- Tools
- Downloads
- Links
- Community
- Species
- About
- Help
FB2025_02
,
released April 17, 2025
Dm_3L:26493 , lincRNA.447
Drosophila ortholog of TIAM1 - a guanine nucleotide exchange factor for Rho family GTPases - localized to periactive zone of presynaptic terminals in both the central nervous system and neuromuscular junction - regulates synaptic growth at NMJs - a model for pathogenic TIAM-1 in mutation in humans - Loss of function reduces the survival rate, and the surviving adults exhibit climbing defects, are prone to severe seizures, and have a short lifespan
Please see the JBrowse view of Dmel\sif for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 6.10
Gene model reviewed during 6.02
Gene model reviewed during 5.48
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.55
Gene model reviewed during 6.13
A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).
Gene model reviewed during 6.46
Gene model reviewed during 5.51
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Stop-codon suppression (UAG) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.46
9.233, 7.854 (compiled cDNA)
2064, 2044 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sif using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Expression in stage P3 pupal leg discs is ubiquitous.
In stage 14 embryos, sif transcripts are expressed in several cells per segment in the CNS. At stage 17, expression is observed exclusively in the brain and ventral nerve cord.
sif protein is located in neuropil of the ventral nerve cord in stage 17 embryos. In third instar larvae, it is detected in body wall muscle in the boutons of neuromuscular junctions. sif protein is also found in neuropil in the adult brain. Thus, it is exclusively localized to synaptic regions primarily after the synapses have undergone maturation.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sif in JBrowse3-15
3-13.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New annotation (CG32414) in release 3 of the genome annotation.
Expression of a truncated sif protein results in defects in neuronal morphology and induces membrane ruffling with altered actin localisation in human KB cells.
sif may regulate the change of axon terminal morphology with differentiation into mature synapses.
The sif gene product may regulate synaptic differentiation through the organization of the actin cytoskeleton by activating Rho-like GTPases.
Source for merge of: sif CG5256 CG5406
Source for merge of: sif CG32414
One or more of the processed transcripts for these genes contain several non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG46320 (FBgn0284236) and CG34418 (FBgn0085447).
Annotations CG5406 and CG32414 merged as CG34418 in release 5.2 of the genome annotation.
Source for identity of: sif CG5256
Source for identity of: sif CG5406
