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Gene Dmel\Hmx

General Information
Symbol	Dmel\Hmx	Species	D. melanogaster
Name	H6-like-homeobox	Annotation symbol	CG34419
Feature type	protein_coding_gene	FlyBase ID	FBgn0085448
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CG5832
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	90B5-90B5	Sequence location	3R:13,384,652..13,394,126 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene H6-like-homeobox is referred to in FlyBase by the symbol Dmel\Hmx (CG34419, FBgn0085448). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of transcription, DNA-dependent. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox; Homeobox, conserved site; Homeobox, eukaryotic; Homeodomain-like; Homeodomain-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 3R:13384652..13394126.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA15884 BKN28562 HFA16706 BKN31721
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90B5-90B5   Limits computationally determined from genome sequence between P{PZ}l(3)0788207882 and P{EP}cpoEP3679
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hmx for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hmx-RC FBtr0273220  NM_169763   2691   592
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hmx-PC   FBpp0271728   62.6   592   8.74     NP_732244   AAF55432
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain-related (IPR012287) Homeodomain-like (IPR009057) Homeobox (IPR001356) Homeobox, eukaryotic (IPR020479)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55432   BT028828   BT028860   BT030410   EL879037   EL879038   U17647 AAC46606
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VEI9 Q24016
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 12   procephalic neurogenic region | restricted   (Wang et al., 2000) embryonic stage 10 -- 12   procephalic neuroblast   (Wang et al., 2000) embryonic stage 11 -- 14   ventral nerve cord primordium | restricted & segmentally repeated   (Wang et al., 2000) Comment:single cluster of neuronal precursors per hemisegment embryonic stage 13   germ band | dorsal & segmentally repeated   (Wang et al., 2000) embryonic stage 13 -- 15   protocerebrum primordium | restricted   (Wang et al., 2000) embryonic stage 15 -- 16   ventral nerve cord | restricted & segmentally repeated   (Wang et al., 2000) Comment:two clusters of neuronal precursors per hemisegment embryonic stage 16 -- 17   embryonic optic lobe | restricted   (Wang et al., 2000)
Additional Descriptive Data
	Hmx transcript is first expressed at cellular blastoderm, in bilateral dorsolateral patches in the procephalic neurogenic region, located at about 75% egg length. At embryonic stage 8, a second pair of patches of expression appear 3-4 cell lengths posterior to the first pair, just anterior to the cephalic furrow. At embryonic stage 9, a third pair of patches of expression, anterior to the first pair, appears as the central and posterior patches become fragmented. At embryonic stage 10, Hmx-expressing neuroblasts develop in the Hmx-expressing areas of the procephalic neurogenic region. At stages 13-14, expression is localized to three regions of the protocerebrum primordium. At late stages Hmx is expressed in the embryonic optic lobes. Expression is also observed from stage 11 in a single cluster of neurogenic precursors in each hemisegment of the ventral neurogenic region. By stage 15, Hmx is expressed in two clusters per hemisegment of the ventral nerve cord. (Wang et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0085448    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0085448 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0085448 expression level Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr  (269) embryo 04-06hr  (462) embryo 06-08hr  (343) embryo 08-10hr  (322) embryo 10-12hr  (297) embryo 12-14hr  (226) embryo 14-16hr  (440) embryo 16-18hr  (298) embryo 18-20hr  (355) embryo 20-22hr  (185) embryo 22-24hr  (138) larva L1  (144) larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr  102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0085448 expression level Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr  (269) embryo 04-06hr  (462) embryo 06-08hr  (343) embryo 08-10hr  (322) embryo 10-12hr  (297) embryo 12-14hr  (226) embryo 14-16hr  (440) embryo 16-18hr  (298) embryo 18-20hr  (355) embryo 20-22hr  (185) embryo 22-24hr  138 larva L1  (144) larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr  102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    269 embryo 04-06hr    462 embryo 06-08hr    343 embryo 08-10hr    322 embryo 10-12hr    297 embryo 12-14hr    226 embryo 14-16hr    440 embryo 16-18hr    298 embryo 18-20hr    355 embryo 20-22hr    185 embryo 22-24hr    138 larva L1    144 larva L2    25 larva L3 12hr old    16 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    75 larva L3 puffstage 7-9    66 white prepupae new    73 white prepupae 12hr    102 white prepupae 24hr    89 pupae 2d postWPP    58 pupae 3d postWPP    42 pupae 4d postWPP    31 adult male 01day    30 adult male 05day    47 adult male 30day    50 adult female 01day    18 adult female 05day    4 adult female 30day    5 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0085448    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0085448 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085448 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5829-RA;CG5832-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 HmxGD4361 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Hmx Class Mutagen Stocks Known lesion HmxDG08604 1 -- Hmxf06831 1 -- HmxMB05774 1 -- HmxMI02025 1 -- HmxMI02896 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hmx Class Mutagen Stocks Known lesion HmxGD11781 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HmxGD4361 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4361} NA P{GD11781} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}HmxMI02025 NA Mi{MIC}HmxMI02896 NA P{SUPor-P}KG05113 NA P{wHy}HmxDG08604 NA PBac{WH}Hmxf06831 NA insertion of enhancer trap binary system Mi{ET1}HmxMB05774 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR017970 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:AJ009935 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR012287, InterPro:IPR017970 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:AJ009935 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hmx allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67143 DroID - A comprehensive database of gene and protein interactions. • FBgn0085448 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42110
