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Gene Dmel\CG33768

General Information
Symbol	Dmel\CG33768	Species	D. melanogaster
Name		Annotation symbol	CG33768
Feature type	protein_coding_gene	FlyBase ID	FBgn0053768
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	79F3-79F3	Sequence location	3L:22,640,287..22,640,848 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG33768 (FBgn0053768). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein of unknown function DM8; Protein of unknown function DUF1091. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of CG33768. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of CG33768. Gene sequence location is 3L:22640287..22640848.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 79F3-79F3   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG33768 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene split based on protein alignment (BLASTX) data Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG33768-RA FBtr0091769  NM_001031971   504   167
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG33768-PA   FBpp0091030   19.0   167   9.67     NP_001027142   AAZ66073
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1091 (IPR010512) Protein of unknown function DM8 (IPR006617)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAZ66073
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q4ABH8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053768
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG33768GD8335 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG33768 Class Mutagen Stocks Known lesion CG33768MI03321 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG33768 Class Mutagen Stocks Known lesion CG33768GD8335 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG33768KK105200 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8335} NA P{KK105200} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG33768MI03321 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a biological process, cellular component or molecular function term for this gene. (Based on a review of available data on: 2006-05-23)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG33768 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0053768
Orthologs
OrthoDB Orthologs (9) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6960C7 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6960C7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG33768     Drosophila simulans   Dsim\GD15037 Y   Drosophila sechellia   Dsec\GM22456 Y   Drosophila erecta   Dere\GG16265 Y   Drosophila yakuba   Dyak\GE22623 Y   Drosophila ananassae   Dana\GF20140 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28452 Y   Drosophila persimilis   Dper\GL18087 Y   Drosophila willistoni   Dwil\GK19261 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15037 Drosophila sechellia Dsec\GM22456 Drosophila erecta Dere\GG16265 Drosophila yakuba Dyak\GE22623 Drosophila ananassae Dana\GF20140 Drosophila pseudoobscura pseudoobscura Dpse\GA28452 Drosophila persimilis Dper\GL18087 Drosophila willistoni Dwil\GK19261
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	36232 y1 w*; Mi{MIC}CG33768MI03321/TM3, Sb1 Ser1
VDRC	v101612 P{KK105200}VIE-260B v17632 w1118; P{GD8335}v17632 v17633 w1118; P{GD8335}v17633
Genomic Clones ( 1 )
	BACR15C16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053768 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3771840
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Release 3.2 annotation CG14458 split into CG33767, CG33768, CG33769, CG33770 and CG33771 in release 4.2 of the genome annotation. Also, release 4.2 annotation CG33766 contains sequences corresponding to the 5' exon of the release 2 CG14458 annotation. (FlyBase Genome Annotators, 2005)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001031971 RefSeq (Proteins) • NP_001027142 DDBJ / EMBL / GenBank • AAZ66073 Entrez Gene - A searchable database of RefSeq genes. • 3771840 UniProtKB/TrEMBL • Q4ABH8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1091 (IPR010512) Protein of unknown function DM8 (IPR006617)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0053768 DRSC - Results from RNAi screens. • FBgn0053768 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053768 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053768 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3771840 modMine - Data generated by the modENCODE project. • FBgn0053768
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG14458 (Ponting et al., 2001, ) CG33768 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0037173
References ( 9 )
Research paper	Ponting et al., 2001, Genome Res. 11(12): 1996--2008 Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. [FBrf0141558]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2011.5.31, set938.xml set938.xml [FBrf0213719] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase Genome Annotators, 2005, Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. [FBrf0182792] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]