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General Information
Symbol
Dmel\shakB
Species
D. melanogaster
Name
shaking B
Annotation Symbol
CG34358
Feature Type
FlyBase ID
FBgn0085387
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As

Pas, shak-B, R-9-29, passover, inx8

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:20,761,071..20,927,050 [-]
Recombination map

1-65

RefSeq locus
NC_004354 REGION:20761071..20927050
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the pannexin family. (P33085)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Summaries
Gene Group (FlyBase)
INNEXINS -
Gap junctions are intercellular channels that link the cytoplasm of neighboring cells facilitating cell-cell communication. In non-chordates they are composed of innexins. Innexins are four transmembrane proteins that assemble into hexamers around a central channel. The association of hemichannels on adjacent membranes forms the gap junction which allows the direct passage of ions and small molecules. Gap junctions may be formed from homo- or heteromultimers. (Adapted from FBrf0219962).
Protein Function (UniProtKB)
Structural component of the gap junctions at electrical synapses in distal and mid-depth levels in the lamina. Isoform Lethal forms voltage sensitive intercellular channels through homotypic interactions.
(UniProt, P33085)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
shakB: shaking B (J.C. Hall)
Some of the shakB mutants are viable but defective in their neural phenotypes as homo-, hemi-, or heterozygotes, but other mutants are homozygous lethals that may or may not complement the viable shakB alleles. The viable mutants have difficulty in controlling leg movements and show leg tremors under ether anesthesia (Homyk et al., 1980). They show no escape response; the flies are unable to jump into the air and fly away at a light off stimulus (Thomas, 1980; Thomas and Wyman, 1984). Unlike the mutant Sh, the leg tremors of shakB are weak and end when the legs are severed from the body (indicating a central nervous system defect). In wild-type flies, the thoracic muscles involved in the escape response are driven by the giant fiber (GF) neuron pathway connecting the brain and thoracic ganglia. In the mutant shakB, the synapse between the GF axon and the post-synaptic interneuron (PSI) or between the PSI and the dorsal longitudinal muscle (DLM) seems to be defective; thus the DLM does not respond to visual stimulation by depressing the wings in flight. The synapse between the GF axon and the motor neuron of the tergotrochanter muscle (TTM) also seems to be defective, resulting in a weak response or no response from the TTM, the muscle that extends the leg in jumping. The motor neurons "pass over" the midline of the thoracic central nervous system and send aberrant branches into each contralateral mesothoracic ganglion. The abnormal neural phenotype is more pronounced if shakB is uncovered by a deficiency (Wyman and Thomas, 1983; Baird and Hillis, 1985; Baird et al., 1990). The muscles themselves and their neuro-muscular junctions are not abnormal (Thomas and Wyman, 1984). Viable shakB mutants are also characterized by electroretinogram (ERG) abnormalities; the corneal negative component is reduced and the on- and off- transients are reduced or absent. Neurons in the brain are affected, as indicated by failure of one of the superoesophageal brain commissures to fill with cobalt when the antennal nerve is backfilled (Aceves-Pina). shakB3 (= Pas) is partially dominant to wild type in regard to the mutant's elimination of the jump response, but the other viable alleles are recessive. +/Df(1)16-3-35 and +/Df(1)A118 are behaviorally normal, but Df(1)16-3-35/Df(1)A118 females are shakB in phenotype.
Summary (Interactive Fly)

gap junction protein - innexin - motor neuron pattern regulation - giant fiber system -Johnston's organ neurons - optic lobe

Gene Model and Products
Number of Transcripts
8
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\shakB or the JBrowse view of Dmel\shakB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Gene model reviewed during 5.45

Gene model reviewed during 5.40

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0112571
3273
372
FBtr0112570
7558
361
FBtr0112569
3025
532
FBtr0112572
3773
316
FBtr0114645
2514
292
FBtr0309369
9299
377
FBtr0309370
14683
377
FBtr0342859
14924
377
Additional Transcript Data and Comments
Reported size (kB)

2.726 (longest cDNA)

