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Gene Dmel\trpm

General Information
Symbol	Dmel\trpm	Species	D. melanogaster
Name		Annotation symbol	CG34123
Feature type	protein_coding_gene	FlyBase ID	FBgn0083959
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	CG30079, CG30078, dTRPM
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51E11-51F2	Sequence location	2R:11,150,309..11,180,386 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\trpm (CG34123, FBgn0083959). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: metal ion transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: divalent metal ion transport; cell growth; magnesium ion homeostasis; zinc ion homeostasis; mitochondrion organization. 22 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval anterior Malpighian tubule; salivary gland; embryonic/larval fat body; mitochondrion. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Ion transport. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Gene sequence location is 2R:11150309..11180386.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Matsuura et al., 2009, BMC Evol. Biol. 9: 228
FB2012_01	References Adamson et al., 2011, Genetics 189(2): 495--506 Sequence features BKN45514 BKN22966 HFA06629 BKN50538 BKN32299 BKN50899
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51E11-51F2
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\trpm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene split based on EST data DGC clone GH04950 appears problematic: probable genomic contamination Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) trpm-RB FBtr0110832  NM_001043083   4856   1131 trpm-RC FBtr0110831  NM_001043085   4389   1078 trpm-RD FBtr0110833  NM_001043084   7007   1921 trpm-RE FBtr0113485  NM_001103850   6991   2023 trpm-RF FBtr0114579  NM_001144200   7070   1942 trpm-RG FBtr0114580  NM_001144201   6767   1928
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein trpm-PB   FBpp0110129   129.3   1131   7.65     NP_001036548   AAF58153 trpm-PC   FBpp0110128   123.1   1078   7.36     NP_001036550   AAM68528 trpm-PD   FBpp0110130   214.6   1921   6.34     NP_001036549   ABI31097 trpm-PE   FBpp0112395   225.5   2023   6.94     NP_001097320   ABV53803 trpm-PF   FBpp0113071   217.0   1942   6.48     NP_001137672   ACL83126 trpm-PG   FBpp0113072   215.2   1928   6.63     NP_001137673   ACL83127
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ion transport (IPR005821)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698741   AE013599 AAF58153   AE013599 AAM68528   AE013599 ABI31097   AE013599 ABV53803   AE013599 ACL83126   AE013599 ACL83127   AI064501   AI403379   AI546534   AI546535   AW940185   AW940871   AY069181 AAL39326   BF497893   BF506516   BT001390 AAN71145   BT021423 AAX33571   CA805809   CO185325   CO289861   CO294576   CO315049   CO327331   CO327822   CO340517   CO343797   CZ468201   CZ485816   CZ489400   EC056867   EC057139   EC070191   EC083816   EC201389   EC203007   EC246794   EC257058   EL885453   EL885677
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	B2N016 B7YZH3 B7YZH4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0083959    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0083959 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0083959 expression level Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (947) embryo 02-04hr  (398) embryo 04-06hr  (506) embryo 06-08hr  (416) embryo 08-10hr  (585) embryo 10-12hr  (440) embryo 12-14hr  (453) embryo 14-16hr  (871) embryo 16-18hr  (950) embryo 18-20hr  (978) embryo 20-22hr  (1248) embryo 22-24hr  (1225) larva L1  (728) larva L2  (405) larva L3 12hr old  (422) larva L3 puffstage 1-2  (344) larva L3 puffstage 3-6  (582) larva L3 puffstage 7-9  (610) white prepupae new  (716) white prepupae 12hr  (987) white prepupae 24hr  (709) pupae 2d postWPP  (588) pupae 3d postWPP  (666) pupae 4d postWPP  (759) adult male 01day  (781) adult male 05day  (952) adult male 30day  (1019) adult female 01day  (1014) adult female 05day  (998) adult female 30day  (1053) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0083959 expression level Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (947) embryo 