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Gene Dmel\Fili

General Information
Symbol	Dmel\Fili	Species	D. melanogaster
Name	Fish-lips	Annotation symbol	CG34368
Feature type	protein_coding_gene	FlyBase ID	FBgn0085397
Gene Model Status	Current	Stock availability	11 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58A3-58A4	Sequence location	2R:17,759,537..17,833,769 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Fish-lips is referred to in FlyBase by the symbol Dmel\Fili (CG34368, FBgn0085397). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Leucine-rich repeat; Leucine-rich repeat, typical subtype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 2R:17759537..17833769.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	References Carreira et al., 2011, BMC Dev. Biol. 11: 32 Sequence features BKN30020 HFA04132 BKN27139 HFA03907 HFA04445
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58A3-58A4
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fili for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fili-RC FBtr0112593  NM_001103932   4862   738
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fili-PC   FBpp0111505   82.4   738   6.45     NP_001097402   ABV53873
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat, typical subtype (IPR003591) Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 ABV53873   BI162987   BI164988   BI168122   BI229905   BI363000   BI366789   BI368511   BI485248   BI568437   BI589584   BI590431   BI629106   BI630254   BT015985   BT125762   BT125775   BT125776   CK135324   CO189414   CO266471   CO271293   CO283203   CO284618   CO295069   CO295627   CO298848   CO303376   CO306269   CO309662   CO328402   CO330111   CO332861   CO333239   CO334074   CO339036   CO340212   EC056928   EC060068   EC063747   EC065658   EC067431   EC067461   EC077268   EC079456   EC083973   EC195330   EC197999   EC201601   EC205364   EC206796   EC212542   EC213295   EC223845   EC227671   EC240574   EC244417   EC244773   EC252763   EC253332   EC255463   GH944247   GH946999   GH947786   GH947792   GH950259   GH951444   GH952706   GH959584   GH959734   GH960158   GH965046   GH966607   GH967760   GH968687   GH969903   GH969956   GH970988   GH978167   GH979110   GH980142   GH981023   GH981683   GH983799   GH983823   GH984417
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0085397    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0085397 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0085397 expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr    1815 embryo 10-12hr    2475 embryo 12-14hr    2993 embryo 14-16hr    2373 embryo 16-18hr    2444 embryo 18-20hr    1610 embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr    2015 white prepupae 24hr    2184 pupae 2d postWPP    1540 pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr  (164) embryo 06-08hr  (1002) embryo 08-10hr  (1815) embryo 10-12hr  (2475) embryo 12-14hr  (2993) embryo 14-16hr  (2373) embryo 16-18hr  (2444) embryo 18-20hr  (1610) embryo 20-22hr  (448) embryo 22-24hr  (570) larva L1  (353) larva L2  (223) larva L3 12hr old  103 larva L3 puffstage 1-2  (158) larva L3 puffstage 3-6  (490) larva L3 puffstage 7-9  (832) white prepupae new  (1230) white prepupae 12hr  (2015) white prepupae 24hr  (2184) pupae 2d postWPP  (1540) pupae 3d postWPP  (498) pupae 4d postWPP  (176) adult male 01day  (121) adult male 05day  (142) adult male 30day  (114) adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr  (1815) embryo 10-12hr  (2475) embryo 12-14hr  (2993) embryo 14-16hr  (2373) embryo 16-18hr  (2444) embryo 18-20hr  (1610) embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr  (2015) white prepupae 24hr  (2184) pupae 2d postWPP  (1540) pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr    1815 embryo 10-12hr    2475 embryo 12-14hr    2993 embryo 14-16hr    2373 embryo 16-18hr    2444 embryo 18-20hr    1610 embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr    2015 white prepupae 24hr    2184 pupae 2d postWPP    1540 pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr    1815 embryo 10-12hr    2475 embryo 12-14hr    2993 embryo 14-16hr    2373 embryo 16-18hr    2444 embryo 18-20hr    1610 embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr    2015 white prepupae 24hr    2184 pupae 2d postWPP    1540 pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0085397 expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr    1815 embryo 10-12hr    2475 embryo 12-14hr    2993 embryo 14-16hr    2373 embryo 16-18hr    2444 embryo 18-20hr    1610 embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr    2015 white prepupae 24hr    2184 pupae 2d postWPP    1540 pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr  (164) embryo 06-08hr  (1002) embryo 08-10hr  (1815) embryo 10-12hr  (2475) embryo 12-14hr  (2993) embryo 14-16hr  (2373) embryo 16-18hr  (2444) embryo 18-20hr  (1610) embryo 20-22hr  (448) embryo 22-24hr  (570) larva L1  (353) larva L2  (223) larva L3 12hr old  103 larva L3 puffstage 1-2  (158) larva L3 puffstage 3-6  (490) larva L3 puffstage 7-9  (832) white prepupae new  (1230) white prepupae 12hr  (2015) white prepupae 24hr  (2184) pupae 2d postWPP  (1540) pupae 3d postWPP  (498) pupae 4d postWPP  (176) adult male 01day  121 adult male 05day  142 adult male 30day  114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr  1815 embryo 10-12hr  (2475) embryo 12-14hr  (2993) embryo 14-16hr  2373 embryo 16-18hr  2444 embryo 18-20hr  1610 embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr  2015 white prepupae 24hr  2184 pupae 2d postWPP  1540 pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr    1815 embryo 10-12hr    2475 embryo 12-14hr    2993 embryo 14-16hr    2373 embryo 16-18hr    2444 embryo 18-20hr    1610 embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr    2015 white prepupae 24hr    2184 pupae 2d postWPP    1540 pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    62 embryo 04-06hr    164 embryo 06-08hr    1002 embryo 08-10hr    1815 embryo 10-12hr    2475 embryo 12-14hr    2993 embryo 14-16hr    2373 embryo 16-18hr    2444 embryo 18-20hr    1610 embryo 20-22hr    448 embryo 22-24hr    570 larva L1    353 larva L2    223 larva L3 12hr old    103 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    490 larva L3 puffstage 7-9    832 white prepupae new    1230 white prepupae 12hr    2015 white prepupae 24hr    2184 pupae 2d postWPP    1540 pupae 3d postWPP    498 pupae 4d postWPP    176 adult male 01day    121 adult male 05day    142 adult male 30day    114 adult female 01day    65 adult female 05day    32 adult female 30day    28 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0085397    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0085397 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085397 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4054-RA;CG13487-RA;S.C2R002361
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 FiliGD431 FiliGD2136 Phenotype manifest in Allele wing disc | somatic clone FiliΔ102
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Fili Class Mutagen Stocks Known lesion Filie02018 1 -- Filie04279 1 -- Filif04573 1 -- Filif04884 1 -- FililacZ 1 -- FiliMB02223 1 -- FiliMI01398 1 -- Filic05119 0 -- FiliΔ102 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fili Class Mutagen Stocks Known lesion FiliGD431 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes FiliGD2136 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes FiliHM05054 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes FiliScer\UAS.cAa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7169 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD431} NA P{GD2136} NA P{TRiP.HM05054} NA P{UAS-Fili.A} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}FiliMI01398 NA PBac{PB}Filic05119 NA PBac{RB}Filie02018 NA PBac{RB}Filie04279 NA PBac{WH}Filif04573 NA PBac{WH}Filif04884 NA insertion of enhancer trap P{lacW}FililacZ No insertion of enhancer trap binary system Mi{ET1}FiliMB02223 No
