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Gene Dmel\pan

General Information
Symbol	Dmel\pan	Species	D. melanogaster
Name	pangolin	Annotation symbol	CG34403
Feature type	protein_coding_gene	FlyBase ID	FBgn0085432
Gene Model Status	Current	Stock availability	89 publicly available
Also Known As	dTcf, TCF, l(4)13, CG17964, LEF-1, Lef, Tcf/LEF, LEF/TCF, lef1, CG32005
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102A3-102A4	Sequence location	4:89,956..134,454 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pangolin is referred to in FlyBase by the symbol Dmel\pan (CG34403, FBgn0085432). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: kinase binding; sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; repressing transcription factor binding. There is experimental evidence that it is involved in the biological process: positive regulation of gene expression; regulation of Wnt receptor signaling pathway; regulation of stem cell proliferation; positive regulation of transcription from RNA polymerase II promoter; spiracle morphogenesis, open tracheal system; embryonic pattern specification; regulation of hemocyte differentiation; positive regulation of transcription, DNA-dependent; imaginal disc-derived wing morphogenesis; salivary gland morphogenesis. 44 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; non-connected developing system; thoracic segment; late extended germ band embryo; portion of tissue; external compound sense organ; imaginal precursor; acellular anatomical structure. It has 12 annotated transcripts and 12 annotated polypeptides. Protein features are: CTNNB1 binding, N-teminal; High mobility group, HMG1/HMG2; High mobility group, superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Gene sequence location is 4:89956..134454.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Eivers et al., 2011, Sci. Signal. 4(194): Gibert et al., 2011, PLoS Genet. 7(1): e1001280 Sequence features BKN23793 BKN22291 BKN46216 HFA17176 Controlled Vocabulary Terms nucleus positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription positive regulation of gene expression sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102A3-102A4   Limits computationally determined from genome sequence between P{SUPor-P}KG01127&PBac{5HPw+}A173 and PBac{5HPw+}A437
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Located at the base of chromosome 4 by in situ hybridisation.   (Brunner et al., 1997) 101F-101F   (determined by in situ hybridisation)   (van de Wetering et al., 1997)   Located at the border of segments 101 and 102.   (Dooijes et al., 1998)
Experimentally Determined Recombination Data
Location	4- (Brunner et al., 1997, Kronhamn and Rasmuson-Lestander, 1997)
Left of (cM)
Right of (cM)
Notes	Maps close to ci. (Kronhamn and Rasmuson-Lestander, 1997)
Gene Model & Products
Please see the GBrowse view of Dmel\pan for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Gene model reviewed during 5.39 Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pan-RA FBtr0089161  NM_166718   4121   751 pan-RB FBtr0089159  NM_079880   2870   751 pan-RC FBtr0089160  NM_166719   4529   751 pan-RD FBtr0089162  NM_166720   4094   751 pan-RE FBtr0089156  NM_166721   4123   751 pan-RF FBtr0089158  NM_166722   3997   751 pan-RG FBtr0089157  NM_166723   4055   751 pan-RH FBtr0100245  NM_001014685   3942   747 pan-RI FBtr0100246  NM_001038709   3518   410 pan-RJ FBtr0112657  NM_166724   5146   1192 pan-RQ FBtr0308615     4677   494 pan-RR FBtr0309803     7890   751
Additional Transcript Data & Comments
Reported size (kB)	2.8 (compiled cDNA) (Brunner et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pan-PA   FBpp0088228   81.9   751   7.20     NP_726522   AAF59371 pan-PB   FBpp0088226   81.9   751   7.20     NP_524619   AAN06544 pan-PC   FBpp0088227   81.9   751   7.20     NP_726523   AAF59370 pan-PD   FBpp0088229   81.9   751   7.20     NP_726524   AAN06545 pan-PE   FBpp0088223   81.9   751   7.20     NP_726525   AAN06546 pan-PF   FBpp0088225   81.9   751   7.20     NP_726526   AAN06547 pan-PG   FBpp0088224   81.9   751   7.20     NP_726527   AAN06548 pan-PH   FBpp0099631   81.4   747   7.29     NP_001014685   AAX52517 pan-PI   FBpp0099632   46.3   410   9.21     NP_001033798   ABC65830 pan-PJ   FBpp0111569   132.1   1192   7.13     NP_726528   AAN06549 pan-PQ   FBpp0300839   53.5   494   9.00       pan-PR   FBpp0301556   81.9   751   7.20
Additional Polypeptide Data & Comments
Reported size (kDa)	751 (aa) (Brunner et al., 1997)
Comments	A fusion construct containing amino acids 1 to 130 of wild-type pan protein (panwt.cBa) binds 4-5 fold more of the vertebrate arm protein homolog beta-catenin in-vitro than fusion constructs containing amino acids 1 to 130 of either panS25 or panS28 protein. The panS25 and panS28 proteins each differ from wild type pan protein by one amino acid. (Brunner et al., 1997) Repeats 3-8 of the arm protein interact with aa 1-90 of pan in a yeast two-hybrid assay. The DNA binding site of the pan HMG box was assayed, and revealed the consensus CCTTTGATCTT. Cotransfection of arm and pan vectors resulted in transcriptional activation of a Cat or a Ppyr\LUC reporter, and the C-terminus of arm protein was necessary for this activation. The transactivation capacity of the C-terminus of arm was further demonstrated by fusing it to a GAL4-DNA binding domain, and assaying expression of a CAT reporter. (van de Wetering et al., 1997)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CTNNB1 binding, N-teminal (IPR013558) High mobility group, superfamily (IPR009071) High mobility group, HMG1/HMG2 (IPR000910)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695697   AA698063   AA801821   AE014135 AAF59370   AE014135 AAF59371   AE014135 AAN06544   AE014135 AAN06545   AE014135 AAN06546   AE014135 AAN06547   AE014135 AAN06548   AE014135 AAN06549   AE014135 AAX52517   AE014135 ABC65830   AI402472   AW941213   AY075359   AY312729 AAQ67543   AY312730 AAQ67544   AY312731 AAQ67545   AY312732 AAQ67546   AY312733 AAQ67547   