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Gene Dmel\tmod

General Information
Symbol	Dmel\tmod	Species	D. melanogaster
Name	tropomodulin	Annotation symbol	CG1539
Feature type	protein_coding_gene	FlyBase ID	FBgn0082582
Gene Model Status	Current	Stock availability	18 publicly available
Also Known As	spdo, l(3)00848
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99F7-99F8	Sequence location	3R:26,358,329..26,404,627 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tropomodulin is referred to in FlyBase by the symbol Dmel\tmod (CG1539, FBgn0082582). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing morphogenesis. 31 alleles are reported. The phenotypes of these alleles are annotated with: striated muscle thin filament; indirect flight muscle. It has 17 annotated transcripts and 17 annotated polypeptides. Protein features are: Tropomodulin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval hindgut, larval Malpighian tubules, adult heart, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis. Gene sequence location is 3R:26358329..26404627.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles tmod[MI07502]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99F7-99F8   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99F10-99F11   (determined by in situ hybridisation)   (Spradling et al., 1999) 99F6-99F9   (determined by in situ hybridisation)   (Dye et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tmod for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tmod-RA FBtr0085662  NM_057683   2537   367 tmod-RB FBtr0085663  NM_057684   2508   403 tmod-RC FBtr0085661  NM_170506   2716   409 tmod-RD FBtr0085659  NM_170503   2906   439 tmod-RE FBtr0085658  NM_170504   2685   439 tmod-RF FBtr0085660  NM_170505   2770   439 tmod-RG FBtr0113483  NM_001104512   3192   526 tmod-RH FBtr0302110  NM_001170304   2717   372 tmod-RI FBtr0302111  NM_001170305   3000   439 tmod-RJ FBtr0302112  NM_001170306   2753   409 tmod-RK FBtr0302600  NM_001202390   3232   424 tmod-RL FBtr0302601  NM_001202391   2662   439 tmod-RM FBtr0306685  NM_001260442   2299   449 tmod-RN FBtr0306686  NM_001260443   2699   567 tmod-RO FBtr0306687  NM_001260444   3484   424 tmod-RP FBtr0336446  NM_001276182   4701   438 tmod-RQ FBtr0336447  NM_001276183   3182   454
Additional Transcript Data & Comments
Reported size (kB)	7.9, 7.3, 5.8, 3.6, 3.1, 2.7 (northern blot) (Dye et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tmod-PA   FBpp0085024   41.4   367   4.83     NP_477031   AAF57066 tmod-PB   FBpp0085025   45.5   403   5.86     NP_477032   AAF57067 tmod-PC   FBpp0085023   46.2   409   4.80     NP_733385   AAF57065 tmod-PD   FBpp0085021   49.4   439   4.54     NP_733382   AAF57064 tmod-PE   FBpp0085020   49.4   439   4.54     NP_733383   AAN14242 tmod-PF   FBpp0085022   49.4   439   4.54     NP_733384   AAN14243 tmod-PG   FBpp0112393   58.8   526   4.33     NP_001097982   ABW08810 tmod-PH   FBpp0291320   41.9   372   4.78     NP_001163775   ACZ95069 tmod-PI   FBpp0291321   49.4   439   4.54     NP_001163776   ACZ95070 tmod-PJ   FBpp0291322   46.2   409   4.80     NP_001163777   ACZ95071 tmod-PK   FBpp0291756   48.2   424   4.86     NP_001189319   ADV37409 tmod-PL   FBpp0291757   49.4   439   4.54     NP_001189320   ADV37410 tmod-PM   FBpp0297624   50.5   449   4.54     NP_001247371   AFH06688 tmod-PN   FBpp0297625   63.4   567   4.52     NP_001247372   AFH06689 tmod-PO   FBpp0297626   48.2   424   4.86     NP_001247373   AFH06690 tmod-PP   FBpp0307552   49.1   438   4.43     NP_001263111   AGB96490 tmod-PQ   FBpp0307553   51.3   454   4.58     NP_001263112   AGB96491
Additional Polypeptide Data & Comments
Reported size (kDa)	367 (aa) (Dye et al., 1998) 367, 45 (aa); 403, 43 (kD) (Mardahl-Dumesnil and Fowler, 2001)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tropomodulin (IPR004934)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264337   AA697437   AE014297 AAF57064   AE014297 AAF57065   AE014297 AAF57066   AE014297 AAF57067   AE014297 AAN14242   AE014297 AAN14243   AE014297 ABW08810   AC008299   AE014297 ACZ95069   AE014297 ACZ95070   AE014297 ACZ95071   AE014297 ADV37409   AE014297 ADV37410   AE014297 AFH06688   AE014297 AFH06689   AE014297 AFH06690   AE014297 AGB96490   AE014297 AGB96491   AI293895   AI295112   AI403765   AQ034044   AW940897   AY094727 AAM11080   BI172373   BI227695   BI227923   BI234685   BI484373   BI487096   BI567294   BI568234   BI576568   BI578376   BI592821   BI608899   BI613155   BI613379   BI614607   BI625288   BI627620   BI634976   BP558736   BT014640   BT072890   BT099547   BT099728   BT099746   BT100046   BT120257   BT133205   BT133473   CO185323   CO185722   CO187691   CO188746   CO190680   CO263220   CO263669   CO265092   CO277669   CO278390   CO281711   CO282626   CO286769   CO292633   CO296081   CO299906   CO299911   CO304670   CO305283   CO305728   CO306451   CO309422   CO314435   CO314789   CO315136   CO321243   CO323186   CO324830   CO325974   CO326063   CO331033   CO333261   CO339423   CO342150   CZ467313   CZ467324   CZ468708   CZ470564   CZ478701   CZ483140   CZ486118   CZ487584   CZ488298   EC056964   EC057770   EC065819   EC068419   EC069534   EC070811   EC072776   EC073759   EC075693   EC079838   EC080013   EC080912   EC084087   EC085041   EC086565   EC091138   EC200695   EC203466   EC211118   EC214349   EC215339   EC216405   EC225826   EC226873   EC228300   EC233161   EC235299   EC236430   EC242665   EC242739   EC244221   EC244364   EC254357   EC256730   EC256791   EV594197   EV596590   GH953794   GH954605   GH965368   GH967465   U92490 AAC04506
