Caps, dCAPS, calcium-activated protein for secretion, Calcium activated protein for secretion
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; RNA-Seq coverage and junction data). May be specific to sequenced strain; not included in gene model.
None of the polypeptides share 100% sequence identity.
The PH domain is essential for regulated exocytosis and binds phospholipids.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cadps using the Feature Mapper tool.
Caps transcript is first detected at embryonic stage 9-10, coinciding with the onset of neural development. It accumulates from embryonic stage 12 in the region of embryonic central nervous system occupied by neuroblasts and their neuronal progeny. Caps transcript is progressively enriched in the brain and ventral nerve cord during the rest of embryonic development. Caps transcript is not detected in the peripheral nervous system, or in non-neuronal tissues.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cadps in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Cadps Caps
Source for merge of: Caps BcDNA:GH07283 CG18026
Renamed from 'Caps' to 'Cadps' to reduce confusion with the 'caps' ('capricious') gene symbol, from which it differed only by case. 'Cadps' is the symbol used for the mammalian ortholog.
Annotation CG40477 corresponds to the 5' portion of Caps. This annotation is separate from the rest of the Caps annotation due to an inversion of a BAC on scaffold AE003846 in the Release 3 sequence. New annotation (CG40477) in release 3.2 of the genome annotation.
Annotation CG18026 corresponds to part of Caps, but the annotation is incomplete due to a sequencing gap and should extend further 5'.
Neuromuscular junctions in Caps mutant embryos show a 50% loss in evoked glutamatergic transmission and an accumulation of synaptic vesicles at active zones. They show a highly specific 3-fold accumulation of dense-core vesicles in synaptic terminals.
Identified with: GH07283 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.
Annotation CG17881 was eliminated in the September 2000 Celera release of annotated sequence.