Would you like to get involved in the improvement of your favorite website?
Join the FlyBase Community Advisory Group!
FB2021_04, released August 17, 2021

Gene: Dmel\TrissinR

Open Close
General Information
Symbol
Dmel\TrissinR
Species
D. melanogaster
Name
Trissin receptor
Annotation Symbol
CG34381
Feature Type
protein_coding_gene
FlyBase ID
FBgn0085410
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
G-protein coupled receptor which is activated by the Trissin peptide in vitro, leading to increased intracellular calcium ion levels. (UniProt, Q9VML9)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:5,824,004..5,856,767 [+]
Recombination map
2-17
RefSeq locus
NT_033779 REGION:5824004..5856767
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables G protein-coupled peptide receptor activity
inferred from physical interaction with FLYBASE:Trissin; FB:FBgn0038343
(Ida et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables G protein-coupled peptide receptor activity
inferred from sequence or structural similarity with FLYBASE:TkR99D; FB:FBgn0004622
(Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000662653
(assigned by GO_Central )
(Gaudet et al., 2011)
enables neuropeptide receptor activity
inferred from sequence model
(Hewes and Taghert, 2001)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in G protein-coupled receptor signaling pathway
inferred from direct assay
(Ida et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity with FLYBASE:TkR99D; FB:FBgn0004622
(Brody and Cravchik, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000662653
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence model
(Hewes and Taghert, 2001)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Ida et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity with FLYBASE:TkR99D; FB:FBgn0004622
(Brody and Cravchik, 2000)
inferred from sequence model
(Hewes and Taghert, 2001)
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000662653
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (Q9VML9)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -
The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).
Protein Function (UniProtKB)
G-protein coupled receptor which is activated by the Trissin peptide in vitro, leading to increased intracellular calcium ion levels.
(UniProt, Q9VML9)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\TrissinR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
TrissinR-RB
FBtr0112619
NM_001103622
2826
669
TrissinR-RC
FBtr0330221
NM_135118
2811
664
TrissinR-RD
FBtr0330222
NM_001273179
3637
659
TrissinR-RE
FBtr0342612
NM_001298712
3601
664
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
TrissinR-PB
FBpp0111531
74.5
669
9.37
NP_001097092
AAF52294
TrissinR-PC
FBpp0303254
73.9
664
9.44
NP_608962
AAF52292
TrissinR-PD
FBpp0303255
73.4
659
9.52
NP_001260108
AGB92644
TrissinR-PE
FBpp0309550
73.9
664
9.44
NP_001285641
AHN54156
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