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O46231 Q9VA56 Q9VA58 Q9VA59 A8JRH3 E1JJ21
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Dye et al., 1998) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) central brain anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi head mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi hindgut anlage in statu nascendi   (Fisher et al., 2012) mesectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 9 -- 17   presumptive embryonic/larval central nervous system | precursor   (Dye et al., 1998) embryonic stage 11 -- 12   hindgut proper primordium   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 12 -- 17   presumptive embryonic/larval peripheral nervous system   (Dye et al., 1998) embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012) embryonic stage 14 -- 16   trichogen cell   (Dye et al., 1998) tormogen cell   (Dye et al., 1998) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Dye et al., 1998) embryonic stage 13 -- adult stage     (Dye et al., 1998) Comment:reference states expression starts at 9-12 hr AEL larval stage -- pupal stage     (Dye et al., 1998) larval stage -- adult stage     (Dye et al., 1998) pupal stage     (Dye et al., 1998)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   muscle cell   • myofibril (Mardahl-Dumesnil and Fowler, 2001) Comment:post-eclosion day 1 mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mardahl-Dumesnil and Fowler, 2001) pupal stage   muscle cell   • myofibril (Mardahl-Dumesnil and Fowler, 2001) pupal stage & adult stage   muscle cell   • striated muscle thin filament (Mardahl-Dumesnil and Fowler, 2001) adult stage   indirect flight muscle   (Mardahl-Dumesnil and Fowler, 2001) muscle cell   • striated muscle thin filament (Mardahl-Dumesnil and Fowler, 2001) adult thorax   (Mardahl-Dumesnil and Fowler, 2001) adult head   (Mardahl-Dumesnil and Fowler, 2001) adult abdomen   (Mardahl-Dumesnil and Fowler, 2001)   (Mardahl-Dumesnil and Fowler, 2001) adult stage | male     (Mardahl-Dumesnil and Fowler, 2001) adult stage | female     (Mardahl-Dumesnil and Fowler, 2001)
Additional Descriptive Data
	The small spdo isoform was detected at all developmental stages tested. In adults, it was enriched in the head and abdomen. The 43kD isoform is the only form detected in myofibrils in pupae, where it is associated with the pointed ends of thin filaments. It is still detected in day 1 adults. (Mardahl-Dumesnil and Fowler, 2001) The 45kD spdo isoform is detected in adult flies, where it is enriched in thoraces and dissected IFM. The 45kD spdo isoform is not detected until 8-12hr after eclosion but is the major form in 2 day adults. It is associated with the thin filament pointed ends. (Mardahl-Dumesnil and Fowler, 2001)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
fusome inferred from direct assay (Lighthouse et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval hindgut, larval Malpighian tubules, adult heart, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    80 central nervous system, pupae P8    106 head, virgin 1-day female    113 head, virgin 4-day female    90 head, virgin 20-day female    32 head, mated 1-day female    119 head, mated 4-day female    66 head, mated 20-day female    35 head, mated 1-day male    125 head, mated 4-day male    102 head, mated 20-day male    80 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    87 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae    32 fat body, pupae P8    75 carcass, larvae L3 wandering    207 carcass, 1-day adult    103 carcass, 4-day adult    87 carcass, 20-day adult    37 ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (80) central nervous system, pupae P8  (106) head, virgin 1-day female  (113) head, virgin 4-day female  (90) head, virgin 20-day female  (32) head, mated 1-day female  (119) head, mated 4-day female  (66) head, mated 20-day female  (35) head, mated 1-day male  (125) head, mated 4-day male  (102) head, mated 20-day male  (80) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (87) digestive system, larvae L3 wandering  (49) digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae  (32) fat body, pupae P8  (75) carcass, larvae L3 wandering  (207) carcass, 1-day adult  (103) carcass, 4-day adult  (87) carcass, 20-day adult  (37) ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    80 central nervous system, pupae P8  106 head, virgin 1-day female  (113) head, virgin 4-day female    90 head, virgin 20-day female    32 head, mated 1-day female  (119) head, mated 4-day female    66 head, mated 20-day female    35 head, mated 1-day male  (125) head, mated 4-day male  102 head, mated 20-day male    80 