Gene Dmel\Ctr1C

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General Information

Symbol

Dmel\Ctr1C

Species

D. melanogaster

Name

Copper transporter 1C

Annotation symbol

CG15551

Feature type

protein_coding_gene

FlyBase ID

FBgn0062411

Gene Model Status

Current

Stock availability

2 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

100B1-100B1

Sequence location

3R:26,789,012..26,790,042 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Copper transporter 1C is referred to in FlyBase by the symbol Dmel\Ctr1C (CG15551, FBgn0062411). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: copper ion transmembrane transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: copper ion transmembrane transport. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ctr copper transporter. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1634214_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Ctr1C. Gene sequence location is 3R:26789012..26790042.

User Contributed Data

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Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100B1-100B1

Limits computationally determined from genome sequence between P{lacW}l(3)s2500^s2500 and P{PZ}Aph-4⁰⁷⁰²⁸&P{PZ}dco^rK215

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Ctr1C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Ctr1C-RA

FBtr0085749

NM_143580

1031

270

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Ctr1C-PA

FBpp0085111

30.8

270

8.29

NP_651837

AAF57103

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ctr copper transporter (IPR007274)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		2.2
Larval Midgut		2.2
Larval Hindgut		2.4
Larval Malpighian Tubules		3.5
Larval Fat Body		38.9
Larval Salivary Gland		2.2
Larval Trachea		2.45
Larval Carcass		6.8
Adult Head		1.2
Adult Eye		1.15
Adult Brain		2.5
Adult Thoracic-Abdominal Ganglion		3.6
Adult Crop		4.2
Adult Midgut		3
Adult Hindgut		3.2
Adult Malpighian Tubules		3.5
Adult Fat Body		5
Adult Salivary Gland		2.1
Adult Heart		1.025
Adult VirginFemale Spermatheca		3.2
Adult InseminatedFemale Spermatheca		3.1
Adult Ovary		2.4
Adult Testis		208.9
Adult Male Accessory Gland		5.3
Adult Carcass		7
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	1.2
NA	Eye	1.15
NA	Brain	2.5
2.2	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	3.6
NA	Crop	4.2
2.2	Midgut	3
2.4	Hindgut	3.2
3.5	Malpighian Tubules	3.5
no informative data	Fat Body	5
2.2	Salivary Gland	2.1
NA	Heart	1.025
2.45	Trachea	NA
NA	VirginFemale Spermatheca	3.2
NA	InseminatedFemale Spermatheca	3.1
NA	Ovary	2.4
NA	Testis	208.9
NA	Male Accessory Gland	5.3
6.8	Carcass	7

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		37
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		(37)
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		37
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		37
accessory gland, mated 4-day male		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		37
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		(37)
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		37
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		2
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		37
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		3
white prepupae new		2
white prepupae 12hr		4
white prepupae 24hr		6
pupae 2d postWPP		6
pupae 3d postWPP		5
pupae 4d postWPP		5
adult male 01day		7
adult male 05day		11
adult male 30day		11
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		1
heat shock, 4-day adult		2
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		1
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		1
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(Graveley et al., 2011)

mE1_20_mRNA_expression_cluster_20

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0062411

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG15551-RB

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

Ctr1C^GD3136

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Ctr1C	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Ctr1C	Mutagen	Stocks	Known lesion
Ctr1C^GD3136	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Ctr1C^KK110883	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Ctr1C^Act5C.PZ	in vitro construct - regulatory fusion	0	Yes
Ctr1C^NIG.15551R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)Exel6260

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD3136}

P{KK110883}

P{NIG.15551R}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

copper ion transmembrane transporter activity

inferred from sequence or structural similarity with NCBI_gi:4507015

(FlyBase, 1992-)

non-traceable author statement

(Zhou et al., 2002)

Biological Process

CV term

Evidence

References

copper ion transmembrane transport

inferred from electronic annotation with InterPro:IPR007274

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

integral to membrane

inferred from electronic annotation with InterPro:IPR007274

(FlyBase Curators et al., 2004-)

plasma membrane

non-traceable author statement

(Zhou et al., 2002)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Ctr1C allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0062411

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

43668

Orthologs

OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6NCN0J

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

EOG6HTNP0

Orthologs in Drosophila Species (EOG6NCN0J)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13809

Drosophila persimilis

Dper\GL13975

Drosophila willistoni

Dwil\GK13100

Drosophila virilis

Dvir\GJ10663

Drosophila mojavensis

Dmoj\GI10446

Drosophila grimshawi

Dgri\GH14352

Drosophila grimshawi

Dgri\GH23297

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (None identified)

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (EOG6HTNP0)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\K12C11.3

