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General Information
Symbol
Dmel\nub
Species
D. melanogaster
Name
nubbin
Annotation Symbol
CG34395
Feature Type
FlyBase ID
FBgn0085424
Gene Model Status
Stock Availability
Gene Snapshot
nubbin (nub) encodes a POU/homeodomain transcription factor that is expressed in the nascent wing primordium and is required for wing formation. [Date last reviewed: 2019-03-14]
Also Known As
pdm-1, Pdm1, Pdm, POU domain protein 1, dPOU-19
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:12,587,625..12,628,135 [+]
Recombination map
2-47
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the POU transcription factor family. Class-2 subfamily. (P31368)
Summaries
Gene Group (FlyBase)
POU HOMEOBOX TRANSCRIPTION FACTORS -
POU homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by a POU-specific domain N-terminal to a homeodomain. POU proteins can bind as homodimers or heterodimers to DNA. (Adapted from FBrf0232555 and PMID:18797923).
Protein Function (UniProtKB)
DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins.
(UniProt, P31368)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
nub: nubbin
Wings very small, opaque, curved spoonlike up or down; inflated at eclosion. Wing margins interrupted. Only one vein (L2 or L3) present. Halteres somewhat reduced. Viability excellent. RK1.
nub2
Wings small and spoonlike but less extreme than nub. Patches of dried blood on wings. Veins L1 to L4 almost indiscernible; L5 and alula frequently absent. Viability and fertility excellent. RK1.
nub62d
Wings very small and spoonlike. RK1.
Summary (Interactive Fly)
transcription factor - homeodomain and pou domain - involved in cell fate determination of a subset of temporally determined neural subtypes - morphology ofsensory neurons is diversified through a series of suppressive transcriptional interactions involving Nubbin and Pdm2, Cut and transcription factors Scalloped and Vestigial - Nubbin and Teashirt mark barriers to clonal growth along the proximal-distal axis of the wing
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\nub or the JBrowse view of Dmel\nub for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.51
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0112642
4497
961
FBtr0112643
3267
601
FBtr0342628
2829
601
Additional Transcript Data and Comments
Reported size (kB)
3.3, 2.9, 2.8 (northern blot)
3.1 (northern blot)
4.9, 3.1, 2.6 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0111554
103.9
961
6.71
FBpp0111555
65.2
601
9.35
FBpp0309559
65.2
601
9.35
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

601 aa isoforms: nub-PD, nub-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
nub protein was shown to be a weak octamer-dependent activator of transcription when expressed in yeast and is thought to require additional coactivators to function efficiently.
The pdm2 and nub proteins are most closely related to the human OCT1 and OCT2 proteins and most resemble class II POU proteins.
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nub using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (10 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states >=6 hr AEL

in situ
Stage
Tissue/Position (including subcellular localization)
Reference
antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-6 hr AEL

Comment: reference states 0-12 hr AEL

Additional Descriptive Data
Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.
expressed first in SOP of this lineage expression subsequently decreases in presumptive glial cell, is re-established once gcm expression has been established, and then disappears by stage 16
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
wing pouch

