FlyBase Gene Report: Dmel\CG13197

General Information

Symbol

Dmel\CG13197

Species

D. melanogaster

Name

Annotation Symbol

CG13197

Feature Type

protein_coding_gene

FlyBase ID

FBgn0062449

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

Polynucleotide 5'-phosphatase (3.1.3.33)

Protein-tyrosine-phosphatase (3.1.3.48)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

48C2-48C2

Sequence location

2R:11,691,285..11,697,785 [+]

Recombination map

2-65

RefSeq locus

NT_033778 REGION:11691285..11697785

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables polynucleotide 5'-phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000042417

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein tyrosine phosphatase activity

inferred from electronic annotation with InterPro:IPR016130

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables protein tyrosine/serine/threonine phosphatase activity

inferred from electronic annotation with InterPro:IPR000340

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein dephosphorylation

inferred from electronic annotation with InterPro:IPR000340

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (0 terms)

There is no information supporting a Cellular Component term for this gene. (Based on a review of available data on: 2015-05-15 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

DUAL SPECIFICITY PROTEIN PHOSPHATASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate (3.1.3.33)

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)

Summaries

Gene Group (FlyBase)

DUAL SPECIFICITY PROTEIN PHOSPHATASES -: Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG13197 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG13197-RA

FBtr0088078

NM_136852

1274

343

CG13197-RB

FBtr0345619

NM_001299390

3613

343

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG13197-PA

FBpp0087183

40.8

343

10.02

NP_610696

AAF58626

CG13197-PB

FBpp0311687

40.8

343

10.02

NP_001286319

AHN56117

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

343 aa isoforms: CG13197-PA, CG13197-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8SX38

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG13197 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG13197_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG13197 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG13197

View exonic expression by tissue for Dmel\CG13197

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36253/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0062449

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0062449

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0062449

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13197

Flygut - An atlas of the Drosophila adult midgut

FBgn0062449

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG13197

Transgenic constructs containing regulatory region of CG13197

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

CG13197^GD14623

viable, with Scer\GAL4^pnr-MD237

CG13197^GD14623

viable, with Scer\GAL4^tin.CΔ4

CG13197^GD14623

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

CG13197^HMS01972

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DUSP11

13 of 15

Yes

Hsap\RNGTT

2 of 15

Hsap\DUSP23

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dusp11

12 of 15

Yes

Mmus\Rngtt

1 of 15

Rattus norvegicus (Norway rat) (3)

Rnor\LOC103690006

6 of 13

Yes

Rnor\Dusp11

4 of 13

Yes

Rnor\Rngtt

2 of 13

Xenopus tropicalis (Western clawed frog) (3)

Xtro\dusp11.2

7 of 12

Yes

Xtro\dusp11

2 of 12

Yes

Xtro\rngtt

2 of 12

Danio rerio (Zebrafish) (2)

Drer\dusp11

10 of 15

Yes

Drer\rngtt

2 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\pir-1

9 of 15

Yes

Cele\F54C8.4

7 of 15

Yes

Cele\cel-1

2 of 15

Cele\ptp-4

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\AT3G09100

3 of 9

Yes

Atha\AT5G01290

3 of 9

Yes

Atha\AT5G28210

3 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CEG1

2 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\ceg1

1 of 12

Yes

Spom\clp1

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A1J )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA12112

Drosophila persimilis

Dper\GL10081

Drosophila willistoni

Dwil\GK17880

Drosophila virilis

Dvir\GJ20873

Drosophila mojavensis

Dmoj\GI21271

Drosophila grimshawi

Dgri\GH22885

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504QV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17007010

Musca domestica

House fly

Mdoa\17004921

Musca domestica

House fly

Mdoa\17004994

Glossina morsitans

Tsetse fly

Gmor\GMOY000047

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09859

Mayetiola destructor

Hessian fly

Mdes\Mdes004583

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004437

Anopheles gambiae

Malaria mosquito

Agam\AGAP011155

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0JOZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Danaus plexippus

Monarch butterfly

Dple\DPOGS212291-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014940

Apis florea

Little honeybee

Aflo\2147532835

Apis florea

Little honeybee

Aflo\4732235860

Apis mellifera

Western honey bee

Amel\GB42332

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14534

Bombus terrestris

Buff-tailed bumblebee

Bter\15205381

Bombus terrestris

Buff-tailed bumblebee

Bter\15203474

Linepithema humile

Argentine ant

Lhum\LH17952

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001ef9

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000660

Tribolium castaneum

Red flour beetle

Tcas\TC032238

Pediculus humanus

Human body louse

Phum\PHUM512120

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI44172

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI010111

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10219

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0JU9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003304

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71931.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g07510

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_320429

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_326892

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_98101

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_16505

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_109145

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_338314

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_118640

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HD0 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dusp11

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000014482

Gallus gallus

Domestic chicken

Ggal\DUSP11

Gallus gallus

Domestic chicken

Ggal\LOC419511

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

4 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DUSP11; dual specificity phosphatase 11

13 of 15

603092

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62040

DroID - A comprehensive database of gene and protein interactions.

FBgn0062449

MIST (protein-protein) - An integrated Molecular Interaction Database

CG13197

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-65

Cytogenetic map

48C2-48C2

Sequence location

2R:11,691,285..11,697,785 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

48C2-48C2

Limits computationally determined from genome sequence between P{EP}wal^EP825&P{PZ}wal⁰²⁵¹⁶ and P{PZ}Ef1α48D⁰¹²⁷⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-65

(FlyBase, 2016)

2-65.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

85188

w¹¹¹⁸; PBac{WH}CG13197^f00871

83198

y¹ w^*; TI{CRIMIC.TG4.0}CG13197^{CR00900-TG4.0}/SM6a

39052

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01972}attP2/TM3, Sb¹

VDRC

v105122

P{KK101454}VIE-260B

v36423

w¹¹¹⁸; P{GD14623}v36423

v342241

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01896}attP40/CyO-GFP

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (24)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE27552

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0062449

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0062449

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36253

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: BcDNA:RE27552 CG13197

(FlyBase, 1996-)

Additional comments

Source for merge of BcDNA:RE27552 CG13197 was a shared cDNA ( date:030206 ).

(FlyBase, 1996-)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36253

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8SX38

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0062449

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36253/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0062449

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG13197_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0062449

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0062449

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13197

Flygut - An atlas of the Drosophila adult midgut

FBgn0062449

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36253

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG13197

MARRVEL_MODEL - MARRVEL (model organism gene)

36253

modMine - A data warehouse for the modENCODE project

FBgn0062449

Linkouts

BioGRID - A database of protein and genetic interactions.

62040

DroID - A comprehensive database of gene and protein interactions.

FBgn0062449

DRSC - Results frm RNAi screens

FBgn0062449

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0062449

FlyMine - An integrated database for Drosophila genomics

FBgn0062449

MIST (protein-protein) - An integrated Molecular Interaction Database

CG13197

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

BcDNA:RE27552

CG13197

(Wu et al., 2020, Gene Disruption Project members, 2018-, Hatzihristidis et al., 2015, Sopko et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Kadam et al., 2009, Keleman et al., 2009.8.5, Kwon et al., 2009, Rehwinkel et al., 2006)

Name Synonyms

Secondary FlyBase IDs

FBgn0033647

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (34)

Report Sections

Open Close