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Gene Dmel\nub

General Information
Symbol	Dmel\nub	Species	D. melanogaster
Name	nubbin	Annotation symbol	CG34395
Feature type	protein_coding_gene	FlyBase ID	FBgn0085424
Gene Model Status	Current	Stock availability	34 publicly available
Also Known As	pdm-1, pdm1, Pdm, nb, CG15489, dPOU-19, Oct-1, CG6246, CG15488, dPOU19
Genomic Location
Chromosome (arm)	2L	Recombination map	2-47.0
Cytogenetic map	33F1-33F1	Sequence location	2L:12,587,871..12,628,143 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene nubbin is referred to in FlyBase by the symbol Dmel\nub (CG34395, FBgn0085424). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. There is experimental evidence that it is involved in the biological process: wing disc development. 25 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; adult antennal lobe; thoracic segment; embryonic/larval neuron; antennal olfactory receptor neuron; peripheral nervous system; organ system; integumentary specialisation; adult uniglomerular antennal lobe projection neuron adPN. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related; Lambda repressor-like, DNA-binding; POU; POU-specific. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult hindgut. Gene sequence location is 2L:12587871..12628143.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	nub: nubbin Wings very small, opaque, curved spoonlike up or down; inflated at eclosion. Wing margins interrupted. Only one vein (L2 or L3) present. Halteres somewhat reduced. Viability excellent. RK1. nub2 Wings small and spoonlike but less extreme than nub. Patches of dried blood on wings. Veins L1 to L4 almost indiscernible; L5 and alula frequently absent. Viability and fertility excellent. RK1. nub62d Wings very small and spoonlike. RK1.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Grad et al., 2004, Bioinformatics 20(16): 2738--2750 Nakajima et al., 2010, PLoS Comput. Biol. 6(4): e1000760
FB2012_01	References Kazemian et al., 2010, PLoS Biol. 8(8): Mace et al., 2010, Bioinformatics 26(6): 761--769 Sequence features BKN24744 HFA02498 BKN33120 BKN21810 HFA02499 HFA01260 HFA03583 Controlled Vocabulary Terms RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33F1-33F1   Limits computationally determined from genome sequence between P{lacW}bunk00612&P{EP}EP682EP682 and P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639
Experimentally Determined Cytological Location
Cytogenetic map Notes References 33F-33F   (determined by in situ hybridisation)   (Dick et al., 1991) 33F1-33F2   (determined by in situ hybridisation)   (Lloyd and Sakonju, 1991) 33F-33F   (determined by in situ hybridisation)   (Billin et al., 1991)
Experimentally Determined Recombination Data
Location	2-47 (Seiger, 1963) 2-47.0
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\nub for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) nub-RB FBtr0112642  NM_001103683   4259   961 nub-RD FBtr0112643  NM_057311   3264   601
Additional Transcript Data & Comments
Reported size (kB)	4.9, 3.1, 2.6 (northern blot) (Lloyd and Sakonju, 1991) 3.3, 2.9, 2.8 (northern blot) (Billin et al., 1991) 3.1 (northern blot) (Dick et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein nub-PB   FBpp0111554   103.9   961   6.71     NP_001097153   ABV53675 nub-PD   FBpp0111555   65.2   601   9.35     NP_476659   AAF53205
Additional Polypeptide Data & Comments
Reported size (kDa)	601 (aa); 65 (kD) (Lloyd and Sakonju, 1991, Billin et al., 1991, Dick et al., 1991)
Comments	nub protein was shown to be a weak octamer-dependent activator of transcription when expressed in yeast and is thought to require additional coactivators to function efficiently. (Prakash et al., 1992) The pdm2 and nub proteins are most closely related to the human OCT1 and OCT2 proteins and most resemble class II POU proteins. (Dick et al., 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) POU-specific (IPR000327) Homeobox (IPR001356) Homeodomain-like (IPR009057) Lambda repressor-like, DNA-binding (IPR010982) Homeodomain-related (IPR012287) POU (IPR013847)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53205   AE014134 ABV53675   AC005418   AC006470   AC093439   AF035264   AY118387 AAM48416   BI167254   BI238365   BI358473   BI362196   BI362500   BI365637   BI367843   BI579317   CO176890   CO187644   CO188977   CO261853   CO263411   CO263738   CO265889   CO269254   CO272343   CO276072   CO281774   CO283191   CO290869   CO298183   CO315863   CO316937   CO323937   CO332672   CO334013   DN154345   EC058952   EC059298   EC059393   EC064669   EC067999   EC072952   EC082170   EC082279   EC082594   EC084340   EC086206   EC205443   EC206042   EC211151   EC217962   EC220339   EC227655   EC228809   EC229680   EC234276   EC235898   EC238533   EC249749   EV596365   GH759954   GH774105   GH801429   GH862087   GH868536   GH875242   GH875733   M65015 AAA28480   M81957 AAA28829   S80561 AAB21409
