FlyBase Gene Report: Dmel\Sol1

General Information

Symbol

Dmel\Sol1

Species

D. melanogaster

Name

Sol1

Annotation Symbol

CG34402

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085431

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

dSol-1

Key Links

Genomic Location

Cytogenetic map

87B9-87B9

Sequence location

3R:12,386,249..12,402,902 [+]

Recombination map

3-52

RefSeq locus

NT_033777 REGION:12386249..12402902

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables channel activator activity

inferred from mutant phenotype

(Kiragasi et al., 2020)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

acts_upstream_of positive regulation of glutamate secretion, neurotransmission

inferred from mutant phenotype

(Kiragasi et al., 2020)

involved_in positive regulation of synaptic transmission, glutamatergic

inferred from mutant phenotype

(Kiragasi et al., 2020)

involved_in presynaptic modulation of chemical synaptic transmission

inferred from mutant phenotype

(Kiragasi et al., 2020)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in presynaptic membrane

inferred from mutant phenotype

(Kiragasi et al., 2020)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002372555

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sol1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8JQY3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sol1-RC

FBtr0112654

NM_001104286

2110

695

Sol1-RD

FBtr0112656

NM_001104288

1960

486

Sol1-RE

FBtr0344385

NM_001300376

2077

682

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sol1-PC

FBpp0111566

77.8

695

6.83

FBpp0111568

54.5

486

7.00

FBpp0310758

76.3

682

6.90

Q15KK8

NP_001287305

AHN57304

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sol1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34402_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.86

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT1-4

(Xu et al., 2011)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in presynaptic membrane

inferred from mutant phenotype

(Kiragasi et al., 2020)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sol1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sol1

View exonic expression by tissue for Dmel\Sol1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41513/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085431

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085431

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085431

Flygut - An atlas of the Drosophila adult midgut

FBgn0085431

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sol1

Transgenic constructs containing regulatory region of Sol1

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3R)Exel6164

(Ryder, 2004.4.26)

Df(3R)Exel6165

(Ryder, 2004.4.26)

Df(3R)Exel7315

(Kiragasi et al., 2020, Ryder, 2004.4.26)

Inferred from location ( 13 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Sol1^c02594

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sol1^GD14648

Sterility

Allele

fertile

Sol1^c02594

Other Phenotypes

Allele

abnormal neurophysiology | third instar larval stage

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

Sol1^UAS.cKa

abnormal neurophysiology | third instar larval stage (with Df(3R)Exel7315)

Sol1^bk1

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | third instar larval stage

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

Sol1^UAS.cKa

embryonic/larval neuromuscular junction | third instar larval stage (with Df(3R)Exel7315)

Sol1^bk1

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

Sol1^UAS.cKa

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with Df(3R)Exel7315)

Sol1^bk1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (30)

Hsap\CUBN

2 of 14

Yes

Hsap\PCOLCE2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\KREMEN1

1 of 14

Yes

Hsap\KREMEN2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\NRP2

1 of 14

Yes

Hsap\OVCH2

1 of 14

Hsap\PCOLCE

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Cubn

2 of 14

Yes

Rnor\Bmp1

1 of 14

Rnor\Kremen2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ovch2

1 of 14

Rnor\PCOLCE2

1 of 14

Yes

Rnor\Pcolce

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Bmp1

1 of 14

Yes

Mmus\Csmd3

1 of 14

Yes

Mmus\Cubn

1 of 14

Yes

Mmus\Kremen2

1 of 14

Yes

Mmus\Masp2

1 of 14

Yes

Mmus\Myl2

1 of 14

Yes

Mmus\Myl7

1 of 14

Yes

Mmus\Myl9

1 of 14

Yes

Mmus\Myl10

1 of 14

Yes

Mmus\Myl12a

1 of 14

Yes

Mmus\Myl12b

1 of 14

Yes

Mmus\Mylpf

1 of 14

Yes

Mmus\Nrp1

1 of 14

Yes

Mmus\Ovch2

1 of 14

Yes

Mmus\Pcolce2

1 of 14

Yes

Mmus\Pcolce

1 of 14

Yes

Mmus\Pdgfc

1 of 14

Yes

Mmus\Pdgfd

1 of 14

Yes

Mmus\Tll1

1 of 14

Yes

Mmus\Tll2

1 of 14

Yes

Mmus\Vegfc

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (18)

