FB2020_06, released Dec 22, 2020

Gene: Dmel\GstE8

Open Close
General Information
Symbol
Dmel\GstE8
Species
D. melanogaster
Name
Glutathione S transferase E8
Annotation Symbol
CG17533
Feature Type
protein_coding_gene
FlyBase ID
FBgn0063492
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

Gst3-2, DmGSTE8

Key Links
Genomic Location
Cytogenetic map
55C7-55C8
Sequence location
2R:18,407,834..18,408,955 [+]
Recombination map

2-85

RefSeq locus
NT_033778 REGION:18407834..18408955
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables glutathione transferase activity
inferred from sequence or structural similarity with FLYBASE:GstE1; FB:FBgn0034335
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN001679864
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in glutathione metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001679864
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with FLYBASE:GstE1; FB:FBgn0034335
(FlyBase Curators, 2008--)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from sequence or structural similarity with RGD:70952
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN001679864
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CYTOSOLIC GLUTATHIONE S-TRANSFERASES -
Glutathione transferases (glutathione S-transferases, GST) catalyze nucleophilic attack by reduced glutathione on nonpolar compounds that contain an electrophilic carbon, nitrogen, or sulfur atom. At least 14 classes of cytosolic GSTs have been identified in prokaryotes and eukaryotes: Theta, Omega, Sigma and Zeta exist in all eukaryotes. D. melanogaster has two additional classes, Delta and Epsilon. In D. mel, the class is indicated by the letter after the Gst prefix. (Adapted from FBrf0217315 and PMID:15822171).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\GstE8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.43

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
GstE8-RA
FBtr0086676
NM_137486
758
222
GstE8-RB
FBtr0345798
NM_001299642
1122
222
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
GstE8-PA
FBpp0085857
24.9
222
6.02
NP_611330
AAF57694
GstE8-PB
FBpp0311784
24.9
222
6.02
NP_001286571
AHN56366
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

