FlyBase Gene Report: Dmel\Drgx

General Information

Symbol

Dmel\Drgx

Species

D. melanogaster

Name

Dorsal root ganglia homeobox

Annotation Symbol

CG34340

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085369

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:3,662,745..3,692,114 [+]

Recombination map

2-10

RefSeq locus

NT_033779 REGION:3662745..3692114

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004692309

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004692309

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004692309

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

PAIRED-LIKE HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PAIRED-LIKE HOMEOBOX TRANSCRIPTION FACTORS -: Paired-like (PRD-like) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. PRD-like transcription factors lack a paired domain but possess a homeodomain characteristic of the paired homeobox transcription factors. Some members also possess an Engrailed Homology 1 (EH1) and/or an OAR motif near the C-terminus. (Adapted from FBrf0232555 and FBrf0106517).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Drgx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0AVV3)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Drgx-RE

FBtr0302391

NM_001103605

2612

587

Drgx-RF

FBtr0339572

NM_001298663

2989

587

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Drgx-PE

FBpp0291586

61.5

587

7.41

NP_001097075

ABV53614

Drgx-PF

FBpp0308648

61.5

587

7.41

NP_001285592

AHN54107

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

587 aa isoforms: Drgx-PE, Drgx-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

A0AVV3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drgx using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34340_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Drgx in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Drgx

View exonic expression by tissue for Dmel\Drgx

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085369

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740176/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085369

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085369

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085369

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2808

Flygut - An atlas of the Drosophila adult midgut

FBgn0085369

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Drgx

Transgenic constructs containing regulatory region of Drgx

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel7018

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal, with Scer\GAL4^ey.PU

Drgx^GLO

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Drgx^GD5038

viable, with Scer\GAL4^Mef2.PR

Drgx^GD5038

viable, with Scer\GAL4^pnr-MD237

Drgx^GD5038

Other Phenotypes

Allele

abnormal cell migration | somatic clone, with Scer\GAL4^Act5C.PP

Drgx^GLO

visible, with Scer\GAL4^Bx-MS1096

Drgx^{UAS.ORF.GW.Tag:HA}

visible, with Scer\GAL4^ey.PU

Drgx^GLO

visible, with Scer\GAL4^GMR.PU

Drgx^GLO

Phenotype manifest in

Allele

eye, with Scer\GAL4^ey.PU

Drgx^GLO

eye, with Scer\GAL4^GMR.PU

Drgx^GLO

follicle cell | somatic clone, with Scer\GAL4^Act5C.PP

Drgx^GLO

head, with Scer\GAL4^ey.PU

Drgx^GLO

wing, with Scer\GAL4^Bx-MS1096

Drgx^{UAS.ORF.GW.Tag:HA}

wing vein, with Scer\GAL4^Bx-MS1096

Drgx^GLO

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DRGX

7 of 15

Yes

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\RHOXF2B

1 of 15

Hsap\RHOXF2

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Prrxl1

7 of 15

Yes

Mmus\Alx3

3 of 15

Yes

3 of 15

3 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Rhox10

1 of 15

Yes

Mmus\Rhox11

1 of 15

Yes

Mmus\Rhox12

1 of 15

Yes

Mmus\Rhox13

1 of 15

Yes

Rattus norvegicus (Norway rat) (14)

Rnor\Drgx

6 of 13

Yes

Rnor\Alx1

2 of 13

Rnor\Alx3

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Rnor\Isx

1 of 13

Yes

Rnor\Phox2b

1 of 13

Rnor\Rhox10

1 of 13

Yes

Rnor\Rhox11

1 of 13

Rnor\Rhox12

1 of 13

Yes

Rnor\Rhox13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (9)

Xtro\drgx

5 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

Xtro\rax

1 of 12

Xtro\sebox

1 of 12

Yes

Danio rerio (Zebrafish) (17)

Drer\drgx

7 of 15

Yes

Drer\alx3

3 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\si:dkey-43p13.5

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\ceh-8

3 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (5)

Atha\HB-7

2 of 9

Yes

Atha\AtHB23

1 of 9

Atha\HB-1

1 of 9

Atha\HB-12

1 of 9

Yes

Atha\HB17

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (11)

Gene Symbol

Score

Source

Alignment

2 of 10

hbn

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

Gsc

1 of 10

repo

1 of 10

Vsx2

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DRGX; dorsal root ganglia homeobox

7 of 15

606701

ALX3; ALX homeobox 3

3 of 15

606014

FRONTONASAL DYSPLASIA 1; FND1

PHOX2A; paired like homeobox 2A

3 of 15

602753

FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 2; CFEOM2

congenital fibrosis of the extraocular muscles 2

PHOX2B; paired like homeobox 2B

3 of 15

603851

congenital central hypoventilation syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Drgx - REPTOR-BP

two hybrid array

(Shokri et al., 2019)

Drgx - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Drgx - l(1)sc

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

624807

DroID - A comprehensive database of gene and protein interactions.

FBgn0085369

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-10

Cytogenetic map

24A5-24B1

Sequence location

2L:3,662,745..3,692,114 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

24A5-24B1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-10

(FlyBase, 2016)

2-8.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

92369

y¹ w^*; P{Drgx-GFP.FPTB}attP40

38045

y¹ w^*; Mi{MIC}Drgx^MI04684

42422

y¹ w^*; Mi{MIC}Drgx^MI06689

51138

y¹ w^*; Mi{MIC}Drgx^MI08993

56323

y¹ w^*; Mi{MIC}Drgx^MI11472/SM6a

56546

w^*; Mi{Hto-WP}Drgx^GLO Sfp24Bd^GLO

81192

y¹ w^*; TI{CRIMIC.TG4.1}Drgx^{CR01147-TG4.1}/SM6a

80268

y¹ sc^* v¹ sev²¹; P{TOE.GS02838}attP40

FlyORF

F004839

M{UAS-Drgx.ORF-VN}ZH-86Fb

F001861

M{UAS-Drgx.ORF.3xHA.GW}ZH-86Fb

VDRC

v109018

P{KK111117}VIE-260B

v30703

w¹¹¹⁸; P{GD5038}v30703

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP09201

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085369

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085369

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

5740176

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Drgx CG34340

(Javeed et al., 2015)

Source for database merge of

Source for merge of: CG10017 CG2808

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG10017 and CG2808 merged as CG34340 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Other Comments

dsRNA has been made from templates generated with primers directed against this gene. RNAi of CG2808 results in reduced arborization of ddaD and ddaE neurons, defects in muscle and defects in dendrite morphogenesis.

(Parrish et al., 2006)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5740176

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BI584585

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0AVV3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0AVV3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.