AY312734 AAQ67548   AY312735 AAQ67549   AY312736 AAQ67550   AY312737 AAQ67551   AY312738 AAQ67552   AY312739 AAQ67553   AY312740 AAQ67554   AY312741 AAQ67555   AY312742 AAQ67556   AY312743 AAQ67557   AY312744 AAQ67558   AY312745 AAQ67559   AY312746 AAQ67560   AY312747 AAQ67561   AY312748 AAQ67562   AY312749 AAQ67563   AY312750 AAQ67564   AY312751 AAQ67565   AY312752 AAQ67566   BI372507   BT011132   BT021431 AAX33579   BT029282   BT029289   BT044547   BT053747   BZ286237   CA803247   CA803489   CO177395   CO177630   CO178301   CO178492   CO178759   CO186358   CO186586   CO186599   CO186943   CO188140   CO190219   CO190934   CO193521   CO195300   CO196355   CO196357   CO265020   CO266779   CO267439   CO268044   CO268646   CO269014   CO269785   CO270070   CO270399   CO270949   CO272722   CO272804   CO272894   CO272901   CO272905   CO273040   CO275315   CO276125   CO277488   CO279037   CO280908   CO283623   CO284300   CO284369   CO284850   CO286003   CO286270   CO286315   CO286599   CO286633   CO286906   CO287495   CO288978   CO289043   CO289276   CO289325   CO289556   CO291813   CO291954   CO292031   CO293536   CO293795   CO293843   CO295169   CO295786   CO297032   CO297386   CO297437   CO297804   CO298003   CO298141   CO298506   CO299620   CO300984   CO302062   CO302283   CO302567   CO303236   CO304689   CO305112   CO305878   CO306593   CO307319   CO307643   CO308103   CO308588   CO310183   CO312604   CO313578   CO313770   CO313821   CO315017   CO315955   CO316596   CO316933   CO317065   CO318622   CO318636   CO318774   CO319100   CO319289   CO323031   CO323105   CO324542   CO324787   CO325361   CO326516   CO326690   CO327415   CO327963   CO331506   CO333010   CO333290   CO333707   CO334142   CO340890   CO341400   CO341858   CO342278   CO343099   CO344605   CO345238   CZ470551   CZ482871   CZ484725   CZ485006   EC052258   EC053746   EC056763   EC058344   EC058523   EC059495   EC059501   EC059626   EC060391   EC060415   EC062241   EC064340   EC064388   EC064441   EC064487   EC064620   EC066828   EC066988   EC069089   EC070211   EC072224   EC074628   EC074838   EC076963   EC077898   EC078060   EC078313   EC079315   EC080903   EC081371   EC083214   EC084517   EC084597   EC086508   EC087963   EC088134   EC090737   EC194908   EC195693   EC196075   EC197924   EC197948   EC199344   EC200309   EC200804   EC200947   EC203091   EC203614   EC205422   EC205475   EC207118   EC207723   EC207856   EC208497   EC208755   EC208908   EC210832   EC212212   EC214151   EC215230   EC215336   EC217889   EC218376   EC219778   EC221066   EC222206   EC222283   EC223006   EC223692   EC223815   EC225734   EC227212   EC229269   EC230664   EC231427   EC231885   EC232135   EC232399   EC232405   EC233072   EC234812   EC235516   EC236102   EC236970   EC238530   EC239599   EC239616   EC240754   EC241378   EC241388   EC241650   EC241800   EC244541   EC245712   EC247169   EC247253   EC247414   EC248331   EC248336   EC249039   EC249233   EC249321   EC249402   EC253219   EC254734   EC256583   EC257420   EC258444   FF579126   FF579170   GH941255   GH941365   GH941964   GH942078   GH942245   GH942820   GH942882   GH943676   GH944154   GH945140   GH945259   GH945433   GH946302   GH946706   GH947707   GH947950   GH948808   GH949735   GH949801   GH949899   GH950617   GH950747   GH952181   GH952234   GH952416   GH953826   GH953836   GH954159   GH955079   GH956231   GH957282   GH957344   GH958010   GH958419   GH958490   GH958757   GH958860   GH960602   GH960630   GH962216   GH962355   GH963715   GH965193   GH965450   GH966221   GH966412   GH966541   GH966854   GH967175   GH967270   GH969166   GH969271   GH969513   GH969609   GH971102   GH972102   GH973172   GH973716   GH973829   GH974752   GH975172   GH975866   GH976392   GH976481   GH977404   GH977535   GH977690   GH977764   GH979411   GH979920   GH980239   GH980263   GH980559   GH983817   GH984412   GH984795   U88538 AAC47464   Y09125 CAA70343
UniProtKB/Swiss-Prot	P91943 Q8IMA8
UniProtKB/TrEMBL	Q8IMA8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Brunner et al., 1997) embryonic stage     (van de Wetering et al., 1997) embryonic stage 7     (Schweizer and Basler, 1998) embryonic stage 13   visceral mesoderm   (Brunner et al., 1997) procephalic segment   (Brunner et al., 1997) pcr Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4     (van de Wetering et al., 1997) Comment:reference states 0-2 hr AEL
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0085432    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0085432 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0085432 expression level Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr  (235) embryo 04-06hr  (525) embryo 06-08hr  (386) embryo 08-10hr  (461) embryo 10-12hr  (311) embryo 12-14hr  (610) embryo 14-16hr  (231) embryo 16-18hr  (320) embryo 18-20hr  (280) embryo 20-22hr  (254) embryo 22-24hr  (422) larva L1  (227) larva L2  (169) larva L3 12hr old  (167) larva L3 puffstage 1-2    85 larva L3 puffstage 3-6  (261) larva L3 puffstage 7-9  (423) white prepupae new  (504) white prepupae 12hr  (501) white prepupae 24hr  (596) pupae 2d postWPP  (591) pupae 3d postWPP  (502) pupae 4d postWPP  (282) adult male 01day  (336) adult male 05day  (259) adult male 30day  (196) adult female 01day  (175) adult female 05day  (154) adult female 30day  (141) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0085432 expression level Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr  (235) embryo 04-06hr  (525) embryo 06-08hr  (386) embryo 08-10hr  (461) embryo 10-12hr  (311) embryo 12-14hr  (610) embryo 14-16hr  (231) embryo 16-18hr  (320) embryo 18-20hr  (280) embryo 20-22hr  (254) embryo 22-24hr  (422) larva L1  (227) larva L2  (169) larva L3 12hr old  (167) larva L3 puffstage 1-2    85 larva L3 puffstage 3-6  (261) larva L3 puffstage 7-9  (423) white prepupae new  (504) white prepupae 12hr  (501) white prepupae 24hr  (596) pupae 2d postWPP  (591) pupae 3d postWPP  (502) pupae 4d postWPP  (282) adult male 01day  (336) adult male 05day  (259) adult male 30day  (196) adult female 