Gene model reviewed during 5.53
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
The att locus encodes two proteins, att-ORFA and att-ORFB, that overlap in the DNA sequences that encode them but not in amino acid sequence, due to use of different reading frames (FBrf0089733).
Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region; overlap >20aa.
Unconventional translation start (CUG) postulated; FBrf0089733.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\DPCoAC using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\DPCoAC in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The "att" locus is alternatively expressed at both the RNA and protein levels. The locus encodes RNAs expressed in the soma and a testis specific RNA. The somatic RNAs encode a protein (att-ORFA) with homology to the mammalian Graves' disease carrier proteins. The testis RNA encodes two different proteins from two reading frames. One of these initiates at a CUG codon and represents an N-terminally truncated version of the protein encoded by the somatic RNAs (att-ORFA). The other protein (att-ORFB) initiates at an AUG codon in testis-specific exon 3 (in a different frame from att-ORFA) and is completely novel. Overall orientation not stated: anon-92Ee+ att-ORFA+ anon-92Ef?