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    87 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae    32 fat body, pupae P8    75 carcass, larvae L3 wandering  (207) carcass, 1-day adult  103 carcass, 4-day adult    87 carcass, 20-day adult    37 ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    80 central nervous system, pupae P8    106 head, virgin 1-day female    113 head, virgin 4-day female    90 head, virgin 20-day female    32 head, mated 1-day female    119 head, mated 4-day female    66 head, mated 20-day female    35 head, mated 1-day male    125 head, mated 4-day male    102 head, mated 20-day male    80 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    87 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae    32 fat body, pupae P8    75 carcass, larvae L3 wandering    207 carcass, 1-day adult    103 carcass, 4-day adult    87 carcass, 20-day adult    37 ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    80 central nervous system, pupae P8    106 head, virgin 1-day female    113 head, virgin 4-day female    90 head, virgin 20-day female    32 head, mated 1-day female    119 head, mated 4-day female    66 head, mated 20-day female    35 head, mated 1-day male    125 head, mated 4-day male    102 head, mated 20-day male    80 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    87 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae    32 fat body, pupae P8    75 carcass, larvae L3 wandering    207 carcass, 1-day adult    103 carcass, 4-day adult    87 carcass, 20-day adult    37 ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (80) central nervous system, pupae P8  (106) head, virgin 1-day female  (113) head, virgin 4-day female  (90) head, virgin 20-day female  32 head, mated 1-day female  (119) head, mated 4-day female  (66) head, mated 20-day female  (35) head, mated 1-day male  (125) head, mated 4-day male  (102) head, mated 20-day male  (80) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (87) digestive system, larvae L3 wandering  (49) digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae  32 fat body, pupae P8  (75) carcass, larvae L3 wandering  (207) carcass, 1-day adult  (103) carcass, 4-day adult  (87) carcass, 20-day adult  (37) ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    80 central nervous system, pupae P8  106 head, virgin 1-day female  113 head, virgin 4-day female    90 head, virgin 20-day female    32 head, mated 1-day female  119 head, mated 4-day female    66 head, mated 20-day female    35 head, mated 1-day male  125 head, mated 4-day male  102 head, mated 20-day male    80 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    87 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae    32 fat body, pupae P8    75 carcass, larvae L3 wandering  (207) carcass, 1-day adult  103 carcass, 4-day adult    87 carcass, 20-day adult    37 ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    80 central nervous system, pupae P8    106 head, virgin 1-day female    113 head, virgin 4-day female    90 head, virgin 20-day female    32 head, mated 1-day female    119 head, mated 4-day female    66 head, mated 20-day female    35 head, mated 1-day male    125 head, mated 4-day male    102 head, mated 20-day male    80 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    87 digestive system, larvae L3 wandering    49 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    15 fat body, larvae L3 wandering    6 fat body, white prepupae    32 fat body, pupae P8    75 carcass, larvae L3 wandering    207 carcass, 1-day adult    103 carcass, 4-day adult    87 carcass, 20-day adult    37 ovary, virgin 4-day female    16 ovary, mated 4-day female    23 testis, mated 4-day male    13 accessory gland, mated 4-day male    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr    31 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    35 embryo 18-20hr    31 embryo 20-22hr    32 embryo 22-24hr    42 larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    44 white prepupae new    86 white prepupae 12hr    158 white prepupae 24hr    131 pupae 2d postWPP    102 pupae 3d postWPP    55 pupae 4d postWPP    76 adult male 01day    66 adult male 05day    32 adult male 30day    20 adult female 01day    40 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr  (31) embryo 12-14hr  (40) embryo 14-16hr  (30) embryo 16-18hr  (35) embryo 18-20hr  (31) embryo 20-22hr  (32) embryo 22-24hr  (42) larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9  (44) white prepupae new  (86) white prepupae 12hr  (158) white prepupae 24hr  (131) pupae 2d postWPP  (102) pupae 3d postWPP  (55) pupae 4d postWPP  (76) adult male 01day  (66) adult male 05day  (32) adult male 30day    20 adult female 01day  (40) adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr    31 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    35 embryo 18-20hr    31 embryo 20-22hr    32 embryo 22-24hr    42 larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    44 white prepupae new    86 white prepupae 12hr  (158) white prepupae 24hr  (131) pupae 2d postWPP  102 pupae 3d postWPP    55 pupae 4d postWPP    76 