UniProtKB/Swiss-Prot	P31368
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ectoderm | striped   (Dick et al., 1991) embryonic/larval hypopharynx   (Dick et al., 1991) embryonic/larval labral segment sense organ   (Dick et al., 1991) optic lobe   (Dick et al., 1991) central nervous system | restricted   (Dick et al., 1991) labral segment   (Dick et al., 1991) embryonic stage | late   dorsal thoracic bd1   (Lloyd and Sakonju, 1991) abdominal neuroblast of abdominal segment 1 -- abdominal segment 7   (Lloyd and Sakonju, 1991) chordotonal organ of lateral thoracic cluster of prothoracic segment   (Lloyd and Sakonju, 1991) abdominal 1 dorsal bipolar neuron dbp -- abdominal 7 dorsal bipolar neuron dbp   (Lloyd and Sakonju, 1991) central nervous system | restricted   (Lloyd and Sakonju, 1991) hypophysis   (Lloyd and Sakonju, 1991) embryonic stage 5   parasegment 11   (Lloyd and Sakonju, 1991) embryonic stage 9   organism | segment polarity expression pattern   (Lloyd and Sakonju, 1991) embryonic stage 11 -- 17     (Lloyd and Sakonju, 1991) Comment:reference states >=6 hr AEL embryonic stage 12   abdominal dorsal bipolar neuron dbp   (Umesono et al., 2002) multidendritic sensory organ precursor cell   (Umesono et al., 2002) embryonic stage 16   abdominal dorsal bipolar neuron dbp   (Umesono et al., 2002) second instar larval stage     (Lloyd and Sakonju, 1991) pupal stage     (Lloyd and Sakonju, 1991) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   embryonic/larval labral segment sense organ | precursor   (Lloyd and Sakonju, 1991) abdominal dorsal multidendritic neuron   (Lloyd and Sakonju, 1991) scolopidial ligament cell of dorsal thoracic cluster of metathoracic segment & scolopidial ligament cell of dorsal thoracic cluster of mesothoracic segment   (Lloyd and Sakonju, 1991) presumptive embryonic/larval peripheral nervous system | restricted   (Lloyd and Sakonju, 1991) scolopidial ligament cell of lateral abdominal cluster of abdominal segment 1 -- abdominal segment 7   (Lloyd and Sakonju, 1991) embryonic stage   embryonic brain   (Dick et al., 1991) presumptive embryonic/larval peripheral nervous system | restricted   (Dick et al., 1991) embryonic/larval pharynx   (Dick et al., 1991) hypophysis   (Dick et al., 1991) neurogenic region   (Dick et al., 1991) embryonic stage 5   parasegment 7   (Lloyd and Sakonju, 1991) organism | 30-50% egg length   (Dick et al., 1991, Berman et al., 2004) embryonic stage 6   organism | odd pair rule expression pattern   (Lloyd and Sakonju, 1991) larval stage   ventral thoracic disc   (Ng et al., 1995) wing disc   (Ng et al., 1995) haltere disc   (Ng et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid -- embryonic stage | late     (Billin et al., 1991) embryonic stage 1 -- 11     (Billin et al., 1991) Comment:reference states 0-6 hr AEL embryonic stage 1 -- 15     (Lloyd and Sakonju, 1991) Comment:reference states 0-12 hr AEL larval stage & pupal stage     (Billin et al., 1991) larval stage -- adult stage     (Lloyd and Sakonju, 1991) third instar larval stage     (Lloyd and Sakonju, 1991)
Additional Descriptive Data
	expressed first in SOP of this lineage expression subsequently decreases in presumptive glial cell, is re-established once gcm expression has been established, and then disappears by stage 16 (Umesono et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 11   tritocerebral neuroblast | subset   (Urbach and Technau, 2003) procephalic neurogenic region | restricted   (Urbach and Technau, 2003) protocerebral neuroblast | subset   (Urbach and Technau, 2003) deuterocerebral neuroblast | subset   (Urbach and Technau, 2003) embryonic stage 11   ganglion mother cell GMC4-2a   (Yeo et al., 1995) embryonic stage 16   abdominal dorsal multidendritic neuron ddaE | subset   • nucleus (Brewster et al., 2001) Comment:reference states dda1 abdominal dorsal bipolar neuron dbp   • nucleus (Brewster et al., 2001) Comment:reference states dbd scolopidial ligament cell of abdominal lateral