01day  (175) adult female 05day  (154) adult female 30day  141 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    235 embryo 04-06hr    525 embryo 06-08hr    386 embryo 08-10hr    461 embryo 10-12hr    311 embryo 12-14hr    610 embryo 14-16hr    231 embryo 16-18hr    320 embryo 18-20hr    280 embryo 20-22hr    254 embryo 22-24hr    422 larva L1    227 larva L2    169 larva L3 12hr old    167 larva L3 puffstage 1-2    85 larva L3 puffstage 3-6    261 larva L3 puffstage 7-9    423 white prepupae new    504 white prepupae 12hr    501 white prepupae 24hr    596 pupae 2d postWPP    591 pupae 3d postWPP    502 pupae 4d postWPP    282 adult male 01day    336 adult male 05day    259 adult male 30day    196 adult female 01day    175 adult female 05day    154 adult female 30day    141 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0085432    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0085432 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085432 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17964-RE;CG32005-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for pan Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4bs-1348 panΔN.Scer\UAS lethal, with Scer\GAL4elav-C155 panScer\UAS.cWa lethal, with Scer\GAL4hs.2sev panScer\UAS.cWa lethal | embryonic stage, with Scer\GAL4arm.PS panΔN.Scer\UAS lethal | embryonic stage, with Scer\GAL4e22c panΔN.Scer\UAS lethal | embryonic stage, with Scer\GAL4unspecified panScer\UAS.T:Hsim\VP16 lethal | embryonic stage | recessive pan3 pan13a panIA5 lethal | embryonic stage | rescuable maternal effect | segment polarity expression pattern pan2 lethal | embryonic stage | segment polarity expression pattern, with Scer\GAL4e22c panΔN.Scer\UAS lethal | larval stage | recessive pan13 pan13a lethal | male, with Scer\GAL4Bx-MS1096 panΔN.Scer\UAS lethal | pharate adult stage, with Scer\GAL430A panΔN.Scer\UAS lethal | pupal stage, with Scer\GAL4dpp.blk1 panΔN.Scer\UAS lethal | recessive pan13 panΔ31 lethal | recessive | heat sensitive panER1 semi-lethal | pupal stage, with Scer\GAL4dpp.blk1 panScer\UAS.cWa viable panS25 panS28 viable, with Scer\GAL4pnr-MD237 panGD1506 panGD10429 Other Phenotypes Allele cell shape defective | pupal stage, with Scer\GAL4GMR.PU panΔN.Scer\UAS cell shape defective | pupal stage, with Scer\GAL4sv.PJ panΔN.Scer\UAS decreased cell number, with Scer\GAL4byn-Gal4, Scer\GAL80ts.αTub84B panΔN.Scer\UAS decreased cell number | pupal stage, with Scer\GAL4GMR.PU panΔN.Scer\UAS decreased cell number | pupal stage, with Scer\GAL4sv.PJ panΔN.Scer\UAS decreased cell number | third instar larval stage, with Scer\GAL4GMR.PU panΔN.Scer\UAS flightless, with Scer\GAL4ebd1.PB panΔN.Scer\UAS increased cell death, with Scer\GAL4byn-Gal4, Scer\GAL80ts.αTub84B panΔN.Scer\UAS Minute | dominant panΔ3M panΔ9M mitotic cell cycle defective, with Scer\GAL4bbg-C96 panΔN.Scer\UAS neuroanatomy defective | somatic clone | third instar larval stage, with Scer\GAL4elav.PH panScer\UAS.cWa size defective | somatic clone pan2 visible panER1 visible, with Scer\GAL4GMR.PU panΔN.Scer\UAS visible, with Scer\GAL4sev.EP panScer\UAS.cWa visible, with Scer\GAL4T155 panΔN.Scer\UAS visible, with Scer\GAL4vg.int2.1 panScer\UAS.cWa visible | recessive pan13a wild-type panhs.PW wild-type, with Scer\GAL4e22c panScer\UAS.cWa Phenotype manifest in Allele abdominal sternite bristle panER1 abdominal ventral acute muscle 1 founder cell, with Scer\GAL4twi.PB panΔN.Scer\UAS abdominal ventral acute muscle 2 founder cell, with Scer\GAL4twi.PB panΔN.Scer\UAS abdominal ventral acute muscle 3 founder cell, with Scer\GAL4twi.PB panΔN.Scer\UAS abdominal ventral denticle belt | embryonic stage, with Scer\GAL4e22c panΔN.Scer\UAS adult cuticle, with Scer\GAL430A panΔN.Scer\UAS adult hindgut, with Scer\GAL4byn-Gal4, Scer\GAL80ts.αTub84B panΔN.Scer\UAS antenna panER1 cone cell | pupal stage, with Scer\GAL4GMR.PU panΔN.Scer\UAS cone cell | pupal stage, with Scer\GAL4sv.PJ panΔN.Scer\UAS denticle | ectopic pan2 denticle | ectopic, with Scer\GAL4da.G32 panΔN.Scer\UAS denticle belt pan2 pan3 denticle belt, with Scer\GAL4e22c panΔN.Scer\UAS panScer\UAS.cWa denticle belt, with Scer\GAL4ptc-559.1 panΔN.Scer\UAS denticle belt, with Scer\GAL4wg.PM panΔN.Scer\UAS dorsal denticle, with Scer\GAL4da.G32 panΔN.Scer\UAS dorsal denticle | ectopic, with Scer\GAL4ptc-559.1 panΔN.Scer\UAS dorsal fine hair, with Scer\GAL4ptc-559.1 panΔN.Scer\UAS dorsal medial muscle, with Scer\GAL41151 panΔN.Scer\UAS dorsal thick hair | ectopic, with Scer\GAL4ptc-559.1 panΔN.Scer\UAS embryo | segment polarity expression pattern, with Scer\GAL469B panΔN.Scer\UAS embryo | segment polarity expression pattern, with Scer\GAL4e22c panΔN.Scer\UAS embryonic/first instar larval cuticle pan3 embryonic/first instar larval cuticle, with Scer\GAL4da.G32 panΔN.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4e22c panΔN.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4wg.PM panΔN.Scer\UAS embryonic/first instar larval cuticle | germline clone | rescuable maternal effect pan2 embryonic/first instar larval cuticle | ventral pan13a embryonic/larval cuticle | segment polarity expression pattern pan13 embryonic/larval dorsal trunk, with Scer\GAL4btl.PS panΔN.Scer\UAS embryonic/larval dorsal trunk, with Scer\GAL4salm-LP39 panΔN.Scer\UAS embryonic/larval dorsal vessel | precursor, with Scer\GAL4how-24B, Scer\GAL4twi.PG panΔN.Scer\UAS embryonic/larval epidermis | segment polarity expression pattern pan13 embryonic/larval ganglionic branch, with Scer\GAL4btl.PS panΔN.Scer\UAS embryonic/larval hindgut, with Scer\GAL4byn-Gal4, Scer\GAL80ts.