FB2020_06, released Dec 22, 2020

Gene: Dmel\CG13197

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General Information
Symbol
Dmel\CG13197
Species
D. melanogaster
Name
Annotation Symbol
CG13197
Feature Type
protein_coding_gene
FlyBase ID
FBgn0062449
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
48C2-48C2
Sequence location
2R:11,691,285..11,697,785 [+]
Recombination map

2-65

RefSeq locus
NT_033778 REGION:11691285..11697785
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables polynucleotide 5'-phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000042417
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein tyrosine phosphatase activity
inferred from electronic annotation with InterPro:IPR016130
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein tyrosine/serine/threonine phosphatase activity
inferred from electronic annotation with InterPro:IPR000340
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein dephosphorylation
inferred from electronic annotation with InterPro:IPR000340
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
There is no information supporting a Cellular Component term for this gene. (Based on a review of available data on: 2015-05-15 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
DUAL SPECIFICITY PHOSPHATASES -
Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG13197 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG13197-RA
FBtr0088078
NM_136852
1274
343
CG13197-RB
FBtr0345619
NM_001299390
3613
343
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG13197-PA
FBpp0087183
40.8
343
10.02
NP_610696
AAF58626
CG13197-PB
FBpp0311687
40.8
343
10.02
NP_001286319
AHN56117
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

343 aa isoforms: CG13197-PA, CG13197-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG13197 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG13197 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG13197
Transgenic constructs containing regulatory region of CG13197
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DUSP11
13 of 15
Yes
Yes
Hsap\RNGTT
2 of 15
No
No
6  
Hsap\DUSP23
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dusp11
12 of 15
Yes
Yes
Mmus\Rngtt
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\LOC103690006
6 of 13
Yes
Yes
Rnor\Dusp11
4 of 13
No
Yes
Rnor\Rngtt
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\dusp11.2
7 of 12
Yes
Yes
Xtro\dusp11
2 of 12
No
Yes
Xtro\rngtt
2 of 12
No
No
Danio rerio (Zebrafish) (2)
Drer\dusp11
10 of 15
Yes
Yes
Drer\rngtt
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\pir-1
9 of 15
Yes
Yes
Cele\F54C8.4
7 of 15
No
Yes
Cele\cel-1
2 of 15
No
No
Cele\ptp-4
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\AT3G09100
3 of 9
Yes
No
Atha\AT5G01290
3 of 9
Yes
No
Atha\AT5G28210
3 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CEG1
2 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ceg1
1 of 12
Yes
No
Spom\clp1
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A1J )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002447
Drosophila simulans
Dsim\GD10810
Drosophila sechellia
Dsec\GM21302
Drosophila erecta
Dere\GG20215
Drosophila yakuba
Dyak\GE12375
Drosophila ananassae
Dana\GF11454
Drosophila pseudoobscura pseudoobscura
Dpse\GA12112
Drosophila persimilis
Dper\GL10081
Drosophila willistoni
Dwil\GK17880
Drosophila virilis
Dvir\GJ20873
Drosophila mojavensis
Dmoj\GI21271
Drosophila grimshawi
Dgri\GH22885
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504QV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007010
Musca domestica
House fly
Mdoa\17004921
Musca domestica
House fly
Mdoa\17004994
Glossina morsitans
Tsetse fly
Gmor\GMOY000047
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09859
Mayetiola destructor
Hessian fly
Mdes\Mdes004583
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004437
Anopheles gambiae
Malaria mosquito
Agam\AGAP011155
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0JOZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Dple\DPOGS212291-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014940
Apis florea
Little honeybee
Aflo\2147532835
Apis florea
Little honeybee
Aflo\4732235860
Apis mellifera
Western honey bee
Amel\GB42332
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14534
Bombus terrestris
Buff-tailed bumblebee
Bter\15205381
Bombus terrestris
Buff-tailed bumblebee
Bter\15203474
Linepithema humile
Argentine ant
Lhum\LH17952
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ef9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000660
Tribolium castaneum
Red flour beetle
Tcas\TC032238
Pediculus humanus
Human body louse
Phum\PHUM512120
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI44172
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010111
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10219
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0JU9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003304
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71931.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07510
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_320429
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_326892
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_98101
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_16505
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_109145
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_338314
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_118640
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HD0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dusp11
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014482
Gallus gallus
Domestic chicken
Ggal\DUSP11
Gallus gallus
Domestic chicken
Ggal\LOC419511
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
mRNA-cap
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DUSP11; dual specificity phosphatase 11
    13 of 15
    603092
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-65

        Cytogenetic map
        48C2-48C2
        Sequence location
        2R:11,691,285..11,697,785 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        48C2-48C2
        Limits computationally determined from genome sequence between P{EP}walEP825&P{PZ}wal02516 and P{PZ}Ef1α48D01275
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-65

        (FlyBase, 2016)

        2-65.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (24)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: BcDNA:RE27552 CG13197

            (FlyBase, 1996-)
            Additional comments

            Source for merge of BcDNA:RE27552 CG13197 was a shared cDNA ( date:030206 ).

            (FlyBase, 1996-)
            Other Comments

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            (Kiger et al., 2003)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 34 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (2)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (33)