Caenorhabditis elegans

Nematode

Cele\Y58A7A.1

Caenorhabditis elegans

Nematode

Cele\F58G6.9

Caenorhabditis elegans

Nematode

Cele\F27C1.2

Caenorhabditis elegans

Nematode

Cele\F58G6.3

Caenorhabditis elegans

Nematode

Cele\K12C11.6

Caenorhabditis elegans

Nematode

Cele\F31E8.4

Caenorhabditis elegans

Nematode

Cele\F01G12.1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_012675gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_000048gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_013043gn

Danio rerio

Zebrafish

Drer\slc31a1

Xenopus tropicalis

Western clawed frog

Xtro\slc31a1

Xenopus tropicalis

Western clawed frog

Xtro\slc31a2

Gallus gallus

Domestic chicken

Ggal\SLC31A2

Gallus gallus

Domestic chicken

Ggal\SLC31A1

Mus musculus

House mouse

Mmus\Slc31a2

Mus musculus

House mouse

Mmus\Slc31a1

Rattus norvegicus

Norway rat

Rnor\Slc31a2

Rattus norvegicus

Norway rat

Rnor\Slc31a1

Homo sapiens

Human

Hsap\SLC31A1

Homo sapiens

Human

Hsap\SLC31A2

Human Orthologs (2)

Gene

OMIM

HGNC

Hsap\SLC31A1

Hsap\SLC31A2

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13809

Drosophila persimilis

Dper\GL13975

Drosophila willistoni

Dwil\GK13100

Drosophila virilis

Dvir\GJ10663

Drosophila mojavensis

Dmoj\GI10446

Drosophila grimshawi

Dgri\GH23297

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v102136

P{KK110883}VIE-260B

v10263

w¹¹¹⁸; P{GD3136}v10263

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 1 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

AT31946

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0062411

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

43668

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: CG15551 BcDNA:AT31946

(FlyBase, 1996-)

Source for merge of: Ctr1C CG15551

(Zhou et al., 2003)

Additional comments

Source for merge of CG15551 BcDNA:AT31946 was a shared cDNA (date:030728).

(FlyBase, 1996-)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_143580

RefSeq (Proteins)

•

NP_651837

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

43668

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ctr copper transporter (IPR007274)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0062411

DRSC - Results from RNAi screens.

•

FBgn0062411

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0062411

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG15551-RB

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0062411

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

43668

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

43668

modMine - Data generated by the modENCODE project.

•

FBgn0062411

Synonyms & Secondary IDs ( 5 )

Reported As

Symbol Synonym

BcDNA:AT31946

CG15551

(Zhou et al., 2003, Keleman et al., 2009.8.5)

Ctr1C

(Yepiskoposyan et al., 2006, Steiger et al., 2010, Hua et al., 2010, Japanese National Institute of Genetics, 2012.5.21)

FBgn0039813

Name Synonym

Copper transporter 1C

(Zhou et al., 2002)

Secondary FlyBase IDs

FBgn0039813
FBgn0061424

References ( 20 )

Research paper

Hua et al., 2010, J. Biol. Inorg. Chem. 15(1): 107--113: Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects. [FBrf0209805]
Steiger et al., 2010, J. Biol. Chem. 285(22): 17089--17097: The Drosophila Copper Transporter Ctr1C Functions in Male Fertility. [FBrf0210824]
Yepiskoposyan et al., 2006, Nucleic Acids Res. 34(17): 4866--4877: Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. [FBrf0193346]
Selvaraj et al., 2005, Genes Dev. 19(8): 891--896: Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. [FBrf0187596]
Southon et al., 2004, Biochem. J. 383(2): 303--309: Copper homoeostasis in Drosophila melanogaster S2 cells. [FBrf0179972]
Zhou et al., 2003, J. Biol. Chem. 278(48): 48210--48218: A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. [FBrf0167752]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

Abstract

Turski et al., 2005, A. Dros. Res. Conf. 46: 261C: Analysis of Drosophila Copper Transporters: The Essential Role of Copper in Development. [FBrf0183575]
Zhou et al., 2003, A. Dros. Res. Conf. 44: 270C: The role of the essential nutrient copper in Drosophila development: function and transcriptional regulation of the Ctr1B copper transporter. [FBrf0154433]
Zhou et al., 2002, A. Dros. Res. Conf. 43 Suppl.: 1009A: Understanding Copper Homeostasis in Drosophila Physiology and Development. [FBrf0146685]

FlyBase analysis

FlyBase, 1996-, FlyBase inference based on genome sequence analysis.: FlyBase inference based on genome sequence analysis. [FBrf0104946]
FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Curated genome annotation

Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126679]