FlyBase Gene Report: Dmel\side-V

SIDE FAMILY -: SIDE is a closely related family encoding immunoglobulin superfamily proteins. They can interact with BEAT family members. Interactions between side and beat-Ia have been shown to play a role in the control of motor axon guidance. (Adapted from FBrf0207934 and FBrf0222007).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\side-V or the JBrowse view of Dmel\side-V for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

side-V-RA

FBtr0112596

NM_137923

5760

1140

side-V-RB

FBtr0330239

NM_137921

5760

1174

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

side-V-PA

FBpp0111508

122.6

1140

7.77

NP_611767

AAF46967

side-V-PB

FBpp0303272

126.1

1174

7.64

NP_611765

AAF46965

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\side-V using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34371_1

Linkouts

Gene Ontology (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\side-V in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\side-V

View exonic expression by tissue for Dmel\side-V

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0085400

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG13548-RA;CG30188-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30188

Flygut - An atlas of the Drosophila adult midgut

FBgn0085400

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of side-V

Transgenic constructs containing regulatory region of side-V

Deletions and Duplications ( 1 )

Disrupted in

Df(2R)Exel7177

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

side-V^{MI04721-GFSTF.1}

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

side-V^GD2175

viable, with Scer\GAL4^pnr-MD237

side-V^GD2175

Other Phenotypes

Allele

pain response defective | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

side-V^GD12830

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\MERTK

1 of 15

Yes

Hsap\NPHS1

1 of 15

Yes

Hsap\PSG1

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Nphs1

1 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Nphs1

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\nphs1

1 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\nphs1

1 of 15

Yes

Drer\siglec15l

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\syg-2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901MU )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\side-V

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24669

Drosophila persimilis

Dper\GL11291

Drosophila willistoni

Dwil\GK19588

Drosophila virilis

Dvir\GJ20976

Drosophila mojavensis

Dmoj\GI21128

Drosophila grimshawi

Dgri\GH23057

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500XQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17014943

Glossina morsitans

Tsetse fly

Gmor\GMOY009377

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05180

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005560

Anopheles darlingi

American malaria mosquito

Adar\ADAC009990

Anopheles gambiae

Malaria mosquito

Agam\AGAP001925

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ015257

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04T1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_52

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Nphs1L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028889gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_000407gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_020210gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_014032gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_1693

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Igf_22

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_012353gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_017577gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Igf_4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_004544gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf_34

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_1098

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Igf_20

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf_10

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Egff_6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf_40

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Igf_6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Igf_16

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf_28

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (17)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

5 of 10

5 of 10

4 of 10

4 of 10

4 of 10

2 of 10

hbs

2 of 10

nrm

2 of 10

sns

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

rst

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0085400

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-102

Cytogenetic map

59D1-59D2

Sequence location

2R:23,163,012..23,203,973 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

59D1-59D2

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-102

(FlyBase, 2016)

2-106.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Bloomington

33274

w¹¹¹⁸; P{EP}side-V^G8004/SM6a

61953

y¹ v¹; P{TRiP.HMJ23537}attP40

37845

y¹ w^*; Mi{MIC}side-V^MI04721

22886

y¹ w^67c23; Mi{ET1}side-V^MB00740

63174

y¹ w^67c23; Mi{PT-GFSTF.1}side-V^{MI04721-GFSTF.1}

82073

y¹ sc^* v¹ sev²¹; P{TKO.GS04543}attP40

Harvard

c01679

PBac{PB}side-V^c01679

f06650

PBac{WH}side-V^f06650

VDRC

v22710

w¹¹¹⁸; P{GD12830}v22710

v44997

w¹¹¹⁸; P{GD2175}v44997/TM3

v44998

w¹¹¹⁸; P{GD2175}v44998/CyO

Genomic Clones (39)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (108)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

RE72153

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085400

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE16605

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085400

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37679

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: side-V CG34371

(Li et al., 2017)

Source for database merge of

Source for merge of: CG13548 CG30188

(FlyBase Genome Annotators, 2007)

Source for merge of: CG13546 CG13547

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG13548 and CG30188 merged as CG34371 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Annotations CG13546 and CG13547 merged as CG30188 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Origin and Etymology

Discoverer

Etymology

Named 'side-V' based on its phylogenetic relationship to 'side'.

(Li et al., 2017)

Identification

External Crossreferences and Linkouts ( 30 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37679

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085400

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34371_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30188

Flygut - An atlas of the Drosophila adult midgut

FBgn0085400

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37679

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG34371

modMine - A data warehouse for the modENCODE project

FBgn0085400

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0085400

DRSC - Results frm RNAi screens

FBgn0085400

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0085400

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG13548-RA;CG30188-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0085400

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

34371

(Ozkan et al., 2013)

CG13546

CG13547

CG13548

CG30188

(Firth and Baker, 2007)

CG34371

(Li et al., 2017, Aradska et al., 2015, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Ozkan et al., 2013, Sen et al., 2013, Jungreis et al., 2011, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

CT32921

(Hynes and Zhao, 2000)

CT32922

(Hynes and Zhao, 2000)

side-V

(Li et al., 2017, Transgenic RNAi Project members, 2017-)

Name Synonyms

CG13548

CG30188

sidestep V

Secondary FlyBase IDs

FBgn0034831
FBgn0034830
FBgn0034832
FBgn0050188

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (37)

Report Sections

Open Close