FlyBase Gene Report: Dmel\His2A:CG33820

General Information

Symbol

Dmel\His2A:CG33820

Species

D. melanogaster

Name

His2A:CG33820

Annotation Symbol

CG33820

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053820

Gene Model Status

Current

Stock Availability

None publicly available

Gene Summary

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProt, P84051)

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All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

39D4-39D4

Sequence location

2L:21,463,055..21,463,547 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:21463055..21463547

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

inferred from sequence or structural similarity with UniProtKB:Q7L7L0

(Gene Ontology Curators, 2002-)

inferred from sequence or structural similarity with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Matsuo and Yamazaki, 1989)

inferred from electronic annotation with InterPro:IPR002119, InterPro:IPR007125

(InterPro Project Members, 2004-)

enables protein heterodimerization activity

inferred from electronic annotation with InterPro:IPR009072

(InterPro Project Members, 2004-)

enables structural constituent of chromatin

inferred from electronic annotation with InterPro:IPR002119

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in larval somatic muscle development

inferred from mutant phenotype

(Schnorrer et al., 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in chromatin organization

inferred from sequence or structural similarity with MGI:MGI:2448285

(Gene Ontology Curators, 2002-)

inferred from sequence or structural similarity with MGI:MGI:2448285 with MGI:MGI:2448285 with MGI:MGI:2448285 with MGI:MGI:2448285 with MGI:MGI:2448285 with MGI:MGI:2448285

(Gene Ontology Curators, 2002-)

involved_in heterochromatin formation

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

involved_in nucleosome assembly

non-traceable author statement

(Matsuo and Yamazaki, 1989)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in chromosome

inferred from direct assay

(Leach et al., 2000)

located_in nucleus

inferred from direct assay

(Leach et al., 2000)

located_in polytene chromosome band

inferred from direct assay

(Leach et al., 2000)

located_in polytene chromosome

inferred from direct assay

(Leach et al., 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of nucleosome

non-traceable author statement

(Matsuo and Yamazaki, 1989)

traceable author statement

(Leach et al., 2000)

inferred from sequence or structural similarity with UniProtKB:Q7L7L0

(Gene Ontology Curators, 2002-)

inferred from sequence or structural similarity with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0 with UniProtKB:Q7L7L0

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002119

(InterPro Project Members, 2004-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the histone H2A family. (P84051)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

39D4-39D4

Sequence location

2L:21,463,055..21,463,547 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

39D4-39D4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-54.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (2)

Datasets (0)

External Crossreferences and Linkouts ( 38 )

References (8)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

NA

Gene ToolKit

Disease Model Summary Ribbon

Report Sections