spdo, l(3)00848, sanpodo
Please see the JBrowse view of Dmel\tmod for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Multiphase exon postulated: exon reading frame differs in alternative transcripts.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.32
7.9, 7.3, 5.8, 3.6, 3.1, 2.7 (northern blot)
367, 45 (aa); 403, 43 (kD)
367 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tmod using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as ventral nerve cord anlage
Comment: reported as dorsal/lateral sensory complexes
Comment: reference states expression starts at 9-12 hr AEL
tmod mainly localized to
the M line during the period of indirect flight muscle sarcomere growth, with diffused signal
throughout the sarcomere.
in the germarium, tmod is enriched in spectrosomes and fusomes from the germline stem cell to the fusome remnants in budding egg chambers. It is also found in fusomes throughout male cyst development.
The small spdo isoform was detected at all developmental stages tested. In adults, it was enriched in the head and abdomen. The 43kD isoform is the only form detected in myofibrils in pupae, where it is associated with the pointed ends of thin filaments. It is still detected in day 1 adults.
JBrowse - Visual display of RNA-Seq signals
View Dmel\tmod in JBrowse3-100
3-98.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
The "spdo" complementation group corresponds to the CG31020 annotation and not to "tmod" as previously reported in FBrf0102830; molecular lesions in the CG31020 annotation have been identified in 12 spdo alleles, RNAi against CG31020 results in a central nervous system (CNS) phenotype essentially identical to that of spdo mutants and expression of CG31020 throughout the CNS of spdo mutant embryos results in complete to near-complete rescue of the spdo CNS phenotype.
Annotations CG1539, CG15540, CG11493 merged as CG1539 in release 3 of the genome annotation.
FlyBase curator comment: FBrf0102830 states that the "spdo" complementation group corresponds to the "tmod, tropomodulin" gene. However, FBrf0162056 shows that this was an error and the spdo complementation group actually corresponds to the CG31020 annotation.
The "spdo" complementation group corresponds to the CG31020 annotation and not to the CG1539 annotation. It was reported in FBrf0102830 that "spdo" corresponds to the "tmod, tropomodulin" gene (the CG1539 annotation). However, this was subsequently shown to be an error. FBrf0162056 shows that the "spdo" complementation group corresponds instead to the CG31020 annotation.
Source for identity of: tmod CG1539
