FlyBase Gene Report: Dmel\dcma

General Information

Symbol

Dmel\dcma

Species

D. melanogaster

Name

decima

Annotation Symbol

CG34351

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085380

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

25A3-25A3

Sequence location

2L:4,694,721..4,722,465 [+]

Recombination map

2-13

RefSeq locus

NT_033779 REGION:4694721..4722465

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

RGS7BP/RGS9BP family

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\dcma for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dcma-RC

FBtr0112561

NM_001103615

3223

226

dcma-RD

FBtr0329978

NM_001273115

3223

233

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

dcma-PC

FBpp0111473

26.0

226

7.60

NP_001097085

ABV53624

dcma-PD

FBpp0303013

26.7

233

7.12

NP_001260044

AGB92580

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

RGS7BP/RGS9BP family

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dcma using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34351_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dcma in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dcma

View exonic expression by tissue for Dmel\dcma

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0085380

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11928-RA;CG15633-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0085380

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dcma

Transgenic constructs containing regulatory region of dcma

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

dcma^GD15126

viable, with Scer\GAL4^pnr-MD237

dcma^GD15126

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RGS7BP

5 of 15

Yes

Hsap\RGS9BP

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rgs7bp

7 of 15

Yes

Mmus\Rgs9bp

1 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Rgs7bp

4 of 13

Yes

Rnor\Rgs9bp

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\rgs7bp

6 of 12

Yes

Xtro\rgs9bp

2 of 12

Yes

Xtro\LOC100489221

1 of 12

Yes

Xtro\rgs9bp

1 of 12

Yes

Danio rerio (Zebrafish) (5)

Drer\rgs7bpa

6 of 15

Yes

Drer\rgs7bpb

5 of 15

Yes

Drer\rgs9bp

1 of 15

Yes

Drer\si:ch73-167i17.6

1 of 15

Yes

Drer\zgc:109913

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\rsbp-1

2 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190F2I )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11284

Drosophila persimilis

Dper\GL14468

Drosophila willistoni

Dwil\GK23755

Drosophila virilis

Dvir\GJ23396

Drosophila mojavensis

Dmoj\GI22848

Drosophila grimshawi

Dgri\GH13136

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150IF8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17019270

Musca domestica

House fly

Mdoa\17023586

Glossina morsitans

Tsetse fly

Gmor\GMOY004099

Glossina morsitans

Tsetse fly

Gmor\GMOY004098

Glossina morsitans

Tsetse fly

Gmor\GMOY010432

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_14288

Mayetiola destructor

Hessian fly

Mdes\Mdes011046

Mayetiola destructor

Hessian fly

Mdes\Mdes011044

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002220

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002188

Anopheles gambiae

Malaria mosquito

Agam\AGAP009306

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008070

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008073

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AIP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003751

Danaus plexippus

Monarch butterfly

Dple\DPOGS203851-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006719

Apis florea

Little honeybee

Aflo\5425339028

Apis mellifera

Western honey bee

Amel\GB55642

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16962

Bombus terrestris

Buff-tailed bumblebee

Bter\15214949

Linepithema humile

Argentine ant

Lhum\LH24298

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000b14

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007967

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02489

Tribolium castaneum

Red flour beetle

Tcas\TC013654

Pediculus humanus

Human body louse

Phum\PHUM505830

Cimex lectularius

Bed bug

Clec\CLEC003500

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI29994

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02979

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0AF6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011815

Ixodes scapularis

Black-legged tick

Isca\ISCW013075

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80046.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72190.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80424.1

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

5 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RGS7BP; regulator of G protein signaling 7 binding protein

5 of 15

610890

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0085380

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-13

Cytogenetic map

25A3-25A3

Sequence location

2L:4,694,721..4,722,465 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25A3-25A3

Limits computationally determined from genome sequence between P{lacW}Tps1^k08903&P{EP}morgue^EP1184 and P{lacW}l(2)k10004^k10004&P{EP}CG3036^EP963

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-13

(FlyBase, 2016)

2-14.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

33173

y¹ w^*; Mi{MIC}dcma^MI02190

59379

y¹ w^*; Mi{MIC}dcma^MI14800

VDRC

v109021

P{KK112048}VIE-260B

v30160

w¹¹¹⁸; P{GD15125}v30160

v30163

w¹¹¹⁸; P{GD15126}v30163/TM3

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP05215

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085380

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085380

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

5740672

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: dcma CG34351

(Wilson et al., 2020)

Source for database merge of

Source for merge of: CG11928 CG15633

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG11928 and CG15633 merged as CG34351 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Other Comments

Origin and Etymology

Discoverer

Etymology

Due to its role in modulation of lifespan, the gene is named 'decima', after the Roman goddess of fate, who used threads to measure one's length of life.

(Wilson et al., 2020)

Identification

External Crossreferences and Linkouts ( 23 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5740672

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones