FB2019_06, released Dec 19, 2019

Gene: Dmel\pan

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General Information
Symbol
Dmel\pan
Species
D. melanogaster
Name
pangolin
Annotation Symbol
CG34403
Feature Type
protein_coding_gene
FlyBase ID
FBgn0085432
Gene Model Status
Current
Stock Availability
122 publicly available
Gene Snapshot
pangolin (pan) encodes an HMG-domain transcription factor that is a key component of the canonical Wingless signaling pathway. It toggles between acting as a transcriptional repressor (when bound to the product of gro) and activator (when bound to the product of arm) to promote cell fate specification. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
dTCF, TCF, l(4)13, T cell factor, LEF-1
Key Links
Genomic Location
Cytogenetic map
101F1-102A4
Sequence location
4:69,326..114,270 [+]
Recombination map
4-0
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the TCF/LEF family. (P91943Q8IMA8)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; kinase binding; protein binding; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Predictions / Assertions
beta-catenin binding; DNA-binding transcription factor activity; sequence-specific DNA binding; transcription regulatory region DNA binding
Summaries
Gene Group (FlyBase)
HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -
The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).
WNT ENHANCEOSOME -
The Wnt enhanceosome complex binds to Wnt/wg-enhancer elements via the TCF/LEF protein, pan. In the absence nuclear β-catenin (arm), Wnt/wg-responsive genes are silenced by the repressor gro binding to the enhanceosome. Activation of the canonical Wnt signaling pathway leads to arm accumulation in the nucleus, incorporation into the enhanceosome and the stimulation of transcription. (Adapted from FBrf0235074 and FBrf0229654).
Pathway (FlyBase)
Wnt-TCF Signaling Pathway Core Components -
The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Protein Function (UniProtKB)
Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
(UniProt, P91943Q8IMA8)
Summary (Interactive Fly)
transcription factor - HMG domain - segment polarity - acts to transduce the Wingless signal - toggles between acting as a transcriptional repressor (when bound to Groucho) and activator (when bound to Armadillo) to promote cell fate specification
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\pan or the JBrowse view of Dmel\pan for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.41
Gene model reviewed during 5.39
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
pan-RA
FBtr0089161
NM_166718
4129
751
pan-RB
FBtr0089159
NM_079880
3023
751
pan-RD
FBtr0089162
NM_166720
4095
751
pan-RH
FBtr0100245
NM_001014685
4219
747
pan-RI
FBtr0100246
NM_001038709
3795
410
pan-RJ
FBtr0112657
NM_166724
6005
1192
pan-RQ
FBtr0308615
NM_001258476
4954
494
pan-RR
FBtr0309803
NM_001258477
8472
751
pan-RS
FBtr0334301
NM_166723
3101
733
Additional Transcript Data and Comments
Reported size (kB)
2.8 (compiled cDNA)
(Brunner et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
pan-PA
FBpp0088228
81.9
751
7.20
NP_726522
AAF59371
pan-PB
FBpp0088226
81.9
751
7.20
NP_524619
AAN06544
pan-PD
FBpp0088229
81.9
751
7.20
NP_726524
AAN06545
pan-PH
FBpp0099631
81.4
747
7.29
NP_001014685
AAX52517
pan-PI
FBpp0099632
46.3
410
9.21
NP_001033798
ABC65830
pan-PJ
FBpp0111569
132.1
1192
7.13
NP_726528
AAN06549
pan-PQ
FBpp0300839
53.5
494
9.00
NP_001245405
AFH06765
pan-PR
FBpp0301556
81.9
751
7.20
NP_001245406
AFH06766
pan-PS
FBpp0306416
79.9
733
7.37
NP_726527
AAN06548
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

751 aa isoforms: pan-PA, pan-PB, pan-PD, pan-PR
Additional Polypeptide Data and Comments
Reported size (kDa)
751 (aa)
(Brunner et al., 1997)
Comments
A fusion construct containing amino acids 1 to 130 of wild-type pan protein (panwt.cBa) binds 4-5 fold more of the vertebrate arm protein homolog beta-catenin in-vitro than fusion constructs containing amino acids 1 to 130 of either panS25 or panS28 protein. The panS25 and panS28 proteins each differ from wild type pan protein by one amino acid.
(Anonymous, 1997)
Repeats 3-8 of the arm protein interact with aa 1-90 of pan in a yeast two-hybrid assay. The DNA binding site of the pan HMG box was assayed, and revealed the consensus CCTTTGATCTT. Cotransfection of arm and pan vectors resulted in transcriptional activation of a CAT or a Ppyr\LUC reporter, and the C-terminus of arm protein was necessary for this activation. The transactivation capacity of the C-terminus of arm was further demonstrated by fusing it to a GAL4-DNA binding domain, and assaying expression of a CAT reporter.
(van de Wetering et al., 1997)
External Data
Subunit Structure (UniProtKB)
Binds to the beta-catenin homolog arm or to gro.