αTub84B panΔN.Scer\UAS embryonic/larval neuromuscular junction | somatic clone, with Scer\GAL4elav.PH panScer\UAS.cWa embryonic/larval tracheal system, with Scer\GAL4btl.PS panΔN.Scer\UAS embryonic/larval tracheal system, with Scer\GAL4esg-p127 panΔN.Scer\UAS embryonic epidermis pan3 embryonic epidermis, with Scer\GAL4e22c panΔN.Scer\UAS embryonic epidermis, with Scer\GAL4ptc-559.1 panΔN.Scer\UAS embryonic epidermis, with Scer\GAL4unspecified panΔN.Scer\UAS embryonic epidermis | dorsal, with Scer\GAL4arm.T:Hsim\VP16 panΔN.Scer\UAS embryonic epidermis | dorsal, with Scer\GAL4da.G32 panΔN.Scer\UAS embryonic epidermis | ventral pan2 embryonic procephalic segment panIA5 eye, with Scer\GAL4GMR.PU panΔN.Scer\UAS filzkorper, with Scer\GAL4ems.HRE panΔN.Scer\UAS hemocyte, with Scer\GAL430A panΔN.Scer\UAS hemocyte, with Scer\GAL4He.PZ panΔN.Scer\UAS hemocyte, with Scer\GAL4Hml.PG panΔN.Scer\UAS indirect flight muscle, with Scer\GAL41151 panΔN.Scer\UAS indirect flight muscle, with Scer\GAL4ebd1.PB panΔN.Scer\UAS interommatidial bristle, with Scer\GAL4sev.EP panScer\UAS.cWa intestinal stem cell | somatic clone, with Scer\GAL4tub.PU panΔN.Scer\UAS lamellocyte, with Scer\GAL4He.PZ panΔN.Scer\UAS lamellocyte, with Scer\GAL4Hml.PG panΔN.Scer\UAS leg panER1 melanotic mass, with Scer\GAL430A panΔN.Scer\UAS melanotic mass, with Scer\GAL4He.PZ panΔN.Scer\UAS melanotic mass, with Scer\GAL4Hml.PG panΔN.Scer\UAS muscle founder cell, with Scer\GAL4prd.RG1 panΔN.Scer\UAS NMJ bouton | somatic clone, with Scer\GAL4elav.PH panScer\UAS.cWa ovary | somatic clone, with Scer\GAL4Act5C.PP panΔN.Scer\UAS parasegment, with Scer\GAL4ptc-559.1 panΔN.Scer\UAS photoreceptor pan13 panER1 pleural membrane panER1 presumptive embryonic/larval digestive system panIA5 presumptive embryonic/larval muscle system, with Scer\GAL4prd.RG1 panΔN.Scer\UAS presumptive embryonic salivary gland, with Scer\GAL4fkh.PZ panΔN.Scer\UAS segment pan13a pan2 pan3 segment, with Scer\GAL469B panΔN.Scer\UAS segment, with Scer\GAL4e22c panΔN.Scer\UAS sternite panER1 sternite, with Scer\GAL4T155 panΔN.Scer\UAS stigmatophore, with Scer\GAL4salm-459.2 panΔN.Scer\UAS tergite, with Scer\GAL4T155 panΔN.Scer\UAS ventral thoracic disc, with Scer\GAL4Dll-md23 panΔN.Scer\UAS visceral branch, with Scer\GAL4twi.PGa panΔN.Scer\UAS wing panER1 wing, with Scer\GAL430A panΔN.Scer\UAS wing, with Scer\GAL4Bx-MS1096 panΔN.Scer\UAS wing, with Scer\GAL4vg.PM panΔN.Scer\UAS wing disc, with Scer\GAL4bbg-C96 panΔN.Scer\UAS wing disc | somatic clone, with Scer\GAL4Act5C.PP panΔN.Scer\UAS wing hinge primordium, with Scer\GAL4ap-md544 panΔN.Scer\UAS wing margin, with Scer\GAL4Bx-MS1096 panΔN.Scer\UAS wing margin, with Scer\GAL4vg.PM panΔN.Scer\UAS wing margin | posterior, with Scer\GAL4vg.int2.1 panScer\UAS.cWa wing margin bristle | cell non-autonomous | ectopic | somatic clone pan2
Classical Alleles ( 24 )
For All Classical Alleles Show
Allele of pan Class Mutagen Stocks Known lesion panciD 63 Yes pan2 amorphic allele - genetic evidence 2 Yes pan13a hypomorphic allele - genetic evidence ethyl methanesulfonate 2 Yes panED6366 FLPase 2 -- pan3 amorphic allele - genetic evidence 1 Yes panc06268 piggyBac transposase 1 -- panCB-6424-3 1 -- panf00404 piggyBac transposase 1 -- panf02215 piggyBac transposase 1 -- panf02487 piggyBac transposase 1 -- panKG01431 P-element activity 1 -- pan[EY06866] P-element activity 1 -- pan13 loss of function allele X ray 0 Yes pan1 0 -- panCB-5204-3 Delta2-3 0 Yes panCB-5204-3r FLPase 0 -- panER1 0 -- panIA5 P-element activity 0 Yes panS25 ethyl methanesulfonate 0 Yes panS28 ethyl methanesulfonate 0 Yes panunspecified 0 -- panΔ31 Delta2-3 0 Yes panΔ3M Delta2-3 0 Yes panΔ9M Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pan Class Mutagen Stocks Known lesion panScer\UAS.cWa in vitro construct 4 Yes panΔN.Scer\UAS gain of function allele in vitro construct - deletion in vitro construct - regulatory fusion 4 Yes panGD10429 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes panGD1506 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes panJF02306 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes panKK103601 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes panciD.Scer\UAS in vitro construct - regulatory fusion 0 Yes pandsRNA.cLa in vitro construct - RNAi 0 Yes pandsRNA.cMa in vitro construct - RNAi 0 -- panhs.PW in vitro construct - regulatory fusion 0 Yes panK25A.Scer\UAS in vitro construct - amino acid replacement 0 Yes panScer\FRT.Rnor\CD2.Scer\UAS.T:Avic\GFP in vitro construct - coding region fusion 0 Yes panScer\FRT.Rnor\CD2.Scer\UAS.T:Hsim\VP16 in vitro construct - coding region fusion 0 Yes panScer\FRT.Rnor\CD2.Scer\UAS in vitro construct - regulatory fusion 0 Yes panScer\FRT.Rnor\CD2.Δ.Scer\UAS.T:Avic\GFP in vitro construct - deletion 0 Yes panScer\UAS.cCa FLPase 0 Yes panScer\UAS.T:Avic\GFP FLPase 0 Yes panScer\UAS.T:Hsim\VP16 FLPase 0 Yes panαTub84B.PC in vitro construct - regulatory fusion 0 Yes panΔ.Scer\UAS.T:Avic\GFP FLPase 0 Yes
Aneuploid Aberrations
Disrupted in	Df(4)ED6364 (Roote, 2004.6.24, Ryder et al., 2004, Ryder and Roote, 2004.11.10) Df(4)ED6366 (Roote, 2004.6.24, Ryder et al., 2004, Ryder and Roote, 2004.11.10) Df(4)M101-62f (Dooijes et al., 1998, Cavallo et al., 1998, Kronhamn and Rasmuson-Lestander, 1999, Brunner et al., 1997, van de Wetering et al., 1997) Df(4)Δ3M (Kronhamn and Rasmuson-Lestander, 1999) Df(4)Δ9M (Kronhamn and Rasmuson-Lestander, 1999) In(4)ciD (Schweizer and Basler, 1998, Brunner et al., 1997)
Not disrupted in	Df(4)ED6382 (Ryder and Roote, 2004.11.10) Df(4)M101-63a (Dooijes et al., 1998, Kronhamn and Rasmuson-Lestander, 1999) T(1;4)scH (Sousa-Neves, 1999.11.10, Sousa-Neves, 2000)
Not duplicated in	Dp(4;3)f (Sousa-Neves, 1999.11.10, Matthews, 2002.1.16)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1506} NA P{GD10429} NA P{KK103601} NA P{TRiP.JF02306} NA P{UAS(FRT.CD2,y+)pan.C} NA P{UAS(FRT.CD2,y+)pan.GFP} NA P{UAS(FRT.CD2,y+)pan.VP16} NA P{UAS(FRT.CD2,y+)pan.Δ.GFP} NA P{UAS(-FRT)pan.C} NA P{UAS(-FRT)pan.GFP} NA P{UAS(-FRT)pan.VP16} NA P{UAS(-FRT)pan.Δ.GFP} NA P{UAS-pan.ciD} NA P{UAS-pan.dTCF} NA P{UAS-pan.dTCFΔN} NA P{UAS-pan.K25A} NA heat-shock construct P{hsdTCF} NA characterization construct P{tub-pan.C} NA P{UAS-armC-ΔNpan} NA P{UAS-ci::pan.ciD.S28N} NA P{UAS-ci::pan.ciD.ΔN} NA P{UAS-ci::pan.ciD} NA P{UAS-ci::pan.ciDΔ} NA P{UAS-pygoΔPHD-ΔNpan} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{3'.RS5+3.3'}CG2316ED6366 NA P{RS3}panCB-5204-3 NA P{RS3}panCB-6424-3 NA P{RS3r}panCB-5204-3r NA P{SUPor-P}panKG01431 NA PBac{PB}panc06268 NA PBac{WH}panf00404 NA PBac{WH}panf02215 NA PBac{WH}panf02487 NA insertion of enhancer trap P{lacW}panIA5 No P{lacW}panΔ31 No insertion of mobile activating element P{EPgy2}panEY06866 NA P{GSV1}C705C705 NA