02-04hr  (398) embryo 04-06hr  (506) embryo 06-08hr  (416) embryo 08-10hr  (585) embryo 10-12hr  (440) embryo 12-14hr  (453) embryo 14-16hr  (871) embryo 16-18hr  (950) embryo 18-20hr  (978) embryo 20-22hr  (1248) embryo 22-24hr  (1225) larva L1  (728) larva L2  (405) larva L3 12hr old  (422) larva L3 puffstage 1-2  (344) larva L3 puffstage 3-6  (582) larva L3 puffstage 7-9  (610) white prepupae new  (716) white prepupae 12hr  (987) white prepupae 24hr  (709) pupae 2d postWPP  (588) pupae 3d postWPP  (666) pupae 4d postWPP  (759) adult male 01day  (781) adult male 05day  (952) adult male 30day  (1019) adult female 01day  (1014) adult female 05day  (998) adult female 30day  (1053) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    947 embryo 02-04hr    398 embryo 04-06hr    506 embryo 06-08hr    416 embryo 08-10hr    585 embryo 10-12hr    440 embryo 12-14hr    453 embryo 14-16hr    871 embryo 16-18hr    950 embryo 18-20hr    978 embryo 20-22hr    1248 embryo 22-24hr    1225 larva L1    728 larva L2    405 larva L3 12hr old    422 larva L3 puffstage 1-2    344 larva L3 puffstage 3-6    582 larva L3 puffstage 7-9    610 white prepupae new    716 white prepupae 12hr    987 white prepupae 24hr    709 pupae 2d postWPP    588 pupae 3d postWPP    666 pupae 4d postWPP    759 adult male 01day    781 adult male 05day    952 adult male 30day    1019 adult female 01day    1014 adult female 05day    998 adult female 30day    1053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0083959    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0083959 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland     Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0083959 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30078-RA;CG30078-RB;CG30078-RB;CG30079-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for trpm Stages(s) 1-3 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)XTE-18) trpm1 trpmEY01618 lethal (with trpm1) trpm2 trpmEY01618 lethal (with trpm2) trpm1 lethal (with trpmEY01618) trpm1 lethal | larval stage | maternal effect trpm28 lethal | prepupal stage trpm28 lethal | prepupal stage | recessive trpm21 trpm28 trpmEY01618 lethal | pupal stage | recessive trpm1 trpm2 viable trpm37 viable, with Scer\GAL4pnr-MD237 trpmGD4541 trpmGD9986 Other Phenotypes Allele decreased cell size trpm28 decreased cell size, with Scer\GAL4AB1 trpmGD4541 developmental rate defective | larval stage trpm28 Phenotype manifest in Allele embryonic/larval anterior Malpighian tubule trpm1 embryonic/larval fat body trpm2 mitochondrion trpm28 mitochondrion, with Scer\GAL434B trpmGD4541 salivary gland, with Scer\GAL4AB1 trpmGD4541
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of trpm Class Mutagen Stocks Known lesion trpmEY01618 amorphic allele - genetic evidence, hypomorphic allele - molecular evidence P-element activity 2 Yes trpm2 recombination SCEI endonuclease FLPase 1 Yes trpmc02782 piggyBac transposase 1 -- trpmf03209 1 -- trpmf03275 piggyBac transposase 1 -- trpmf04840 1 -- trpmf06683 piggyBac transposase 1 -- trpm21 amorphic allele - molecular evidence FLPase 0 Yes trpm28 amorphic allele - genetic evidence, hypomorphic allele - molecular evidence Delta2-3 0 Yes trpm1 Delta2-3 0 Yes trpm37 wild-type allele Delta2-3 0 Yes trpmf04797 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of trpm Class Mutagen Stocks Known lesion trpmGD4541 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes trpmGD9986 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes trpmGL00173 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trpmJF01236 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trpmJF01465 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trpmKK112299 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trpm2.Scer\SceI.RS in vitro construct 0 Yes trpmdsRNA.cRa in vitro construct - RNAi 0 Yes trpmdsRNA.cRb in vitro construct - RNAi 0 Yes trpmKK102870 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)XTE-11 (Georgiev et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK102870} NA P{TRiP.GL00173} NA P{TRiP.JF01236} NA P{TRiP.JF01465} NA characterization construct P{FRT(trpm.2.Scer\SceI.RS)} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}trpmc02782 NA PBac{WH}trpmf03209 NA PBac{WH}trpmf03275 NA PBac{WH}trpmf04797 NA PBac{WH}trpmf04840 NA PBac{WH}trpmf06683 NA insertion of mobile activating element P{EPgy2}trpmEY01618 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