(UniProt, P91943, Q8IMA8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pan using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (31 terms)
Molecular Function (10 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Thompson, 2004, Lee and Frasch, 2000)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Han et al., 2002)
kinase binding
inferred from physical interaction with FLYBASE:Hipk; FB:FBgn0035142
(Lee et al., 2009)
protein binding
inferred from physical interaction with UniProtKB:P16371
(assigned by UniProt )
(Levanon et al., 1998)
inferred from physical interaction with UniProtKB:P18824
(assigned by UniProt )
(Levanon et al., 1998)
repressing transcription factor binding
inferred from physical interaction with FLYBASE:Coop; FB:FBgn0263240
(Song et al., 2010)
RNA polymerase II proximal promoter sequence-specific DNA binding
inferred from direct assay
(Lee and Frasch, 2000)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
beta-catenin binding
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN000043083
(assigned by GO_Central )
(Gaudet et al., 2011)
sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription regulatory region DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (18 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
canonical Wnt signaling pathway
inferred from mutant phenotype
(Chao et al., 2007, Thompson, 2004)
inferred from genetic interaction with FLYBASE:arm; FB:FBgn0000117
(Cavallo et al., 1998)
inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084
(Brunner et al., 1997)
inferred from direct assay
(Franz et al., 2017, Yanagawa et al., 2000)
cell elongation involved in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Widmann and Dahmann, 2009)
chitin-based larval cuticle pattern formation
inferred from genetic interaction with FLYBASE:SoxN; FB:FBgn0029123
(Chao et al., 2007)
embryonic pattern specification
inferred from mutant phenotype
(Schweizer et al., 2003)
heart development
inferred from mutant phenotype
(Casad et al., 2012)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Schweizer et al., 2003)
negative regulation of transcription, DNA-templated
inferred from mutant phenotype
(assigned by UniProt )
(van de Wetering et al., 1997)
positive regulation of gene expression
inferred from mutant phenotype
(Ward et al., 2006)
positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Thompson, 2004, Lee and Frasch, 2000)
inferred from expression pattern
(Han et al., 2002)
positive regulation of transcription, DNA-templated
inferred from mutant phenotype
(assigned by UniProt )
(van de Wetering et al., 1997)
inferred from mutant phenotype
(Dichtel-Danjoy et al., 2009)
regulation of stem cell proliferation
inferred from mutant phenotype
(Takashima et al., 2008)
regulation of transcription, DNA-templated
inferred from mutant phenotype
(assigned by UniProt )
(van de Wetering et al., 1997)
salivary gland morphogenesis
inferred from mutant phenotype
(Harris and Beckendorf, 2007)
segment polarity determination
inferred from genetic interaction with FLYBASE:SoxN; FB:FBgn0029123
(Chao et al., 2007)
spiracle morphogenesis, open tracheal system
inferred from mutant phenotype
(Merabet et al., 2005)
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
embryonic pattern specification
inferred from sequence or structural similarity with UniProtKB:P91943
(assigned by UniProt )
(UniProt Curators, 2002-)
heart development
traceable author statement
(Cripps and Olson, 2002, Chen and Fishman, 2000)
imaginal disc-derived wing morphogenesis
inferred from sequence or structural similarity with UniProtKB:P91943
(assigned by UniProt )
(UniProt Curators, 2002-)
mesodermal cell fate determination
traceable author statement
(Cripps and Olson, 2002)
regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of transcription, DNA-templated
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
spiracle morphogenesis, open tracheal system
inferred from sequence or structural similarity with UniProtKB:P91943
(assigned by UniProt )
(UniProt Curators, 2002-)
Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
beta-catenin-TCF complex
inferred from physical interaction with UniProtKB:P18824
(Kramps et al., 2002)
inferred from mutant phenotype
(Thompson, 2004)
nucleus
inferred from direct assay
(Thompson, 2004)
transcription factor complex
inferred from physical interaction with FLYBASE:Coop; FB:FBgn0263240
(Song et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription factor complex
inferred from biological aspect of ancestor with PANTHER:PTN000042967
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
beta-catenin-TCF complex
inferred from physical interaction with UniProtKB:P18824
(Kramps et al., 2002)
inferred from mutant phenotype
(Thompson, 2004)
nucleus
inferred from direct assay
(Thompson, 2004)
transcription factor complex
inferred from physical interaction with FLYBASE:Coop; FB:FBgn0263240
(Song et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\pan in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of pan
Transgenic constructs containing regulatory region of pan
Deletions and Duplications ( 11 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4bs-1348
lethal, with Scer\GAL4elav-C155
lethal, with Scer\GAL4hs.2sev
lethal | male, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal | recessive | heat sensitive
lethal - all die before end of embryonic stage, with Scer\GAL4arm.PS
lethal - all die before end of embryonic stage, with Scer\GAL4e22c
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of embryonic stage | rescuable maternal effect
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage, with Scer\GAL430A
lethal - all die before end of pupal stage, with Scer\GAL4dpp.blk1
partially lethal - majority die, with Scer\GAL4dpp.blk1
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
cell shape defective | embryonic stage, with Scer\GAL4svp.PT
cell shape defective | pupal stage, with Scer\GAL4GMR.PU
cell shape defective | pupal stage, with Scer\GAL4sv.PJ
decreased cell number | adult stage, with Scer\GAL4NP5130
decreased cell number | pupal stage, with Scer\GAL4GMR.PU
decreased cell number | pupal stage, with Scer\GAL4sv.PJ
decreased cell number | third instar larval stage, with Scer\GAL4GMR.PU
decreased occurrence of cell division | adult stage, with Scer\GAL4NP5130
decreased occurrence of cell division | third instar larval stage, with Scer\GAL4byn-Gal4
flightless, with Scer\GAL4ebd1.PB
hypoplasia, with Scer\GAL4Mef2.PR
hypoplasia, with Scer\GAL4twi.PG
increased cell death, with Scer\GAL4byn-Gal4, Scer\GAL80ts.αTub84B
increased cell number | larval stage, with Scer\GAL4He.PZ
increased cell number | larval stage, with Scer\GAL4Hml.PG
increased occurrence of cell division | adult stage, with Scer\GAL4NP0001
increased occurrence of cell division | larval stage, with Scer\GAL4bbg-C96
Minute | dominant
mitotic cell cycle defective, with Scer\GAL4bbg-C96
neuroanatomy defective | somatic clone | third instar larval stage, with Scer\GAL4elav.PH