1.804 (longest cDNA)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0111483
44.4
372
8.91
FBpp0111482
42.9
361
8.87
FBpp0111481
61.4
532
9.95
FBpp0111484
37.7
316
9.48
FBpp0113137
35.1
292
9.45
FBpp0301271
44.8
377
9.01
FBpp0301272
44.8
377
9.01
FBpp0309671
44.8
377
9.01
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

377 aa isoforms: shakB-PG, shakB-PH, shakB-PI
Additional Polypeptide Data and Comments
Reported size (kDa)

361 (aa); 43 (kD)

Comments
External Data
Subunit Structure (UniProtKB)

Monomer (isoform Lethal).

(UniProt, P33085)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\shakB using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000223951
(assigned by GO_Central )
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:Inx3; FB:FBgn0265274
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000223951
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000223951
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Expression is isoform-specific

shakB expression was detected in the giant fibres of young adult brains and at the posterior border of the wing neuromere in T2. Expression is seen in the same cells during pupariation (from 75 hr after pupariation onward).

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Expression of shakB is observed in regions where the Giant fibers contact the peripherally synapsing interneuron (PSI), and where the giant fiber contacts the tergotrochanteral muscle motor neuron (TTMn).

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\shakB in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 46 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of shakB
Transgenic constructs containing regulatory region of shakB
Deletions and Duplications ( 137 )
Disrupted in
Not disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
giant fibers & synapse
tergal depressor of trochanter muscle motor neuron & synapse
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (2)
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (25)
7 of 15
Yes
Yes
5 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
Yes
4 of 15
No
Yes
4 of 15
No
No
4 of 15
No
Yes
4 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190A8I )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509PI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0I49 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0I7M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
5 of 10
5 of 10
5 of 10
5 of 10
5 of 10
5 of 10
5 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Monomer (isoform Lethal).
    (UniProt, P33085 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map

    1-65

    Cytogenetic map
    Sequence location
    X:20,761,071..20,927,050 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    19E2-19E3
    Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    19E3-19E3
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (74)
    cDNA Clones (114)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: shakB CG1321

    Source for database merge of

    Source for merge of: shakB CG12678

    Source for merge of: shakB CG15451

    Additional comments

    Annotations CG32508 and CG12678 merged as CG34358 in release 5.2 of the genome annotation.

    Annotations CG1321 and CG15451 merged as CG32508 in release 3 of the genome annotation.

    A number of homozygous lethal alleles have been located in the shakB region. Six of them do not complement the shakB neural phenotype; two of the remainder have been tested and found to complement this neural phenotype, but do not complement the lethality of the other lethal alleles. The six noncomplementing lethals also fail to complement Df(1)16-3-35 (distal deficiency) and Df(1)A118 (proximal deficiency), while the two complementing lethals complement Df(1)A118 but not Df(1)16-3-35.

    Other Comments

    Domain-swapping experiments for shakB and ogre indicate that residues crucial for innexin function are found in the intracellular loop and well as a short stretch N-terminal to the second transmembrane domain.

    Electroretinograms for molecular chimeras and rescue constructs for shakB and ogre indicate that innexins are not interchangeable in their roles of promoting normal neural development in flies.

    Mutations in shakB eliminate electrical, but not chemical synapses in the giant fiber escape system.

    shakB expressed in paired Xenopus oocytes localises to the membrane and its presence induces the formation of intercellular channels.

    shakB causes a reduction in number of structural gap junctions relative to wild type, this action is localised to the middle and upper depths of the lamina.

    Expression of neuronal shakB protein coincides with, and is essential for, the establishment of functional electrical (gap-junctional) synapses.

    shakB is necessary for gap-junctional communication between the neurons of the giant fibre system.

    Multiple transcripts are produced from shakB by differential splicing and alternate promoter usage. Essential and neural transcripts of shakB are differentially expressed in the embryonic mesoderm and pupal nervous system. On the basis of its expression pattern and the phenotypes of mutants at shakB and homologous genes, shakB and its homologues may be involved in the organization of cellular membranes.

    shakB locus encodes two proteins, one necessary for the giant fibre system and one necessary for viability. Neural only mutations map to neural specific exons, lethal mutations map to viable specific exons and inactivate the other protein, neural lethal mutations map to the common exons and inactivate both proteins.