adult male 01day    66 adult male 05day    32 adult male 30day    20 adult female 01day    40 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr    31 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    35 embryo 18-20hr    31 embryo 20-22hr    32 embryo 22-24hr    42 larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    44 white prepupae new    86 white prepupae 12hr    158 white prepupae 24hr    131 pupae 2d postWPP    102 pupae 3d postWPP    55 pupae 4d postWPP    76 adult male 01day    66 adult male 05day    32 adult male 30day    20 adult female 01day    40 adult female 05day    11 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr    31 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    35 embryo 18-20hr    31 embryo 20-22hr    32 embryo 22-24hr    42 larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    44 white prepupae new    86 white prepupae 12hr    158 white prepupae 24hr    131 pupae 2d postWPP    102 pupae 3d postWPP    55 pupae 4d postWPP    76 adult male 01day    66 adult male 05day    32 adult male 30day    20 adult female 01day    40 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr  31 embryo 12-14hr  (40) embryo 14-16hr  30 embryo 16-18hr  (35) embryo 18-20hr  31 embryo 20-22hr  32 embryo 22-24hr  (42) larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9  (44) white prepupae new  (86) white prepupae 12hr  (158) white prepupae 24hr  (131) pupae 2d postWPP  (102) pupae 3d postWPP  (55) pupae 4d postWPP  (76) adult male 01day  (66) adult male 05day  32 adult male 30day    20 adult female 01day  (40) adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr    31 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    35 embryo 18-20hr    31 embryo 20-22hr    32 embryo 22-24hr    42 larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    44 white prepupae new    86 white prepupae 12hr  (158) white prepupae 24hr  131 pupae 2d postWPP  102 pupae 3d postWPP    55 pupae 4d postWPP    76 adult male 01day    66 adult male 05day    32 adult male 30day    20 adult female 01day    40 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    10 embryo 04-06hr    20 embryo 06-08hr    18 embryo 08-10hr    21 embryo 10-12hr    31 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    35 embryo 18-20hr    31 embryo 20-22hr    32 embryo 22-24hr    42 larva L1    22 larva L2    20 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    44 white prepupae new    86 white prepupae 12hr    158 white prepupae 24hr    131 pupae 2d postWPP    102 pupae 3d postWPP    55 pupae 4d postWPP    76 adult male 01day    66 adult male 05day    32 adult male 30day    20 adult female 01day    40 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    13 embryonic 1182-4H    62 embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3    88 leg disc CME L1    27 wing disc CME-W2    15 wing disc ML-DmD8    49 wing disc ML-DmD9    60 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    21 wing disc ML-DmD32    192 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    86 ovary fGS/OSS    105 ovary OSC    140 ovary OSS    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (74) Schneider line 2 Sg4    13 embryonic 1182-4H  (62) embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3  (88) leg disc CME L1  (27) wing disc CME-W2    15 wing disc ML-DmD8  (49) wing disc ML-DmD9  (60) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21    21 wing disc ML-DmD32  (192) haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (35) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1  (93) CNS ML-DmBG1-c1  (30) CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  (86) ovary fGS/OSS  (105) ovary OSC  (140) ovary OSS  (65) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    13 embryonic 1182-4H    62 embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3    88 leg disc CME L1    27 wing disc CME-W2    15 wing disc ML-DmD8    49 wing disc ML-DmD9    60 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    21 wing disc ML-DmD32  (192) haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    86 ovary fGS/OSS  105 ovary OSC  (140) ovary OSS    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    13 embryonic 1182-4H    62 embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3    88 leg disc CME L1    27 wing disc CME-W2    15 wing disc ML-DmD8    49 wing disc ML-DmD9    60 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    21 wing disc ML-DmD32    192 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    86 ovary fGS/OSS    105 ovary OSC    140 ovary OSS    65 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    13 embryonic 1182-4H    62 embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3    88 leg disc CME L1    27 wing disc CME-W2    15 wing disc ML-DmD8    49 wing disc ML-DmD9    60 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    21 wing disc ML-DmD32    192 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    86 ovary fGS/OSS    105 ovary OSC    140 ovary OSS    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (74) Schneider line 2 Sg4    13 embryonic 1182-4H  (62) embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3  (88) leg disc CME L1  27 wing disc CME-W2    15 wing disc ML-DmD8  (49) wing disc ML-DmD9  (60) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21    21 wing disc ML-DmD32  (192) haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (35) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1  (93) CNS ML-DmBG1-c1  30 CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  (86) ovary fGS/OSS  (105) ovary OSC  (140) ovary OSS  (65) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    13 embryonic 1182-4H    62 embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3    88 leg disc CME L1    27 wing disc CME-W2    15 wing disc ML-DmD8    49 wing disc ML-DmD9    60 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    21 wing disc ML-DmD32  (192) haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    86 ovary fGS/OSS  105 ovary OSC  140 ovary OSS    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    13 embryonic 1182-4H    62 embryonic GM2    12 embryonic Kc167    20 embryonic S1    25 embryonic S3    88 leg disc CME L1    27 wing disc CME-W2    15 wing disc ML-DmD8    49 wing disc ML-DmD9    60 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    21 wing disc ML-DmD32    192 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    86 ovary fGS/OSS    105 ovary OSC    140 ovary OSS    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    46 cold shock, 4-day adult    34 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    47 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    97 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (46) cold shock, 4-day adult  (34) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3  (29) Cadmium 50 mM 12 hrs, larvae L3  (64) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (47) Copper 15 mM 48 hrs, 4-day adult  (101) Zinc 5 mM 12 hrs, larvae L3  (61) Zinc 4.5 mM 48 hrs, 4-day adult  (97) Ethanol 2.5% 3 hrs, larvae L3  (27) Ethanol 5% 3 hrs, larvae L3  (40) Ethanol 10% 3 hrs, larvae L3  (35) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (44) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult  (47) Paraquat 5 mM 48 hrs, 4-day adult  (54) Paraquat 10 mM 48 hrs, 4-day adult  (42) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    46 cold shock, 4-day adult    34 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    47 Copper 15 mM 48 hrs, 4-day adult  101 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    97 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    46 cold shock, 4-day adult    34 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    47 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    97 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    46 cold shock, 4-day adult    34 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    47 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    97 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (46) cold shock, 4-day adult  (34) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3  29 Cadmium 50 mM 12 hrs, larvae L3  (64) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (47) Copper 15 mM 48 hrs, 4-day adult  (101) Zinc 5 mM 12 hrs, larvae L3  (61) Zinc 4.5 mM 48 hrs, 4-day adult  (97) Ethanol 2.5% 3 hrs, larvae L3  27 Ethanol 5% 3 hrs, larvae L3  (40) Ethanol 10% 3 hrs, larvae L3  (35) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (44) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult  (47) Paraquat 5 mM 48 hrs, 4-day adult  (54) Paraquat 10 mM 48 hrs, 4-day adult  (42) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    46 cold shock, 4-day adult    34 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    47 Copper 15 mM 48 hrs, 4-day adult  101 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    97 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    46 cold shock, 4-day adult    34 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    47 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    97 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH23271 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0082582 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1539-RE;HDC16429
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal tmodCA07346 lethal, with Scer\GAL4Mef2.PR tmodGD9005 lethal | embryonic stage tmodH7 tmodS130910 lethal | embryonic stage, with Scer\GAL4Mef2.PR tmodScer\UAS.cBa lethal | larval stage, with Scer\GAL4Mef2.PR tmodScer\UAS.cBa lethal | recessive tmod00848 tmod02288 tmodf00674 tmodf04997 tmodrG347 tmodS130910 viable tmodCC00416 viable, with Scer\GAL4pnr-MD237 tmodGD9005 Sterility Allele female fertile | germline clone tmod00848 tmodf00674 tmodf04997 Other Phenotypes Allele flight defective | heat sensitive tmodhs.PDL Phenotype manifest in Allele indirect flight muscle tmodhs.PDL indirect flight muscle & striated muscle thick filament tmodhs.PDL indirect flight muscle & striated muscle thin filament tmodhs.PDL indirect flight muscle & Z disc tmodhs.PDL striated muscle thin filament, with Scer\GAL4Mef2.PR tmodScer\UAS.cBa