222 aa isoforms: GstE8-PA, GstE8-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GstE8 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
wing disc
(Organista et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\GstE8 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of GstE8
Transgenic constructs containing regulatory region of GstE8
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GSTT2B
4 of 15
Yes
No
Hsap\GSTT2
4 of 15
Yes
No
1  
Hsap\GSTT1
3 of 15
No
No
1  
Hsap\GSTT4
3 of 15
No
No
Hsap\LOC100652871
2 of 15
No
Yes
Hsap\CLIC1
1 of 15
No
No
1  
Hsap\CLIC2
1 of 15
No
No
1  
Hsap\CLIC3
1 of 15
No
No
Hsap\CLIC4
1 of 15
No
No
Hsap\CLIC5
1 of 15
No
No
Hsap\CLIC6
1 of 15
No
No
Hsap\EEF1E1
1 of 15
No
No
Hsap\EEF1G
1 of 15
No
No
Hsap\GDAP1
1 of 15
No
No
1  
Hsap\GDAP1L1
1 of 15
No
No
1  
Hsap\GSTO1
1 of 15
No
No
1  
Hsap\GSTO2
1 of 15
No
No
2  
Hsap\GSTZ1
1 of 15
No
No
Hsap\MARS
1 of 15
No
No
Hsap\VARS
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gstt1
5 of 15
Yes
No
Mmus\Gstt2
5 of 15
Yes
No
Mmus\Gstt3
5 of 15
Yes
No
Mmus\Gstt4
4 of 15
No
No
Mmus\Clic1
1 of 15
No
No
Mmus\Clic3
1 of 15
No
No
Mmus\Clic4
1 of 15
No
No
Mmus\Clic5
1 of 15
No
No
Mmus\Clic6
1 of 15
No
No
Mmus\Eef1e1
1 of 15
No
No
Mmus\Eef1g
1 of 15
No
No
Mmus\Gdap1l1
1 of 15
No
No
Mmus\Gdap1
1 of 15
No
No
Mmus\Gsto1
1 of 15
No
No
Mmus\Gsto2
1 of 15
No
No
Mmus\Gstp3
1 of 15
No
No
Mmus\Gstz1
1 of 15
No
No
Mmus\Mars
1 of 15
No
No
2  
Mmus\Vars
1 of 15
No
No
Rattus norvegicus (Norway rat) (24)
Rnor\Gstt1
4 of 13
Yes
No
Rnor\Gstt3
4 of 13
Yes
No
Rnor\Gstt4
4 of 13
Yes
No
Rnor\Gstt2
3 of 13
No
No
Rnor\LOC103694878
3 of 13
No
No
Rnor\LOC103694879
3 of 13
No
No
Rnor\LOC103694882
2 of 13
No
Yes
Rnor\Clic1
1 of 13
No
No
Rnor\Clic2
1 of 13
No
No
Rnor\Clic3
1 of 13
No
No
Rnor\Clic4
1 of 13
No
No
Rnor\Clic5
1 of 13
No
No
Rnor\Clic6
1 of 13
No
No
Rnor\Eef1e1
1 of 13
No
No
Rnor\Eef1g
1 of 13
No
No
Rnor\Gdap1l1
1 of 13
No
No
Rnor\Gdap1
1 of 13
No
No
Rnor\Gsto1
1 of 13
No
No
Rnor\Gsto2
1 of 13
No
No
Rnor\Gstz1
1 of 13
No
No
Rnor\LOC100911464
1 of 13
No
Yes
Rnor\LOC103690044
1 of 13
No
No
Rnor\Mars
1 of 13
No
No
Rnor\Vars
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\gstt1
3 of 12
Yes
No
Xtro\gstt1
3 of 12
Yes
No
Xtro\clic1
1 of 12
No
No
Xtro\clic3
1 of 12
No
No
Xtro\clic4
1 of 12
No
No
Xtro\clic5
1 of 12
No
No
Xtro\clic6
1 of 12
No
No
Xtro\eef1e1
1 of 12
No
No
Xtro\eef1g
1 of 12
No
No
Xtro\gdap1l1
1 of 12
No
No
Xtro\gstz1
1 of 12
No
No
Danio rerio (Zebrafish) (19)
Drer\gstt2
5 of 15
Yes
No
Drer\gstt1a
4 of 15
No
No
Drer\gstr
3 of 15
No
No
Drer\gstt1b
3 of 15
No
No
Drer\clic1
1 of 15
No
No
Drer\clic2
1 of 15
No
No
Drer\clic3
1 of 15
No
No
Drer\clic4
1 of 15
No
No
Drer\clic5a
1 of 15
No
No
Drer\clic5b
1 of 15
No
No
Drer\eef1e1
1 of 15
No
No
Drer\eef1g
1 of 15
No
No
Drer\gdap1
1 of 15
No
No
Drer\gdap1l1
1 of 15
No
No
Drer\gsto1
1 of 15
No
No
Drer\gsto2
1 of 15
No
No
Drer\LOC100333907
1 of 15
No
No
Drer\mars
1 of 15
No
No
Drer\vars
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\gst-43
2 of 15
Yes
No
Cele\Y53G8B.1
2 of 15
Yes
No
Cele\eef-1G
1 of 15
No
No
Cele\exl-1
1 of 15
No
No
Cele\gst-15
1 of 15
No
No
Cele\gst-21
1 of 15
No
No
Cele\gst-24
1 of 15
No
No
Cele\gst-27
1 of 15
No
No
Cele\gst-29
1 of 15
No
No
Cele\gst-42
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (17)
Atha\ATGSTF13
4 of 9
Yes
Yes
Atha\GSTF9
4 of 9
Yes
No
Atha\GSTF10
4 of 9
Yes
No
Atha\GSTF2
3 of 9
No
Yes
Atha\GSTF3
3 of 9
No
Yes
Atha\GSTF4
3 of 9
No
Yes
Atha\GSTF5
3 of 9
No
Yes
Atha\GSTF6
3 of 9
No
Yes
Atha\GSTF7
3 of 9
No
Yes
Atha\GSTF12
3 of 9
No
Yes
Atha\GSTF14
3 of 9
No
No
Atha\GSTF8
2 of 9
No
No
Atha\GSTF11
2 of 9
No
Yes
Atha\GSTT1
2 of 9
No
No
Atha\GSTT2
2 of 9
No
No
Atha\GSTT3
2 of 9
No
No
Atha\AT2G47720
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\GTT2
5 of 15
Yes
Yes
Scer\CAM1
2 of 15
No
No
Scer\TEF4
2 of 15
No
No
Scer\URE2
2 of 15
No
No
Scer\YGR201C
2 of 15
No
No
Scer\GTT1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\gst1
3 of 12
Yes
No
Spom\gst2
3 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190F0Q )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD11377
Drosophila simulans
Dsim\GD11375
Drosophila simulans
Dsim\GD11374
Drosophila simulans
Dsim\GD11376
Drosophila sechellia
Dsec\GM21881
Drosophila sechellia
Dsec\GM21880
Drosophila sechellia
Dsec\GM21882
Drosophila erecta
Dere\GG21889
Drosophila erecta
Dere\GG21888
Drosophila erecta
Dere\GG21887
Drosophila erecta
Dere\GG21890
Drosophila yakuba
Dyak\GE11962
Drosophila yakuba
Dyak\GE11963
Drosophila yakuba
Dyak\GE11965
Drosophila yakuba
Dyak\GE11964
Drosophila ananassae
Dana\GF12173
Drosophila ananassae
Dana\GF12172
Drosophila ananassae
Dana\GF12171
Drosophila ananassae
Dana\GF12174
Drosophila pseudoobscura pseudoobscura
Dpse\GA14545
Drosophila persimilis
Dper\GL17773
Drosophila willistoni
Dwil\GK22990
Drosophila willistoni
Dwil\GK22989
Drosophila willistoni
Dwil\GK22991
Drosophila virilis
Dvir\GJ19892
Drosophila virilis
Dvir\GJ19893
Drosophila mojavensis
Dmoj\GI20123
Drosophila mojavensis
Dmoj\GI20122
Drosophila grimshawi
Dgri\GH21669
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AC4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016259
Musca domestica
House fly
Mdoa\17021511
Musca domestica
House fly
Mdoa\17008533
Musca domestica
House fly
Mdoa\17021507
Musca domestica
House fly
Mdoa\17024696
Musca domestica
House fly
Mdoa\17014051
Musca domestica
House fly
Mdoa\17021508
Musca domestica
House fly
Mdoa\17017452
Musca domestica
House fly
Mdoa\17011601
Musca domestica
House fly
Mdoa\17011599
Musca domestica
House fly
Mdoa\17014052
Musca domestica
House fly
Mdoa\17011600
Musca domestica
House fly
Mdoa\17024697
Musca domestica
House fly
Mdoa\17008532
Musca domestica
House fly
Mdoa\17021509
Glossina morsitans
Tsetse fly
Gmor\GMOY002000
Glossina morsitans
Tsetse fly
Gmor\GMOY006685
Glossina morsitans
Tsetse fly
Gmor\GMOY004361
Glossina morsitans