Gene Ontology: Function, Process & Cellular Component ( 24 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function
CV term Evidence References
kinase binding inferred from physical interaction with hipk (Lee et al., 2009) repressing transcription factor binding inferred from physical interaction with Coop (Song et al., 2010) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Thompson, 2004) sequence-specific distal enhancer binding RNA polymerase II transcription factor activity inferred from direct assay (Han et al., 2002) sequence-specific DNA binding inferred from direct assay (Lee and Frasch, 2000)
Biological Process
CV term Evidence References
embryonic pattern specification inferred from mutant phenotype (Schweizer et al., 2003) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Schweizer et al., 2003) positive regulation of gene expression inferred from mutant phenotype (Ward et al., 2006) positive regulation of transcription, DNA-dependent inferred from mutant phenotype (Dichtel-Danjoy et al., 2009) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Thompson, 2004) inferred from expression pattern (Han et al., 2002) regulation of hemocyte differentiation inferred from mutant phenotype (Zettervall et al., 2004) regulation of stem cell proliferation inferred from mutant phenotype (Takashima et al., 2008) regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Chao et al., 2007) salivary gland morphogenesis inferred from mutant phenotype (Harris and Beckendorf, 2007) spiracle morphogenesis, open tracheal system inferred from mutant phenotype (Merabet et al., 2005)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008) nucleus inferred from direct assay (Thompson, 2004) transcription factor complex inferred from physical interaction with Coop (Song et al., 2010)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
heart development traceable author statement (Chen and Fishman, 2000, Cripps and Olson, 2002) mesodermal cell fate determination traceable author statement (Cripps and Olson, 2002) negative regulation of Wnt receptor signaling pathway non-traceable author statement (Harden, 2002) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with mouse Tcf7l2 (FlyBase, 1992-) segment polarity determination non-traceable author statement (Swiss-Prot Project Members, 1997.5.1) Wnt receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1997.5.1) traceable author statement (Chen and Fishman, 2000)
Cellular Component
CV term Evidence References
transcription factor complex inferred from sequence or structural similarity with mouse Tcf7l2 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pan allele Gene References pan1 arm (Cavallo et al., 1998) pan2 arm (Cavallo et al., 1998, Freeman and Bienz, 2001, Barker et al., 2001) puc (McEwen et al., 2000) sgg (Schweizer et al., 2003) shg (Barker et al., 2001) pan3 arm (Cavallo et al., 1998) wg (Cavallo et al., 1998) pan13 Apc (Ahmed et al., 1998) panciD Apc (Ahmed et al., 1998) panS25 wg (Brunner et al., 1997) panS28 wg (Brunner et al., 1997) panScer\UAS.cWa Pka-C1 (Kiger et al., 2001) panunspecified arm (Cox et al., 2000) panΔN.Scer\UAS arm (Cavallo et al., 1998) Axn (Lee and Treisman, 2001) BacA\p35 (Johnston and Sanders, 2003) eyg (Hazelett et al., 1998) gro (Cavallo et al., 1998) nmo (Verheyen et al., 2001) ovo (Payre et al., 1999) tws (Bajpai et al., 2004) wg (Cavallo et al., 1998, Cadigan et al., 2002) Wnt2 (Willert et al., 1999) unspecified arm (Brunner et al., 1997) L (Singh et al., 2006) lin (Hatini et al., 2000) nej (Kumar et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68607 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0085432 DroID - A comprehensive database of gene and protein interactions. • FBgn0085432 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43769
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA14746   Dpse\GA16606   Dsim\pan
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000661-PA Aedes aegypti (mosquito) XP_001604298.1 Nasonia vitripennis (wasp) Smp_125630 Schistosoma mansoni (trematode parasite) NP_001034490.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15871 NV16805 LH21542 ISCW001287 FBgn0232135 FBgn0215627 FBgn0209095 FBgn0067493 FBgn0178106 JGI_V11_8813 FBgn0074773 FBgn0155998 FBgn0136868 FBgn0131443 FBgn0108608 FBgn0096342 CPIJ013913 BGIBMGA005719 ACYPI003084 GB30205 GB10718 AGAP012389 AAEL000656 PHUM222010 GLEAN_03728
Stocks & Reagents
Stocks Listed in FlyBase ( 89 )
Bloomington	22312 y1; P{EPgy2}panEY06866 4838 y1 w1118; P{UAS-pan.dTCF}4 26743 y1 v1; P{TRiP.JF02306}attP2
Harvard	- PBac{PB}panc06268 - PBac{WH}panf00404 - PBac{WH}panf02215 - PBac{WH}panf02487
Kyoto	124097 w1118; P{RS3}panCB-6424-3 107900 y1 w1118; P{UAS-pan.dTCF}4
VDRC	v108679 P{KK103601}VIE-260B v3014 w1118; P{GD1506}v3014 v25940 w1118; P{GD10429}v25940/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR05L22 BACR21B19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 313 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH23203 GM04312 HL03718 IP15537 RE55961 RE59509
Other clones	DPiM_RE59509 RT01139
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH21704 GM13083 RE59484
