FB2020_06, released Dec 22, 2020

Gene: Dmel\CG34133

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General Information
Symbol
Dmel\CG34133
Species
D. melanogaster
Name
Annotation Symbol
CG34133
Feature Type
protein_coding_gene
FlyBase ID
FBgn0083969
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
99C5-99C5
Sequence location
3R:29,869,365..29,875,159 [+]
Recombination map

3-99

RefSeq locus
NT_033777 REGION:29869365..29875159
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (1 term)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables small GTPase binding
inferred from biological aspect of ancestor with PANTHER:PTN000368508
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\CG34133 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Conservation across Drosophila species: merge triggered by cross-species new exon data.

Gene model reviewed during 5.46

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG34133-RB
FBtr0110888
NM_001043308
3831
1078
CG34133-RC
FBtr0301073
NM_001043307
4263
1108
CG34133-RE
FBtr0335004
NM_143485
4209
1090
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG34133-PB
FBpp0110188
117.7
1078
8.14
NP_001036773
ABI31217
CG34133-PC
FBpp0290295
121.2
1108
7.81
NP_001036772
AAN14200
CG34133-PE
FBpp0307012
119.1
1090
7.92
NP_651742
AAF56961
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG34133 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG34133 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG34133
Transgenic constructs containing regulatory region of CG34133
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\WDR44
11 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Wdr44
11 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Wdr44
8 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\wdr44
10 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\wdr44
11 of 15
Yes
Yes
Drer\wdr26a
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\sym-4
8 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (9)
Atha\AT1G64610
6 of 9
Yes
Yes
Atha\AT2G37670
6 of 9
Yes
Yes
Atha\AT3G15470
6 of 9
Yes
Yes
Atha\AT5G02430
6 of 9
Yes
Yes
Atha\AT5G24320
6 of 9
Yes
Yes
Atha\AT5G42010
6 of 9
Yes
Yes
Atha\AT5G53500
6 of 9
Yes
Yes
Atha\AT5G54200
6 of 9
Yes
Yes
Atha\AT1G48870
5 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\DGR2
8 of 15
Yes
Yes
Scer\YMR102C
8 of 15
Yes
Yes
Scer\TUP1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC3H5.08c
7 of 12
Yes
Yes
Spom\SPBC18H10.05
3 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901KF )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008506
Drosophila simulans
Dsim\GD21477
Drosophila sechellia
Dsec\GM12834
Drosophila erecta
Dere\GG11704
Drosophila yakuba
Dyak\GE23895
Drosophila ananassae
Dana\GF18800
Drosophila pseudoobscura pseudoobscura
Dpse\GA30040
Drosophila persimilis
Dper\GL14035
Drosophila willistoni
Dwil\GK13362
Drosophila virilis
Dvir\GJ10490
Drosophila mojavensis
Dmoj\GI22303
Drosophila grimshawi
Dgri\GH16706
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501IZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025902
Glossina morsitans
Tsetse fly
Gmor\GMOY002075
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03507
Mayetiola destructor
Hessian fly
Mdes\Mdes000793
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013866
Anopheles darlingi
American malaria mosquito
Adar\ADAC000581
Anopheles gambiae
Malaria mosquito
Agam\AGAP000142
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012657
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01ZE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002214
Danaus plexippus
Monarch butterfly
Dple\DPOGS208319-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011499
Apis florea
Little honeybee
Aflo\2181410580
Apis mellifera
Western honey bee
Amel\GB49961
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14940
Bombus terrestris
Buff-tailed bumblebee
Bter\15205498
Linepithema humile
Argentine ant
Lhum\LH20423
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003022
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013698
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08115
Tribolium castaneum
Red flour beetle
Tcas\TC002668
Pediculus humanus
Human body louse
Phum\PHUM268100
Rhodnius prolixus
Kissing bug
Rpro\RPRC005643
Cimex lectularius
Bed bug
Clec\CLEC002248
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008044
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10318
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01WY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013562
Ixodes scapularis
Black-legged tick
Isca\ISCW002911
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71183.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_201342
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0290 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_68
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006063
Gallus gallus
Domestic chicken
Ggal\WDR44
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    WDR44; WD repeat domain 44
    11 of 15
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        CG34133 - Eip55E
        experimental knowledge based
        (Guruharsha et al., 2011)
        CG34133 - Rab11
        pull down, peptide massfingerprinting
        (Gillingham et al., 2014)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map

        3-99

        Cytogenetic map
        99C5-99C5
        Sequence location
        3R:29,869,365..29,875,159 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        99C5-99C5
        Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-99

        (FlyBase, 2016)

        3-97.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (15)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (50)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: CG7814 anon-WO0118547.417

        (FlyBase Genome Annotators, 2006, FlyBase, 1996-)
        Additional comments

        Source for merge of CG7814 anon-WO0118547.417 was sequence comparison ( date:051113 ).

        (FlyBase Genome Annotators, 2006, FlyBase, 1996-)
        Other Comments

        New annotation (CG31035) in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)

        Area matching Drosophila EST AA948996. This EST forms 781bp EST contig with AA541068 and AA950730. Probable intron in gene represented by EST AA948996.

        (Davies, 2001.3.15)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 47 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        CG31035
        CG34133
        (Transgenic RNAi Project members, 2017-, Hosono et al., 2015, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Keleman et al., 2009.8.5)
        CG7814
        (Ma et al., 2004, Wayne and McIntyre, 2002, Davies et al., 2001)
        anon-WO0118547.417
        Name Synonyms
        Secondary FlyBase IDs
        • FBan0007814
        • FBgn0039715
        • FBgn0051035
        • FBgn0062023
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (35)