FB2020_06, released Dec 22, 2020

Gene: Dmel\CG34031

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General Information
Symbol
Dmel\CG34031
Species
D. melanogaster
Name
Annotation Symbol
CG34031
Feature Type
protein_coding_gene
FlyBase ID
FBgn0054031
Gene Model Status
Current
Stock Availability
2 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

BP1068

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:23,174,446..23,185,750 [+]
Recombination map

3-47

RefSeq locus
NT_037436 REGION:23174446..23185750
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR017970
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription, DNA-templated
inferred from electronic annotation with InterPro:IPR017970
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS -
NK-like (NKL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. NKL transcription factors are homeobox genes closely related to Hox-like genes, a number of which are found in the NK cluster. Many of the NKL members contain an Engrailed Homology 1 (EH1) motif. (Adapted from FBrf0232555 and PMID:22094586).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG34031 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.46

Gene model reviewed during 5.40

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
(FlyBase Genome Annotators, 2011)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG34031-RC
FBtr0308948
NM_001259965
740
219
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG34031-PC
FBpp0301047
25.3
219
10.79
NP_001246894
AFH04565
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG34031 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG34031 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG34031
Transgenic constructs containing regulatory region of CG34031
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Scer\GAL4Tub.PU
Sterility
Allele
fertile, with Scer\GAL4Tub.PU
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BARHL1
1 of 15
Yes
No
Hsap\BARHL2
1 of 15
Yes
No
Hsap\BARX1
1 of 15
Yes
No
Hsap\BARX2
1 of 15
Yes
No
Hsap\DBX1
1 of 15
Yes
No
Hsap\DBX2
1 of 15
Yes
No
Hsap\HLX
1 of 15
Yes
No
Hsap\LBX1
1 of 15
Yes
No
Hsap\LBX2
1 of 15
Yes
No
2  
Hsap\NKX1-1
1 of 15
Yes
No
Hsap\NKX1-2
1 of 15
Yes
No
Hsap\NPM1
1 of 15
Yes
No
0  
Hsap\TLX1
1 of 15
Yes
No
Hsap\TLX2
1 of 15
Yes
No
Hsap\TLX3
1 of 15
Yes
No
Hsap\VENTX
1 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Barhl1
1 of 15
Yes
No
Mmus\Barhl2
1 of 15
Yes
No
Mmus\Barx1
1 of 15
Yes
No
Mmus\Barx2
1 of 15
Yes
No
Mmus\Dbx1
1 of 15
Yes
No
Mmus\Dbx2
1 of 15
Yes
No
Mmus\Hlx
1 of 15
Yes
No
Mmus\Lbx1
1 of 15
Yes
No
Mmus\Lbx2
1 of 15
Yes
No
Mmus\Nkx1-1
1 of 15
Yes
No
Mmus\Nkx1-2
1 of 15
Yes
No
Mmus\Npm1
1 of 15
Yes
No
Mmus\Obox6
1 of 15
Yes
Yes
Mmus\Tlx1
1 of 15
Yes
No
Mmus\Tlx2
1 of 15
Yes
No
Mmus\Tlx3
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (14)
Rnor\Barhl1
1 of 13
Yes
No
Rnor\Barhl2
1 of 13
Yes
No
Rnor\Barx1
1 of 13
Yes
No
Rnor\Barx2
1 of 13
Yes
No
Rnor\Dbx1
1 of 13
Yes
No
Rnor\Dbx2
1 of 13
Yes
No
Rnor\Hlx
1 of 13
Yes
No
Rnor\Lbx1
1 of 13
Yes
No
Rnor\LOC103692168
1 of 13
Yes
No
Rnor\Nkx1-1
1 of 13
Yes
No
Rnor\Nkx1-2
1 of 13
Yes
No
Rnor\Npm1
1 of 13
Yes
No
Rnor\Tlx1
1 of 13
Yes
No
Rnor\Tlx3
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\barhl1
1 of 12
Yes
No
Xtro\barhl2
1 of 12
Yes
No
Xtro\barx1
1 of 12
Yes
No
Xtro\dbx1
1 of 12
Yes
No
Xtro\hlx
1 of 12
Yes
No
Xtro\nkx1-1
1 of 12
Yes
No
Xtro\nkx1-2
1 of 12
Yes
No
Xtro\npm1
1 of 12
Yes
No
Xtro\tlx1
1 of 12
Yes
No
Xtro\tlx2
1 of 12
Yes
No
Xtro\tlx3
1 of 12
Yes
No
Xtro\ventx1.2
1 of 12
Yes
No
Xtro\ventx2.1
1 of 12
Yes
No
Xtro\ventx2.2
1 of 12
Yes
No
Danio rerio (Zebrafish) (20)
Drer\barhl1a
1 of 15
Yes
No
Drer\barhl1b
1 of 15
Yes
No
Drer\barhl2
1 of 15
Yes
No
Drer\barx1
1 of 15
Yes
No
Drer\barx2
1 of 15
Yes
No
Drer\dbx1b
1 of 15
Yes
No
Drer\hlx1
1 of 15
Yes
No
Drer\lbx1a
1 of 15
Yes
No
Drer\lbx1b
1 of 15