pentascolopidial chordotonal organ lch5   • nucleus (Brewster et al., 2001) embryonic stage 17   EW2 neuron   (Lundell et al., 2003, Lundell and Hirsh, 1998) third instar larval stage   ventral thoracic disc | proximal   (Mirth and Akam, 2002) wing disc   (Wu and Cohen, 2002) ventro-lateral serotonergic neuron | subset   (Lundell and Hirsh, 1998) dopaminergic neuron | subset   (Lundell and Hirsh, 1998) pupal stage   leg & joint | proximal & subset   (Mirth and Akam, 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	nub is expressed in early stages of the developing CNS in a highly dynamic pattern that includes roughly half of the neuroblasts and several ganglion mother cells. Here, nub and pdm2 are shown to be coexpressed in GMC4-2a but not in its progenitor neuroblast or its mature progeny. (Yeo et al., 1995) Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages. (Lundell et al., 2003) Protein is detected in ring pattern in proximal joint of third instar larval leg discs. At 34-38 hours after pupal formation protein is expressed in the tibial and not the tarsal leg joints in the proximal joint tissue and a subset of bristle lineage. (Mirth and Akam, 2002) Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d1-6, v1, v5; deuterocerebrum - d1-8, v2-8; protocerebrum - ad1, ad2, ad4-9, ad12, ad15, ad17, av1, cd1-6, cd8-14, cd17, cd20, cd21, cv1, cv3-9, pd2, pd4, pd5, pd8, pd9, pd12, pd16, pv1-3 (Urbach and Technau, 2003) nub protein is expressed in the wing pouch region of the third instar wing disc. (Wu and Cohen, 2002) nub is expressed in the lateral, but not the medial, of the paired ventro-lateral serotonergic neurons. (Lundell and Hirsh, 1998)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0085424    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0085424 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0085424 expression level Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr    2302 embryo 06-08hr    2130 embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr  (1193) embryo 04-06hr  (2302) embryo 06-08hr  (2130) embryo 08-10hr  (1192) embryo 10-12hr  (1239) embryo 12-14hr  (827) embryo 14-16hr  (846) embryo 16-18hr  (703) embryo 18-20hr  (803) embryo 20-22hr  (433) embryo 22-24hr  (445) larva L1  (366) larva L2  (211) larva L3 12hr old  (109) larva L3 puffstage 1-2  (209) larva L3 puffstage 3-6  (375) larva L3 puffstage 7-9  (501) white prepupae new  (484) white prepupae 12hr  (499) white prepupae 24hr  (592) pupae 2d postWPP  (352) pupae 3d postWPP  (200) pupae 4d postWPP  (207) adult male 01day  (186) adult male 05day  (243) adult male 30day  (232) adult female 01day  (217) adult female 05day  (112) adult female 30day  (132) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr  (2302) embryo 06-08hr  (2130) embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr    2302 embryo 06-08hr    2130 embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr    2302 embryo 06-08hr    2130 embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0085424 expression level Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr    2302 embryo 06-08hr    2130 embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr  (1193) embryo 04-06hr  (2302) embryo 06-08hr  (2130) embryo 08-10hr  (1192) embryo 10-12hr  (1239) embryo 12-14hr  (827) embryo 14-16hr  (846) embryo 16-18hr  (703) embryo 18-20hr  (803) embryo 20-22hr  (433) embryo 22-24hr  (445) larva L1  (366) larva L2  (211) larva L3 12hr old  109 larva L3 puffstage 1-2  (209) larva L3 puffstage 3-6  (375) larva L3 puffstage 7-9  (501) white prepupae new  (484) white prepupae 12hr  (499) white prepupae 24hr  (592) pupae 2d postWPP  (352) pupae 3d postWPP  (200) pupae 4d postWPP  (207) adult male 01day  (186) adult male 05day  (243) adult male 30day  (232) adult female 01day  (217) adult female 05day  112 adult female 30day  132 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr  2302 embryo 06-08hr  2130 embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr    2302 embryo 06-08hr    2130 embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    1193 embryo 04-06hr    2302 embryo 06-08hr    2130 embryo 08-10hr    1192 embryo 10-12hr    1239 embryo 12-14hr    827 embryo 14-16hr    846 embryo 16-18hr    703 embryo 18-20hr    803 embryo 20-22hr    433 embryo 22-24hr    445 larva L1    366 larva L2    211 larva L3 12hr old    109 larva L3 puffstage 1-2    209 larva L3 puffstage 3-6    375 larva L3 puffstage 7-9    501 white