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA19162   Dpse\GA30058
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001121341.1 Apis mellifera (honey bee) ENSBTAP00000023806 Bos taurus (bovine) CE28148 Caenorhabditis elegans (worm) ENSCAFP00000018666 Canis familiaris (dog) ENSCPOP00000019581 Cavia porcellus (guinea pig) RP00463 Caenorhabditis remanei (nematode) ENSECAP00000011541 Equus caballus (horse) ENSGACP00000012789 Gymnopilus aculeatus (mushroom) ENSGALP00000018022 Gallus gallus (chicken) ENSP00000350549 Homo sapiens (human) ENSMODP00000009369 Monodelphis domestica (gray opossum) ENSMMUP00000027862 Macaca mulatta (rhesus monkey) ENSMUSP00000042716 Mus musculus (house mouse) ENSORLP00000007026 Oryzias latipes (japanese killifish) ENSPPYP00000003191 Pongo pygmaeus (orangutan) ENSPTRP00000046252 Pan troglodytes (chimpanzee) ENSRNOP00000002928 Rattus norvegicus (norway rat) XP_001186022.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967446.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016340 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002665 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000007590 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12622 LH21156 FBgn0242546 FBgn0220980 FBgn0211523 FBgn0189316 FBgn0170162 JGI_V11_29098 JGI_V11_28491 FBgn0151384 FBgn0147517 FBgn0121062 FBgn0114479 CPIJ009678 BGIBMGA010810 ACYPI56493 AAEL014125 PB25801 PHUM433410 GLEAN_12136
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	25233 w1118; Mi{ET1}HmxMB05774 36161 y1 w*; Mi{MIC}HmxMI02896 21666 y1 w67c23; P{wHy}HmxDG08604 32816 y1 w*; Mi{MIC}HmxMI02025/TM3, Sb1 Ser1
Harvard	- PBac{WH}Hmxf06831
VDRC	v16755 w1118; P{GD4361}v16755 v52505 w1118; P{GD11781}v52505
Genomic Clones ( 2 )
	BACR11L13 BACR21K03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP08946 RT01040 RT01140
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP08947
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0085448 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42110 49799
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Hmx CG5829 (FlyBase Genome Annotators, 2007) Source for merge of: Hmx CG5832 (Misra, 2000.7.28)
Additional comments	Annotations CG5832 and CG5829 merged as CG34419 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007) An Hmx knock in to the Mmus\Hmx3 locus (producing a gene with Hmx expression controlled by Mmus\Hmx3 regulatory sequences) rescues the neuroendocrine and inner ear phenotypes of Mmus\Hmx2-, Mmus\Hmx3- double homozygous mice. (Wang et al., 2004)
Other Comments
	Identified as a PCR fragment amplified using primers for the mammalian H6 homeobox gene family.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169763 RefSeq (Proteins) • NP_732244 DDBJ / EMBL / GenBank • AAC46606 AAF55432 U17647 Entrez Gene - A searchable database of RefSeq genes. • 42110 UniProtKB/TrEMBL • Q9VEI9 Q24016
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain-related (IPR012287) Homeodomain-like (IPR009057) Homeobox (IPR001356) Homeobox, eukaryotic (IPR020479)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67143 DroID - A comprehensive database of gene and protein interactions. • FBgn0085448 DRSC - Results from RNAi screens. • FBgn0085448 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0085448 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5829-RA;CG5832-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0085448 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42110 49799 InParanoid A subset of ortholog calls from InParanoid. • XP_001121341.1 Apis mellifera (honey bee) ENSBTAP00000023806 Bos taurus (bovine) CE28148 Caenorhabditis elegans (worm) ENSCAFP00000018666 Canis familiaris (dog) ENSCPOP00000019581 Cavia porcellus (guinea pig) RP00463 Caenorhabditis remanei (nematode) ENSECAP00000011541 Equus caballus (horse) ENSGACP00000012789 Gymnopilus aculeatus (mushroom) ENSGALP00000018022 Gallus gallus (chicken) ENSP00000350549 Homo sapiens (human) ENSMODP00000009369 Monodelphis domestica (gray opossum) ENSMMUP00000027862 Macaca mulatta (rhesus monkey) ENSMUSP00000042716 Mus musculus (house mouse) ENSORLP00000007026 Oryzias latipes (japanese killifish) ENSPPYP00000003191 Pongo pygmaeus (orangutan) ENSPTRP00000046252 Pan troglodytes (chimpanzee) ENSRNOP00000002928 Rattus norvegicus (norway rat) XP_001186022.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967446.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016340 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002665 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000007590 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42110 modMine - Data generated by the modENCODE project. • FBgn0085448 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12622 LH21156 FBgn0242546 FBgn0220980 FBgn0211523 FBgn0189316 FBgn0170162 JGI_V11_29098 JGI_V11_28491 FBgn0151384 FBgn0147517 FBgn0121062 FBgn0114479 CPIJ009678 BGIBMGA010810 ACYPI56493 AAEL014125 PB25801 PHUM433410 GLEAN_12136
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG5829   CG5832 (Popovici et al., 2001, Coulier et al., 2000, ) CG34419 (FlyBase Genome Annotators, 2007) DHmx (Wang et al., 2004) Hmx (Hoskins et al., 2005, )
Name Synonym	CG5829   H6-like-homeobox
Secondary FlyBase IDs
	FBgn0014858 FBgn0038520 FBgn0038521
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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