segment polarity phenotype
segment polarity phenotype, with Scer\GAL469B
segment polarity phenotype, with Scer\GAL4e22c
segment polarity phenotype | embryonic stage, with Scer\GAL4e22c
segment polarity phenotype | embryonic stage | rescuable maternal effect
short lived, with Scer\GAL4NP0001
size defective | adult stage, with Scer\GAL4vg.PU
size defective | somatic clone
some die during embryonic stage, with Scer\GAL4arm.PS
some die during embryonic stage, with Scer\GAL4e22c
some die during embryonic stage | recessive
some die during embryonic stage | rescuable maternal effect
some die during larval stage | recessive
some die during pharate adult stage, with Scer\GAL430A
some die during pupal stage, with Scer\GAL4dpp.blk1
visible
visible, with Scer\GAL4Act88F.PD
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4sd-SG29.1
visible, with Scer\GAL4sev.EP
visible, with Scer\GAL4T155
visible, with Scer\GAL4vg.int2.1
visible | adult stage, with Scer\GAL4vg.PU
visible | male limited, with Scer\GAL4Bx-MS1096
visible | recessive
wild-type
wild-type, with Scer\GAL4e22c
Phenotype manifest in
Allele
abdominal sternite bristle
abdominal ventral acute muscle 1 founder cell, with Scer\GAL4twi.PB
abdominal ventral acute muscle 2 founder cell, with Scer\GAL4twi.PB
abdominal ventral acute muscle 3 founder cell, with Scer\GAL4twi.PB
abdominal ventral denticle belt | embryonic stage, with Scer\GAL4e22c
adult cuticle, with Scer\GAL430A
adult heart, with Scer\GAL4tin.CΔ4
adult hindgut, with Scer\GAL4byn-Gal4, Scer\GAL80ts.αTub84B
adult midgut, with Scer\GAL4NP0001
adult midgut epithelium, with Scer\GAL4NP5130
antenna
cone cell | pupal stage, with Scer\GAL4GMR.PU
cone cell | pupal stage, with Scer\GAL4sv.PJ
denticle | ectopic
denticle | ectopic, with Scer\GAL4da.G32
denticle belt
denticle belt, with Scer\GAL4e22c
denticle belt, with Scer\GAL4ptc-559.1
denticle belt, with Scer\GAL4wg.PM
dorsal denticle, with Scer\GAL4da.G32
dorsal denticle | ectopic, with Scer\GAL4ptc-559.1
dorsal fine hair, with Scer\GAL4ptc-559.1
dorsal medial indirect flight muscle, with Scer\GAL41151
dorsal thick hair | ectopic, with Scer\GAL4ptc-559.1
embryo, with Scer\GAL469B
embryo, with Scer\GAL4e22c
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4da.G32
embryonic/first instar larval cuticle, with Scer\GAL4e22c
embryonic/first instar larval cuticle, with Scer\GAL4wg.PM
embryonic/first instar larval cuticle | germline clone | rescuable maternal effect
embryonic/first instar larval cuticle | ventral
embryonic/larval cuticle
embryonic/larval dorsal trunk, with Scer\GAL4btl.PS
embryonic/larval dorsal trunk, with Scer\GAL4salm-LP39
embryonic/larval dorsal vessel | precursor, with Scer\GAL4how-24B, Scer\GAL4twi.PG
embryonic/larval epidermis
embryonic/larval ganglionic branch, with Scer\GAL4btl.PS
embryonic/larval heart, with Scer\GAL4HCH.Hand
embryonic/larval heart, with Scer\GAL4Mef2.PR
embryonic/larval heart, with Scer\GAL4twi.PG
embryonic/larval hindgut, with Scer\GAL4byn-Gal4, Scer\GAL80ts.αTub84B
embryonic/larval neuromuscular junction | somatic clone, with Scer\GAL4elav.PH
embryonic/larval ostium, with Scer\GAL4HCH.Hand
embryonic/larval ostium, with Scer\GAL4Mef2.PR
embryonic/larval ostium, with Scer\GAL4twi.PG
embryonic/larval ostium | embryonic stage, with Scer\GAL4svp.PT
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic/larval tracheal system, with Scer\GAL4btl.PS
embryonic/larval tracheal system, with Scer\GAL4esg-p127
embryonic cardioblast, with Scer\GAL4HCH.Hand
embryonic cardioblast, with Scer\GAL4Mef2.PR
embryonic cardioblast, with Scer\GAL4twi.PG
embryonic epidermis
embryonic epidermis, with Scer\GAL4e22c
embryonic epidermis, with Scer\GAL4ptc-559.1
embryonic epidermis, with Scer\GAL4unspecified
embryonic epidermis | dorsal, with Scer\GAL4da.G32
embryonic epidermis | dorsal, with Scer\GAL4VP16.arm
embryonic epidermis | ventral
embryonic procephalic segment
eye, with Scer\GAL4GMR.PU
filzkorper, with Scer\GAL4ems.HRE
hemocyte, with Scer\GAL430A
hemocyte, with Scer\GAL4He.PZ
hemocyte, with Scer\GAL4Hml.PG
indirect flight muscle, with Scer\GAL41151
indirect flight muscle, with Scer\GAL4ebd1.PB
interommatidial bristle, with Scer\GAL4sev.EP
intestinal stem cell | somatic clone, with Scer\GAL4Tub.PU
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP5130
lamellocyte, with Scer\GAL4He.PZ
lamellocyte, with Scer\GAL4Hml.PG
leg
melanotic mass, with Scer\GAL430A
melanotic mass, with Scer\GAL4He.PZ
melanotic mass, with Scer\GAL4Hml.PG
muscle founder cell, with Scer\GAL4prd.RG1
NMJ bouton | somatic clone, with Scer\GAL4elav.PH
ovary | somatic clone, with Scer\GAL4Act5C.PP
parasegment, with Scer\GAL4ptc-559.1
photoreceptor
pleural membrane
posterior signalling center of lymph gland primary lobe, with Scer\GAL4kn-col85-GAL4
presumptive embryonic/larval digestive system
presumptive embryonic/larval muscle system, with Scer\GAL4prd.RG1
presumptive embryonic salivary gland, with Scer\GAL4fkh.PZ
segment
segment, with Scer\GAL469B
segment, with Scer\GAL4e22c
sternite
sternite, with Scer\GAL4T155
stigmatophore, with Scer\GAL4salm-459.2
tergite, with Scer\GAL4T155
tracheal fusion cell, with Scer\GAL4btl.PS
ventral thoracic disc, with Scer\GAL4Dll-md23
visceral branch, with Scer\GAL4twi.PGa
wing
wing, with Scer\GAL430A
wing, with Scer\GAL4Act88F.PD
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4sd-SG29.1
wing, with Scer\GAL4vg.PM
wing, with Scer\GAL4vg.PU
wing | male limited, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4bbg-C96
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing hinge primordium, with Scer\GAL4ap-md544
wing margin, with Scer\GAL4Bx-MS1096
wing margin, with Scer\GAL4sd-SG29.1
wing margin, with Scer\GAL4vg.PM
wing margin | posterior, with Scer\GAL4vg.int2.1
wing margin | temperature conditional, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
wing margin bristle | cell non-autonomous | ectopic | somatic clone
wing sensillum | ectopic, with Scer\GAL4Bx-MS1096
wing vein | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
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Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TCF7L2
9 of 15
Yes
Yes
Hsap\LEF1
6 of 15
No
Yes
 
Hsap\TCF7L1
6 of 15
No
Yes
Hsap\TCF7
4 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tcf7l2
8 of 15
Yes
Yes
Mmus\Lef1
7 of 15
No
Yes
 
Mmus\Tcf7l1
7 of 15
No
Yes
Mmus\Tcf7
4 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Lef1
6 of 13
Yes
Yes
Rnor\Tcf7l1
4 of 13
No
Yes
Rnor\Tcf7
4 of 13
No
Yes
Rnor\Tcf7l2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\tcf7l1
5 of 12
Yes
Yes
Xtro\tcf7
4 of 12
No
Yes
Xtro\lef1
3 of 12
No
Yes
Xtro\tcf7l2
3 of 12
No
Yes
Danio rerio (Zebrafish) (5)
Drer\lef1
7 of 15
Yes
Yes
Drer\tcf7l1a
7 of 15
Yes
Yes
Drer\tcf7l1b
7 of 15
Yes
Yes
Drer\tcf7
5 of 15
No
Yes
Drer\tcf7l2
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\pop-1
9 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT2G34450
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\ABF2
1 of 15
Yes
No
Scer\NHP10
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC28F2.11
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902BP )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\pan
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007141
Drosophila simulans
Dsim\pan
Drosophila sechellia
Dsec\GM23239
Drosophila erecta
Dere\GG16376
Drosophila yakuba
Dyak\GE14535
Drosophila ananassae
Dana\GF19332
Drosophila pseudoobscura pseudoobscura
Dpse\GA14746
Drosophila persimilis
Dper\GL18397
Drosophila willistoni
Dwil\GK13619
Drosophila virilis
Dvir\GJ21981
Drosophila mojavensis
Dmoj\GI14114
Drosophila grimshawi
Dgri\GH23986
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150HK5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17005667
Musca domestica
House fly
Mdoa\17008787
Musca domestica
House fly
Mdoa\17010796
Musca domestica
House fly
Mdoa\17005672
Glossina morsitans
Tsetse fly
Gmor\GMOY011719
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10756
Mayetiola destructor
Hessian fly
Mdes\Mdes001041
Mayetiola destructor
Hessian fly
Mdes\Mdes001040
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000656
Anopheles darlingi
American malaria mosquito
Adar\ADAC000419
Anopheles gambiae
Malaria mosquito
Agam\AGAP012389
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013913
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0C2Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005719
Danaus plexippus
Monarch butterfly
Dple\DPOGS208615-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016588
Apis florea
Little honeybee
Aflo\2147493921
Apis florea
Little honeybee
Aflo\2147484385
Apis mellifera
Western honey bee
Amel\GB53167
Apis mellifera
Western honey bee
Amel\GB53166
Apis mellifera
Western honey bee
Amel\GB53168
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13825
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13826
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13827
Bombus terrestris
Buff-tailed bumblebee
Bter\15216101
Linepithema humile
Argentine ant
Lhum\LH21540
Linepithema humile
Argentine ant
Lhum\LH21542
Linepithema humile
Argentine ant
Lhum\LH21544
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0007b6
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0007b7
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014832
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04552
Tribolium castaneum
Red flour beetle
Tcas\TC032496
Pediculus humanus
Human body louse
Phum\PHUM222010
Rhodnius prolixus
Kissing bug
Rpro\RPRC010782
Cimex lectularius
Bed bug
Clec\CLEC006659
Cimex lectularius
Bed bug
Clec\CLEC006660
Cimex lectularius
Bed bug
Clec\CLEC006661
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003084
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10574
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0C0T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011680
Ixodes scapularis
Black-legged tick
Isca\ISCW001287
Ixodes scapularis
Black-legged tick
Isca\ISCW001288
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82214.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81965.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g03680
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g03690
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g03640
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_8813
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TCF7L2; transcription factor 7 like 2
    model of  type 2 diabetes mellitus
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TCF7L2; transcription factor 7 like 2
    9 of 15
    602228
    LEF1; lymphoid enhancer binding factor 1
    6 of 15
    153245
         
        TCF7L1; transcription factor 7 like 1
        6 of 15
        604652
            TCF7; transcription factor 7
            4 of 15
            189908
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                pan
                pull down, western blot, two hybrid, bimolecular fluorescence complementation, fluorescence microscopy, two hybrid array
                (Shokri et al., 2019, Hu et al., 2017.6.13, Ravindranath and Cadigan, 2014)
                pan - Abd-B
                bimolecular fluorescence complementation, fluorescence microscopy
                (Baëza et al., 2015)
                pan - Blos1
                two hybrid array
                (Shokri et al., 2019)
                pan - CG13220
                two hybrid
                (Hu et al., 2017.6.13)
                pan - CG14232
                two hybrid
                (Hu et al., 2017.6.13)
                pan - CG4073
                two hybrid
                (Hu et al., 2017.6.13)
                pan - CG7737
                experimental knowledge based
                (Guruharsha et al., 2011)
                pan - Coop
                anti tag coimmunoprecipitation, anti tag western blot
                (Song et al., 2010)
                pan - HIP-R
                experimental knowledge based
                (Guruharsha et al., 2011)
                pan - Hipk
                anti tag coimmunoprecipitation, anti tag western blot
                (Lee et al., 2009)
                pan - Hr78
                two hybrid array
                (Shokri et al., 2019)
                pan - Mad
                anti tag coimmunoprecipitation, anti tag western blot
                (Eivers et al., 2011, Zeng et al., 2008)
                pan - Rel
                two hybrid array
                (Shokri et al., 2019)
                pan - Sox21b
                two hybrid array
                (Shokri et al., 2019)
                pan - Ubx
                bimolecular fluorescence complementation, fluorescence microscopy
                (Baëza et al., 2015)
                pan - abd-A
                bimolecular fluorescence complementation, fluorescence microscopy
                (Bischof et al., 2018)
                pan - arm
                anti bait coimmunoprecipitation, anti tag western blot, two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, western blot
                (Gonsalves et al., 2011, Staedeli and Basler, 2005, Kramps et al., 2002, Von Ohlen and Hooper, 1999, Levanon et al., 1998, Brunner et al., 1997, van de Wetering et al., 1997)
                pan - br
                anti tag coimmunoprecipitation, anti tag western blot
                (Xu et al., 2018)
                pan - ebd1
                pull down, anti tag western blot, anti tag coimmunoprecipitation
                (Benchabane et al., 2011)
                pan - foxo
                anti tag coimmunoprecipitation, anti tag western blot
                (Zhang et al., 2016)
                pan - gro
                pull down, autoradiography
                (Mieszczanek et al., 2008, Levanon et al., 1998)
                pan - lms
                two hybrid array
                (Shokri et al., 2019)
                RNA-RNA
                Physical Interaction
                Assay
                References
                pan - mir-310
                luminiscence technology
                (Pancratov et al., 2013)
                pan - mir-311
                luminiscence technology
                (Pancratov et al., 2013)
                pan - mir-312
                luminiscence technology
                (Pancratov et al., 2013)
                pan - mir-313
                luminiscence technology
                (Pancratov et al., 2013)
                pan - mir-8
                western blot
                (Kennell et al., 2008)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                pan
                suppressible
                arm
                (Benchabane et al., 2011, Lawrence et al., 2000)
                pan
                enhanceable
                ewg
                (Xin et al., 2011)
                pan
                suppressible
                gro
                (Lawrence et al., 2000, Cavallo et al., 1998)
                pan
                suppressible
                nmo
                (Verheyen et al., 2001)
                pan
                suppressible
                ovo
                (Payre et al., 1999)
                pan
                suppressible
                puc
                (McEwen et al., 2000)
                pan
                suppressible
                Rbf
                (Duman-Scheel et al., 2004)
                pan
                enhanceable
                SoxN
                (Chao et al., 2007)
                pan
                suppressible
                SoxN
                (Overton et al., 2007)
                pan
                enhanceable
                tws
                (Bajpai et al., 2004)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Adv
                enhanceable
                pan
                (Srivastava et al., 2002)
                aop
                suppressible
                pan
                (Caviglia and Luschnig, 2013, Olson et al., 2011)
                Apc2|Apc
                suppressible
                pan
                (Wang et al., 2013, Lee et al., 2009)
                Apc2|Apc|Ras85D
                suppressible
                pan
                (Wang et al., 2013)
                Apc
                suppressible
                pan
                (Ahmed et al., 1998)
                arm
                suppressible
                pan
                (Barker et al., 2001, Freeman and Bienz, 2001, Cox et al., 2000, Cavallo et al., 1998)
                Axn
                suppressible
                pan
                (Lee et al., 2009, Lee and Treisman, 2001)
                brk
                suppressible
                pan
                (Yang et al., 2013)
                Chi
                suppressible
                pan
                (van Tienen et al., 2017)
                E2f1
                suppressible
                pan
                (Morris et al., 2008)
                egr
                suppressible
                pan
                (Zhang et al., 2015)
                eyg
                suppressible
                pan
                (Hazelett et al., 1998)
                hep
                suppressible
                pan
                (Zhang et al., 2015)
                hid
                suppressible
                pan
                (Ryoo et al., 2004)
                Hipk
                enhanceable
                pan
                (Blaquiere et al., 2018)
                L
                suppressible
                pan
                (Singh et al., 2006)
                N
                suppressible
                pan
                (Fre et al., 2009)
                nkd
                suppressible
                pan
                (Chan et al., 2007)
                nmo
                suppressible
                pan
                (Verheyen et al., 2001)
                Pka-C1
                suppressible
                pan
                (Kiger et al., 2001)
                puc
                suppressible
                pan
                (Zhang et al., 2015)
                Ret
                suppressible
                pan
                (Perea et al., 2017)
                sgg
                suppressible
                pan
                (Schweizer et al., 2003)
                SH3PX1
                suppressible
                pan
                (Zhang et al., 2019)
                shg
                enhanceable
                pan
                (Barker et al., 2001)
                Sin3A
                suppressible
                pan
                (Das et al., 2013)
                SoxN
                enhanceable
                pan
                (Chao et al., 2007)
                Src42A
                enhanceable
                pan
                (Shindo et al., 2008)
                Uvrag
                suppressible
                pan
                (Nagy et al., 2016)
                wg
                enhanceable
                pan
                (Cavallo et al., 1998)
                wg
                suppressible
                pan
                (Bejsovec and Chao, 2012, Tran et al., 2008, Cadigan et al., 2002, Cavallo et al., 1998, Brunner et al., 1997)
                Wnt2
                suppressible
                pan
                (Willert et al., 1999)
                External Data
                Subunit Structure (UniProtKB)
                Binds to the beta-catenin homolog arm or to gro.
                (UniProt, P91943, Q8IMA8 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Wnt-TCF Signaling Pathway Core Components -
                The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
                Metabolic Pathways
                External Data
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                4
                Recombination map
                4-0
                Cytogenetic map
                101F1-102A4
                Sequence location
                4:69,326..114,270 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                101F1-102A4
                Limits computationally determined from genome sequence between P{SUPor-P}KG01127&PBac{5HPw+}A173 and PBac{5HPw+}A437
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                101F-101F
                (determined by in situ hybridisation)
                (van de Wetering et al., 1997)
                Located at the base of chromosome 4 by in situ hybridisation.
                (Brunner et al., 1997)
                Located at the border of segments 101 and 102.
                (Dooijes et al., 1998)
                Experimentally Determined Recombination Data
                Location
                4-0
                (FlyBase, 2016)
                4-
                (Brunner et al., 1997, Kronhamn and Rasmuson-Lestander, 1997)
                Left of (cM)
                Right of (cM)
                Notes
                Maps close to ci.
                (Kronhamn and Rasmuson-Lestander, 1997)
                Stocks and Reagents
                Stocks (122)
                Genomic Clones (11)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (196)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                polyclonal
                (Junion et al., 2012, de la Roche and Bienz, 2007)
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of
                Source for merge of: pan IA5
                (Kronhamn and Rasmuson-Lestander, 1999)
                Source for merge of: pan CG32005
                (FlyBase Genome Annotators, 2007)
                Additional comments
                Annotations CG17964 and CG32005 merged as CG34403 in release 5.2 of the genome annotation.
                (FlyBase Genome Annotators, 2007)
                Other Comments
                DNA-protein interactions: genome-wide binding profile assayed for pan protein in stage 9-11 embryos; ArrayExpress accession number E-MTAB-1184.
                (Junion et al., 2012)
                dsRNA made from templates generated with primers directed against this gene has been transfected into Kc cells.
                (Fang et al., 2006)
                The pan product prevents rho expression in egg chambers.
                (Ward et al., 2006)
                ChEST reveals this is a target of Mef2.
                (Junion et al., 2005)
                In order to activate pan protein, arm protein must enter the nucleus and form a complex with lgs and pygo proteins.
                (Thompson, 2004)
                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                (Kiger et al., 2003)
                pan may have both activator and repressor roles during embryonic patterning, while for wing development pan operates primarily in the activator mode.
                (Schweizer et al., 2003)
                New annotation (CG32005) in release 3 of the genome annotation.
                (FlyBase Genome Annotators, 2002-2003)
                Induction of slp1 by wg involves pan binding to multiple binding sites within a wg-responsive enhancer in the 5' region of slp1.
                (Lee and Frasch, 2000)
                arm and pan act together with JNK signalling pathways in both ventral patterning and dorsal closure.
                (McEwen et al., 2000)
                The primary function of pan protein binding to the dpp visceral mesoderm enhancer is repression throughout the visceral mesoderm.
                (Yang et al., 2000)
                The arm/pan protein complex has a role in the activation of apoptosis during retinal development.
                (Ahmed et al., 1998)
                The pan gene product can function as either an activator or a repressor of wg-responsive genes depending on the state of the wg signalling pathway and thus the availability of arm, the pan product coactivator. In the absence of arm, pan acts to repress wg responsive genes, with the gro protein acting as a corepressor.
                (Cavallo et al., 1998)
                Genomic organisation of pan is determined: a single copy gene spanning approximately 50kb and composed of 13 exons that share conservation with the exon/intron boundaries of human TCF-1.
                (Dooijes et al., 1998)
                The nej gene product represses pan to antagonise wg signalling.
                (Waltzer and Bienz, 1998)
                The pan segment polarity gene encodes a product required downstream of arm for wg signal transduction in vivo.
                (Brunner et al., 1997)
                pan complexes with arm to form a transcriptional activator of wg target genes.
                (Cavallo et al., 1997)
                pan forms a bipartite transcription factor with arm which can potently activate transcription.
                (Peifer et al., 1997)
                Mutations in pan cause a segment polarity phenotype.
                (Peifer et al., 1997)
                pan functions directly downstream of arm in the establishment of segment polarity and provides a molecular mechanism for gene control by wg signalling.
                (van de Wetering et al., 1997)
                Origin and Etymology
                Discoverer
                Etymology
                The gene is named 'pangolin' due to the 'lawn of denticles' phenotype of pan13 homozygotes.
                (Brunner et al., 1997)
                Identification
                External Crossreferences and Linkouts ( 151 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DPiM - Drosophila Protein interaction map
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (40)
                Reported As
                Symbol Synonym
                CG17964
                (Schertel et al., 2013, Perkins et al., 2009.3.31, Gandhi et al., 2007, Molnar et al., 2006, Philipps et al., 2004)
                CG32005
                (Hughes et al., 2008, Masly et al., 2006)
                CG34403
                (Ni et al., 2010.12.1, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)
                DTCF
                (Chihara and Hayashi, 2000, Hepker et al., 1999)
                DTcf
                (Perrimon and Nusse, 1998, Cadigan and Nusse, 1997)
                Dm Pan
                (Konikoff et al., 2010)
                IA5
                (Kronhamn and Rasmuson-Lestander, 1999)
                LEF
                (Jenny and Basler, 2014)
                LEF-1
                (Luo et al., 2007, Martinez Arias et al., 2002, Gellon and McGinnis, 1998)
                LEF/TCF
                (Hartmann et al., 2009, Moon et al., 2002)
                LEF/TCF-1
                (Vo and Goodman, 2001)
                LEF1
                (Marques, 2005)
                LEF1/TCF
                (Lee and Stallcup, 2006)
                Lef
                (Chao et al., 2007, Bejsovec et al., 2006)
                Lef1
                (Marques, 2005)
                PAN
                (Percival-Smith et al., 2017, Takaesu et al., 2005)
                Pan
                (Zhang et al., 2019, Bischof et al., 2018, Newcomb et al., 2018, Waghmare and Page-McCaw, 2018, Mbodj et al., 2016, Ravindranath and Cadigan, 2016, Baëza et al., 2015, Archbold et al., 2014, Bhambhani et al., 2014, Jenny and Basler, 2014, Zhang et al., 2014, Mbodj et al., 2013, Buechling et al., 2011, Song et al., 2010, Song et al., 2009, Lin et al., 2008, Chao et al., 2007, Sessa and Bianchi, 2007, Kwon et al., 2004, Orian et al., 2003, Grienenberger et al., 2000)
                TCF
                (Liu et al., 2019, Tsai and Galko, 2019, Wu et al., 2019, Requena et al., 2017, Chen et al., 2016, Nagy et al., 2016, Oyallon et al., 2016, Ravindranath and Cadigan, 2016, Bieli et al., 2015, Luo et al., 2015, Herranz et al., 2014, Jenny and Basler, 2014, Slattery et al., 2014, Zhang et al., 2014, Das et al., 2013, Morozov and Ioshikhes, 2013, Wang et al., 2013, Yang et al., 2013, Gistelinck et al., 2012, Bhambhani et al., 2011, Olson et al., 2011, Singh et al., 2011, Xin et al., 2011, Xu et al., 2011, You et al., 2011, Cordero and Cagan, 2010, Itasaki and Hoppler, 2010, Ayers et al., 2009, Bernard et al., 2009, Dichtel-Danjoy et al., 2009, Widmann and Dahmann, 2009, Blauwkamp et al., 2008, Chang et al., 2008, Chang et al., 2008, Chang et al., 2008, Deb et al., 2008, Estella and Mann, 2008, Estella et al., 2008, Kennell et al., 2008, Liu et al., 2008, Newfeld et al., 2008, Parker et al., 2008, Shindo et al., 2008, Takaesu et al., 2008, Takashima et al., 2008, Chang et al., 2007, Hayden et al., 2007, Li et al., 2007, Luo et al., 2007, Singh et al., 2007, Fang et al., 2006, Franch-Marro et al., 2006, Hayden et al., 2006, Parker et al., 2006, Stadeli, 2006, Bejsovec, 2005, Takaesu et al., 2005, Bajpai et al., 2004, Bienz and Hamada, 2004, Check, 2004, Ryoo et al., 2004, Yan et al., 2004, Lin et al., 2003, Veeman et al., 2003, Wernet et al., 2003, Adachi-Yamada and O'Connor, 2002, Bienz, 2002, Cadigan, 2002, Cadigan et al., 2002, Cohen et al., 2002, Kalderon, 2002, Mlodzik, 2002, Marcu et al., 2001, Nusse, 2001, Behrens, 2000, Peifer and Polakis, 2000, Potter et al., 2000, Bienz, 1999, Morin, 1999, Zhang and Derynck, 1999, Bienz, 1997)
                TCF/LEF
                (Gumbinger, 1997)
                TCF/LEF1
                (Barth et al., 1997)
                TCF/Pan
                (Ravindranath and Cadigan, 2014)
                Tcf
                (Komori et al., 2014, Bejsovec, 2013, Bejsovec and Chao, 2012, Zhu et al., 2012, Jones et al., 2010, Lee et al., 2009, Estella et al., 2008, Bejsovec et al., 2007, Chao et al., 2007, Harris and Beckendorf, 2007, Tolwinski, 2007, Bejsovec et al., 2006, Clevers, 2006, He and Axelrod, 2006, Papadopoulou et al., 2004, Grienenberger et al., 2003, Barth and Nelson, 2002, Cadigan, 2002, Ahmed et al., 2001, Cox and Baylies, 2001, Sharpe et al., 2001, Lawrence et al., 2000, Ahmed et al., 1999, Novak and Dedhar, 1999, Jones, 1998, Verrijzer, 1998, Verrijzer, 1998)
                Tcf-1
                (Klein and Martinez Arias, 1999)
                Tcf/LEF
                (Nybakken and Perrimon, 2002)
                d-TCF
                (Blanco et al., 2009)
                dTCF
                (Tian et al., 2019, Won et al., 2019, Zhang et al., 2019, Magri et al., 2018, Frasch, 2016, Tare et al., 2016, Tian et al., 2016, Monfort and Furlong, 2015.1.15, Wittkorn et al., 2015, Caviglia and Luschnig, 2013, Moran et al., 2013, Aboukhalil and Bulyk, 2012, Gistelinck et al., 2012, Junion et al., 2012, Legent et al., 2012, Benchabane et al., 2011, Benchabane et al., 2011, Liu et al., 2010, Metcalfe et al., 2010, Singh et al., 2010, Taniue et al., 2010, Dichtel-Danjoy et al., 2009, Guruharsha et al., 2009, Tokusumi et al., 2009, DeFalco et al., 2008, Herranz et al., 2008, Kennell and Cadigan, 2008, Lin et al., 2008, Mieszczanek et al., 2008, Morris et al., 2008, Tran et al., 2008, Chan et al., 2007, Chung et al., 2007, de la Roche and Bienz, 2007, Parker et al., 2007, Silver et al., 2007, Tanaka et al., 2007, Theisen et al., 2007, Zirin and Mann, 2007, Maqbool et al., 2006, Philippakis et al., 2006, Berger et al., 2005, Furlong, 2005, Newfeld and Takaesu, 2005, Newfeld and Takaesu, 2005, Newfeld et al., 2005, Furlong, 2004, Guruharsha et al., 2004, Jagla et al., 2004, Johnson and Newfeld, 2004, Syed et al., 2004, Thompson, 2004, Townsley et al., 2004, Zirin and Mann, 2004, Bienz and Clevers, 2003, Butler et al., 2003, Carrera et al., 2003, Farge, 2003, Jones and Bejsovec, 2003, Barolo and Posakony, 2002, Barolo and Posakony, 2002, Cavodeassi et al., 2002, Galis et al., 2002, Klochendler-Yeivin et al., 2002, Nakagoshi et al., 2002, Pandur et al., 2002, Singh et al., 2002, Thompson et al., 2002, Thompson et al., 2002, Baylies and Michelson, 2001, Freeman and Bienz, 2001, Lawrence, 2001, Lee and Treisman, 2001, Tolwinski and Wieschaus, 2001, Verheyen et al., 2001, Bienz and Clevers, 2000, Buratovich et al., 2000, Casares and Mann, 2000, Collins and Treisman, 2000, Cox et al., 2000, Ghazi and VijayRaghavan, 2000, Glass and Rosenfeld, 2000, Goodman and Smolik, 2000, Halfon et al., 2000, Halfon et al., 2000, Llimargas, 2000, McEwen and Peifer, 2000, Pages and Kerridge, 2000, Pichaud and Casares, 2000, Seidensticker and Behrens, 2000, Simon, 2000, Bejsovec, 1999, Cox et al., 1999, Gritzan et al., 1999, Hays et al., 1999, Helms et al., 1999, Johnston et al., 1999, Kouzarides, 1999, Lavery et al., 1999, McCartney et al., 1999, McCartney et al., 1999, Moline et al., 1999, Roose and Clevers, 1999, Vousden, 1999, Willert et al., 1999, Ahmed et al., 1998, Ben-Ze'ev and Geiger, 1998, Bienz, 1998, Cadigan et al., 1998, Cavallo et al., 1998, Cox and Peifer, 1998, Hazelett et al., 1998, Johnston and Edgar, 1998, Park et al., 1998, Polevoy et al., 1998, Russ, 1998, van Beest et al., 1998, Waltzer and Bienz, 1998, Yu et al., 1998, Cavallo et al., 1997, Cavallo et al., 1997, Clevers and van de Wetering, 1997, Cox et al., 1997, Kronhamn and Rasmuson-Lestander, 1997, Peifer et al., 1997, van de Wetering et al., 1997, van de Wetering, 1996.10.31)
                dTcf
                (van Tienen et al., 2017, Hirabayashi et al., 2013, Li et al., 2010, Benítez et al., 2009, Zeng et al., 2008, DasGupta et al., 2005, Theisen et al., 2005, Chinnadurai, 2003, Johnston and Sanders, 2003, Kaltschmidt et al., 2002, Markstein and Levine, 2002, Syed and Marsh, 2002, Barker et al., 2001, Marsh et al., 2001, Chen and Courey, 2000, Lawrence et al., 2000, Theisen et al., 2000, Yang et al., 2000, Eastman and Grosschedl, 1999, Payre et al., 1999, Payre et al., 1999, Cavallo et al., 1998, Gallet et al., 1998, Miska, 1998, Miska, 1998, Russ, 1998)
                l(4)102ABb
                l(4)13
                (van Beest et al., 1998, Kronhamn and Rasmuson-Lestander, 1997, Locke and Hanna, 1996, Slusarski et al., 1995, Locke and Tartof, 1994, Orr, 1992, Eaton and Kornberg, 1990, Hochman, 1976, Hochman, 1974, Hochman, 1971)
                lef1
                (Hacker and Perrimon, 1997)
                pan
                (Banerjee et al., 2019, Luhur et al., 2019, Shokri et al., 2019, Trinh et al., 2019, Baranski et al., 2018, Billmann et al., 2018, Wiese et al., 2018, Batut and Gingeras, 2017, Franz et al., 2017, Houtz et al., 2017, Hu et al., 2017.6.13, Lobell et al., 2017, Transgenic RNAi Project members, 2017-, Bielmeier et al., 2016, Morimoto et al., 2016, Oyallon et al., 2016, Trujillo et al., 2016, Zhang et al., 2016, Kok et al., 2015, Schertel et al., 2015, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Boyle et al., 2014, Kerr et al., 2014, Schilling et al., 2014, Shukla et al., 2014, Tang et al., 2014, Taylor et al., 2014, Westholm et al., 2014, Bonke et al., 2013, Howlett et al., 2013, Kwon et al., 2013, Pancratov et al., 2013, Schertel et al., 2013, Tang et al., 2013, Casad et al., 2012, Dupont et al., 2012, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Sousa-Neves and Schinaman, 2012, Giorgianni and Mann, 2011, Gonsalves et al., 2011, Strand and Micchelli, 2011, Toku et al., 2011, Metcalfe et al., 2010, Swaminathan et al., 2010, Tokusumi et al., 2010, Jiang et al., 2009, Lee et al., 2009, Mulinari and Häcker, 2009, Benchabane et al., 2008, Buechling et al., 2008, Haussmann et al., 2008, Kennell et al., 2008, Miech et al., 2008, Takacs et al., 2008, Aerts et al., 2007, Beltran et al., 2007, Bhat, 2007, DasGupta et al., 2007, Haerty et al., 2007, Junion et al., 2007, Ma et al., 2006, Masly et al., 2006, Molnar et al., 2006, Sato et al., 2006, Singh et al., 2006, DasGupta et al., 2005, Jordan et al., 2005, Mok et al., 2005, Staedeli and Basler, 2005, Philipps et al., 2004, Stanyon et al., 2004)
                pan.dTCF
                (Chiang et al., 2009)
                tcf
                (Hirabayashi et al., 2013, Takemura and Adachi-Yamada, 2011, Blauwkamp et al., 2006, Jaiswal et al., 2006)
                Name Synonyms
                CG32005
                Pangolin
                (Ahmed-de-Prado and Baonza, 2018, Bischof et al., 2018, Jenny and Basler, 2014, Ravindranath and Cadigan, 2014, Bonke et al., 2013, Casad et al., 2012, Cordero et al., 2012, Eivers et al., 2011, Takemura and Adachi-Yamada, 2011, Cordero and Cagan, 2010, Song et al., 2010, Dichtel-Danjoy et al., 2009, Mulinari and Häcker, 2009, Song et al., 2009, Widmann and Dahmann, 2009, Wright and Tjian, 2009, Song et al., 2008, Arbouzova and McNeill, 2007, Theisen et al., 2007, Tountas and Fortini, 2007, Staedeli and Basler, 2005, Kwon et al., 2004)
                T cell factor
                (Aboukhalil and Bulyk, 2012, Chang et al., 2008, Philippakis et al., 2006)
                T-cell Factor
                (Wittkorn et al., 2015)
                T-cell factor
                (Widmann and Dahmann, 2009)
                TCF
                (Ahmad, 2017, Zimmerman et al., 2010)
                lethal 13
                (Hochman et al., 1964)
                lymphocyte enhancer binding factor 1/T cell factor
                (Lee and Stallcup, 2006)
                pangolin
                (Wiese et al., 2018, Oyallon et al., 2016, Shukla et al., 2014, Howlett et al., 2013, Khan et al., 2013, Tang et al., 2013, Sousa-Neves and Schinaman, 2012, Singh et al., 2011, Strand and Micchelli, 2011, Metcalfe et al., 2010, Swaminathan et al., 2010, Fre et al., 2009, Lee et al., 2009, Buechling et al., 2008, Kennell et al., 2008, Takashima et al., 2008, Overton et al., 2007, Silver et al., 2007, Ma et al., 2006, Ward et al., 2006, Jordan et al., 2005, Mok et al., 2005, Takaesu et al., 2005, Brunner et al., 1997)
                Secondary FlyBase IDs
                • FBgn0022393
                • FBgn0052005
                • FBgn0019664
                Datasets (1)
                Study focus (1)
                Experimental Role
                Project
                Project Type
                Title
                • bait_protein
                Furlong_ChIP-chip
                ChIP-chip identification of binding sites for transcription factors that regulate mesodermal development.
                References (558)