Tsetse fly
Gmor\GMOY010887
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11521
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02361
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11870
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13061
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11871
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02363
Mayetiola destructor
Hessian fly
Mdes\Mdes008687
Mayetiola destructor
Hessian fly
Mdes\Mdes005306
Mayetiola destructor
Hessian fly
Mdes\Mdes003866
Mayetiola destructor
Hessian fly
Mdes\Mdes008686
Mayetiola destructor
Hessian fly
Mdes\Mdes008691
Mayetiola destructor
Hessian fly
Mdes\Mdes008690
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTD2
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTE3
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTE1
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTE5
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTD6
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTe2
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTE6
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTD11
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTD1
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTE7
Aedes aegypti
Yellow fever mosquito
Aaeg\GSTe4
Anopheles darlingi
American malaria mosquito
Adar\ADAC008205
Anopheles darlingi
American malaria mosquito
Adar\ADAC000834
Anopheles darlingi
American malaria mosquito
Adar\ADAC008208
Anopheles darlingi
American malaria mosquito
Adar\ADAC008212
Anopheles darlingi
American malaria mosquito
Adar\ADAC000801
Anopheles darlingi
American malaria mosquito
Adar\ADAC008211
Anopheles darlingi
American malaria mosquito
Adar\ADAC008209
Anopheles darlingi
American malaria mosquito
Adar\ADAC000802
Anopheles darlingi
American malaria mosquito
Adar\ADAC008200
Anopheles darlingi
American malaria mosquito
Adar\ADAC000833
Anopheles gambiae
Malaria mosquito
Agam\GSTE2
Anopheles gambiae
Malaria mosquito
Agam\GstD1
Anopheles gambiae
Malaria mosquito
Agam\GSTE4
Anopheles gambiae
Malaria mosquito
Agam\GSTD4
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018631
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010814
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002661
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018624
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018627
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018630
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002681
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018629
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018628
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002683
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018625
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018632
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002680
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0C51 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\GST delta
Bombyx mori
Silkmoth
Bmor\BGIBMGA002211
Bombyx mori
Silkmoth
Bmor\BGIBMGA006537
Bombyx mori
Silkmoth
Bmor\BGIBMGA002279
Bombyx mori
Silkmoth
Bmor\BGIBMGA006538
Bombyx mori
Silkmoth
Bmor\BGIBMGA010094
Bombyx mori
Silkmoth
Bmor\BGIBMGA010093
Bombyx mori
Silkmoth
Bmor\BGIBMGA009951
Danaus plexippus
Monarch butterfly
Dple\DPOGS208312-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200213-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210477-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210488-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200212-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207576-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202622-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011501
Heliconius melpomene
Postman butterfly
Hmel\HMEL002451
Heliconius melpomene
Postman butterfly
Hmel\HMEL010769
Heliconius melpomene
Postman butterfly
Hmel\HMEL006527
Apis florea
Little honeybee
Aflo\2147574195
Apis florea
Little honeybee
Aflo\2167436642
Apis florea
Little honeybee
Aflo\2147493505
Apis mellifera
Western honey bee
Amel\GB50265
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14888
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14887
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14889
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20389
Bombus terrestris
Buff-tailed bumblebee
Bter\15204716
Bombus terrestris
Buff-tailed bumblebee
Bter\15201179
Bombus terrestris
Buff-tailed bumblebee
Bter\15201481
Bombus terrestris
Buff-tailed bumblebee
Bter\15201382
Bombus terrestris
Buff-tailed bumblebee
Bter\15203984
Linepithema humile
Argentine ant
Lhum\LH25411
Linepithema humile
Argentine ant
Lhum\LH12900
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b34
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d29
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d2a
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d2b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012852
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005033
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005031
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001186
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02643
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08747
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03782
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02641
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02644
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03783
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03784
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02640
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02642
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03429
Tribolium castaneum
Red flour beetle
Tcas\TC032323
Tribolium castaneum
Red flour beetle
Tcas\TC003104
Tribolium castaneum
Red flour beetle