Xtro\cdcp2

1 of 13

Yes

Xtro\csmd2

1 of 13

Yes

Xtro\csmd3

1 of 13

Yes

Xtro\cubn

1 of 13

Yes

Xtro\gprin3

1 of 13

Yes

Xtro\kremen2

1 of 13

Yes

Xtro\krt8.1

1 of 13

Yes

Xtro\LOC100490440

1 of 13

Yes

Xtro\LOC100492280

1 of 13

Yes

Xtro\LOC105946018

1 of 13

Yes

Xtro\masp2

1 of 13

Yes

Xtro\neto1

1 of 13

Yes

Xtro\nrp2

1 of 13

Yes

Xtro\ocm3

1 of 13

Yes

Xtro\ovch2

1 of 13

Yes

Xtro\pcolce2

1 of 13

Yes

Xtro\tll1

1 of 13

Yes

Xtro\tll2l

1 of 13

Yes

Danio rerio (Zebrafish) (25)

Drer\pcolce2a

3 of 14

Yes

Drer\mfrp

2 of 14

Yes

Drer\pcolce2b

2 of 14

Yes

Drer\pcolcea

2 of 14

Yes

Drer\pcolceb

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\pdgfd

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\sol-1

11 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP004160

6 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\rlc1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sol1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sqh

1 of 13

tld

1 of 13

tok

1 of 13

uif

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Sol1

suppressible

KaiR1D

(Kiragasi et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0085431

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-52

Cytogenetic map

87B9-87B9

Sequence location

3R:12,386,249..12,402,902 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87B9-87B9

Limits computationally determined from genome sequence between P{PZ}svp⁰⁷⁸⁴² and P{lacW}Vha55^j2E9

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-52

(FlyBase, 2016)

3-49.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

10938

w¹¹¹⁸; PBac{PB}Sol1^c02594

26016

y¹ v¹; P{TRiP.JF02041}attP2

34151

y¹ w^*; Mi{MIC}Sol1^MI01130

59472

y¹ w^*; Mi{MIC}Sol1^MI14035

11303

w¹¹¹⁸; PBac{PB}DNAlig3^c03514 Sol1^c03514

56102

y¹ w^*; Mi{MIC}CG10096^MI10990 CG10097^MI10990 Sol1^MI10990

93835

y¹ w^*; TI{CRIMIC.TG4.0}CG10097^{CR70331-TG4.0} Sol1^{CR70331-TG4.0-X} CG10096^{CR70331-TG4.0-X}/TM3, Sb¹ Ser¹

VDRC

v107524

P{KK111760}VIE-260B

v109516

P{KK110411}VIE-260B

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085431

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085431

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG17793 CG31218 CG4940

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG17793, CG31218 and CG4940 merged as CG34402 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Original annotation in this location (CG4940) utilized wrong ORF; current ORF (CG34402) supported by conservation across Drosophila species.

(FlyBase Genome Annotators, 2007)

Annotation CG17756 split into CG33098 and CG31218 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: sol-1 CG31218

(Walker et al., 2006)

Source for identity of: Sol1 CG34402

(Kiragasi et al., 2020)

Nomenclature comments

Etymology

Named 'Sol1' after the C. elegans ortholog.

(Kiragasi et al., 2020)

'sol-1' is named for its similarity to, and ability to functionally substitute for, the 'suppressor of Lurcher movement defect' gene in C.elegans.

(Walker et al., 2006)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG17756

CG17793

CG31218

(Walker et al., 2006, Lawniczak and Begun, 2004)

CG34402

(Kiragasi et al., 2020, Meltzer et al., 2019, Crocker et al., 2016, Xu et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, FlyBase Genome Annotators, 2007)

CG4940

(Matthews, 2008.4.15, FlyBase Genome Annotators, 2007)

CT39356

(Hynes and Zhao, 2000)

SOL-1

(Walker et al., 2006)

Sol1

(Gene Disruption Project members, 2018-)

dSol-1

(Muttathukunnel et al., 2022, Kiragasi et al., 2020)

sol-1

(Walker et al., 2006)

Name Synonyms

CG17793

CG31218

CG4940

Sol1

suppressor of Lurcher movement defect-1

Secondary FlyBase IDs

FBgn0038030
FBgn0051218
FBgn0038036
FBgn0038031

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41513

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

DQ015970

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8JQY3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8JQY3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41513/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085431

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085431

FlyMine - An integrated database for Drosophila genomics

FBgn0085431

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34402

MARRVEL_MODEL - MARRVEL (model organism gene)

41513

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085431

DroID - A comprehensive database of gene and protein interactions.

FBgn0085431

DRSC - Results frm RNAi screens

FBgn0085431

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34402_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085431

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085431

Flygut - An atlas of the Drosophila adult midgut

FBgn0085431

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0085431

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031333

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (39)

The following external sites may use different assemblies or annotations than FlyBase.

-0.86

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