Comment: area that corresponds to distal region of wing

mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Antibody used is specific to the nub-PB and nub-PD epitopes.
Early in third instar, nub is expressed in a broad region from the pretarsus through the presumptive tarsal segments, up to the distal part of the dac domain in presumptive tarsal segment 2. By late third instar, nub expression disappears from the intersegmental region of true segments and the pretarsal region, remaining only in the joint-forming cells.
Between 4 and 12 hr APF, nub expression is proximally adjacent to Ecol\lacZodd-rK111, which labels the proximal parts of all leg joints except those between tarsal subsegments.
nub protein is localized to proximal half of the true leg segments of leg discs; localization is proximal to that of bowl and TfAP-2.
tsh protein is expressed in the wing pouch and distal wing hinge, but not in the presumptive notum. Expression is mutually exclusive with that of tsh.
Expression first seen in the wing disc during middle to late second instar in an area that corresponds to the distal region of the wing. The nub domain is a bit broader than the rn domain.
Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages.
Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d1-6, v1, v5; deuterocerebrum - d1-8, v2-8; protocerebrum - ad1, ad2, ad4-9, ad12, ad15, ad17, av1, cd1-6, cd8-14, cd17, cd20, cd21, cv1, cv3-9, pd2, pd4, pd5, pd8, pd9, pd12, pd16, pv1-3
Protein is detected in ring pattern in proximal joint of third instar larval leg discs. At 34-38 hours after pupal formation protein is expressed in the tibial and not the tarsal leg joints in the proximal joint tissue and a subset of bristle lineage.
nub protein is expressed in the wing pouch region of the third instar wing disc.
nub is expressed in the lateral, but not the medial, of the paired ventro-lateral serotonergic neurons.
nub is expressed in early stages of the developing CNS in a highly dynamic pattern that includes roughly half of the neuroblasts and several ganglion mother cells. Here, nub and pdm2 are shown to be coexpressed in GMC4-2a but not in its progenitor neuroblast or its mature progeny.
Marker for
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\nub in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of nub
Transgenic constructs containing regulatory region of nub
Deletions and Duplications ( 10 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
7 of 15
No
Yes
5 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
7 of 15
No
Yes
5 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
6 of 13
Yes
Yes
5 of 13
No
No
3 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
2 of 12
Yes
Yes
2 of 12
Yes
No
2 of 12
Yes
No
2 of 12
Yes
Yes
2 of 12
Yes
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (12)
8 of 15
Yes
Yes
5 of 15
No
Yes
5 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
4 of 15
Yes
No
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919050K )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915022K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DUP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DT0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0U0S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
4 of 10
4 of 10
3 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-47
    Cytogenetic map
    Sequence location
    2L:12,587,625..12,628,135 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    33F1-33F1
    Limits computationally determined from genome sequence between P{lacW}bunk00612&P{EP}EP682EP682 and P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    33F-33F
    (determined by in situ hybridisation)
    33F1-33F2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (40)
    Genomic Clones (36)
    cDNA Clones (46)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: nub CG6246
    Source for database merge of
    Source for merge of: nub CG15488 CG15489
    Additional comments
    Annotations CG6246, CG15489 and CG15488 merged as CG34395 in release 5.2 of the genome annotation.
    Other Comments
    nub/pdm2 and cas regulate late-born motor neuron identity within the NB7-1 lineage; nub/pdm2 specifies fourth-born U4 motor neuron identity, while nub/pdm2/cas together specify fifth-born U5 motor neuron identity.
    The embryonic CNS contains sequentially generated neuroblast sublineages that can be distinguished by their expression of either hb, nub or cas. hb and cas may directly silence nub expression in early and late developing sublineages, given that nub cis-regulatory DNA contains approximately 32 hb/cas-binding sites and its enhancer(s) are ectopically activated in cas- neuroblasts. Targeted misexpression of cas in all neuronal lineages reduces nub expression without altering hb expression. By ensuring correct POU gene expression boundaries hb and cas maintain temporal subdivisions in the cell-identity circuitry controlling CNS development.
    The POU domain protein encoded by nub contributes to the formation of a sharp dorsoventral boundary in the wing.
    The expression patterns of crustacean homologues of nub and ap support the hypothesis that insect wings evolved from gill-like appendages that were present in the aquatic ancestors of both crustaceans and insects.
    nub gene is important for correct proximal-distal specification of the growing wing imaginal disc.
    Incorrect specification of the proximal-distal axis of the growing wing imaginal disc due to mutations in nub leads to failures in growth along both the D-V and A-P axis.
    Isolated from a Drosophila 10-22 hour embryo cDNA expression library, using a 22bp sequence from the Cha upstream regulatory region as a probe. This 22bp sequence has been shown to be bound by specific binding factor(s) in embryo nuclear extracts.
    nub mutants do not interact genetically with mutations in ap, Bx, ct, sens, N, sd, Ser, wg, vg, wg. The mutant wing phenotype is distinct from those of ap, vg, sd and fu.
    nub is required for the normal growth and patterning of the wing. Mosaic analysis reveals a localized requirement for nub activity in the wing hinge.
    Within the hierarchy of genes expressed in GMC4-2a nub and pdm2 lie downstream of pros and ftz and upstream of eve.
    nub and pdm2 both contribute toward the development of a full complement of mature RP2 neurons by being expressed in and acting on ganglion mother cell 2a (GMC-2a), the RP2 progenitor cell. nub plays a quantitatively less important role than pdm2. nub and pdm2 act to specify GMC-2a cell identity and not merely act to positively regulate GMC-2a cell division.
    Proper spatial regulation of nub involves the interaction between the mesoderm and the endoderm, but uses a different genetic cascade than that regulating lab : dpp is not the signal that dictates central nub repression across germ layers.
    One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus en binding site.
    nub is transcribed in elements of the developing nervous system suggesting a functional role in neurogenesis and neurospecification.
    nub contains a POU domain, and is expressed at maximum levels during early development.
    Origin and Etymology
    Discoverer
    Mickey, 10th May 1948.
    Etymology
    Identification
    External Crossreferences and Linkouts ( 56 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (31)
    Reported As
    Symbol Synonym
    twn
    Secondary FlyBase IDs
    • FBgn0032438
    • FBan0015488
    • FBgn0002970
    • FBan0006246
    • FBgn0032440
    • FBgn0004393
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (378)