• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\ppk11

General Information
Symbol	Dmel\ppk11	Species	D. melanogaster
Name	pickpocket 11	Annotation symbol	CG34058
Feature type	protein_coding_gene	FlyBase ID	FBgn0065109
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	30C8-30C9	Sequence location	2L:9,773,108..9,775,030 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pickpocket 11 is referred to in FlyBase by the symbol Dmel\ppk11 (CG34058, FBgn0065109). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: sodium channel activity. There is experimental evidence that it is involved in the biological process: sensory perception of salty taste; liquid clearance, open tracheal system. 9 alleles are reported. The phenotypes of these alleles are annotated with: terminal organ; adult tracheal system. It has one annotated transcript and one annotated polypeptide. Protein features are: Na+ channel, amiloride-sensitive; Na+ channel, amiloride-sensitive, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. , at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of ppk11. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of ppk11. Gene sequence location is 2L:9773108..9775030.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms integral to membrane
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 30C8-30C9   Limits computationally determined from genome sequence between P{lacW}zf30Ck02506&P{EP}undEP424 and P{lacW}l(2)k06416k06416&P{lacW}sopk04603
Experimentally Determined Cytological Location
Cytogenetic map Notes References 30D1-30D1     (Welsh, 2003.1.15)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ppk11 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ppk11-RA FBtr0100831  NM_001038798   1551   516
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ppk11-PA   FBpp0100162   60.0   516   8.27     NP_001033887   AAF52812
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Na+ channel, amiloride-sensitive, conserved site (IPR020903) Na+ channel, amiloride-sensitive (IPR001873)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52812   AY226542 AAO47368
UniProtKB/Swiss-Prot	Q9VL84
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 15 -- 17   trachea   (Liu et al., 2003) embryonic/larval dorsal trunk   (Liu et al., 2003) embryonic stage 16 -- 17   embryonic/larval transverse connective   (Liu et al., 2003) embryonic stage 17   secondary trachea   (Liu et al., 2003) tracheal tip cell   (Liu et al., 2003)
Additional Descriptive Data
	ppk11 expression is first detected in the posterior dorsal trunk at embryonic stage 15. Expression extends to the anterior dorsal trunk, then to primary branches at stage 16. During stage 17, expression extends to the secondary branches. (Liu et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{ppk11-GAL4.L} Stage Tissue/Position (including subcellular localization) Reference larval stage   embryonic/larval trachea   (Liu et al., 2003) tracheal tip cell   (Liu et al., 2003) embryonic/larval dorsal trunk   (Liu et al., 2003) primary trachea   (Liu et al., 2003) secondary trachea   (Liu et al., 2003) embryonic/larval transverse connective   (Liu et al., 2003) second instar larval stage   terminal organ | subset   (Liu et al., 2003) neuron | subset of terminal organ   (Liu et al., 2003) neuron | subset   (Liu et al., 2003) embryonic/larval tracheal system   (Liu et al., 2003) adult stage   neuron of taste bristle of wing margin | subset   (Liu et al., 2003) neuron of labellar taste bristle   (Liu et al., 2003) neuron | subset   (Liu et al., 2003) labellar taste bristle   (Liu et al., 2003) tibia | male & restricted   (Liu et al., 2003) taste bristle | subset   (Liu et al., 2003) femur | male & restricted   (Liu et al., 2003) eo support cell | subset of labellar taste bristle   (Thistle et al., 2012) adult stage | male   prothoracic leg taste bristle | subset   (Liu et al., 2003) tarsal segment | restricted   (Liu et al., 2003) neuron of prothoracic leg taste bristle | subset of tarsal segment   (Liu et al., 2003) neuron of prothoracic leg taste bristle | subset of femur   (Liu et al., 2003) neuron of prothoracic leg taste bristle | subset of tibia   (Liu et al., 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0065109
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable ppk11f02053 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW ppk11KK106798 Sterility Allele fertile ppk11f02053 Other Phenotypes Allele neurophysiology defective, with Scer\GAL4elav.PLu ppk11DN.Scer\UAS ppk11dsRNA.Scer\UAS taste perception defective, with Scer\GAL4elav.PLu ppk11DN.Scer\UAS ppk11dsRNA.Scer\UAS taste perception defective, with Scer\GAL4GH86 ppk11DN.Scer\UAS taste perception defective, with Scer\GAL4hs.PB ppk11dsRNA.Scer\UAS Phenotype manifest in Allele adult tracheal system ppk11dsRNA.cLa terminal organ, with Scer\GAL4elav.PLu ppk11DN.Scer\UAS ppk11dsRNA.Scer\UAS
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of ppk11 Class Mutagen Stocks Known lesion ppk11f02053 piggyBac transposase 2 -- ppk11MB02012 1 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ppk11 Class Mutagen Stocks Known lesion ppk11JF02152 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ppk11KK106798 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ppk11DN.MtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ppk11DN.Scer\UAS in vitro construct - regulatory fusion 0 Yes ppk11dsRNA.cLa in vitro construct - RNAi 0 Yes ppk11dsRNA.Scer\UAS in vitro construct - RNAi 0 Yes ppk11MtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK106798} NA P{TRiP.JF02152} NA P{UAS-ppk11.DN} NA P{UAS-ppk11.dsRNA} NA characterization construct P{ppk11-GAL4.L} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}ppk11f02053 NA insertion of enhancer trap binary system Mi{ET1}ppk11MB02012 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