metal ion transmembrane transporter activity inferred from direct assay (Georgiev et al., 2010)
Biological Process
CV term Evidence References
cell growth inferred from mutant phenotype (Georgiev et al., 2010) divalent metal ion transport inferred from direct assay (Georgiev et al., 2010) magnesium ion homeostasis inferred from mutant phenotype (Hofmann et al., 2010) mitochondrion organization inferred from mutant phenotype (Georgiev et al., 2010) NOT thermotaxis inferred from mutant phenotype (Rosenzweig et al., 2005) zinc ion homeostasis inferred from mutant phenotype (Georgiev et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ion channel activity inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Manning, 2002.11.16)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Stapleton et al., 2006) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions trpm allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62431 DroID - A comprehensive database of gene and protein interactions. • FBgn0083959 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36694
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA15628   Dpse\GA15629
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP006825-PA Anopheles gambiae (mosquito) XP_395849.3 Apis mellifera (honey bee) 88112 Branchiostoma floridae (lancelet) ENSBTAP00000010233 Bos taurus (bovine) CBP32613 Caenorhabditis briggsae (nematode) CE30390 Caenorhabditis elegans (worm) ENSCAFP00000002719 Canis familiaris (dog) JA13594 Caenorhabditis japonica (nematode) CPIJ014513 Culex pipens (mosquito) ENSCPOP00000010239 Cavia porcellus (guinea pig) RP43353 Caenorhabditis remanei (nematode) ENSCSAVP00000009468 Ciona savignyi (sedentary tunicate) 120255 Capitella spl (polychaete worm) 51222 Daphnia pulex (daphnia) ENSDARP00000082466 Danio rerio (zebra fish) ENSECAP00000007396 Equus caballus (horse) ENSGACP00000014132 Gymnopilus aculeatus (mushroom) ENSGALP00000024365 Gallus gallus (chicken) 169845 Hypsipyla robusta (cedar shoot borer) ENSP00000379587 Homo sapiens (human) ISCW013405-PA Ixodes scapularis (deer tick) 229069 Lottia gigantea (owl limpet) 27446 Monocosta brevicollis (choanoflagellate) ENSMODP00000003351 Monodelphis domestica (gray opossum) ENSMMUP00000008096 Macaca mulatta (rhesus monkey) ENSMUSP00000084857 Mus musculus (house mouse) 85952 Nematostella vectensis (starlet anemone) XP_001600197.1 Nasonia vitripennis (wasp) ENSOANP00000007966 Ornithorynchus anatinus (platypus) ENSORLP00000013466 Oryzias latipes (japanese killifish) PHUM002516-PA Pediculus humanus (human body louse) PP16981 Pristionchus pacificus (nematode) ENSPPYP00000007334 Pongo pygmaeus (orangutan) ENSPTRP00000040572 Pan troglodytes (chimpanzee) ENSRNOP00000018521 Rattus norvegicus (norway rat) Smp_147140 Schistosoma mansoni (trematode parasite) XP_001198216.1 Strongylocentrotus purpuratus (purple sea urchin) 60588 Trichoplax adhaerens (metazoa) XP_974857.2 Tribolium castaneum (red flour beetle) ENSTNIP00000011233 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019365 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000035969 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15535 NV17636 LH11689 ISCW013405 FBgn0230011 FBgn0222750 FBgn0202304 FBgn0196913 FBgn0175031 JGI_V11_51380 JGI_V11_51222 FBgn0075645 FBgn0148625 FBgn0142676 FBgn0128924 FBgn0114536 FBgn0088917 CPIJ014511 CPIJ014512 BGIBMGA001988 BGIBMGA001987 ACYPI005378 GB11960 AGAP006825 AAEL013378 AAEL011034 PHUM046090 GLEAN_09942 GLEAN_09943
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	35527 w*; trpm2/CyO 31291 y1 v1; P{TRiP.JF01236}attP2
Harvard	- PBac{PB}trpmc02782 - PBac{WH}trpmf03209 - PBac{WH}trpmf03275 - PBac{WH}trpmf04840 - PBac{WH}trpmf06683
VDRC	v107537 P{KK112299}VIE-260B v33670 w1118 P{GD9986}v33670 v30609 w1118; P{GD4541}v30609 v30610 w1118; P{GD4541}v30610 v33669 w1118; P{GD9986}v33669/CyO
	More stocks available...