prepupae new    484 white prepupae 12hr    499 white prepupae 24hr    592 pupae 2d postWPP    352 pupae 3d postWPP    200 pupae 4d postWPP    207 adult male 01day    186 adult male 05day    243 adult male 30day    232 adult female 01day    217 adult female 05day    112 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0085424    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0085424 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085424 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15489-RA;CG15488-RA;CG6246-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for nub Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal nubR5 lethal | pupal stage, with Scer\GAL4pnr-MD237 nubGD9039 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 nubGD9038 viable nub1 nub2 nub62d viable, with Scer\GAL4pnr-MD237 nubGD1498 Sterility Allele fertile nub62d Other Phenotypes Allele neuroanatomy defective nub2 size defective | adult stage A1 nub1 visible nub1 nub2 nub62d visible, with Scer\GAL4pnr-MD237 nubGD1498 visible | adult stage A1 nub1 visible | dominant nubPrl Phenotype manifest in Allele adult antennal lobe projection neuron DC3 adPN nub2 adult antennal lobe projection neuron VA2 adPN nub2 adult antennal lobe projection neuron VM2 adPN nub2 adult olfactory receptor neuron nub2 adult olfactory receptor neuron Or42a nub2 adult olfactory receptor neuron Or43b nub2 adult olfactory receptor neuron Or83c nub2 adult olfactory receptor neuron Or85a nub2 adult olfactory receptor neuron Or92a nub2 antennal lobe glomerulus DA4 medial compartment nub2 antennal lobe glomerulus DC3 nub2 antennal lobe glomerulus DL2 nub2 antennal lobe glomerulus DM5 nub2 antennal lobe glomerulus DM6 nub2 antennal lobe glomerulus DP1 lateral compartment nub2 antennal lobe glomerulus VA1 nub2 antennal lobe glomerulus VA1 ventral compartment nub2 antennal lobe glomerulus VA2 nub2 antennal lobe glomerulus VA7 lateral compartment nub2 antennal lobe glomerulus VA7 medial compartment nub2 antennal lobe glomerulus VL2 anterior compartment nub2 antennal lobe glomerulus VL2 posterior compartment nub2 antennal lobe glomerulus VM5 nub2 antennal lobe glomerulus VM5 ventral compartment nub2 antennal lobe glomerulus VM7 nub2 anterior notal wing process nubPrl nub2 nub1 cephalopharyngeal skeleton nubhs.PC chaeta | supernumerary, with Scer\GAL4pnr-MD237 nubGD1498 crossvein nub2 nub1 dorsal triple row nub2 nub1 ganglion mother cell | ectopic, with Scer\GAL4ftz.ng nubScer\UAS.cNa ganglion mother cell GMC4-2a nubE37 haltere nub2 nub1 larval abdominal segment 1 nubhs.PC larval abdominal segment 2 nubhs.PC larval head nubhs.PC larval mesothoracic segment nubhs.PC larval metathoracic segment nubhs.PC leg nub1 medial triple row nub2 nub1 neuroblast NB4-2 | ectopic, with Scer\GAL4ftz.ng nubScer\UAS.cNa olfactory receptor neuron nub2 pleural wing process nubPrl nub2 nub1 posterior notal wing process nubPrl nub2 nub1 RP1 neuron nubhs.P RP2 neuron nubhs.P nubE37 RP2 neuron | ectopic, with Scer\GAL4ftz.ng nubScer\UAS.cNa RP3 neuron nubhs.P RP4 neuron nubhs.P sensory mother cell | ectopic nub1 ventral triple row nub2 nub1 wing nubPrl nub62d nub2 nub1 wing disc nub2 nub1 wing hinge nub2 wing margin bristle nub1 wing margin bristle | ectopic nub1 wing margin bristle | ectopic | somatic clone nub1 wing vein L2 nub1 wing vein L4 nub2 nub1 wing vein L5 nub1
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of nub Class Mutagen Stocks Known lesion nub1 hypomorphic allele - genetic evidence spontaneous 14 Yes nub2 hypomorphic allele - genetic evidence X ray 6 Yes nubKG07049 2 -- nubPrl loss of function allele 2 Yes nubE37 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes nub62d X ray 0 -- nubA6 0 -- nubHX1 hypomorphic allele - genetic evidence X ray 0 -- nubHX2 X ray 0 -- nubPrd 0 -- nubR5 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of nub Class Mutagen Stocks Known lesion nubGD1498 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes nubGD9038 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes nubGD9039 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nubJF02973 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nubKK101759 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nubKK105608 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nubKK113120 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nub18cos402 in vitro construct - genomic fragment 0 -- nubdsRNA.CG15488.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes nubdsRNA.CG15489.