 146067 214353.34 214405.42 214507.37 214565.32 CK01.7A.E11 CK01.34B.A12 CK01.59D.B2 CK01.120C.H11 CK01.170C.D3 EK029227 EK048337 EK053204 EK092024 EK113927 EK146510 EK194330 EK233018 EP00445 EP04918 EP14252 EP18928 EP19614 IP09214 IP09514 IP15671 IP15771 LP02621
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41792 46210 3346167
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: btsz CG31306 (FlyBase, 1996-)
Source for database merge of	Source for merge of: l(3)10418 BcDNA:GH06647 (FlyBase, 1996-) Source for merge of: l(3)10418 CG14858 (Levis, 2002.6.25) Source for merge of: l(3)10418 CG18280 (FlyBase Genome Annotators, 2005, FlyBase Genome Annotators, 2002-2003)
Additional comments	Source for identity of btsz CG31306 was sequence comparison (date:030917). (FlyBase Genome Annotators, 2005, FlyBase, 1996-) Annotations CG14858 and CG18280 merged as CG31306 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of l(3)10418 BcDNA:GH06647 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Embryos injected with dsRNA made from templates generated with primers directed against this gene show defects in the organisation of the epithelium at the end of cellularisation. Gastrulation is completely arrested as the epithelium no longer elongates along the anteroposterior axis due to the epithelial cells losing their columnar organisation and becoming mesenchymal. (Pilot et al., 2006) dsRNA made from templates generated with primers directed against this gene severely affects gastrulation, resulting in the epithelium failing to extend properly. Defects are either strong or medium; that is, they are visible at the beginning of gastrulation or about 15 minutes later, respectively. The defects are penetrant (80%) and dose dependent. (Pilot et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001014623 NM_001014624 NM_001014625 NM_001104324 NM_001144583 NM_001144584 RefSeq (Proteins) • NP_001014623 NP_001014624 NP_001014625 NP_001097794 NP_001138055 NP_001138056 DDBJ / EMBL / GenBank • AAM50608 AAP04480 AAP04481 AAP04482 AAX52952 AAX52953 AAX52954 AAX52955 ABW08676 ACL83513 ACL83514 AI113358 AI259248 AQ026231 AQ073020 AY118748 AY229969 AY229970 AY229971 CL525886 CZ469483 CZ471364 CZ476509 Entrez Gene - A searchable database of RefSeq genes. • 3346167 UniProtKB/TrEMBL • A8JR10 B7Z0K1 B7Z0K2 Q6XK18 Q6XK19 Q6XK20 Q8MSJ8 Q59DW9 Q59DX2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium-dependent membrane targeting (IPR000008) Synaptotagmin (IPR001565) C2 calcium/lipid-binding domain, CaLB (IPR008973) C2 membrane targeting protein (IPR018029)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77885 DroID - A comprehensive database of gene and protein interactions. • FBgn0053555 DRSC - Results from RNAi screens. • FBgn0053555 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7343-RA;CG31306-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41792 46210 3346167 InParanoid A subset of ortholog calls from InParanoid. • AGAP005288-PA Anopheles gambiae (mosquito) XP_001947972.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000030362 Bos taurus (bovine) CPIJ001093 Culex pipens (mosquito) ENSCPOP00000006310 Cavia porcellus (guinea pig) 94612 Daphnia pulex (daphnia) 191179 Hypsipyla robusta (cedar shoot borer) ISCW022158-PA Ixodes scapularis (deer tick) XP_001607636.1 Nasonia vitripennis (wasp) ENSORLP00000018896 Oryzias latipes (japanese killifish) PHUM011326-PA Pediculus humanus (human body louse) XP_975183.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3346167 modMine - Data generated by the modENCODE project. • FBgn0053555 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14150 LH24512 ISCW022158 FBgn0243451 FBgn0215843 FBgn0210072 FBgn0191871 FBgn0180681 JGI_V11_94612 FBgn0248064 FBgn0161257 FBgn0133381 FBgn0121561 FBgn0113239 FBgn0095146 CPIJ001094 BGIBMGA012483 ACYPI001625 GB13617 AGAP005288 AAEL003283 PB24723 PHUM597310 GLEAN_01061
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BcDNA:GH06647   btsz (Cavey et al., 2008, Maybeck and Röper, 2009, Liang et al., 2008, Wasbrough et al., 2010) Btsz (Pilot et al., 2006, Pilot, 2006, Halbleib and Nelson, 2006) CG7343 (Jasper et al., 2002, Giot et al., 2003, Pilot et al., 2006) CG14858 (Pilot et al., 2006) CG18280   CG31306   CG33555 (Keleman et al., 2009.8.5) l(3)10418 (Berkeley Drosophila Genome Project, 1993.6.1, Levis, 2002.6.25, Spradling et al., 1999, BDGP Project Members, 1994-1999, )
Name Synonym	bitesize (Fehon, 2006, Weis and Nelson, 2006, Cavey et al., 2008, Maybeck and Röper, 2009) Bitesize (Pilot et al., 2006)
Secondary FlyBase IDs
	FBan0007343 FBan0031306 FBgn0010940 FBgn0038263 FBgn0038264 FBgn0038265 FBgn0051306 FBgn0063267 FBpp0082472 FBpp0082473 FBtr0083013 FBtr0083014
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 1 ) FlyBase analysis  ( 5 ) Computer file  ( 4 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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