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fili allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0085397
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA17921
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003111-PA Aedes aegypti (mosquito) AAEL003115-PA Aedes aegypti (mosquito) AGAP011229-PA Anopheles gambiae (mosquito) XP_001120543.1 Apis mellifera (honey bee) ENSCINP00000026723 Ciona intestinalis (sea squirt) CPIJ005002 Culex pipens (mosquito) ENSCPOP00000020607 Cavia porcellus (guinea pig) 224319 Capitella spl (polychaete worm) ENSECAP00000012972 Equus caballus (horse) ENSGACP00000004528 Gymnopilus aculeatus (mushroom) ENSGALP00000001166 Gallus gallus (chicken) ENSP00000384979 Homo sapiens (human) 53199 Lottia gigantea (owl limpet) ENSMMUP00000022625 Macaca mulatta (rhesus monkey) XP_001603470.1 Nasonia vitripennis (wasp) ENSOANP00000021105 Ornithorynchus anatinus (platypus) PHUM009318-PA Pediculus humanus (human body louse) ENSPPYP00000010489 Pongo pygmaeus (orangutan) ENSPTRP00000017393 Pan troglodytes (chimpanzee) XP_967217.2 Tribolium castaneum (red flour beetle) ENSTNIP00000008348 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041214 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033400 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13179 LH24835 ISCW016292 FBgn0229986 FBgn0229985 FBgn0217936 FBgn0217935 FBgn0208875 FBgn0183373 FBgn0183372 FBgn0170786 FBgn0170787 FBgn0166120 FBgn0246388 FBgn0246387 FBgn0154564 FBgn0154563 FBgn0141475 FBgn0141474 FBgn0128597 FBgn0114320 FBgn0114319 FBgn0090308 FBgn0090307 CPIJ005002 CPIJ016181 BGIBMGA002631 GB19945 AGAP011227 AGAP011229 AAEL003115 AAEL003111 PB23071 PHUM406980 GLEAN_01975
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	23968 w1118; Mi{ET1}FiliMB02223 28568 y1 v1; P{TRiP.HM05054}attP2 34189 y1 w*; Mi{MIC}FiliMI01398
Harvard	- PBac{RB}Filie02018 - PBac{RB}Filie04279 - PBac{WH}Filif04573 - PBac{WH}Filif04884
Kyoto	109637 P{lacW}FililacZ
VDRC	v1701 w1118; P{GD431}v1701 v1702 w1118; P{GD431}v1702 v44532 w1118 P{GD2136}v44532
Genomic Clones ( 2 )
	BACR07I11 BACR30O14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 84 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE58108
Other clones	RT10426 RT10428 RT10433
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE02273 RE04779 RE08676 RE27787 RE47706 RE52401 RE54491 RE68546 RH03034 RH04053 RH57920 RH59258
Other clones	10656 15793 16742 33984 66917 73127 73507 78775 84060 121209 144342 181928 191819 192188 214247.68 214313.63 214405.47 281301 283376 CK01.11C.A12 CK01.16B.D10 CK01.51D.D10 CK01.54C.F7 CK01.168A.G3 EK044224 EK102920 EK146519 EK162606 EK166423 EK173960 EK208543 EK211107 EK218745 EK241221 EK250653 EK294543 EK304904 EK306256 EK308821 EP00651 EP09138 EP10221 RH39885 RP004141025 RP004161477 RP004170572 RP004198905 RP004205430 RP004205508 RP004206464 RP004207020 RP004214473 RP004228940 RP004236654 RP004243028 RP004243198 RP004253540 RP004262655 RP004419492 RP004433794 RP004435793 RP004451311 RP004463557 RP004477823 RP004497020 RP004548232 RP004553185 RP004555704
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0085397 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37494 37495 5740472
Antibody Information
Other Information
Discoverer
Etymology
	The name fish-lips is derived from the observation that the expression pattern of Fili in the wing disc made a fish lips-like shape. (Adachi-Yamada et al., 2005)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Fili CG4054 (Adachi-Yamada et al., 2005)
Source for database merge of	Source for merge of: Fili CG13487 (FlyBase Genome Annotators, 2007)
Additional comments	Annotations CG13487 and CG4054 merged as CG34368 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007)