    Dye coupling between the giant fiber and its post-synaptic targets is absent in neural shakB mutants. The shakB protein may act to stabilise the gap junctions.

    Driving of tergotrochanteral muscle motorneuron by the giant fiber is defective in mutant genotypes, despite its generally normal pathfinding i.e. growing into the normal synaptic region, suggesting that shakB may disrupt cell recognition, synaptogenesis, or synaptic function in the tergotrochanteral muscle motorneuron or its presynaptic partners.

    Gene cloned from a P element induced allele and the sequence suggests a membrane protein gene product.

    shakB encodes a putative 120 amino acid protein with 48% identity to that of ogre.

    Behavioural data suggests antennal and maxillary basiconic sensilla may be important receptors for short chain alcohols and organic acids but less crucial for acetates, aldehydes and ketones.

    shakB locus may contain two functional domains: one required for viability and the other for a normal neuronal phenotype.

    Mutations disrupt the synaptic transmission of the giant fibre (GF) - tergotrochanteral muscle (TTM, jumping muscle) pathway and the giant fibre (GF) - dorso-longitudinal muscle (DLM) pathway.

    Some of the shakB mutants are viable but defective in their neural phenotypes as homo-, hemi-, or heterozygotes, but other mutants are homozygous lethals that may or may not complement the viable shakB alleles. The viable mutants have difficulty in controlling leg movements and show leg tremors under ether anesthesia (Homyk et al., 1980). They show no escape response; the flies are unable to jump into the air and fly away at a light off stimulus (Thomas, 1980; Thomas and Wyman, 1984). Unlike the mutant Sh, the leg tremors of shakB are weak and end when the legs are severed from the body (indicating a central nervous system defect). In wild-type flies, the thoracic muscles involved in the escape response are driven by the giant fiber (GF) neuron pathway connecting the brain and thoracic ganglia. In the mutant shakB, the synapse between the GF axon and the postsynaptic interneuron (PSI) or between the PSI and the dorsal longitudinal muscle (DLM) seems to be defective; thus the DLM does not respond to visual stimulation by depressing the wings in flight. The synapse between the GF axon and the motor neuron of the tergotrochanter muscle (TTM) also seems to be defective, resulting in a weak response or no response from the TTM, the muscle that extends the leg in jumping. The motor neurons 'pass over' the midline of the thoracic central nervous system and send aberrant branches into each contralateral mesothoracic ganglion. The abnormal neural phenotype is more pronounced if shakB is uncovered by a deficiency (Wyman and Thomas, 1983; Baird and Hillis, 1985; Baird, Schalet and Wyman, 1990). The muscles themselves and their neuro-muscular junctions are not abnormal (Thomas and Wyman, 1984). Viable shakB mutants are also characterized by electroretinogram (ERG) abnormalities; the corneal negative component is reduced and the on- and off- transients are reduced or absent. Neurons in the brain are affected, as indicated by failure of one of the superoesophageal brain commissures to fill with cobalt when the antennal nerve is backfilled (Aceves-Pina). shakB3 (= Pas) is partially dominant to wild type in regard to the mutant's elimination of the jump response, but the other viable alleles are recessive. +/Df(1)16-3-35 and +/Df(1)A118 are behaviorally normal, but Df(1)16-3-35/Df(1)A118 females are shakB in phenotype.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 48 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    Synonyms and Secondary IDs (49)
    Reported As
    Symbol Synonym
    CG12678
    CG1321
    CG15451
    CG32508
    l(1)19Eb
    l(1)LB21
    l(1)R-10-14
    l(1)R-10-3
    l(1)R-10-7
    l(1)TH73
    l(1)W3b
    nj-156
    nj156
    Secondary FlyBase IDs
    • FBan0032508
    • FBgn0052508
    • FBgn0031131
    • FBgn0003037
    • FBgn0031133
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (208)