Other clones	7106 9233 9239 9550 9617 9623 9743 15555 16362 19010 20988 36437 37654 39666 40155 41668 43316 50225 52638 55644 59063 59842 63937 64679 65665 66570 66842 66942 67587 71033 71092 73838 74920 77805 79072 81602 82253 82971 83568 97917 104207 104273 104346 105471 107563 108013 108830 120023 120442 122630 145703 147097 148464 148986 159687 160201 161517 161890 162881 172463 172689 174803 272638 273005 280479 281419 282444 283719 Batuco_16_A08 Batuco_16_E09 CK01.23C.D7 CK01.23C.E7 CK01.26A.D11 CK01.32C.G5 CK01.34A.A10 CK01.60A.F7 CK01.60B.E7 CK01.62B.D12 CK01.65C.B8 CK01.66D.B10 CK01.70D.D2 CK01.72D.C9 CK01.79A.A2 CK01.80C.E5 CK01.80D.B10 CK01.81C.H1 CK01.88D.C3 CK01.88D.H3 CK01.89A.F10 CK01.90A.F12 CK01.91A.F3 CK01.96B.B4 CK01.109B.E12 CK01.114C.G12 CK01.118B.F3 CK01.122B.F3 CK01.129C.F5 CK01.132C.A12 CK01.145C.B10 CK01.170A.H8 EC36314 EC40009 EC052258 EC053746 EC254734 EC256583 EC257420 EC258444 EK003335 EK003345 EK019017 EK021340 EK021416 EK024912 EK037714 EK047416 EK050136 EK053340 EK053939 EK056345 EK056902 EK057511 EK061433 EK062319 EK062439 EK063324 EK063420 EK064229 EK066020 EK069810 EK069954 EK070636 EK070756 EK071322 EK090022 EK092221 EK093322 EK095923 EK097310 EK098752 EK101134 EK108140 EK108433 EK108738 EK108746 EK108750 EK109334 EK117109 EK119737 EK125311 EK133323 EK141243 EK147525 EK150130 EK155427 EK163825 EK165711 EK165912 EK167012 EK170563 EK171107 EK171560 EK173144 EK175947 EK179834 EK182964 EK183823 EK184445 EK189531 EK189701 EK194201 EK194835 EK196248 EK198410 EK198848 EK199035 EK203257 EK204842 EK204952 EK208814 EK211601 EK215758 EK216848 EK216960 EK220654 EK229508 EK233464 EK234031 EK234143 EK238804 EK240637 EK245742 EK247449 EK249617 EK251531 EK254338 EK255142 EK256639 EK258762 EK263215 EK265350 EK266322 EK267022 EK273229 EK273247 EK274036 EK276237 EK277550 EK300013 EK305422 EK306414 EK307738 EK309237 EP04041 EP04447 EP06936 EP08334 EP11524 EP12364 EP13304 EP14356 EP16111 EP19602 EP21654 ESG011b.E7_B07 ESG011b.E21_B07 RP004020926 RP004024714 RP004032348 RP004035343 RP004044870 RP004060875 RP004062853 RP004080168 RP004083045 RP004104060 RP004118680 RP004123426 RP004124124 RP004144738 RP004146478 RP004149177 RP004170608 RP004172611 RP004178453 RP004181017 RP004183603 RP004193707 RP004198187 RP004203327 RP004205558 RP004207597 RP004216370 RP004221727 RP004230989 RP004232046 RP004234554 RP004239699 RP004243138 RP004243791 RP004245023 RP004246830 RP004249110 RP004250394 RP004254401 RP004255724 RP004258223 RP004259645 RP004260743 RP004268548 RP004269297 RP004279624 RP004283083 RP004288380 RP004292555 RP004318383 RP004320646 RP004333131 RP004349274 RP004357290 RP004375203 RP004377128 RP004386157 RP004402173 RP004417785 RP004438591 RP004440644 RP004443991 RP004445402 RP004469799 RP004471816 RP004474702 RP004479057 RP004479855 RP004482157 RP004492476 RP004494652 RP004510657 RP004525923 RP004527591 RP004542905 RP004543680
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0085432 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43769 317816
Antibody Information
	polyclonal (de la Roche and Bienz, 2007)
Other Information
Discoverer
Etymology
	The gene is named 'pangolin' due to the 'lawn of denticles' phenotype of pan[13] homozygotes. (Brunner et al., 1997)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: pan CG32005 (FlyBase Genome Annotators, 2007) Source for merge of: pan IA5 (Kronhamn and Rasmuson-Lestander, 1999)
Additional comments	Annotations CG17964 and CG32005 merged as CG34403 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007)
Other Comments
	dsRNA made from templates generated with primers directed against this gene has been transfected into Kc cells. (Fang et al., 2006) The pan product prevents rho expression in egg chambers. (Ward et al., 2006) ChEST reveals this is a target of Mef2. (Junion et al., 2005) In order to activate pan protein, arm protein must enter the nucleus and form a complex with lgs and pygo proteins. (Thompson, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) pan may have both activator and repressor roles during embryonic patterning, while for wing development pan operates primarily in the activator mode. (Schweizer et al., 2003) FlyBase curator comment: FBrf0151816 has been retracted, see Struhl, 2004, Cell 116(3): 481. (Chan and Struhl, 2002) New annotation (CG32005) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Induction of slp1 by wg involves pan binding to multiple binding sites within a wg-responsive enhancer in the 5' region of slp1. (Lee and Frasch, 2000) arm and pan act together with JNK signalling pathways in both ventral patterning and dorsal closure. (McEwen et al., 2000) The primary function of pan protein binding to the dpp visceral mesoderm enhancer is repression throughout the visceral mesoderm. (Yang et al., 2000) The arm/pan protein complex has a role in the activation of apoptosis during retinal development. (Ahmed et al., 1998) The pan gene product can function as either an activator or a repressor of wg-responsive genes depending on the state of the wg signalling pathway and thus the availability of arm, the pan product coactivator. In the absence of arm, pan acts to repress wg responsive genes, with the gro protein acting as a corepressor. (Cavallo et al., 1998) Genomic organisation of pan is determined: a single copy gene spanning approximately 50kb and composed of 13 exons that share conservation with the exon/intron boundaries of human TCF-1. (Dooijes et al., 1998) The nej gene product represses pan to antagonise wg signalling. (Waltzer and Bienz, 1998) The pan segment polarity gene encodes a product required downstream of arm for wg signal transduction in vivo. (Brunner et al., 1997) pan complexes with arm to form a transcriptional activator of wg target genes. (Cavallo et al., 1997) pan forms a bipartite transcription factor with arm which can potently activate transcription. (Peifer et al., 1997) Mutations in pan cause a segment polarity phenotype. (Peifer et al., 1997) pan functions directly downstream of arm in the establishment of segment polarity and provides a molecular mechanism for gene control by wg signalling. (van de Wetering et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079880 NM_166718 NM_166719 NM_166720 NM_166721 NM_166722 NM_166723 NM_166724 NM_001014685 NM_001038709 RefSeq (Proteins) • NP_524619 NP_726522 NP_726523 NP_726524 NP_726525 NP_726526 NP_726527 NP_726528 NP_001014685 NP_001033798 DDBJ / EMBL / GenBank • AA695697 AA698063 AAC47464 AAF59370 AAF59370.2 AAF59371 AAF59371.2 AAN06544 AAN06544.2 AAN06545 AAN06545.1 AAN06546 AAN06546.1 AAN06547 AAN06547.1 AAN06548 AAN06548.1 AAN06549 AAQ67543 AAQ67544 AAQ67545 AAQ67546 AAQ67547 AAQ67548 AAQ67549 AAQ67550 