Genomic Clones ( 1 )
	BACR33K06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 26 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04950 GH22805 HL05615
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09009 AT12219 SD02873 SD02874
Other clones	29927 66830 75312 119239 214405.88 CK01.1D.D7 CK01.19C.H6 CK01.88A.D12 EK008116 EK072246 EK207228 EK238849 EP06806 EP08106 EP10814 EP18047 ESG0119d.B21_D11 IP16838 IP17038
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0083959 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36694 246440
Antibody Information
	polyclonal (Hofmann et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: trpm CG34123 (Hofmann et al., 2010)
Source for database merge of	Source for merge of: CG30079 BcDNA:GH04950 (FlyBase Genome Annotators, 2006, FlyBase, 1996-)
Additional comments	Source for merge of CG30079 BcDNA:GH04950 was a shared cDNA (date:030728). (FlyBase Genome Annotators, 2006, FlyBase, 1996-) Annotation CG16805 split into CG30078 and CG30079 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001043083 NM_001043084 NM_001043085 NM_001103850 NM_001144200 NM_001144201 RefSeq (Proteins) • NP_001036548 NP_001036549 NP_001036550 NP_001097320 NP_001137672 NP_001137673 DDBJ / EMBL / GenBank • AA698741 AAF58153 AAL39326 AAM68528 AAN71145 AAX33571 ABI31097 ABV53803 ACL83126 ACL83127 AI064501 AI403379 AW940185 AW940871 AY069181 BT001390 BT021423 CZ468201 CZ485816 CZ489400 Entrez Gene - A searchable database of RefSeq genes. • 36694 UniProtKB/TrEMBL • B2N016 B7YZH3 B7YZH4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ion transport (IPR005821)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62431 DroID - A comprehensive database of gene and protein interactions. • FBgn0083959 DRSC - Results from RNAi screens. • FBgn0083959 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0083959 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30078-RA;CG30078-RB;CG30078-RB;CG30079-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0083959 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36694 246440 InParanoid A subset of ortholog calls from InParanoid. • AGAP006825-PA Anopheles gambiae (mosquito) XP_395849.3 Apis mellifera (honey bee) 88112 Branchiostoma floridae (lancelet) ENSBTAP00000010233 Bos taurus (bovine) CBP32613 Caenorhabditis briggsae (nematode) CE30390 Caenorhabditis elegans (worm) ENSCAFP00000002719 Canis familiaris (dog) JA13594 Caenorhabditis japonica (nematode) CPIJ014513 Culex pipens (mosquito) ENSCPOP00000010239 Cavia porcellus (guinea pig) RP43353 Caenorhabditis remanei (nematode) ENSCSAVP00000009468 Ciona savignyi (sedentary tunicate) 120255 Capitella spl (polychaete worm) 51222 Daphnia pulex (daphnia) ENSDARP00000082466 Danio rerio (zebra fish) ENSECAP00000007396 Equus caballus (horse) ENSGACP00000014132 Gymnopilus aculeatus (mushroom) ENSGALP00000024365 Gallus gallus (chicken) 169845 Hypsipyla robusta (cedar shoot borer) ENSP00000379587 Homo sapiens (human) ISCW013405-PA Ixodes scapularis (deer tick) 229069 