General Information
Symbol
Dmel\pan
Species
D. melanogaster
Name
pangolin
Annotation Symbol
CG34403
Feature Type
FlyBase ID
FBgn0085432
Gene Model Status
Stock Availability
Gene Snapshot
Pangolin is an HMG-domain transcription factor that is a key component of the canonical Wingless signaling pathway. It toggles between acting as a transcriptional repressor (when bound to gro) and activator (when bound to arm) to promote cell fate specification. [Date last reviewed: 2016-06-09]
Also Known As
dTCF, TCF, l(4)13, LEF-1, IA5
Genomic Location
Cytogenetic map
Sequence location
4:69,326..114,270 [+]
Recombination map
4-0
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
Belongs to the TCF/LEF family. (P91943Q8IMA8)
Summaries
Gene Group Membership
HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -
The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).
Wnt-TCF Signaling Pathway Core Components -
The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
WNT ENHANCEOSOME -
The Wnt enhanceosome complex binds to Wnt/wg-enhancer elements via the TCF/LEF protein, pan. In the absence nuclear β-catenin (arm), Wnt/wg-responsive genes are silenced by the repressor gro binding to the enhanceosome. Activation of the canonical Wnt signaling pathway leads to arm accumulation in the nucleus, incorporation into the enhanceosome and the stimulation of transcription. (Adapted from FBrf0235074 and FBrf0229654).
UniProt Contributed Function Data
Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
(UniProt, P91943Q8IMA8)
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\pan or the JBrowse view of Dmel\pan for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.41
Gene model reviewed during 5.39
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089161
4129
751
FBtr0089159
3023
751
FBtr0089162
4095
751
FBtr0100245
4219
747
FBtr0100246
3795
410
FBtr0112657
6005
1192
FBtr0308615
4954
494
FBtr0309803
8472
751
FBtr0334301
3101
733
Additional Transcript Data and Comments
Reported size (kB)
2.8 (compiled cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088228
81.9
751
7.20
FBpp0088226
81.9
751
7.20
FBpp0088229
81.9
751
7.20
FBpp0099631
81.4
747
7.29
FBpp0099632
46.3
410
9.21
FBpp0111569
132.1
1192
7.13
FBpp0300839
53.5
494
9.00
FBpp0301556
81.9
751
7.20
FBpp0306416
79.9
733
7.37
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

751 aa isoforms: pan-PA, pan-PB, pan-PD, pan-PR
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
A fusion construct containing amino acids 1 to 130 of wild-type pan protein (panwt.cBa) binds 4-5 fold more of the vertebrate arm protein homolog beta-catenin in-vitro than fusion constructs containing amino acids 1 to 130 of either panS25 or panS28 protein. The panS25 and panS28 proteins each differ from wild type pan protein by one amino acid.
Repeats 3-8 of the arm protein interact with aa 1-90 of pan in a yeast two-hybrid assay. The DNA binding site of the pan HMG box was assayed, and revealed the consensus CCTTTGATCTT. Cotransfection of arm and pan vectors resulted in transcriptional activation of a CAT or a Ppyr\LUC reporter, and the C-terminus of arm protein was necessary for this activation. The transactivation capacity of the C-terminus of arm was further demonstrated by fusing it to a GAL4-DNA binding domain, and assaying expression of a CAT reporter.
External Data
Subunit Structure (UniProtKB)
Binds to the beta-catenin homolog arm or to gro.