Tcas\TC031099
Tribolium castaneum
Red flour beetle
Tcas\TC003348
Tribolium castaneum
Red flour beetle
Tcas\TC032324
Tribolium castaneum
Red flour beetle
Tcas\TC004442
Tribolium castaneum
Red flour beetle
Tcas\TC004447
Tribolium castaneum
Red flour beetle
Tcas\TC004448
Tribolium castaneum
Red flour beetle
Tcas\TC004444
Tribolium castaneum
Red flour beetle
Tcas\TC032770
Tribolium castaneum
Red flour beetle
Tcas\TC004942
Tribolium castaneum
Red flour beetle
Tcas\TC009482
Tribolium castaneum
Red flour beetle
Tcas\TC004940
Tribolium castaneum
Red flour beetle
Tcas\TC003345
Tribolium castaneum
Red flour beetle
Tcas\TC003347
Tribolium castaneum
Red flour beetle
Tcas\TC032024
Tribolium castaneum
Red flour beetle
Tcas\TC003103
Tribolium castaneum
Red flour beetle
Tcas\TC004941
Tribolium castaneum
Red flour beetle
Tcas\TC004443
Tribolium castaneum
Red flour beetle
Tcas\TC004449
Pediculus humanus
Human body louse
Phum\PHUM189430
Pediculus humanus
Human body louse
Phum\PHUM097960
Pediculus humanus
Human body louse
Phum\PHUM189440
Rhodnius prolixus
Kissing bug
Rpro\RPRC013179
Cimex lectularius
Bed bug
Clec\CLEC013063
Cimex lectularius
Bed bug
Clec\CLEC000896
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008042
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006899
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085935
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008550
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008657
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005620
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006598
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI38440
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001068
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15569
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04286
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15978
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15570
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13081
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13082
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CEY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007923
Strigamia maritima
European centipede
Smar\SMAR008669
Ixodes scapularis
Black-legged tick
Isca\ISCW024825
Ixodes scapularis
Black-legged tick
Isca\ISCW003686
Ixodes scapularis
Black-legged tick
Isca\ISCW005804
Ixodes scapularis
Black-legged tick
Isca\ISCW015490
Ixodes scapularis
Black-legged tick
Isca\ISCW005805
Ixodes scapularis
Black-legged tick
Isca\ISCW024224
Ixodes scapularis
Black-legged tick
Isca\ISCW008097
Ixodes scapularis
Black-legged tick
Isca\ISCW005803
Ixodes scapularis
Black-legged tick
Isca\ISCW007012
Ixodes scapularis
Black-legged tick
Isca\ISCW024667
Ixodes scapularis
Black-legged tick
Isca\ISCW024802
Ixodes scapularis
Black-legged tick
Isca\ISCW011508
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61050.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73999.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g01490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g01500
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g01510
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g00220
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g07880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g07920
Tetranychus urticae
Two-spotted spider mite
Turt\tetur31g01330
Tetranychus urticae
Two-spotted spider mite
Turt\tetur31g01390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g01450
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g02802
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g02801
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02510
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02230
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02470
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g01460
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02500
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_196080
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_230826
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304194
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_442646
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_442645
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0MS3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006494gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009237gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006495gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016269gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006493gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009239gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_021662gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023452
Ciona intestinalis
Vase tunicate
Cint\LOC100184682
Ciona intestinalis
Vase tunicate
Cint\LOC100178265
Ciona intestinalis
Vase tunicate
Cint\LOC100184961
Ciona intestinalis
Vase tunicate
Cint\LOC100182589
Ciona intestinalis
Vase tunicate
Cint\LOC100187387
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (39)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
GstE1
7 of 10
GstE2
7 of 10
GstE3
7 of 10
GstE4
7 of 10
GstE5
7 of 10
GstE6
7 of 10
GstE7
7 of 10
GstE9
7 of 10
GstE10
7 of 10
GstD1
6 of 10
GstD2
6 of 10
GstD3
6 of 10
GstD4
6 of 10
GstD5
6 of 10
GstD6
6 of 10
GstD7
6 of 10
GstD8
6 of 10
GstD9
6 of 10
GstD10
6 of 10
GstE11
6 of 10
GstE12
6 of 10
GstE13
6 of 10
GstD11
5 of 10
GstE14
5 of 10
GstT1
5 of 10
GstT2
5 of 10
GstT3
5 of 10
gfzf
4 of 10
GstT4
4 of 10
eEF1γ
2 of 10
GstZ1
2 of 10
GstZ2
2 of 10
AIMP3
1 of 10
Clic
1 of 10
Gr59f
1 of 10
GstO1
1 of 10
GstO2
1 of 10
GstO3
1 of 10
se
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GSTT2B; glutathione S-transferase theta 2B
    4 of 15
        GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
        4 of 15
        600437
             