Lottia gigantea (owl limpet) 27446 Monocosta brevicollis (choanoflagellate) ENSMODP00000003351 Monodelphis domestica (gray opossum) ENSMMUP00000008096 Macaca mulatta (rhesus monkey) ENSMUSP00000084857 Mus musculus (house mouse) 85952 Nematostella vectensis (starlet anemone) XP_001600197.1 Nasonia vitripennis (wasp) ENSOANP00000007966 Ornithorynchus anatinus (platypus) ENSORLP00000013466 Oryzias latipes (japanese killifish) PHUM002516-PA Pediculus humanus (human body louse) PP16981 Pristionchus pacificus (nematode) ENSPPYP00000007334 Pongo pygmaeus (orangutan) ENSPTRP00000040572 Pan troglodytes (chimpanzee) ENSRNOP00000018521 Rattus norvegicus (norway rat) Smp_147140 Schistosoma mansoni (trematode parasite) XP_001198216.1 Strongylocentrotus purpuratus (purple sea urchin) 60588 Trichoplax adhaerens (metazoa) XP_974857.2 Tribolium castaneum (red flour beetle) ENSTNIP00000011233 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019365 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000035969 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36694 modMine - Data generated by the modENCODE project. • FBgn0083959 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15535 NV17636 LH11689 ISCW013405 FBgn0230011 FBgn0222750 FBgn0202304 FBgn0196913 FBgn0175031 JGI_V11_51380 JGI_V11_51222 FBgn0075645 FBgn0148625 FBgn0142676 FBgn0128924 FBgn0114536 FBgn0088917 CPIJ014511 CPIJ014512 BGIBMGA001988 BGIBMGA001987 ACYPI005378 GB11960 AGAP006825 AAEL013378 AAEL011034 PHUM046090 GLEAN_09942 GLEAN_09943
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BcDNA:GH04950   CG16805 (Roos et al., 2005) CG30078 (Manning, 2002.11.16, Giot et al., 2003, ) CG30079 (Foley and O'Farrell, 2004, Stapleton et al., 2006) CG34123 (Hofmann et al., 2010, Keleman et al., 2009.8.5, Muse et al., 2007, Ni et al., 2008, Georgiev et al., 2010, Wasbrough et al., 2010, Ni et al., 2011.7.19, Adamson et al., 2011) DmTRPM (Matsuura et al., 2009) dTRPM (Georgiev et al., 2010, Georgiev et al., 2010) TrpM (Rosenzweig et al., 2005) TRPM (Caterina and Montell, 2005) trpm (Hofmann et al., 2010, Kwon et al., 2010)
Name Synonym
Secondary FlyBase IDs
	FBan0030079 FBgn0034006 FBgn0050078 FBgn0050079 FBgn0064975
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 5 ) Computer file  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Adamson et al., 2011, Genetics 189(2): 495--506 A Drosophila model for genetic analysis of influenza viral/host interactions. [FBrf0216397] Georgiev et al., 2010, Cell Metab. 12(4): 386--397 TRPM Channels Mediate Zinc Homeostasis and Cellular Growth during Drosophila Larval Development. [FBrf0211938] Hofmann et al., 2010, PLoS ONE 5(5): e10519 Drosophila TRPM channel is essential for the control of extracellular magnesium levels. [FBrf0210792] Kwon et al., 2010, J. Neurosci. 30(31): 10465--10471 Fine Thermotactic Discrimination between the Optimal and Slightly Cooler Temperatures via a TRPV Channel in Chordotonal Neurons. [FBrf0211446] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...