(UniProt, P91943, Q8IMA8)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pan using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (31 terms)
Molecular Function (10 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002571467
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
Biological Process (18 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:P91943
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P91943
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P91943
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:P91943
(assigned by UniProt )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:P18824
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
Expression Data
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:P18824
inferred from mutant phenotype
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\pan in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 25 )
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of pan
Allele of pan
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of pan
Deletions and Duplications ( 11 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
6 of 15
No
Yes
6 of 15
No
Yes
4 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
7 of 15
No
Yes
 
7 of 15
No
Yes
4 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
6 of 13
Yes
Yes
4 of 13
No
Yes
4 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
5 of 12
Yes
Yes
4 of 12
No
Yes
3 of 12
No
Yes
3 of 12
No
Yes
Danio rerio (Zebrafish) (5)
7 of 15
Yes
Yes
7 of 15
Yes
Yes
7 of 15
Yes
Yes
5 of 15
No
Yes
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
9 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
No
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902BP )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150HK5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0C2Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0C0T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 4 )
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please look at the Interaction Group reports for full details of the physical interactions
    protein-protein
    Interacting group
    Assay
    References
    RNA-RNA
    Interacting group
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Binds to the beta-catenin homolog arm or to gro.
    (UniProt, P91943, Q8IMA8 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Wnt-TCF Signaling Pathway Core Components -
    The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    4
    Recombination map
    4-0
    Cytogenetic map
    Sequence location
    4:69,326..114,270 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    101F1-102A4
    Limits computationally determined from genome sequence between P{SUPor-P}KG01127&PBac{5HPw+}A173 and PBac{5HPw+}A437
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    101F-101F
    (determined by in situ hybridisation)
    Located at the base of chromosome 4 by in situ hybridisation.
    Located at the border of segments 101 and 102.
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Stocks and Reagents
    Stocks (118)
    Genomic Clones (11)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (196)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: pan IA5
    Source for merge of: pan CG32005
    Additional comments
    Annotations CG17964 and CG32005 merged as CG34403 in release 5.2 of the genome annotation.
    Other Comments
    DNA-protein interactions: genome-wide binding profile assayed for pan protein in stage 9-11 embryos; ArrayExpress accession number E-MTAB-1184.
    dsRNA made from templates generated with primers directed against this gene has been transfected into Kc cells.
    The pan product prevents rho expression in egg chambers.
    ChEST reveals this is a target of Mef2.
    In order to activate pan protein, arm protein must enter the nucleus and form a complex with lgs and pygo proteins.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    pan may have both activator and repressor roles during embryonic patterning, while for wing development pan operates primarily in the activator mode.
    New annotation (CG32005) in release 3 of the genome annotation.
    Induction of slp1 by wg involves pan binding to multiple binding sites within a wg-responsive enhancer in the 5' region of slp1.
    arm and pan act together with JNK signalling pathways in both ventral patterning and dorsal closure.
    The primary function of pan protein binding to the dpp visceral mesoderm enhancer is repression throughout the visceral mesoderm.
    The arm/pan protein complex has a role in the activation of apoptosis during retinal development.
    The pan gene product can function as either an activator or a repressor of wg-responsive genes depending on the state of the wg signalling pathway and thus the availability of arm, the pan product coactivator. In the absence of arm, pan acts to repress wg responsive genes, with the gro protein acting as a corepressor.
    Genomic organisation of pan is determined: a single copy gene spanning approximately 50kb and composed of 13 exons that share conservation with the exon/intron boundaries of human TCF-1.
    The nej gene product represses pan to antagonise wg signalling.
    The pan segment polarity gene encodes a product required downstream of arm for wg signal transduction in vivo.
    pan complexes with arm to form a transcriptional activator of wg target genes.
    pan forms a bipartite transcription factor with arm which can potently activate transcription.
    Mutations in pan cause a segment polarity phenotype.
    pan functions directly downstream of arm in the establishment of segment polarity and provides a molecular mechanism for gene control by wg signalling.
    Origin and Etymology
    Discoverer
    Etymology
    The gene is named 'pangolin' due to the 'lawn of denticles' phenotype of pan13 homozygotes.