liquid clearance, open tracheal system inferred from mutant phenotype (Liu et al., 2003) sensory perception of salty taste inferred from mutant phenotype (Liu et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
sodium channel activity inferred from sequence or structural similarity with mouse Scnn1a (Curators, 2008--) non-traceable author statement (Welsh, 2003.1.15)
Biological Process
CV term Evidence References
sodium ion transport inferred by curator from GO:0005272 (Welsh, 2003.1.15) inferred from sequence or structural similarity with mouse Scnn1a (Curators, 2008--)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with mouse Scnn1a (Curators, 2008--)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ppk11 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0065109
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6N5WGN Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6QP0Q0
Orthologs in Drosophila Species (EOG6N5WGN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ppk11     Drosophila simulans   Dsim\GD22335 Y   Drosophila sechellia   Dsec\GM12254 Y   Drosophila erecta   Dere\GG24006 Y   Drosophila yakuba   Dyak\GE10314 Y   Drosophila ananassae   Dana\GF21875 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25876 Y   Drosophila persimilis   Dper\GL19208 Y   Drosophila willistoni   Dwil\GK24817 Y   Drosophila virilis   Dvir\GJ14732 Y   Drosophila mojavensis   Dmoj\GI18203 Y   Drosophila grimshawi   Dgri\GH25067 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6QP0Q0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\del-1 Y Caenorhabditis elegans Nematode  Cele\F28A12.1 Y Caenorhabditis elegans Nematode  Cele\acd-1 Y Caenorhabditis elegans Nematode  Cele\C24G7.1 Y Caenorhabditis elegans Nematode  Cele\asic-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010265gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015892gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010858gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018814gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015895gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027071gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025391gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015718gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015310gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028125gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015893gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025390gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009765gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014519gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010559gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006217gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016076gn Y Danio rerio Zebrafish  Drer\accn4b Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22335 Drosophila sechellia Dsec\GM12254 Drosophila erecta Dere\GG24006 Drosophila yakuba Dyak\GE10314 Drosophila ananassae Dana\GF21875 Drosophila pseudoobscura pseudoobscura Dpse\GA25876 Drosophila persimilis Dper\GL19208 Drosophila willistoni Dwil\GK24817 Drosophila virilis Dvir\GJ14732 Drosophila mojavensis Dmoj\GI18203 Drosophila grimshawi Dgri\GH25067
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	18507 w1118; PBac{WH}ppk11f02053 23781 w1118; Mi{ET1}ppk11MB02012 26253 y1 v1; P{TRiP.JF02152}attP2
Harvard	- PBac{WH}ppk11f02053
VDRC	v107741 P{KK106798}VIE-260B
Genomic Clones ( 1 )
	BACR02I05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0065109 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34299
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Annotation CG4110 split into CG34058 (ppk11) and CG34059 (ppk16) in release 4.3 of the genome annotation. (FlyBase Genome Annotators, 2005) Source for split of CG4110 (into ppk11 ppk16) was sequence comparison (date:030311). (FlyBase, 1996-)
Other Comments
	ppk11 may have a role in liquid clearance from the tracheal system. (Liu et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001038798 RefSeq (Proteins) • NP_001033887 DDBJ / EMBL / GenBank • AAF52812 AAO47368 AY226542 Entrez Gene - A searchable database of RefSeq genes. • 34299 UniProtKB/Swiss-Prot • Q9VL84
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Na+ channel, amiloride-sensitive, conserved site (IPR020903) Na+ channel, amiloride-sensitive (IPR001873)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0065109 DRSC - Results from RNAi screens. • FBgn0065109 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0065109 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0065109 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34299 modMine - Data generated by the modENCODE project. • FBgn0065109
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG4110 (Giannakou and Dow, 2001, ) CG34058 (FlyBase Genome Annotators, 2005, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Tsubouchi et al., 2012) PPK11 (Liu et al., 2003, Welsh, 2003.1.15, Tobin and Bargmann, 2004, Colomb et al., 2007) ppk11 (Sun et al., 2008, Chen et al., 2010, Ben-Shahar, 2012.2.9, Tsubouchi et al., 2012, Ben-Shahar, 2011, Liu et al., 2012)
Name Synonym	pickpocket 11 (Ben-Shahar, 2012.2.9, Tsubouchi et al., 2012) Pickpocket11 (Tobin and Bargmann, 2004)
Secondary FlyBase IDs
	FBgn0032146 FBgn0054058
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 2 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Liu et al., 2012, J. Neurosci. 32(34): 11879--11889 Two Drosophila DEG/ENaC Channel Subunits Have Distinct Functions in Gustatory Neurons That Activate Male Courtship. [FBrf0219294] Thistle et al., 2012, Cell 149(5): 1140--1151 Contact Chemoreceptors Mediate Male-Male Repulsion and Male-Female Attraction during Drosophila Courtship. [FBrf0218411] Show all research papers ...
Recent reviews ( 1 )
	Ben-Shahar, 2011, Adv. Genet. 76: 1--26 Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). [FBrf0218999] Show all reviews ...