AAQ67551 AAQ67552 AAQ67553 AAQ67554 AAQ67555 AAQ67556 AAQ67557 AAQ67558 AAQ67559 AAQ67560 AAQ67561 AAQ67562 AAQ67563 AAQ67564 AAQ67565 AAQ67566 AAX33579 AAX52517 ABC65830 AW941213 AY075359 AY312729 AY312730 AY312731 AY312732 AY312733 AY312734 AY312735 AY312736 AY312737 AY312738 AY312739 AY312740 AY312741 AY312742 AY312743 AY312744 AY312745 AY312746 AY312747 AY312748 AY312749 AY312750 AY312751 AY312752 BT021431 BZ286237 CAA70343 CZ470551 CZ482871 CZ484725 CZ485006 U88538 Y09125 Entrez Gene - A searchable database of RefSeq genes. • 43769 UniProtKB/Swiss-Prot • P91943 Q8IMA8 UniProtKB/TrEMBL • Q8IMA8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CTNNB1 binding, N-teminal (IPR013558) High mobility group, superfamily (IPR009071) High mobility group, HMG1/HMG2 (IPR000910)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68607 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0085432 DroID - A comprehensive database of gene and protein interactions. • FBgn0085432 DRSC - Results from RNAi screens. • FBgn0085432 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085432 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17964-RE;CG32005-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0085432 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 97763 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43769 317816 InParanoid A subset of ortholog calls from InParanoid. • AAEL000661-PA Aedes aegypti (mosquito) XP_001604298.1 Nasonia vitripennis (wasp) Smp_125630 Schistosoma mansoni (trematode parasite) NP_001034490.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/pangoln1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43769 modMine - Data generated by the modENCODE project. • FBgn0085432 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15871 NV16805 LH21542 ISCW001287 FBgn0232135 FBgn0215627 FBgn0209095 FBgn0067493 FBgn0178106 JGI_V11_8813 FBgn0074773 FBgn0155998 FBgn0136868 FBgn0131443 FBgn0108608 FBgn0096342 CPIJ013913 BGIBMGA005719 ACYPI003084 GB30205 GB10718 AGAP012389 AAEL000656 PHUM222010 GLEAN_03728 REDfly - A database of transcriptional regulatory elements. • FBgn0085432
Synonyms & Secondary IDs ( 39 )
Reported As
Symbol Synonym	CG17964 (Molnar et al., 2006, Perkins et al., 2009.3.31, Gandhi et al., 2007, Philipps et al., 2004) CG32005 (Masly et al., 2006, Hughes et al., 2008) CG34403 (FlyBase Genome Annotators, 2007, Keleman et al., 2009.8.5) cTCF (Collins and Treisman, 2000) Dm Pan (Konikoff et al., 2010) dTcf (DasGupta et al., 2005, Theisen et al., 2005, Johnston and Sanders, 2003, Kaltschmidt et al., 2002, Markstein and Levine, 2002, Chinnadurai, 2003, Syed and Marsh, 2002, Barker et al., 2001, Marsh et al., 2001, Yang et al., 2000, Chen and Courey, 2000, Theisen et al., 2000, Payre et al., 1999, Payre et al., 1999, Cavallo et al., 1998, Eastman and Grosschedl, 1999, Miska, 1998, Miska, 1998, Russ, 1998, Gallet et al., 1998, Zeng et al., 2008, Benítez et al., 2009, Li et al., 2010, Lawrence et al., 2000) dTCF (Parker et al., 2007, Furlong, 2005, Newfeld, 2005, Zirin and Mann, 2004, Furlong, 2004, Farge, 2003, Newfeld et al., 2005, Newfeld and Takaesu, 2005, Thompson, 2004, Townsley et al., 2004, Syed et al., 2004, Johnson and Newfeld, 2004, Jagla et al., 2004, Guruharsha et al., 2004, Bienz and Clevers, 2003, Jones and Bejsovec, 2003, Klochendler-Yeivin et al., 2002, Thompson et al., 2002, Galis et al., 2002, Butler et al., 2003, Carrera et al., 2003, Lawrence, 2001, Singh et al., 2002, Pandur et al., 2002, Nakagoshi et al., 2002, Cavodeassi et al., 2002, Barolo and Posakony, 2002, Thompson et al., 2002, Barolo and Posakony, 2002, Baylies and Michelson, 2001, Tolwinski and Wieschaus, 2001, Lee and Treisman, 2001, Verheyen et al., 2001, Freeman and Bienz, 2001, Bienz and Clevers, 2000, Ghazi and VijayRaghavan, 2000, Halfon et al., 2000, Simon, 2000, Goodman and Smolik, 2000, McEwen and Peifer, 2000, Pichaud and Casares, 2000, Llimargas, 2000, Cox et al., 2000, Halfon et al., 2000, Seidensticker and Behrens, 2000, Casares and Mann, 2000, Pages and Kerridge, 2000, Glass and Rosenfeld, 2000, Buratovich et al., 2000, Roose and Clevers, 1999, McCartney et al., 1999, van de Wetering, 1996.10.31, Helms et al., 1999, Bejsovec, 1999, Willert et al., 1999, Moline et al., 1999, McCartney et al., 1999, Johnston et al., 1999, Gritzan et al., 1999, Vousden, 1999, Lavery et al., 1999, Kouzarides, 1999, Hays et al., 1999, Cox et al., 1999, Yu et al., 1998, Ben-Ze'ev and Geiger, 1998, Russ, 1998, Cavallo et al., 1998, van Beest et al., 1998, Waltzer and Bienz, 1998, Hazelett et al., 1998, Johnston and Edgar, 1998, Ahmed et al., 1998, Cadigan et al., 1998, Bienz, 1998, Park et al., 1998, Polevoy et al., 1998, Cox and Peifer, 1998, Cox et al., 1997, Clevers and van de Wetering, 1997, Kronhamn and Rasmuson-Lestander, 1997, Cavallo et al., 1997, van de Wetering et al., 1997, Peifer et al., 1997, Cavallo et al., 1997, Maqbool et al., 2006, Theisen et al., 2007, Chung et al., 2007, Benchabane et al., 2011, Benchabane et al., 2011, Kennell and Cadigan, 2008, Philippakis et al., 2006, Chan et al., 2007, Herranz et al., 2008, DeFalco et al., 2008, de la Roche and Bienz, 2007, Tanaka et al., 2007, Tran et al., 2008, Zirin and Mann, 2007, Lin et al., 2008, Dichtel-Danjoy et al., 2009, Mieszczanek et al., 2008, Tokusumi et al., 2009, Singh et al., 2010, Taniue et al., 2010, Metcalfe et al., 2010, Silver et al., 2007, Liu et al., 2010) DTCF (Chihara and Hayashi, 2000, Hepker et al., 1999) DTcf (Perrimon and Nusse, 1998, Cadigan and Nusse, 1997) d-TCF (Blanco et al., 2009) IA5 (Kronhamn and Rasmuson-Lestander, 1999, ) l(4)13 (van Beest et al., 1998, Kronhamn and Rasmuson-Lestander, 1997, Locke and Hanna, 1996, Slusarski et al., 1995, Locke and Tartof, 1994, Orr, 1992, Eaton and Kornberg, 1990, Hochman, 1976, Hochman, 1974, Hochman, 1971, ) l(4)102ABb   Lef (Chao et al., 2007, Bejsovec et al., 2006) LEF-1 (Martinez Arias et al., 2002, Gellon and McGinnis, 1998, Luo et al., 2007) lef1 (Hacker and Perrimon, 1997) LEF1 (Marques, 2005) Lef1 (Marques, 