    Identification
    External Crossreferences and Linkouts ( 141 )
    Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Synonyms and Secondary IDs (40)
    Reported As
    Symbol Synonym
    TCF
    (Requena et al., 2017, Chen et al., 2016, Nagy et al., 2016, Oyallon et al., 2016, Ravindranath and Cadigan, 2016, Bieli et al., 2015, Luo et al., 2015, Herranz et al., 2014, Jenny and Basler, 2014, Slattery et al., 2014, Zhang et al., 2014, Das et al., 2013, Morozov and Ioshikhes, 2013, Wang et al., 2013, Yang et al., 2013, Gistelinck et al., 2012, Bhambhani et al., 2011, Olson et al., 2011, Singh et al., 2011, Xin et al., 2011, You et al., 2011, Cordero and Cagan, 2010, Ayers et al., 2009, Bernard et al., 2009, Dichtel-Danjoy et al., 2009, Widmann and Dahmann, 2009, Blauwkamp et al., 2008, Chang et al., 2008, Chang et al., 2008, Chang et al., 2008, Deb et al., 2008, Estella and Mann, 2008, Estella et al., 2008, Kennell et al., 2008, Liu et al., 2008, Newfeld et al., 2008, Parker et al., 2008, Shindo et al., 2008, Takaesu et al., 2008, Takashima et al., 2008, Chang et al., 2007, Hayden et al., 2007, Li et al., 2007, Luo et al., 2007, Singh et al., 2007, Fang et al., 2006, Franch-Marro et al., 2006, Hayden et al., 2006, Parker et al., 2006, Stadeli, 2006, Bejsovec, 2005, Takaesu et al., 2005, Bajpai et al., 2004, Bienz and Hamada, 2004, Check, 2004, Ryoo et al., 2004, Yan et al., 2004, Lin et al., 2003, Veeman et al., 2003, Wernet et al., 2003, Adachi-Yamada and O'Connor, 2002, Bienz, 2002, Cadigan, 2002, Cadigan et al., 2002, Cohen et al., 2002, Kalderon, 2002, Mlodzik, 2002, Marcu et al., 2001, Nusse, 2001, Behrens, 2000, Peifer and Polakis, 2000, Potter et al., 2000, Bienz, 1999, Morin, 1999, Zhang and Derynck, 1999, Bienz, 1997)
    dTCF
    (Magri et al., 2018, Frasch, 2016, Tare et al., 2016, Tian et al., 2016, Monfort and Furlong, 2015.1.15, Wittkorn et al., 2015, Caviglia and Luschnig, 2013, Moran et al., 2013, Aboukhalil and Bulyk, 2012, Gistelinck et al., 2012, Junion et al., 2012, Legent et al., 2012, Benchabane et al., 2011, Benchabane et al., 2011, Liu et al., 2010, Metcalfe et al., 2010, Singh et al., 2010, Taniue et al., 2010, Dichtel-Danjoy et al., 2009, Guruharsha et al., 2009, Tokusumi et al., 2009, DeFalco et al., 2008, Herranz et al., 2008, Kennell and Cadigan, 2008, Lin et al., 2008, Mieszczanek et al., 2008, Morris et al., 2008, Tran et al., 2008, Chan et al., 2007, Chung et al., 2007, de la Roche and Bienz, 2007, Parker et al., 2007, Silver et al., 2007, Tanaka et al., 2007, Theisen et al., 2007, Zirin and Mann, 2007, Maqbool et al., 2006, Philippakis et al., 2006, Berger et al., 2005, Furlong, 2005, Newfeld and Takaesu, 2005, Newfeld and Takaesu, 2005, Newfeld et al., 2005, Furlong, 2004, Guruharsha et al., 2004, Jagla et al., 2004, Johnson and Newfeld, 2004, Syed et al., 2004, Thompson, 2004, Townsley et al., 2004, Zirin and Mann, 2004, Bienz and Clevers, 2003, Butler et al., 2003, Carrera et al., 2003, Farge, 2003, Jones and Bejsovec, 2003, Barolo and Posakony, 2002, Barolo and Posakony, 2002, Cavodeassi et al., 2002, Galis et al., 2002, Klochendler-Yeivin et al., 2002, Nakagoshi et al., 2002, Pandur et al., 2002, Singh et al., 