Other Comments
	Fili is a Leucine-Rich Repeat (LRR) family transmembrane protein. (Adachi-Yamada et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001103932 RefSeq (Proteins) • NP_001097402 DDBJ / EMBL / GenBank • ABV53873 Entrez Gene - A searchable database of RefSeq genes. • 5740472
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat, typical subtype (IPR003591) Leucine-rich repeat (IPR001611)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0085397 DRSC - Results from RNAi screens. • FBgn0085397 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085397 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4054-RA;CG13487-RA;S.C2R002361 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0085397 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37494 37495 5740472 InParanoid A subset of ortholog calls from InParanoid. • AAEL003111-PA Aedes aegypti (mosquito) AAEL003115-PA Aedes aegypti (mosquito) AGAP011229-PA Anopheles gambiae (mosquito) XP_001120543.1 Apis mellifera (honey bee) ENSCINP00000026723 Ciona intestinalis (sea squirt) CPIJ005002 Culex pipens (mosquito) ENSCPOP00000020607 Cavia porcellus (guinea pig) 224319 Capitella spl (polychaete worm) ENSECAP00000012972 Equus caballus (horse) ENSGACP00000004528 Gymnopilus aculeatus (mushroom) ENSGALP00000001166 Gallus gallus (chicken) ENSP00000384979 Homo sapiens (human) 53199 Lottia gigantea (owl limpet) ENSMMUP00000022625 Macaca mulatta (rhesus monkey) XP_001603470.1 Nasonia vitripennis (wasp) ENSOANP00000021105 Ornithorynchus anatinus (platypus) PHUM009318-PA Pediculus humanus (human body louse) ENSPPYP00000010489 Pongo pygmaeus (orangutan) ENSPTRP00000017393 Pan troglodytes (chimpanzee) XP_967217.2 Tribolium castaneum (red flour beetle) ENSTNIP00000008348 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041214 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033400 Xenopus tropicalis (frog) modMine - Data generated by the modENCODE project. • FBgn0085397 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13179 LH24835 ISCW016292 FBgn0229986 FBgn0229985 FBgn0217936 FBgn0217935 FBgn0208875 FBgn0183373 FBgn0183372 FBgn0170786 FBgn0170787 FBgn0166120 FBgn0246388 FBgn0246387 FBgn0154564 FBgn0154563 FBgn0141475 FBgn0141474 FBgn0128597 FBgn0114320 FBgn0114319 FBgn0090308 FBgn0090307 CPIJ005002 CPIJ016181 BGIBMGA002631 GB19945 AGAP011227 AGAP011229 AAEL003115 AAEL003111 PB23071 PHUM406980 GLEAN_01975
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG4054   CG13487   CG34368 (FlyBase Genome Annotators, 2007, Perkins et al., 2009) CT13464 (Hynes and Zhao, 2000) CT32855 (Hynes and Zhao, 2000) Fili
Name Synonym	CG13487   Fish-lips (Adachi-Yamada et al., 2005, Adachi-Yamada et al., 2005, )
Secondary FlyBase IDs
	FBgn0034668 FBgn0034669
References ( 15 )
Research paper	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Adachi-Yamada et al., 2005, Molec. Cell. Biol. 25(8): 3140--3150 Wing-to-leg homeosis by Spineless causes apoptosis regulated by Fish-lips, a novel leucine-rich repeat transmembrane protein. [FBrf0184157]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Hynes and Zhao, 2000, J. Cell Biol. 150(2): Table S7. LRR repeat-containing proteins. [FBrf0132111]
Personal communication to FlyBase	Bellen, 2011.1.31, set919.xml set919.xml [FBrf0212923] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Abstract	Adachi-Yamada et al., 2005, A. Dros. Res. Conf. 46 Suppl.: 981C Cell-cell communication mediated by LRR protein Fish-lips suppresses removal of ectopic ventral appendage cells. [FBrf0184545]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase Genome Annotators, 2007, Changes affecting gene model number or type in release 5.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.2 of the annotated D.melanogaster genome. [FBrf0199252] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Milshina, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126686]