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes nubhs.P in vitro construct - regulatory fusion 0 Yes nubhs.PC in vitro construct - regulatory fusion 0 Yes nubhs.PY in vitro construct - regulatory fusion 0 Yes nubScer\UAS.cNa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6033 (Ryder, 2004.4.26) Df(2L)GR4 (Yeo et al., 1995, Brewster et al., 2001) Df(2L)kek13K2X (Musacchio and Perrimon, 1996) Df(2L)kek1RA5 (Musacchio and Perrimon, 1996) Df(2L)pdm1-HX5 (Ng et al., 1995) Df(2L)prd1.7 (Yeo et al., 1995, Ng et al., 1995, Bhat and Schedl, 1994) Df(2L)Prl (Cifuentes and Garcia-Bellido, 1997, Musacchio and Perrimon, 1996, Yeo et al., 1995, Bhat and Schedl, 1994)
Not disrupted in	Df(2L)BSC30 (Deal and Cook, 2003.4.29) Df(2L)pdm2GR19 (Yeo et al., 1995)
Duplicated in	Dp(2;2)GYL (Bhat and Schedl, 1994)
Partially disrupted in	Df(2L)Prl (Yamamoto et al., 2009.2.25)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1498} NA P{GD9038} NA P{GD9039} NA P{KK101759} NA P{KK105608} NA P{KK113120} NA P{TRiP.JF02973} NA P{UAS-nub.N} NA heat-shock construct P{hsp70:pdm1} NA P{HSpdm-1} NA P{hs-pdm-1} NA reporter construct P{nub-lacZ.-2} No characterization construct P{18cos402} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions 412{}nub1 NA P{SUPor-P}nubKG07049 NA insertion of enhancer trap binary system P{GawB}nubbin-AC-62 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Junell et al., 2007)
Biological Process
CV term Evidence References
wing disc development inferred from genetic interaction with Bx (Bronstein et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR017970 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Biological Process
CV term Evidence References
ganglion mother cell fate determination traceable author statement (Skeath and Thor, 2003) neuroblast fate determination non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) pattern specification process non-traceable author statement (Tyler and Baker, 2003) regulation of transcription from RNA polymerase II promoter inferred from sequence or structural similarity with NCBI_gi:4505957 (FlyBase, 1992-) ventral cord development non-traceable author statement (Skeath and Thor, 2003)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with NCBI_gi:4505957 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions nub allele Gene References nub1 dpp (Cifuentes and Garcia-Bellido, 1997) elA (Cifuentes and Garcia-Bellido, 1997) wg (Neumann and Cohen, 1998) nub2 dpp (Cifuentes and Garcia-Bellido, 1997) elA (Cifuentes and Garcia-Bellido, 1997) unspecified D (Nambu et al., 1997) en (Cifuentes and Garcia-Bellido, 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60715 DroID - A comprehensive database of gene and protein interactions. • FBgn0085424 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34669
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA13766   Dpse\GA13767   Dpse\GA19468
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001944692.1 Acyrthosiphon pisum (pea aphid) 117908 Branchiostoma floridae (lancelet) XP_001902346.1 Brugia malayi (roundworm nematode) CE28045 Caenorhabditis elegans (worm) ENSGALP00000036653 Gallus gallus (chicken) 188329 Hypsipyla robusta (cedar shoot borer) 95198 Lottia gigantea (owl limpet) XP_001602856.1 Nasonia vitripennis (wasp) ENSORLP00000015919 Oryzias latipes (japanese killifish) PHUM010655-PA Pediculus humanus (human body louse) ENSRNOP00000042100 Rattus norvegicus (norway rat) Smp_149570 Schistosoma mansoni (trematode parasite) ENSTRUP00000022524 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19068 NV11360 LH15637 FBgn0236001 FBgn0217510 FBgn0203458 FBgn0195214 FBgn0181720 JGI_V11_7063 FBgn0079464 FBgn0156952 FBgn0137238 FBgn0117595 FBgn0115930 FBgn0091227 CPIJ002445 ACYPI005847 GB16262 AGAP009500 AAEL017445 PHUM348630 GLEAN_07645 GLEAN_07646
Stocks & Reagents
Stocks Listed in FlyBase ( 34 )
Bloomington	358 w1118; nub2 8856 nubE37/CyO, P{ftz/lacB}E3 357 nub1 b1 pr1
Kyoto	105872 nub2
VDRC	v101275 P{KK105608}VIE-260B v105044 P{KK113120}VIE-260B v107814 P{KK101759}VIE-260B v43678 w1118 P{GD9038}v43678 v6217 w1118; P{GD1498}v6217 v19507 w1118; P{GD9039}v19507 v43679 w1118; P{GD9038}v43679 v6218 w1118; P{GD1498}v6218/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR28A12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE34782
Other clones	DPiM_RE34782
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE07592 RE45248 RE46701 RE47072 RE51007 RE53691 RE73333
