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Gene Dmel\Prosα2

General Information
Symbol	Dmel\Prosα2	Species	D. melanogaster
Name	Proteasome α2 subunit	Annotation symbol	CG5266
Feature type	protein_coding_gene	FlyBase ID	FBgn0086134
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Pros25, PROS Dm25
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87B10-87B10	Sequence location	3R:8,257,043..8,258,278 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Proteasome α2 subunit is referred to in FlyBase by the symbol Dmel\Prosα2 (CG5266, FBgn0086134). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; cell proliferation; cellular process; mitotic spindle organization. 10 alleles are reported. The phenotype of these alleles is annotated with: ventral furrow. It has one annotated transcript and one annotated polypeptide. Protein features are: Proteasome A-type subunit; Proteasome, alpha-subunit, N-terminal domain; Proteasome, subunit alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1635872_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pros25. Gene sequence location is 3R:8257043..8258278.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87B10-87B10   Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87B-87B   (determined by in situ hybridisation)   (Zaiss and Belote, 1997)
Experimentally Determined Recombination Data
Location	3-48.5 (Belote, 1998.3.17, Smyth and Belote, 1999)
Left of (cM)	sr P{lacW}Vha55j2E9 (Neuburger et al., 2006)
Right of (cM)	st P{PZ}svp07842 (Neuburger et al., 2006) p (Belote, 1998.3.17, Neuburger et al., 2006)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Prosα2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prosα2-RA FBtr0082590  NM_079604   920   234
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prosα2-PA   FBpp0082062   25.9   234   6.68     NP_524328   AAF54814
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome, subunit alpha/beta (IPR001353) Proteasome, alpha-subunit, N-terminal domain (IPR000426) Proteasome A-type subunit (IPR023332) MEROPS - An information resource for peptidases and the proteins that inhibit them • T01.972
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695690   AA803599   AE014297 AAF54814   AI258303   AI388000   AI402328   AI518972   AI534337   AQ254676   AY069280 AAL39425   AY432712   BE976247   BE977432   BI171567   BI215911   BI372467   BI574560   BI586062   BI587528   BI587801   BI588278   BI616805   BI618402   BI623427   BI636254   BI637160   BI639922   BP544446   BP544447   BP551281   BP551282   BP558102   BP558103   BX015707   BX020172   BX060667   BX067263   BX071686   CK661324   CO178852   CO184954   CO191514   CO192563   CO194389   CO276278   CO304198   CO317346   CO321939   CO321952   CO330338   CO330416   EC060004   EC067399   EC074418   EC200422   EC203213   EC222234   EC226980   EC227884   EV575960   EV579830   GH749022   GH749165   GH751790   GH752769   GH761323   GH777156   GH781813   GH782587   GH787509   GH787897   GH788679   GH797303   GH801004   GH804192   GH810293   GH816978   GH817617   GH818647   GH819598   GH821815   GH822815   GH824849   GH824903   GH826157   GH833032   GH833058   GH838180   GH840300   GH840929   GH852540   GH855768   GH858007   GH863876   GH865663   GH867331   GH868826   GH871278   GH875665   GH876060   GH882283   GH883219   GH884064   GH884692   GH892124   GH893754   GH896854   GH897185   GH903467   GH903696   GH904301   GH906253   GH907575   GH910872   GH910982   GH912708   GH912996   GH913849   GH915417   GH918251   GH924772   GH928826   GH931614   GH935622   GH936509   GH937551   GH937686   X70304 CAA49783
UniProtKB/Swiss-Prot	P40301
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   germline cell   (Fisher et al., 2012) embryonic stage 11 -- 12   germline cell   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
proteasome core complex inferred from direct assay (Sumegi et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1106.45 Larval Midgut    1152.3 Larval Hindgut    1195 Larval Malpighian Tubules    1977.7 Larval Fat Body    923.9 Larval Salivary Gland    1467.3 Larval Trachea    1257 Larval Carcass    1776.325 Adult Head    574.2 Adult Eye    537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop    954.9 Adult Midgut    774.4 Adult Hindgut    648.5 Adult Malpighian Tubules    521.5 Adult Fat Body    1604.7 Adult Salivary Gland    529.1 Adult Heart    1729.275 Adult VirginFemale Spermatheca    639.5 Adult InseminatedFemale Spermatheca    615 Adult Ovary    1324.9 Adult Testis    864.1 Adult Male Accessory Gland    1003.3 Adult Carcass    1255.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1106.45) Larval Midgut  (1152.3) Larval Hindgut  (1195) Larval Malpighian Tubules  (1977.7) Larval Fat Body  (923.9) Larval Salivary Gland  (1467.3) Larval Trachea  (1257) Larval Carcass  (1776.325) Adult Head  (574.2) Adult Eye  537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop  (954.9) Adult Midgut  (774.4) Adult Hindgut  (648.5) Adult Malpighian Tubules  521.5 Adult Fat Body  (1604.7) Adult Salivary Gland  529.1 Adult Heart  (1729.275) Adult VirginFemale Spermatheca  (639.5) Adult InseminatedFemale Spermatheca  (615) Adult Ovary  (1324.9) Adult Testis  (864.1) Adult Male Accessory Gland  (1003.3) Adult Carcass  (1255.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1106.45) Larval Midgut  (1152.3) Larval Hindgut  (1195) Larval Malpighian Tubules  (1977.7) Larval Fat Body    923.9 Larval Salivary Gland  (1467.3) Larval Trachea  (1257) Larval Carcass  (1776.325) Adult Head    574.2 Adult Eye    537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop    954.9 Adult Midgut    774.4 Adult Hindgut    648.5 Adult Malpighian Tubules    521.5 Adult Fat Body  (1604.7) Adult Salivary Gland    529.1 Adult Heart  (1729.275) Adult VirginFemale Spermatheca    639.5 Adult InseminatedFemale Spermatheca    615 Adult Ovary  (1324.9) Adult Testis    864.1 Adult Male Accessory Gland  1003.3 Adult Carcass  (1255.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1106.45 Larval Midgut    1152.3 Larval Hindgut    1195 Larval Malpighian Tubules    1977.7 Larval Fat Body    923.9 Larval Salivary Gland    1467.3 Larval Trachea    1257 Larval Carcass    1776.325 Adult Head    574.2 Adult Eye    537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop    954.9 Adult Midgut    774.4 Adult Hindgut    648.5 Adult Malpighian Tubules    521.5 Adult Fat Body    1604.7 Adult Salivary Gland    529.1 Adult Heart    1729.275 Adult VirginFemale Spermatheca    639.5 Adult InseminatedFemale Spermatheca    615 Adult Ovary    1324.9 Adult Testis    864.1 Adult Male Accessory Gland    1003.3 Adult Carcass    1255.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1106.45 Larval Midgut    1152.3 Larval Hindgut    1195 Larval Malpighian Tubules    1977.7 Larval Fat Body    923.9 Larval Salivary Gland    1467.3 Larval Trachea    1257 Larval Carcass    1776.325 Adult Head    574.2 Adult Eye    537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop    954.9 Adult Midgut    774.4 Adult Hindgut    648.5 Adult Malpighian Tubules    521.5 Adult Fat Body    1604.7 Adult Salivary Gland    529.1 Adult Heart    1729.275 Adult VirginFemale Spermatheca    639.5 Adult InseminatedFemale Spermatheca    615 Adult Ovary    1324.9 Adult Testis    864.1 Adult Male Accessory Gland    1003.3 Adult Carcass    1255.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1106.45) Larval Midgut  (1152.3) Larval Hindgut  (1195) Larval Malpighian Tubules  (1977.7) Larval Fat Body  (923.9) Larval Salivary Gland  (1467.3) Larval Trachea  (1257) Larval Carcass  (1776.325) Adult Head  574.2 Adult Eye  537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop  (954.9) Adult Midgut  774.4 Adult Hindgut  648.5 Adult Malpighian Tubules  521.5 Adult Fat Body  (1604.7) Adult Salivary Gland  529.1 Adult Heart  (1729.275) Adult VirginFemale Spermatheca  639.5 Adult InseminatedFemale Spermatheca  615 Adult Ovary  (1324.9) Adult Testis  (864.1) Adult Male Accessory Gland  (1003.3) Adult Carcass  (1255.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1106.45 Larval Midgut  1152.3 Larval Hindgut  1195 Larval Malpighian Tubules  (1977.7) Larval Fat Body    923.9 Larval Salivary Gland  1467.3 Larval Trachea  1257 Larval Carcass  (1776.325) Adult Head    574.2 Adult Eye    537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop    954.9 Adult Midgut    774.4 Adult Hindgut    648.5 Adult Malpighian Tubules    521.5 Adult Fat Body  1604.7 Adult Salivary Gland    529.1 Adult Heart  (1729.275) Adult VirginFemale Spermatheca    639.5 Adult InseminatedFemale Spermatheca    615 Adult Ovary  1324.9 Adult Testis    864.1 Adult Male Accessory Gland  1003.3 Adult Carcass  1255.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1106.45 Larval Midgut    1152.3 Larval Hindgut    1195 Larval Malpighian Tubules    1977.7 Larval Fat Body    923.9 Larval Salivary Gland    1467.3 Larval Trachea    1257 Larval Carcass    1776.325 Adult Head    574.2 Adult Eye    537.925 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    424.6 Adult Crop    954.9 Adult Midgut    774.4 Adult Hindgut    648.5 Adult Malpighian Tubules    521.5 Adult Fat Body    1604.7 Adult Salivary Gland    529.1 Adult Heart    1729.275 Adult VirginFemale Spermatheca    639.5 Adult InseminatedFemale Spermatheca    615 Adult Ovary    1324.9 Adult Testis    864.1 Adult Male Accessory Gland    1003.3 Adult Carcass    1255.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    574.2   NA  Eye    537.925   NA  Brain    354.9   1106.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    424.6   NA  Crop    954.9   1152.3  Midgut    774.4   1195  Hindgut    648.5   1977.7  Malpighian Tubules    521.5   923.9  Fat Body    1604.7   1467.3  Salivary Gland    529.1   NA  Heart    1729.275   1257  Trachea    NA   NA  VirginFemale Spermatheca    639.5   NA  InseminatedFemale Spermatheca    615   NA  Ovary    1324.9   NA  Testis    864.1   NA  Male Accessory Gland    1003.3   1776.325  Carcass    1255.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    214 central nervous system, larvae L3    153 central nervous system, pupae P8    52 head, virgin 1-day female    34 head, virgin 4-day female    34 head, virgin 20-day female    41 head, mated 1-day female    33 head, mated 4-day female    31 head, mated 20-day female    44 head, mated 1-day male    43 head, mated 4-day male    51 head, mated 20-day male    73 salivary gland, larvae L3 wandering    46 salivary gland, white prepupae    83 digestive system, larvae L3 wandering    247 digestive system, 1-day adult    69 digestive system, 4-day adult    76 digestive system, 20-day adult    72 fat body, larvae L3 wandering    51 fat body, white prepupae    130 fat body, pupae P8    92 carcass, larvae L3 wandering    267 carcass, 1-day adult    73 carcass, 4-day adult    93 carcass, 20-day adult    89 ovary, virgin 4-day female    186 ovary, mated 4-day female    158 testis, mated 4-day male    292 accessory gland, mated 4-day male    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (214) central nervous system, larvae L3  (153) central nervous system, pupae P8  (52) head, virgin 1-day female  (34) head, virgin 4-day female  (34) head, virgin 20-day female  (41) head, mated 1-day female  (33) head, mated 4-day female  (31) head, mated 20-day female  (44) head, mated 1-day male  (43) head, mated 4-day male  (51) head, mated 20-day male  (73) salivary gland, larvae L3 wandering  (46) salivary gland, white prepupae  (83) digestive system, larvae L3 wandering  (247) digestive system, 1-day adult  (69) digestive system, 4-day adult  (76) digestive system, 20-day adult  (72) fat body, larvae L3 wandering  (51) fat body, white prepupae  (130) fat body, pupae P8  (92) carcass, larvae L3 wandering  (267) carcass, 1-day adult  (73) carcass, 4-day adult  (93) carcass, 20-day adult  (89) ovary, virgin 4-day female  (186) ovary, mated 4-day female  (158) testis, mated 4-day male  (292) accessory gland, mated 4-day male  (76) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (214) central nervous system, larvae L3  (153) central nervous system, pupae P8    52 head, virgin 1-day female    34 head, virgin 4-day female    34 head, virgin 20-day female    41 head, mated 1-day female    33 head, mated 4-day female    31 head, mated 20-day female    44 head, mated 1-day male    43 head, mated 4-day male    51 head, mated 20-day male    73 salivary gland, larvae L3 wandering    46 salivary gland, white prepupae    83 digestive system, larvae L3 wandering  (247) digestive system, 1-day adult    69 digestive system, 4-day adult    76 digestive system, 20-day adult    72 fat body, larvae L3 wandering    51 fat body, white prepupae  (130) fat body, pupae P8    92 carcass, larvae L3 wandering  (267) carcass, 1-day adult    73 carcass, 4-day adult    93 carcass, 20-day adult    89 ovary, virgin 4-day female  (186) ovary, mated 4-day female  (158) testis, mated 4-day male  (292) accessory gland, mated 4-day male    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    214 central nervous system, larvae L3    153 central nervous system, pupae P8    52 head, virgin 1-day female    34 head, virgin 4-day female    34 head, virgin 20-day female    41 head, mated 1-day female    33 head, mated 4-day female    31 head, mated 20-day female    44 head, mated 1-day male    43 head, mated 4-day male    51 head, mated 20-day male    73 salivary gland, larvae L3 wandering    46 salivary gland, white prepupae    83 digestive system, larvae L3 wandering    247 digestive system, 1-day adult    69 digestive system, 4-day adult    76 digestive system, 20-day adult    72 fat body, larvae L3 wandering    51 fat body, white prepupae    130 fat body, pupae P8    92 carcass, larvae L3 wandering    267 carcass, 1-day adult    73 carcass, 4-day adult    93 carcass, 20-day adult    89 ovary, virgin 4-day female    186 ovary, mated 4-day female    158 testis, mated 4-day male    292 accessory gland, mated 4-day male    76 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    214 central nervous system, larvae L3    153 central nervous system, pupae P8    52 head, virgin 1-day female    34 head, virgin 4-day female    34 head, virgin 20-day female    41 head, mated 1-day female    33 head, mated 4-day female    31 head, mated 20-day female    44 head, mated 1-day male    43 head, mated 4-day male    51 head, mated 20-day male    73 salivary gland, larvae L3 wandering    46 salivary gland, white prepupae    83 digestive system, larvae L3 wandering    247 digestive system, 1-day adult    69 digestive system, 4-day adult    76 digestive system, 20-day adult    72 fat body, larvae L3 wandering    51 fat body, white prepupae    130 fat body, pupae P8    92 carcass, larvae L3 wandering    267 carcass, 1-day adult    73 carcass, 4-day adult    93 carcass, 20-day adult    89 ovary, virgin 4-day female    186 ovary, mated 4-day female    158 testis, mated 4-day male    292 accessory gland, mated 4-day male    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (214) central nervous system, larvae L3  (153) central nervous system, pupae P8  (52) head, virgin 1-day female  (34) head, virgin 4-day female  (34) head, virgin 20-day female  (41) head, mated 1-day female  (33) head, mated 4-day female  31 head, mated 20-day female  (44) head, mated 1-day male  (43) head, mated 4-day male  (51) head, mated 20-day male  (73) salivary gland, larvae L3 wandering  (46) salivary gland, white prepupae  (83) digestive system, larvae L3 wandering  (247) digestive system, 1-day adult  (69) digestive system, 4-day adult  (76) digestive system, 20-day adult  (72) fat body, larvae L3 wandering  (51) fat body, white prepupae  (130) fat body, pupae P8  (92) carcass, larvae L3 wandering  (267) carcass, 1-day adult  (73) carcass, 4-day adult  (93) carcass, 20-day adult  (89) ovary, virgin 4-day female  (186) ovary, mated 4-day female  (158) testis, mated 4-day male  (292) accessory gland, mated 4-day male  (76) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (214) central nervous system, larvae L3  (153) central nervous system, pupae P8    52 head, virgin 1-day female    34 head, virgin 4-day female    34 head, virgin 20-day female    41 head, mated 1-day female    33 head, mated 4-day female    31 head, mated 20-day female    44 head, mated 1-day male    43 head, mated 4-day male    51 head, mated 20-day male    73 salivary gland, larvae L3 wandering    46 salivary gland, white prepupae    83 digestive system, larvae L3 wandering  (247) digestive system, 1-day adult    69 digestive system, 4-day adult    76 digestive system, 20-day adult    72 fat body, larvae L3 wandering    51 fat body, white prepupae  130 fat body, pupae P8    92 carcass, larvae L3 wandering  (267) carcass, 1-day adult    73 carcass, 4-day adult    93 carcass, 20-day adult    89 ovary, virgin 4-day female  (186) ovary, mated 4-day female  (158) testis, mated 4-day male  (292) accessory gland, mated 4-day male    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    214 central nervous system, larvae L3    153 central nervous system, pupae P8    52 head, virgin 1-day female    34 head, virgin 4-day female    34 head, virgin 20-day female    41 head, mated 1-day female    33 head, mated 4-day female    31 head, mated 20-day female    44 head, mated 1-day male    43 head, mated 4-day male    51 head, mated 20-day male    73 salivary gland, larvae L3 wandering    46 salivary gland, white prepupae    83 digestive system, larvae L3 wandering    247 digestive system, 1-day adult    69 digestive system, 4-day adult    76 digestive system, 20-day adult    72 fat body, larvae L3 wandering    51 fat body, white prepupae    130 fat body, pupae P8    92 carcass, larvae L3 wandering    267 carcass, 1-day adult    73 carcass, 4-day adult    93 carcass, 20-day adult    89 ovary, virgin 4-day female    186 ovary, mated 4-day female    158 testis, mated 4-day male    292 accessory gland, mated 4-day male    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    349 embryo 02-04hr    327 embryo 04-06hr    96 embryo 06-08hr    74 embryo 08-10hr    78 embryo 10-12hr    75 embryo 12-14hr    44 embryo 14-16hr    48 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    30 embryo 22-24hr    27 larva L1    69 larva L2    129 larva L3 12hr old    104 larva L3 puffstage 1-2    160 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    313 white prepupae new    339 white prepupae 12hr    151 white prepupae 24hr    165 pupae 2d postWPP    113 pupae 3d postWPP    80 pupae 4d postWPP    151 adult male 01day    124 adult male 05day    148 adult male 30day    155 adult female 01day    185 adult female 05day    207 adult female 30day    220 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (349) embryo 02-04hr  (327) embryo 04-06hr  (96) embryo 06-08hr  (74) embryo 08-10hr  (78) embryo 10-12hr  (75) embryo 12-14hr  (44) embryo 14-16hr  (48) embryo 16-18hr  (34) embryo 18-20hr  (32) embryo 20-22hr  (30) embryo 22-24hr  (27) larva L1  (69) larva L2  (129) larva L3 12hr old  (104) larva L3 puffstage 1-2  (160) larva L3 puffstage 3-6  (256) larva L3 puffstage 7-9  (313) white prepupae new  (339) white prepupae 12hr  (151) white prepupae 24hr  (165) pupae 2d postWPP  (113) pupae 3d postWPP  (80) pupae 4d postWPP  (151) adult male 01day  (124) adult male 05day  (148) adult male 30day  (155) adult female 01day  (185) adult female 05day  (207) adult female 30day  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (349) embryo 02-04hr  (327) embryo 04-06hr    96 embryo 06-08hr    74 embryo 08-10hr    78 embryo 10-12hr    75 embryo 12-14hr    44 embryo 14-16hr    48 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    30 embryo 22-24hr    27 larva L1    69 larva L2  (129) larva L3 12hr old  104 larva L3 puffstage 1-2  (160) larva L3 puffstage 3-6  (256) larva L3 puffstage 7-9  (313) white prepupae new  (339) white prepupae 12hr  (151) white prepupae 24hr  (165) pupae 2d postWPP  (113) pupae 3d postWPP    80 pupae 4d postWPP  (151) adult male 01day  (124) adult male 05day  (148) adult male 30day  (155) adult female 01day  (185) adult female 05day  (207) adult female 30day  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    349 embryo 02-04hr    327 embryo 04-06hr    96 embryo 06-08hr    74 embryo 08-10hr    78 embryo 10-12hr    75 embryo 12-14hr    44 embryo 14-16hr    48 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    30 embryo 22-24hr    27 larva L1    69 larva L2    129 larva L3 12hr old    104 larva L3 puffstage 1-2    160 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    313 white prepupae new    339 white prepupae 12hr    151 white prepupae 24hr    165 pupae 2d postWPP    113 pupae 3d postWPP    80 pupae 4d postWPP    151 adult male 01day    124 adult male 05day    148 adult male 30day    155 adult female 01day    185 adult female 05day    207 adult female 30day    220 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    349 embryo 02-04hr    327 embryo 04-06hr    96 embryo 06-08hr    74 embryo 08-10hr    78 embryo 10-12hr    75 embryo 12-14hr    44 embryo 14-16hr    48 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    30 embryo 22-24hr    27 larva L1    69 larva L2    129 larva L3 12hr old    104 larva L3 puffstage 1-2    160 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    313 white prepupae new    339 white prepupae 12hr    151 white prepupae 24hr    165 pupae 2d postWPP    113 pupae 3d postWPP    80 pupae 4d postWPP    151 adult male 01day    124 adult male 05day    148 adult male 30day    155 adult female 01day    185 adult female 05day    207 adult female 30day    220 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (349) embryo 02-04hr  (327) embryo 04-06hr  (96) embryo 06-08hr  (74) embryo 08-10hr  (78) embryo 10-12hr  (75) embryo 12-14hr  (44) embryo 14-16hr  (48) embryo 16-18hr  (34) embryo 18-20hr  32 embryo 20-22hr  30 embryo 22-24hr  27 larva L1  (69) larva L2  (129) larva L3 12hr old  (104) larva L3 puffstage 1-2  (160) larva L3 puffstage 3-6  (256) larva L3 puffstage 7-9  (313) white prepupae new  (339) white prepupae 12hr  (151) white prepupae 24hr  (165) pupae 2d postWPP  (113) pupae 3d postWPP  (80) pupae 4d postWPP  (151) adult male 01day  (124) adult male 05day  (148) adult male 30day  (155) adult female 01day  (185) adult female 05day  (207) adult female 30day  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (349) embryo 02-04hr  (327) embryo 04-06hr    96 embryo 06-08hr    74 embryo 08-10hr    78 embryo 10-12hr    75 embryo 12-14hr    44 embryo 14-16hr    48 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    30 embryo 22-24hr    27 larva L1    69 larva L2  129 larva L3 12hr old  104 larva L3 puffstage 1-2  (160) larva L3 puffstage 3-6  (256) larva L3 puffstage 7-9  (313) white prepupae new  (339) white prepupae 12hr  (151) white prepupae 24hr  (165) pupae 2d postWPP  113 pupae 3d postWPP    80 pupae 4d postWPP  (151) adult male 01day  124 adult male 05day  (148) adult male 30day  (155) adult female 01day  (185) adult female 05day  (207) adult female 30day  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    349 embryo 02-04hr    327 embryo 04-06hr    96 embryo 06-08hr    74 embryo 08-10hr    78 embryo 10-12hr    75 embryo 12-14hr    44 embryo 14-16hr    48 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    30 embryo 22-24hr    27 larva L1    69 larva L2    129 larva L3 12hr old    104 larva L3 puffstage 1-2    160 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    313 white prepupae new    339 white prepupae 12hr    151 white prepupae 24hr    165 pupae 2d postWPP    113 pupae 3d postWPP    80 pupae 4d postWPP    151 adult male 01day    124 adult male 05day    148 adult male 30day    155 adult female 01day    185 adult female 05day    207 adult female 30day    220 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    366 Schneider line 2 Sg4    339 embryonic 1182-4H    175 embryonic GM2    181 embryonic Kc167    172 embryonic S1    284 embryonic S3    156 leg disc CME L1    289 wing disc CME-W2    211 wing disc ML-DmD8    245 wing disc ML-DmD9    213 wing disc ML-DmD16-c3    252 wing disc ML-DmD21    204 wing disc ML-DmD32    265 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    191 antennal disc ML-DmD20-c5    258 mixed discs ML-DmD4-c1    255 CNS ML-DmBG1-c1    242 CNS ML-DmBG2-c2    245 tumorous blood cells mbn2    204 ovary fGS/OSS    130 ovary OSC    143 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (366) Schneider line 2 Sg4  (339) embryonic 1182-4H  (175) embryonic GM2  (181) embryonic Kc167  (172) embryonic S1  (284) embryonic S3  (156) leg disc CME L1  (289) wing disc CME-W2  (211) wing disc ML-DmD8  (245) wing disc ML-DmD9  (213) wing disc ML-DmD16-c3  (252) wing disc ML-DmD21  (204) wing disc ML-DmD32  (265) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (191) antennal disc ML-DmD20-c5  (258) mixed discs ML-DmD4-c1  (255) CNS ML-DmBG1-c1  (242) CNS ML-DmBG2-c2  (245) tumorous blood cells mbn2  (204) ovary fGS/OSS  (130) ovary OSC  (143) ovary OSS  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (366) Schneider line 2 Sg4  (339) embryonic 1182-4H  (175) embryonic GM2  (181) embryonic Kc167  (172) embryonic S1  (284) embryonic S3  (156) leg disc CME L1  (289) wing disc CME-W2  (211) wing disc ML-DmD8  (245) wing disc ML-DmD9  (213) wing disc ML-DmD16-c3  (252) wing disc ML-DmD21  (204) wing disc ML-DmD32  (265) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (191) antennal disc ML-DmD20-c5  (258) mixed discs ML-DmD4-c1  (255) CNS ML-DmBG1-c1  (242) CNS ML-DmBG2-c2  (245) tumorous blood cells mbn2  (204) ovary fGS/OSS  (130) ovary OSC  (143) ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    366 Schneider line 2 Sg4    339 embryonic 1182-4H    175 embryonic GM2    181 embryonic Kc167    172 embryonic S1    284 embryonic S3    156 leg disc CME L1    289 wing disc CME-W2    211 wing disc ML-DmD8    245 wing disc ML-DmD9    213 wing disc ML-DmD16-c3    252 wing disc ML-DmD21    204 wing disc ML-DmD32    265 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    191 antennal disc ML-DmD20-c5    258 mixed discs ML-DmD4-c1    255 CNS ML-DmBG1-c1    242 CNS ML-DmBG2-c2    245 tumorous blood cells mbn2    204 ovary fGS/OSS    130 ovary OSC    143 ovary OSS    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    366 Schneider line 2 Sg4    339 embryonic 1182-4H    175 embryonic GM2    181 embryonic Kc167    172 embryonic S1    284 embryonic S3    156 leg disc CME L1    289 wing disc CME-W2    211 wing disc ML-DmD8    245 wing disc ML-DmD9    213 wing disc ML-DmD16-c3    252 wing disc ML-DmD21    204 wing disc ML-DmD32    265 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    191 antennal disc ML-DmD20-c5    258 mixed discs ML-DmD4-c1    255 CNS ML-DmBG1-c1    242 CNS ML-DmBG2-c2    245 tumorous blood cells mbn2    204 ovary fGS/OSS    130 ovary OSC    143 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (366) Schneider line 2 Sg4  (339) embryonic 1182-4H  (175) embryonic GM2  (181) embryonic Kc167  (172) embryonic S1  (284) embryonic S3  (156) leg disc CME L1  (289) wing disc CME-W2  (211) wing disc ML-DmD8  (245) wing disc ML-DmD9  (213) wing disc ML-DmD16-c3  (252) wing disc ML-DmD21  (204) wing disc ML-DmD32  (265) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (191) antennal disc ML-DmD20-c5  (258) mixed discs ML-DmD4-c1  (255) CNS ML-DmBG1-c1  (242) CNS ML-DmBG2-c2  (245) tumorous blood cells mbn2  (204) ovary fGS/OSS  (130) ovary OSC  (143) ovary OSS  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (366) Schneider line 2 Sg4  (339) embryonic 1182-4H  (175) embryonic GM2  (181) embryonic Kc167  (172) embryonic S1  (284) embryonic S3  (156) leg disc CME L1  (289) wing disc CME-W2  (211) wing disc ML-DmD8  (245) wing disc ML-DmD9  (213) wing disc ML-DmD16-c3  (252) wing disc ML-DmD21  (204) wing disc ML-DmD32  (265) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (191) antennal disc ML-DmD20-c5  (258) mixed discs ML-DmD4-c1  (255) CNS ML-DmBG1-c1  (242) CNS ML-DmBG2-c2  (245) tumorous blood cells mbn2  (204) ovary fGS/OSS  130 ovary OSC  143 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    366 Schneider line 2 Sg4    339 embryonic 1182-4H    175 embryonic GM2    181 embryonic Kc167    172 embryonic S1    284 embryonic S3    156 leg disc CME L1    289 wing disc CME-W2    211 wing disc ML-DmD8    245 wing disc ML-DmD9    213 wing disc ML-DmD16-c3    252 wing disc ML-DmD21    204 wing disc ML-DmD32    265 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    191 antennal disc ML-DmD20-c5    258 mixed discs ML-DmD4-c1    255 CNS ML-DmBG1-c1    242 CNS ML-DmBG2-c2    245 tumorous blood cells mbn2    204 ovary fGS/OSS    130 ovary OSC    143 ovary OSS    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    73 cold shock, 4-day adult    59 heat shock, 4-day adult    135 Cadmium 50 mM 6 hrs, larvae L3    131 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    121 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    95 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    63 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    172 Ethanol 5% 3 hrs, larvae L3    115 Ethanol 10% 3 hrs, larvae L3    93 Caffeine 1.5 mg/ml 4 hrs, larvae L3    136 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    128 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    140 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    131 Rotenone 8 μg 12 hrs, larvae L3    123 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (73) cold shock, 4-day adult  (59) heat shock, 4-day adult  (135) Cadmium 50 mM 6 hrs, larvae L3  (131) Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  (121) Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3  (95) Copper 15 mM 48 hrs, 4-day adult  (119) Zinc 5 mM 12 hrs, larvae L3  (63) Zinc 4.5 mM 48 hrs, 4-day adult  (73) Ethanol 2.5% 3 hrs, larvae L3  (172) Ethanol 5% 3 hrs, larvae L3  (115) Ethanol 10% 3 hrs, larvae L3  (93) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (136) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (128) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (140) Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  (131) Rotenone 8 μg 12 hrs, larvae L3  (123) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    73 cold shock, 4-day adult    59 heat shock, 4-day adult  (135) Cadmium 50 mM 6 hrs, larvae L3  (131) Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  (121) Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3    95 Copper 15 mM 48 hrs, 4-day adult  (119) Zinc 5 mM 12 hrs, larvae L3    63 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3  (172) Ethanol 5% 3 hrs, larvae L3  (115) Ethanol 10% 3 hrs, larvae L3    93 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (136) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (128) Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult  (140) Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  (131) Rotenone 8 μg 12 hrs, larvae L3  (123) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    73 cold shock, 4-day adult    59 heat shock, 4-day adult    135 Cadmium 50 mM 6 hrs, larvae L3    131 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    121 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    95 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    63 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    172 Ethanol 5% 3 hrs, larvae L3    115 Ethanol 10% 3 hrs, larvae L3    93 Caffeine 1.5 mg/ml 4 hrs, larvae L3    136 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    128 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    140 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    131 Rotenone 8 μg 12 hrs, larvae L3    123 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    73 cold shock, 4-day adult    59 heat shock, 4-day adult    135 Cadmium 50 mM 6 hrs, larvae L3    131 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    121 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    95 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    63 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    172 Ethanol 5% 3 hrs, larvae L3    115 Ethanol 10% 3 hrs, larvae L3    93 Caffeine 1.5 mg/ml 4 hrs, larvae L3    136 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    128 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    140 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    131 Rotenone 8 μg 12 hrs, larvae L3    123 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (73) cold shock, 4-day adult  (59) heat shock, 4-day adult  (135) Cadmium 50 mM 6 hrs, larvae L3  (131) Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  (121) Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3  (95) Copper 15 mM 48 hrs, 4-day adult  (119) Zinc 5 mM 12 hrs, larvae L3  (63) Zinc 4.5 mM 48 hrs, 4-day adult  (73) Ethanol 2.5% 3 hrs, larvae L3  (172) Ethanol 5% 3 hrs, larvae L3  (115) Ethanol 10% 3 hrs, larvae L3  (93) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (136) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (128) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (140) Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  (131) Rotenone 8 μg 12 hrs, larvae L3  (123) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    73 cold shock, 4-day adult    59 heat shock, 4-day adult  135 Cadmium 50 mM 6 hrs, larvae L3  131 Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  121 Cadmium 100 mM 48 hrs, 4-day adult  119 Copper 0.5 mM 12 hrs, larvae L3    95 Copper 15 mM 48 hrs, 4-day adult  119 Zinc 5 mM 12 hrs, larvae L3    63 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3  (172) Ethanol 5% 3 hrs, larvae L3  115 Ethanol 10% 3 hrs, larvae L3    93 Caffeine 1.5 mg/ml 4 hrs, larvae L3  136 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  128 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult  140 Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  131 Rotenone 8 μg 12 hrs, larvae L3  123 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    73 cold shock, 4-day adult    59 heat shock, 4-day adult    135 Cadmium 50 mM 6 hrs, larvae L3    131 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    121 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    95 Copper 15 mM 48 hrs, 4-day adult    119 Zinc 5 mM 12 hrs, larvae L3    63 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    172 Ethanol 5% 3 hrs, larvae L3    115 Ethanol 10% 3 hrs, larvae L3    93 Caffeine 1.5 mg/ml 4 hrs, larvae L3    136 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    128 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    140 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    131 Rotenone 8 μg 12 hrs, larvae L3    123 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GM13604 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086134 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Prosα2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Prosα2GD15087 lethal (with Df(3R)T-32) Prosα2SuDTS lethal | larval stage | recessive Prosα2SuDTS lethal | pupal stage | recessive Prosα2SuDTS Other Phenotypes Allele hypoactive (with Df(3R)T-32) Prosα2SuDTS hypoactive | larval stage | recessive Prosα2SuDTS Phenotype manifest in Allele ventral furrow Prosα2dsRNA.cGa
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Prosα2 Class Mutagen Stocks Known lesion Prosα2EP931 P-element activity 1 -- Prosα2G8948 P-element activity 1 -- Prosα2SuDTS ethyl nitrosourea 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prosα2 Class Mutagen Stocks Known lesion Prosα2GD15087 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosα2GL01088 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosα2KK109089 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosα2+t2 in vitro construct - genomic fragment 0 Yes Prosα2dsRNA.cGa in vitro construct - RNAi 0 Yes Prosα2Scer\UAS.cNa in vitro construct - regulatory fusion 0 Yes Prosα2SuDTS.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6164 (Ryder, 2004.4.26) Df(3R)Exel6165 (Ryder, 2004.4.26) Df(3R)Exel7316 (Ryder, 2004.4.26) Df(3R)T-32 (Neuburger et al., 2006)
Not disrupted in	Df(3R)M-Kx1 (Neuburger et al., 2006) Df(3R)ry85 (Neuburger et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Prosα2EP931 NA P{EP}Prosα2G8948 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell proliferation inferred from mutant phenotype (Goshima et al., 2007) cellular process inferred from mutant phenotype (Boutros et al., 2004) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
proteasome core complex inferred from direct assay (Sumegi et al., 2003)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