Yes
No
Drer\lbx2
1 of 15
Yes
No
Drer\LOC100008066
1 of 15
Yes
No
Drer\mnx2a
1 of 15
Yes
No
Drer\mnx2b
1 of 15
Yes
No
Drer\npm1b
1 of 15
Yes
No
Drer\tlx1
1 of 15
Yes
No
Drer\tlx2
1 of 15
Yes
No
Drer\tlx3b
1 of 15
Yes
No
Drer\ved
1 of 15
Yes
Yes
Drer\vent
1 of 15
Yes
Yes
Drer\vox
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ceh-19
4 of 15
Yes
Yes
Cele\ceh-1
1 of 15
No
No
Cele\ceh-30
1 of 15
No
No
Cele\ceh-31
1 of 15
No
No
Cele\ceh-62
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190GD6 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD29258
Drosophila simulans
Dsim\GD26852
Drosophila simulans
Dsim\GD27597
Drosophila erecta
Dere\GG26529
Drosophila ananassae
Dana\GF26840
Drosophila pseudoobscura pseudoobscura
Dpse\GA31647
Drosophila willistoni
Dwil\GK28065
Drosophila virilis
Dvir\GJ26136
Drosophila mojavensis
Dmoj\GI23625
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BVN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004364
Mayetiola destructor
Hessian fly
Mdes\Mdes007026
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011541
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05QE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012499
Danaus plexippus
Monarch butterfly
Dple\DPOGS201237-PA
Apis florea
Little honeybee
Aflo\2147574019
Apis mellifera
Western honey bee
Amel\LOC726825
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14923
Bombus terrestris
Buff-tailed bumblebee
Bter\15203977
Linepithema humile
Argentine ant
Lhum\LH21788
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002432
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008875
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08078
Tribolium castaneum
Red flour beetle
Tcas\TC001164
Pediculus humanus
Human body louse
Phum\PHUM606500
Rhodnius prolixus
Kissing bug
Rpro\RPRC000954
Cimex lectularius
Bed bug
Clec\CLEC003809
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI42465
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18185
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05MD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006886
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02100
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_29136
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08M2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Phb2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (9)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
B-H1
1 of 10
B-H2
1 of 10
C15
1 of 10
CG11085
1 of 10
Dbx
1 of 10
H2.0
1 of 10
lbe
1 of 10
lbl
1 of 10
slou
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-47

    Cytogenetic map
    80D4-80D4
    Sequence location
    3L:23,174,446..23,185,750 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    80D4-80D4
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-47

    (FlyBase, 2016)

    3-44.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (2)
    Genomic Clones (11)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (12)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: CG34031 BP1068

              (FlyBase Genome Annotators, 2005)
              Source for database merge of
              Additional comments
              Other Comments

              Annotation CR34031 renamed CG34031 in release 5.40 of the genome annotation.

              (FlyBase Genome Annotators, 2011)

              Annotation CR34031 reclassified as a pseudogene in release 5.26 of the genome annotation (renamed CR34031 in the prior release).

              (FlyBase Genome Annotators, 2010)

              New annotation (CG34031) in release 4.3 of the genome annotation.

              (FlyBase Genome Annotators, 2005)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 23 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Synonyms and Secondary IDs (3)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (17)