Other clones	33399 34287 51438 65314 76260 99017 159858 181447 282973 283088 CK01.8D.H1 CK01.16B.C10 CK01.48D.A12 CK01.97B.A2 CK01.105D.D6 CK01.107B.D10 CK01.123C.G10 Dmel_neb_015358_0946_1233 EK031030 EK042634 EK051464 EK075425 EK080647 EK088447 EK089447 EK093959 EK106809 EK119619 EK144361 EK158756 EK162453 EK171662 EK192010 EK221559 EK262860 EK266330 EK304209 EK308615 RP003129834 RP003161617 RP003240850 RP003331267 RP003336063 RP003337137 RP003648856
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0085424 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34666 34668 34669
Antibody Information
	polyclonal (Yeo et al., 1995, Averof and Cohen, 1997, Terriente et al., 2008, Lee et al., 2010)
Other Information
Discoverer
	Mickey, 10th May 1948.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: nub CG6246 (Zhong, 1999.11)
Source for database merge of	Source for merge of: nub CG15488 CG15489 (Jacobsen et al., 2006, FlyBase Genome Annotators, 2007)
Additional comments	Annotations CG6246, CG15489 and CG15488 merged as CG34395 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007)
Other Comments
	nub/pdm2 and cas regulate late-born motor neuron identity within the NB7-1 lineage; nub/pdm2 specifies fourth-born U4 motor neuron identity, while nub/pdm2/cas together specify fifth-born U5 motor neuron identity. (Grosskortenhaus et al., 2006) The embryonic CNS contains sequentially generated neuroblast sublineages that can be distinguished by their expression of either hb, nub or cas. hb and cas may directly silence nub expression in early and late developing sublineages, given that nub cis-regulatory DNA contains approximately 32 hb/cas-binding sites and its enhancer(s) are ectopically activated in cas- neuroblasts. Targeted misexpression of cas in all neuronal lineages reduces nub expression without altering hb expression. By ensuring correct POU gene expression boundaries hb and cas maintain temporal subdivisions in the cell-identity circuitry controlling CNS development. (Kambadur et al., 1998) The POU domain protein encoded by nub contributes to the formation of a sharp dorsoventral boundary in the wing. (Neumann and Cohen, 1998) The expression patterns of crustacean homologues of nub and ap support the hypothesis that insect wings evolved from gill-like appendages that were present in the aquatic ancestors of both crustaceans and insects. (Averof and Cohen, 1997) nub gene is important for correct proximal-distal specification of the growing wing imaginal disc. (Cifuentes and Garcia-Bellido, 1997) Incorrect specification of the proximal-distal axis of the growing wing imaginal disc due to mutations in nub leads to failures in growth along both the D-V and A-P axis. (Cifuentes and Garcia-Bellido, 1997) Isolated from a Drosophila 10-22 hour embryo cDNA expression library, using a 22bp sequence from the Cha upstream regulatory region as a probe. This 22bp sequence has been shown to be bound by specific binding factor(s) in embryo nuclear extracts. (Kitamoto and Salvaterra, 1995) nub mutants do not interact genetically with mutations in ap, Bx, ct, sens, N, sd, Ser, wg, vg, wg. The mutant wing phenotype is distinct from those of ap, vg, sd and fu. (Ng et al., 1995) nub is required for the normal growth and patterning of the wing. Mosaic analysis reveals a localized requirement for nub activity in the wing hinge. (Ng et al., 1995) Within the hierarchy of genes expressed in GMC4-2a nub and pdm2 lie downstream of pros and ftz and upstream of eve. (Yeo et al., 1995) nub and pdm2 both contribute toward the development of a full complement of mature RP2 neurons by being expressed in and acting on ganglion mother cell 2a (GMC-2a), the RP2 progenitor cell. nub plays a quantitatively less important role than pdm2. nub and pdm2 act to specify GMC-2a cell identity and not merely act to positively regulate GMC-2a cell division. (Yeo et al., 1995) Proper spatial regulation of nub involves the interaction between the mesoderm and the endoderm, but uses a different genetic cascade than that regulating lab: dpp is not the signal that dictates central nub repression across germ layers. (Affolter et al., 1993) One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus en binding site. (Kalionis and O'Farrell, 1993) nub is transcribed in elements of the developing nervous system suggesting a functional role in neurogenesis and neurospecification. (Dick et al., 1992) nub contains a POU domain, and is expressed at maximum levels during early development. (Billin et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057311 NM_001103683 RefSeq (Proteins) • NP_476659 NP_001097153 DDBJ / EMBL / GenBank • AAA28480 AAA28829 AAB21409 AAF53205 AAM48416 ABV53675 AC005418 AC006470 AC093439 AF035264 AY118387 BI238365 M65015 M81957 S80561 Entrez Gene - A searchable database of RefSeq genes. • 34669 UniProtKB/Swiss-Prot • P31368