2002, Thompson et al., 2002, Thompson et al., 2002, Baylies and Michelson, 2001, Freeman and Bienz, 2001, Lawrence, 2001, Lee and Treisman, 2001, Tolwinski and Wieschaus, 2001, Verheyen et al., 2001, Bienz and Clevers, 2000, Buratovich et al., 2000, Casares and Mann, 2000, Collins and Treisman, 2000, Cox et al., 2000, Ghazi and VijayRaghavan, 2000, Glass and Rosenfeld, 2000, Goodman and Smolik, 2000, Halfon et al., 2000, Halfon et al., 2000, Llimargas, 2000, McEwen and Peifer, 2000, Pages and Kerridge, 2000, Pichaud and Casares, 2000, Seidensticker and Behrens, 2000, Simon, 2000, Bejsovec, 1999, Cox et al., 1999, Gritzan et al., 1999, Hays et al., 1999, Helms et al., 1999, Johnston et al., 1999, Kouzarides, 1999, Lavery et al., 1999, McCartney et al., 1999, McCartney et al., 1999, Moline et al., 1999, Roose and Clevers, 1999, Vousden, 1999, Willert et al., 1999, Ahmed et al., 1998, Ben-Ze'ev and Geiger, 1998, Bienz, 1998, Cadigan et al., 1998, Cavallo et al., 1998, Cox and Peifer, 1998, Hazelett et al., 1998, Johnston and Edgar, 1998, Park et al., 1998, Polevoy et al., 1998, Russ, 1998, van Beest et al., 1998, Waltzer and Bienz, 1998, Yu et al., 1998, Cavallo et al., 1997, Cavallo et al., 1997, Clevers and van de Wetering, 1997, Cox et al., 1997, Kronhamn and Rasmuson-Lestander, 1997, Peifer et al., 1997, van de Wetering et al., 1997, van de Wetering, 1996.10.31)
    l(4)102ABb
    pan
    (Baranski et al., 2018, Billmann et al., 2018, Wiese et al., 2018, Batut and Gingeras, 2017, Franz et al., 2017, Houtz et al., 2017, Hu et al., 2017.6.13, Lobell et al., 2017, Transgenic RNAi Project members, 2017-, Bielmeier et al., 2016, Morimoto et al., 2016, Oyallon et al., 2016, Trujillo et al., 2016, Zhang et al., 2016, Kok et al., 2015, Schertel et al., 2015, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Boyle et al., 2014, Kerr et al., 2014, Schilling et al., 2014, Shukla et al., 2014, Tang et al., 2014, Taylor et al., 2014, Westholm et al., 2014, Bonke et al., 2013, Howlett et al., 2013, Kwon et al., 2013, Pancratov et al., 2013, Schertel et al., 2013, Tang et al., 2013, Casad et al., 2012, Dupont et al., 2012, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Sousa-Neves and Schinaman, 2012, Giorgianni and Mann, 2011, Gonsalves et al., 2011, Strand and Micchelli, 2011, Toku et al., 2011, Metcalfe et al., 2010, Swaminathan et al., 2010, Tokusumi et al., 2010, Jiang et al., 2009, Lee et al., 2009, Mulinari and Häcker, 2009, Benchabane et al., 2008, Buechling et al., 2008, Haussmann et al., 2008, Kennell et al., 2008, Miech et al., 2008, Takacs et al., 2008, Aerts et al., 2007, Beltran et al., 2007, Bhat, 2007, DasGupta et al., 2007, Haerty et al., 2007, Junion et al., 2007, Ma et al., 2006, Masly et al., 2006, Molnar et al., 2006, Sato et al., 2006, Singh et al., 2006, DasGupta et al., 2005, Jordan et al., 2005, Mok et al., 2005, Staedeli and Basler, 2005, Philipps et al., 2004, Stanyon et al., 2004)
    Secondary FlyBase IDs
    • FBgn0022393
    • FBgn0052005
    • FBgn0019664
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    ChIP-chip identification of binding sites for transcription factors that regulate mesodermal development.
    References (536)