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of tmod Class Mutagen Stocks Known lesion tmod00848 P-element activity 1 -- tmodc01645 piggyBac transposase 1 -- tmodc03546 piggyBac transposase 1 -- tmodc06280 piggyBac transposase 1 -- tmode00860 piggyBac transposase 1 -- tmodf00674 piggyBac transposase 1 -- tmodf03538 piggyBac transposase 1 -- tmodf04997 piggyBac transposase 1 -- tmodf05684 piggyBac transposase 1 -- tmodMI02468 1 -- tmodMI04353 1 -- tmodMI07502 1 -- tmodNP3280 1 -- tmod02288 P-element activity 0 -- tmodc01634 piggyBac transposase 0 -- tmodCA07346 P-element activity 0 Yes tmodCC00416 P-element activity 0 Yes tmodCPTI002716 piggyBac transposase 0 Yes tmodCPTI002773 piggyBac transposase 0 Yes tmodCPTI002889 piggyBac transposase 0 Yes tmodDG23207 P-element activity 0 -- tmodf06991 0 -- tmodH7 0 -- tmodrG347 P-element activity 0 -- tmodS130910 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tmod Class Mutagen Stocks Known lesion tmodGD9005 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes tmodHMS02283 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tmodJF01094 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tmodKK108701 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tmodhs.PDL in vitro construct - regulatory fusion 0 Yes tmodNIG.1539R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes tmodScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC504 (Christensen et al., 2008.4.15) Df(3R)ZZ27 (Skeath, 2004)
Partially disrupted in	Df(3R)Exel6216 (Abrams et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9005} NA P{KK108701} NA P{NIG.1539R} NA P{TRiP.HMS02283} NA P{TRiP.JF01094} NA P{UAS-tmod.B} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}tmodH7 No P{PZ}tmod00848 No P{PZ}tmod02288 No P{PZ}tmodrG347 No miscellaneous insertions Mi{MIC}tmodMI02468 NA Mi{MIC}tmodMI04353 NA Mi{MIC}tmodMI07502 NA P{PTT-GA}tmodCA07346 NA P{PTT-GC}tmodCC00416 NA P{wHy}tmodDG23207 NA PBac{754.P.FSVS-0}tmodCPTI002773 NA PBac{754.P.FSVS-0}tmodCPTI002889 NA PBac{768.FSVS-0}tmodCPTI002716 NA PBac{PB}tmodc01634 NA PBac{PB}tmodc01645 NA PBac{PB}tmodc03546 NA PBac{PB}tmodc06280 NA PBac{RB}tmode00860 NA PBac{WH}tmodf00674 NA PBac{WH}tmodf03538 NA PBac{WH}tmodf04997 NA PBac{WH}tmodf05684 NA PBac{WH}tmodf06991 NA PBac{y+-attP-9A}VK00020 NA insertion of enhancer trap binary system P{GawB}tmodNP3280 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011)
Cellular Component
CV term Evidence References
fusome inferred from direct assay (Lighthouse et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) tropomyosin binding inferred from electronic annotation with InterPro:IPR004934 (FlyBase Curators et al., 2004-) non-traceable author statement (Kiger et al., 2003, Dye, 1997.3.8)
Biological Process
CV term Evidence References
cytoskeleton organization inferred from sequence or structural similarity with mouse Tmod1 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoskeleton inferred from electronic annotation with InterPro:IPR004934 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
tmod - Bsg anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) tmod - CG10209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG10566 experimental knowledge based (Guruharsha et al., 2011) tmod - CG10641 experimental knowledge based (Guruharsha et al., 2011) tmod - CG11248 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG13822 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG14823 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG17260 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG2126 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG30344 experimental knowledge based (Guruharsha et al., 2011) tmod - CG31475 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG3344 experimental knowledge based (Guruharsha et al., 2011) tmod - CG3501 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG3793 experimental knowledge based (Guruharsha et al., 2011) tmod - CG4455 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG5548 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG6712 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG7277 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) tmod - CG7953 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) tmod - CG8026 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG8560 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG8578 experimental knowledge based (Guruharsha et al., 2011) tmod - CG9171 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CG9960 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Cbp20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Cct2 experimental knowledge based (Guruharsha et al., 2011) tmod - Cortactin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Cpr100A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - CtBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Cyp4ae1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) tmod - Dgk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - GstZ1 experimental knowledge based (Guruharsha et al., 2011) tmod - Hs2st anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Ice anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) tmod - IntS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Ipk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Irp-1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Jon99Ci anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Lapsyn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - MED30 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Timp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Uch-L5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - Vha68-2 experimental knowledge based (Guruharsha et al., 2011) tmod - Vps28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - blp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - dlg1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) tmod - slp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tmod allele Gene References tmodhs.PDL spdo (Dye et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68484 DroID - A comprehensive database of gene and protein interactions. • FBgn0082582 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43633 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O46231
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z0BRP Dipteran inclusive ortholog search EOG6WDDMF Insect inclusive ortholog search EOG61C5RW Arthropod inclusive ortholog search EOG6WWQ11 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6Z0BRP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\tmod     Drosophila simulans   Dsim\GD21531 Y   Drosophila sechellia   Dsec\GM12892 Y   Drosophila erecta   Dere\GG11761 Y   Drosophila yakuba   Dyak\GE10889 Y   Drosophila ananassae   Dana\GF22912 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13696 Y   Drosophila persimilis   Dper\GL13473 Y   Drosophila willistoni   Dwil\GK14144 Y   Drosophila virilis   Dvir\GJ24508 Y   Drosophila mojavensis   Dmoj\GI24865 Y   Drosophila grimshawi   Dgri\GH14162 Y
Orthologs in non-Drosophila Dipterans (EOG6WDDMF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007029   Anopheles gambiae Malaria mosquito  Agam\AGAP000969   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016769
Orthologs in non-Dipteran Insects (EOG61C5RW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44842   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020512   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25959   Atta cephalotes Leafcutter ant  Acep\ACEP17527   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17953   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18305   Linepithema humile Argentine ant  Lhum\LH20007   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22210   Solenopsis invicta Red fire ant  Sinv\SINV25567   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007952   Bombyx mori Silkmoth  Bmor\BGIBMGA002509   Pediculus humanus Human body louse  Phum\PHUM017950   Tribolium castaneum Red flour beetle  Tcas\TC011298
Orthologs in non-Insect Arthropods (EOG6WWQ11)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\dlx2   Daphnia pulex Water flea  Dpux\JGI_V11_96240   Ixodes scapularis Deer tick  Isca\ISCW005954
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21531 Drosophila sechellia Dsec\GM12892 Drosophila erecta Dere\GG11761 Drosophila yakuba Dyak\GE10889 Drosophila ananassae Dana\GF22912 Drosophila pseudoobscura pseudoobscura Dpse\GA13696 Drosophila persimilis Dper\GL13473 Drosophila willistoni Dwil\GK14144 Drosophila virilis Dvir\GJ24508 Drosophila mojavensis Dmoj\GI24865 Drosophila grimshawi Dgri\GH14162
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Harvard	- PBac{PB}tmodc01645 - PBac{PB}tmodc03546 - PBac{PB}tmodc06280 - PBac{RB}tmode00860 - PBac{WH}tmodf00674 - PBac{WH}tmodf03538 - PBac{WH}tmodf04997 - PBac{WH}tmodf05684
Kyoto	104438 w*; P{GawB}tmodNP3280
VDRC	v108389 P{KK108701}VIE-260B v32601 w1118; P{GD9005}v32601 v32602 w1118; P{GD9005}v32602
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Genomic Clones ( 2 )
	BACR12J15 BACR48G16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 101 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH23271 LD07593 LP15256 RE70606 RH11839
Other clones	FI18705 FI20012 MIP08125 MIP17057 RE01573
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL02467 LP07149 LP08648 RE14833 RE24909 RE25314 RE30432 RE67462 RE72242 RH10603 RH13618 RH33156 RH37414 RH39641 RH39964 RH42247 RH42528 RH44027 RH65608 RH68976
Other clones	15598 17647 29329 31617 45153 51153 64109 66808 71767 80304 83614 117441 119712 125728 146666 161549 161583 194202 214223.23 214243.34 214353.24 281384 CK01.3B.F8 CK01.5B.C12 CK01.9C.H10 CK01.50D.D2 CK01.61B.D11 CK01.104D.E11 CK01.106D.D7 CK01.117A.F2 Dmel_neb_009960_0630_0768 Dmel_neb_014961_0873_2823 EK008040 EK011147 EK031701 EK041745 EK049116 EK063816 EK087818 EK089216 EK125745 EK129945 EK141520 EK158623 EK160849 EK176902 EK176909 EK189913 EK194931 EK200635 EK212640 EK217546 EK236232 EK237807 EK239501 EK245507 EK247958 EK249319 EK251051 EK290554 EK297314 EK306327 EP01946 EP03012 EP03157 EP13947 FGM316G09 RP004112038 RP004124567 RP004467121 RP004492889
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0082582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43633
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tmod CG1539 (Ye, 1999.11)