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) POU-specific (IPR000327) Homeobox (IPR001356) Homeodomain-like (IPR009057) Lambda repressor-like, DNA-binding (IPR010982) Homeodomain-related (IPR012287) POU (IPR013847)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60715 DroID - A comprehensive database of gene and protein interactions. • FBgn0085424 DRSC - Results from RNAi screens. • FBgn0085424 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085424 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15489-RA;CG15488-RA;CG6246-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0085424 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34666 34668 34669 InParanoid A subset of ortholog calls from InParanoid. • XP_001944692.1 Acyrthosiphon pisum (pea aphid) 117908 Branchiostoma floridae (lancelet) XP_001902346.1 Brugia malayi (roundworm nematode) CE28045 Caenorhabditis elegans (worm) ENSGALP00000036653 Gallus gallus (chicken) 188329 Hypsipyla robusta (cedar shoot borer) 95198 Lottia gigantea (owl limpet) XP_001602856.1 Nasonia vitripennis (wasp) ENSORLP00000015919 Oryzias latipes (japanese killifish) PHUM010655-PA Pediculus humanus (human body louse) ENSRNOP00000042100 Rattus norvegicus (norway rat) Smp_149570 Schistosoma mansoni (trematode parasite) ENSTRUP00000022524 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/pdm-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34669 modMine - Data generated by the modENCODE project. • FBgn0085424 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19068 NV11360 LH15637 FBgn0236001 FBgn0217510 FBgn0203458 FBgn0195214 FBgn0181720 JGI_V11_7063 FBgn0079464 FBgn0156952 FBgn0137238 FBgn0117595 FBgn0115930 FBgn0091227 CPIJ002445 ACYPI005847 GB16262 AGAP009500 AAEL017445 PHUM348630 GLEAN_07645 GLEAN_07646 REDfly - A database of transcriptional regulatory elements. • FBgn0085424
Synonyms & Secondary IDs ( 28 )
Reported As
Symbol Synonym	CG6246 (Poole, 2000.4.14, Kreiman, 2004, Perkins et al., 2009) CG15488 (FlyBase Genome Annotators, 2007, Jacobsen et al., 2006) CG15489 (FlyBase Genome Annotators, 2007, Jacobsen et al., 2006, Bronstein et al., 2010) CG34395 (FlyBase Genome Annotators, 2007, Keleman et al., 2009.8.5) dOct1 (Prakash et al., 1992) dPOU-19 (Dick et al., 1991, Cabrera, 1992, Goodman and Doe, 1993) dPOU19 (Dick et al., 1992, Yeo et al., 1995) dPOU-19/pdm-1 (Kitamoto and Salvaterra, 1995) nb (Gibert et al., 2002, de Celis, 2003, Endo et al., 2007) Nb (Smith-Bolton et al., 2009) nub (Molnar and de Celis, 2006, Wheeler et al., 2006, Kreiman, 2004, Segal et al., 2008, Hueber et al., 2007, Takacs et al., 2008, Berman et al., 2004, Morrow et al., 2005, Barrio et al., 2007, Ciechanska et al., 2007, Yu and Small, 2008, Zirin and Mann, 2007, Terriente et al., 2008, Dichtel-Danjoy et al., 2009, Yamamoto et al., 2009.2.25, Perea et al., 2009, Fang et al., 2009, Averof and Cohen, 1997, Grad et al., 2004, Losada-Pérez et al., 2010, Wasbrough et al., 2010, Kazemian et al., 2010) Nub (Crickmore and Mann, 2006, Crickmore and Mann, 2006, de Navascués and Modolell, 2007, Ayala and Bach, 2008, Fernández et al., 2011, Nusinow et al., 2008, Rafel and Milán, 2008, Noyes et al., 2008, Benítez et al., 2009, Greenberg and Hatini, 2009, Mace et al., 2010) Oct-1 (Gehring et al., 1994, Malin et al., 2005, Lee et al., 2010) Oct1 (Malin et al., 2005) Pdm (Grosskortenhaus et al., 2006, Kabbarah et al., 1998, Cenci et al., 2003, Zhong, 2003, Skeath and Thor, 2003, Pasquinelli and Ruvkun, 2002, Jones, 2005, Doe, 2006, Beebe et al., 2010) pdm (Jockusch and Nagy, 1997, Bellaiche and Schweisguth, 2001, Livesey and Cepko, 2001, Kanai et al., 2003, Pearson and Doe, 2003, Harris, 2001, Abbott, 2003, Grosskortenhaus et al., 2005, Odenwald, 2005, Tran and Doe, 2007, Tsuji et al., 2008, Nakajima et al., 2010) pdm1 (Grosskortenhaus et al., 2006, Bhat et al., 1995, Doe and Skeath, 1996, Buescher and Chia, 1997, Mehta and Bhat, 2001, Brewster et al., 2001, Glaser, 2001, Berman et al., 2002, Pearson and Doe, 2003, Urbach and Technau, 2003, Urbach and Technau, 