            GSTT1; glutathione S-transferase theta 1
            3 of 15
            600436
                 
                GSTT4; glutathione S-transferase theta 4
                3 of 15
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Smox
                    suppressible
                    GstE8
                    (Hevia et al., 2017)
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    External Data
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2R
                    Recombination map

                    2-85

                    Cytogenetic map
                    55C7-55C8
                    Sequence location
                    2R:18,407,834..18,408,955 [+]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    55C7-55C8
                    Limits computationally determined from genome sequence between P{PZ}sbb04525&P{EP}EP1081EP1081 and P{lacW}l(2)08770k04808
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    2-85

                    (FlyBase, 2016)

                    2-89.6

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (4)
                    Genomic Clones (12)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (14)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of

                      Source for identity of: Gst3-2 CG17533

                      (FlyBase, 1996-)
                      Source for database merge of

                      Source for merge of: Gst3-2 BcDNA:GM08326

                      (FlyBase, 1996-)
                      Additional comments

                      Source for identity of Gst3-2 CG17533 was sequence comparison ( date:020320 ).

                      (FlyBase, 1996-)

                      Source for merge of Gst3-2 BcDNA:GM08326 was a shared cDNA ( date:030728 ).

                      (FlyBase, 1996-)
                      Other Comments

                      The form of GstE8 cloned from S2 cells is truncated and lacks part of the active site.

                      (Saisawang et al., 2012)
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 40 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      modMine - A data warehouse for the modENCODE project
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      FlyMine - An integrated database for Drosophila genomics
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Synonyms and Secondary IDs (10)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (50)