664 aa isoforms: TrissinR-PC, TrissinR-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TrissinR using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Ida et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\TrissinR in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of TrissinR
Transgenic constructs containing regulatory region of TrissinR
Aberrations (Deficiencies and Duplications) ( 2 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FFAR4
1 of 15
Yes
Yes
Hsap\GALR2
1 of 15
Yes
No
Hsap\GALR3
1 of 15
Yes
No
Hsap\KISS1R
1 of 15
Yes
No
Hsap\MPO
1 of 15
Yes
No
Hsap\NPBWR1
1 of 15
Yes
No
Hsap\PROKR1
1 of 15
Yes
Yes
Hsap\PROKR2
1 of 15
Yes
Yes
Hsap\QRFPR
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ffar4
1 of 15
Yes
Yes
Mmus\Galr1
1 of 15
Yes
No
Mmus\Galr2
1 of 15
Yes
No
Mmus\Galr3
1 of 15
Yes
No
Mmus\Oprd1
1 of 15
Yes
No
Mmus\Prokr1
1 of 15
Yes
Yes
Mmus\Prokr2
1 of 15
Yes
Yes
Mmus\Qrfprl
1 of 15
Yes
Yes
Mmus\Qrfpr
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (9)
Rnor\Ffar4
1 of 13
Yes
Yes
Rnor\Galr1
1 of 13
Yes
No
Rnor\Galr3
1 of 13
Yes
No
Rnor\Kiss1r
1 of 13
Yes
No
Rnor\LOC103690156
1 of 13
Yes
No
Rnor\Prokr1
1 of 13
Yes
Yes
Rnor\Prokr2
1 of 13
Yes
Yes
Rnor\Qrfpr
1 of 13
Yes
Yes
Rnor\RGD1560028
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\ffar4
1 of 12
Yes
Yes
Xtro\galr1
1 of 12
Yes
No
Xtro\galr2
1 of 12
Yes
No
Xtro\galr3
1 of 12
Yes
No
Xtro\kiss1r
1 of 12
Yes
No
Xtro\kissr1b
1 of 12
Yes
No
Xtro\kissr2
1 of 12
Yes
No
Xtro\LOC100125055
1 of 12
Yes
No
Xtro\prokr1
1 of 12
Yes
Yes
Xtro\prokr2
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (12)
Drer\galr1a
1 of 15
Yes
No
Drer\galr1b
1 of 15
Yes
No
Drer\galr2b
1 of 15
Yes
No
Drer\kiss1ra
1 of 15
Yes
No
Drer\kiss1rb
1 of 15
Yes
No
Drer\LOC101884647
1 of 15
Yes
Yes
Drer\LOC110438944
1 of 15
Yes
No
Drer\npffr2a
1 of 15
Yes
No
Drer\prokr1a
1 of 15
Yes
Yes
Drer\prokr1b
1 of 15
Yes
Yes
Drer\qrfpra
1 of 15
Yes
Yes
Drer\zmp:0000001069
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\npr-20
7 of 15
Yes
Yes
Cele\npr-21
6 of 15
No
Yes
Cele\npr-3
1 of 15
No
No
Cele\npr-9
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907C2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001305
Drosophila simulans
Dsim\GD23366
Drosophila sechellia
Dsec\GM18576
Drosophila erecta
Dere\GG25100
Drosophila yakuba
Dyak\GE25690
Drosophila ananassae
Dana\GF15585
Drosophila pseudoobscura pseudoobscura
Dpse\GA16362
Drosophila persimilis
Dper\GL19038
Drosophila willistoni
Dwil\GK14702
Drosophila virilis
Dvir\GJ12041
Drosophila mojavensis
Dmoj\GI13390
Drosophila grimshawi
Dgri\GH10928
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503CS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17027083
Musca domestica
House fly
Mdoa\17008915
Glossina morsitans
Tsetse fly
Gmor\GMOY010450
Mayetiola destructor
Hessian fly
Mdes\Mdes006938
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRNPR2
Anopheles darlingi
American malaria mosquito
Adar\ADAC005761
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001963
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001962
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05WP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\Bmo.12540
Danaus plexippus
Monarch butterfly
Dple\DPOGS215822-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011637
Heliconius melpomene
Postman butterfly
Hmel\HMEL011636
Apis florea
Little honeybee
Aflo\2147602451
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15437
Bombus terrestris
Buff-tailed bumblebee
Bter\15209321
Linepithema humile
Argentine ant
Lhum\LH11316
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000957
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05821
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05820
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02059
Tribolium castaneum
Red flour beetle
Tcas\TC014731
Pediculus humanus
Human body louse
Phum\PHUM618870
Pediculus humanus
Human body louse
Phum\PHUM447490
Pediculus humanus
Human body louse
Phum\PHUM278660
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17704
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05SE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW009718
Ixodes scapularis
Black-legged tick
Isca\ISCW006418
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g03320
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08VN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-QrfprL_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1132
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
SIFaR
2 of 10
AkhR
1 of 10
AstA-R1
1 of 10
AstA-R2
1 of 10
AstC-R1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    TrissinR - Trissin
    ion exchange chromatography, molecular sieving, Identification by mass spectrometry, inferred by author
    (Ida et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-17
    Cytogenetic map
    25F5-26A1
    Sequence location
    2L:5,824,004..5,856,767 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    25F5-26A1
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-17

    (FlyBase, 2016)

    2-19.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (9)
    Genomic Clones (29)
    cDNA Clones (122)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: TrissinR CG34381

    (Ida et al., 2011)
    Source for database merge of

    Source for merge of: CG14004 CG31645

    (FlyBase Genome Annotators, 2007)

    Source for merge of: CG31645 anon-WO0170980.172 anon-WO0170980.173

    (FlyBase, 1996-)

    Source for merge of: CG14002 CG14003

    (FlyBase Genome Annotators, 2002-2003)
    Additional comments

    Annotations CG14004 and CG31645 merged as CG34381 in release 5.2 of the genome annotation.

    (FlyBase Genome Annotators, 2007)

    Annotations CG14002 and CG14003 merged as CG31645 in release 3 of the genome annotation.

    (FlyBase Genome Annotators, 2002-2003)

    Source for merge of CG31645 anon-WO0170980.172 anon-WO0170980.173 was sequence comparison ( date:051113 ).

    (FlyBase, 1996-)
    Other Comments
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 37 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (10)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (47)