2003, Urbach and Technau, 2004, Junell et al., 2007, Tran and Doe, 2008, Gaziova and Bhat, 2009, Grosskortenhaus et al., 2005, Grieder et al., 2009, Bardin et al., 2010, Mace et al., 2010) pdm-1 (Billin et al., 1991, Affolter et al., 1993, Affolter and Gehring, 1993, Cockerill et al., 1993, Kalionis and O'Farrell, 1993, Skaer, 1993, Affolter et al., 1994, Billin and Poole, 1994, Poole, 1995, Yeo et al., 1995, Chu-LaGraff et al., 1995, Kambadur et al., 1995, McDonald et al., 1995, Skeath, 1995, McDonald and Doe, 1996, Odenwald et al., 1996, Odenwald et al., 1997, Ryan and Rosenfeld, 1997, Nambu et al., 1997, Cifuentes and Garcia-Bellido, 1997, Koizumi et al., 1997, Kambadur et al., 1998, Lundell and Hirsh, 1998, Clyne et al., 1999, Hu and Castelli-Gair, 1999, Eisen, 1998, Billin, 1991.12.16, Lloyd, 1992.5.4, Brody and Odenwald, 2002, Brody et al., 2003, Brody et al., 2005, Grieder et al., 2009) Pdm-1 (Buescher et al., 1998, Brody and Odenwald, 1999, Brody and Odnewald, 1999, Brody and Odenwald, 1999, Odenwald et al., 1999, Ma et al., 2000, Brody and Odenwald, 2000, Novotny et al., 2002, Lee et al., 2010) Pdm1 (Cheah et al., 2000, Isshiki et al., 2001, Koizumi et al., 2001, Isshiki et al., 2001, Lundell et al., 2003, Fichelson et al., 2005, Stollewerk, 2005, Cleary and Doe, 2006, Doe et al., 2005, McDonald et al., 2003, Orgogozo and Grueber, 2005, Lee et al., 2009, Mathur et al., 2010, Ren et al., 2010, Bhat et al., 2011) PDM1 (Fichelson and Gho, 2004) PDM-1 (Jiang et al., 2011) POU33F1 (Affolter et al., 1992) twn
Name Synonym	CG15488   CG15489   Nubbin (Greenberg and Hatini, 2007, Crickmore and Mann, 2006, Ayala and Bach, 2008, Zirin and Mann, 2007, Rafel and Milán, 2008, Orgogozo and Grueber, 2005, Lee et al., 2009, Smith-Bolton et al., 2009, Bardin et al., 2010, Neto-Silva et al., 2010, Silver et al., 2007) nubbin (Wheeler et al., 2006, Hueber et al., 2007, Takacs et al., 2008, Berman et al., 2004, Morrow et al., 2005, Yu and Small, 2008, Dichtel-Danjoy et al., 2009, Stagg et al., 2011, Widmann and Dahmann, 2009, Mace et al., 2010) POU domain protein 1 (Brody et al., 2002) twain
Secondary FlyBase IDs
	FBan0006246 FBan0015488 FBgn0002970 FBgn0004393 FBgn0032438 FBgn0032440
References ( 254 )
Generate a list of	All references relating to this gene ( 254 )
List References by type	Research paper  ( 154 ) Supplementary material  ( 7 ) Review  ( 33 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 37 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Conference report  ( 1 ) Poem  ( 1 )
Recent research papers ( 17 )
	Bhat et al., 2011, Dev. Biol. 351(1): 186--198 Neuralized mediates asymmetric division of neural precursors by two distinct and sequential events: promoting asymmetric localization of Numb and enhancing activation of Notch-signaling. [FBrf0214081] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] Bardin et al., 2010, Development 137(5): 705--714 Transcriptional control of stem cell maintenance in the Drosophila intestine. [FBrf0209974] Beebe et al., 2010, Dev. Biol. 338(1): 28--37 JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. [FBrf0209772] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Bronstein et al., 2010, PLoS Genet. 6(8): e1001063 Transcriptional regulation by CHIP/LDB complexes. [FBrf0211594] Kazemian et al., 2010, PLoS Biol. 8(8): Quantitative analysis of the Drosophila segmentation regulatory network using pattern generating potentials. [FBrf0211688] Lee et al., 2010, J. Biol. Chem. 285(12): 9041--9053 Drosophila octamer elements and pdm-1 dictate the coordinated transcription of core histone genes. [FBrf0210215] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Mace et al., 2010, Bioinformatics 26(6): 761--769 Extraction and comparison of gene expression patterns from 2D RNA in situ hybridization images. [FBrf0210155] Mathur et al., 2010, Science 327(5962): 210--213 A transient niche regulates the specification of Drosophila intestinal stem cells. [FBrf0209706] Nakajima et al., 2010, PLoS Comput. Biol. 6(4): e1000760 Robustness under functional constraint: the genetic network for temporal expression in Drosophila neurogenesis. [FBrf0210747] Neto-Silva et al., 2010, Dev. Cell 19(4): 507--520 Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap. [FBrf0212043] Ren et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(49): 21064--21069 Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. [FBrf0212502] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...