Source for database merge of
Additional comments	The "spdo" complementation group corresponds to the CG31020 annotation and not to "tmod" as previously reported in FBrf0102830; molecular lesions in the CG31020 annotation have been identified in 12 spdo alleles, RNAi against CG31020 results in a central nervous system (CNS) phenotype essentially identical to that of spdo mutants and expression of CG31020 throughout the CNS of spdo mutant embryos results in complete to near-complete rescue of the spdo CNS phenotype. (O'Connor-Giles and Skeath, 2003) Annotations CG1539, CG15540, CG11493 merged as CG1539 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) FlyBase curator comment: FBrf0102830 states that the "spdo" complementation group corresponds to the "tmod, tropomodulin" gene. However, FBrf0162056 shows that this was an error and the spdo complementation group actually corresponds to the CG31020 annotation. (Dye et al., 1998) The "spdo" complementation group corresponds to the CG31020 annotation and not to the CG1539 annotation. It was reported in FBrf0102830 that "spdo" corresponds to the "tmod, tropomodulin" gene (the CG1539 annotation). However, this was subsequently shown to be an error. FBrf0162056 shows that the "spdo" complementation group corresponds instead to the CG31020 annotation. (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057683 NM_057684 NM_170503 NM_170504 NM_170505 NM_170506 NM_001104512 NM_001170304 NM_001170305 NM_001170306 NM_001202390 NM_001202391 NM_001260442 NM_001260443 NM_001260444 NM_001276182 NM_001276183 RefSeq (Proteins) • NP_477031 NP_477032 NP_733382 NP_733383 NP_733384 NP_733385 NP_001097982 NP_001163775 NP_001163776 NP_001163777 NP_001189319 NP_001189320 NP_001247371 NP_001247372 NP_001247373 NP_001263111 NP_001263112 DDBJ / EMBL / GenBank • AA264337 AAC04506 AAF57064 AAF57065 AAF57066 AAF57067 AAM11080 AAN14242 AAN14243 ABW08810 AC008299 ACZ95069 ACZ95070 ACZ95071 ADV37409 ADV37410 AFH06688 AFH06689 AFH06690 AGB96490 AGB96491 AI403765 AQ034044 AW940897 AY094727 BI487096 CZ467313 CZ467324 CZ468708 CZ470564 CZ478701 CZ483140 CZ486118 CZ487584 CZ488298 U92490 Entrez Gene - A searchable database of RefSeq genes. • 43633 UniProtKB/TrEMBL • A8JRH3 E1JJ21 O46231 Q9VA56 Q9VA58 Q9VA59
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tropomodulin (IPR004934) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH23271
Linkouts
	BioGRID - A database of protein and genetic interactions • 68484 DroID - A comprehensive database of gene and protein interactions. • FBgn0082582 DRSC - Results from RNAi screens. • FBgn0082582 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0082582 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1539-RE;HDC16429 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0082582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43633 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43633 modMine - Data generated by the modENCODE project. • FBgn0082582 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O46231
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	1309/10 (Deak et al., 1997) CG1539 (Bellen, 2005.1.25, Skeath, 2004, Goldstein and Gunawardena, 2000, Rogers et al., 2003, Quinones-Coello, 2007, Giot et al., 2003, Keleman et al., 2009.8.5, Ni et al., 2008, Cammarato et al., 2011, Ni et al., 2010.12.1) CG11493   CG15540   CT3919 (Mardahl-Dumesnil and Fowler, 2001) CT41421 (Mardahl-Dumesnil and Fowler, 2001) E42 (Dye et al., 1998) l(3)00848 (Beaton, 2000.1.31, Spradling et al., 1999) l(3)S130910 (Read et al., 2005) spdo (Kiger et al., 2003, Spradling et al., 1999, Dye et al., 1998, Quinones-Coello, 2007) Tmod (Mardahl-Dumesnil and Fowler, 2000, Ong and Tan, 2010, Bai et al., 2007, Mardahl-Dumesnil and Fowler, 2001) tmod (Abrams et al., 2006, Buszczak et al., 2007, Christensen et al., 2008.4.15, Dietzl et al., 2007, O'Connor-Giles and Skeath, 2003, Carreira et al., 2009, Lighthouse et al., 2008, Reis et al., 2010, Irion, 2012, Carreira et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Kaushik et al., 2012) unnamed (Treisman and Rubin, 1996)
Name Synonym	sanpodo (Rogers et al., 2003) tropmodulin (Ong and Tan, 2010) Tropomodulin (Jacinto and Baum, 2003) tropomodulin (Katzemich et al., 2012, Carreira et al., 2009, Lighthouse et al., 2008, Ong et al., 2010, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0010731 FBgn0011716 FBgn0039785 FBgn0039786
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 11 ) Review  ( 2 ) Personal communication to FlyBase  ( 22 ) Abstract  ( 2 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 3 )
	Irion, 2012, PLoS ONE 7(3): e34248 Drosophila muscleblind Codes for Proteins with One and Two Tandem Zinc Finger Motifs. [FBrf0218003] Katzemich et al., 2012, J. Cell Sci. 125(14): 3367--3379 The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila. [FBrf0219368] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Show all research papers ...
Recent reviews ( 1 )
	Kaushik et al., 2012, J. Cell. Mol. Med. 16(8): 1656--1662 Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. [FBrf0219008] Show all reviews ...