2005) LEF1/TCF (Lee and Stallcup, 2006) LEF/TCF (Moon et al., 2002, Berger et al., 2005) LEF/TCF-1 (Vo and Goodman, 2001) pan (Jordan et al., 2005, Singh et al., 2006, DasGupta et al., 2005, Takacs et al., 2008, Masly et al., 2006, Aerts et al., 2007, Gonsalves et al., 2011, Ma et al., 2006, Buechling et al., 2008, Staedeli and Basler, 2005, Molnar et al., 2006, Haerty et al., 2007, Benchabane et al., 2008, Bhat, 2007, Miech et al., 2008, Junion et al., 2007, Mok et al., 2005, Lee et al., 2009, Kennell et al., 2008, Philipps et al., 2004, Mulinari and Häcker, 2009, DasGupta et al., 2007, Haussmann et al., 2008, Metcalfe et al., 2010, Sato et al., 2006, Beltran et al., 2007) Pan (Chao et al., 2007, Orian et al., 2003, Grienenberger et al., 2000, Sessa and Bianchi, 2007, Lin et al., 2008, Kwon et al., 2004, Song et al., 2010) PAN (Takaesu et al., 2005) pan.dTCF (Chiang et al., 2009) TCF (Franch-Marro et al., 2006, Fang et al., 2006, Stadeli, 2006, Singh et al., 2007, Chang et al., 2007, Ryoo et al., 2004, Bejsovec, 2005, Veeman et al., 2003, Bienz and Hamada, 2004, Kalderon, 2002, Bajpai et al., 2004, Wernet et al., 2003, Yan et al., 2004, Check, 2004, Lin et al., 2003, Mlodzik, 2002, Cadigan et al., 2002, Adachi-Yamada and O'Connor, 2002, Cadigan, 2002, Bienz, 2002, Cohen et al., 2002, Nusse, 2001, Marcu et al., 2001, Behrens, 2000, Peifer and Polakis, 2000, Morin, 1999, Potter et al., 2000, Bienz, 1999, Zhang and Derynck, 1999, Bienz, 1997, Parker et al., 2006, Hayden et al., 2006, Takaesu et al., 2005, Newfeld et al., 2008, Cordero and Cagan, 2010, Parker et al., 2008, Luo et al., 2007, Blauwkamp et al., 2008, Takashima et al., 2008, Estella and Mann, 2008, Takaesu et al., 2008, Liu et al., 2008, Hayden et al., 2007, Chang et al., 2008, Chang et al., 2008, Dichtel-Danjoy et al., 2009, Widmann and Dahmann, 2009, Ayers et al., 2009, Bernard et al., 2009, Kennell et al., 2008, Li et al., 2007, Deb et al., 2008, Ji et al., 2008, Bhambhani et al., 2011) Tcf (Clevers, 2006, He and Axelrod, 2006, Chao et al., 2007, Bejsovec et al., 2007, Barth and Nelson, 2002, Cadigan, 2002, Sharpe et al., 2001, Novak and Dedhar, 1999, Cox and Baylies, 2001, Ahmed et al., 2001, Verrijzer, 1998, Ahmed et al., 1999, Jones, 1998, Verrijzer, 1998, Bejsovec et al., 2006, Tolwinski, 2007, Papadopoulou et al., 2004, Harris and Beckendorf, 2007, Estella et al., 2008, Lee et al., 2009, Jones et al., 2010, Grienenberger et al., 2003, Lawrence et al., 2000) tcf (Blauwkamp et al., 2006, Jaiswal et al., 2006) Tcf-1 (Klein and Martinez Arias, 1999) Tcf/LEF (Nybakken and Perrimon, 2002) TCF/LEF (Gumbinger, 1997) TCF/LEF1 (Barth et al., 1997) unnamed (Tearle and Nusslein-Volhard, 1987)
Name Synonym	CG32005   lethal 13 (Hochman et al., 1964) lymphocyte enhancer binding factor 1/T cell factor (Lee and Stallcup, 2006) pangolin (Jordan et al., 2005, Brunner et al., 1997, Takaesu et al., 2005, Ward et al., 2006, Ma et al., 2006, Buechling et al., 2008, Overton et al., 2007, Takashima et al., 2008, Mok et al., 2005, Lee et al., 2009, Metcalfe et al., 2010, Silver et al., 2007) Pangolin (Arbouzova and McNeill, 2007, Tountas and Fortini, 2007, Theisen et al., 2007, Song et al., 2008, Staedeli and Basler, 2005, Cordero and Cagan, 2010, Dichtel-Danjoy et al., 2009, Wright and Tjian, 2009, Widmann and Dahmann, 2009, Mulinari and Häcker, 2009, Kwon et al., 2004, Song et al., 2010) T cell factor (Philippakis et al., 2006, Chang et al., 2008) T-cell factor (Widmann and Dahmann, 2009) TCF (Zimmerman et al., 2010)
Secondary FlyBase IDs
	FBgn0019664 FBgn0022393 FBgn0052005
References ( 392 )
Generate a list of	All references relating to this gene ( 392 )
List References by type	Research paper  ( 207 ) Supplementary material  ( 8 ) Review  ( 88 ) Retraction  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 58 ) FlyBase analysis  ( 4 ) Meeting report  ( 1 ) Conference report  ( 6 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 15 )
	Benchabane et al., 2011, EMBO J. 30(8): 1444--1458 Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. [FBrf0213544] Bhambhani et al., 2011, EMBO J. 30(10): 2031--2043 The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets. [FBrf0213805] Eivers et al., 2011, Sci. Signal. 4(194): Phosphorylation of Mad Controls Competition Between Wingless and BMP Signaling. [FBrf0216411] Gibert et al., 2011, PLoS Genet. 7(1): e1001280 Segregating Variation in the Polycomb Group Gene cramped Alters the Effect of Temperature on Multiple Traits. [FBrf0212864] Gonsalves et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(15): 5954--5963 An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. [FBrf0214389] Cordero and Cagan, 2010, Dev. Dyn. 239(3): 875--884 Canonical wingless signaling regulates cone cell specification in the Drosophila retina. [FBrf0210104] Jones et al., 2010, J. Cell Sci. 123(13): 2179--2189 Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. [FBrf0211056] Konikoff et al., 2010, J. Mol. Evol. 70(4): 303--312 Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways. [FBrf0210842] Li et al., 2010, Genes Dev. 24(9): 933--946 Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. [FBrf0210675] Liu et al., 2010, J. Cell. Biochem. 109(5): 992--999 JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. [FBrf0210433] Metcalfe et al., 2010, J. Cell Sci. 123(9): 1588--1599 Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization. [FBrf0210630] Singh et al., 2010, Development 137(8): 1351--1360 Dendritic refinement of an identified neuron in the Drosophila CNS is regulated by neuronal activity and Wnt signaling. [FBrf0210379] Song et al., 2010, Genes Dev. 24(9): 881--886 Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling. [FBrf0213249] Taniue et al., 2010, Development 137(10): 1755--1764 Sunspot, a link between Wingless signaling and endoreplication in Drosophila. [FBrf0210642] Zimmerman et al., 2010, Dev. Biol. 340(1): 54--66 Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. [FBrf0210185] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...