endopeptidase activity inferred from sequence or structural similarity with UniProtKB:P17220 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1995.2.1) contributes_to endopeptidase activity inferred by curator from GO:0005839 (Sumegi et al., 2003) threonine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001353, InterPro:IPR023332 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteasomal ubiquitin-dependent protein catabolic process inferred by curator from GO:0005839 (Sumegi et al., 2003) proteolysis non-traceable author statement (Swiss-Prot Project Members, 1995.2.1) ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR000426 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1995.2.1)
Cellular Component
CV term Evidence References
proteasome complex non-traceable author statement (Swiss-Prot Project Members, 1995.2.1) proteasome core complex inferred from sequence or structural similarity with UniProtKB:P17220 (FlyBase, 1992-) proteasome core complex, alpha-subunit complex inferred from electronic annotation with InterPro:IPR000426 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Prosα2 - 4EHP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - Aos1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Art8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Bx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG11190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG11191 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG11885 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - CG12065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG12321 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - CG13319 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - CG15011 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG15717 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - CG1598 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG2046 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα2 - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG30195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG31445 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG3544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG3795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG3995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG42678 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG5196 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG5660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG6034 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG6145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG7675 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG8314 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - CG8525 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - CR18854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Clp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Corp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Csp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Cyp4g15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Dak1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Dlc90F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Elongin-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Eno anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Gad1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Gadd34 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Hcf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Ime4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Jon65Ai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Klc experimental knowledge based (Guruharsha et al., 2011) Prosα2 - LanB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Mul1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - NAA20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - NimB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - PH4αSG1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - PI31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Patsas anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Pomp experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα2 - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Prosα1 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - Prosα3 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosα4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosα5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosα6 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosα6T anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Prosα7 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosβ1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosβ2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosβ2R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Prosβ2R2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Prosβ3 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα2 - Prosβ4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosβ4R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Prosβ4R2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosβ5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Prosβ7 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - REG anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Rab18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Rpn1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα2 - Rpn11 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα2 - Rpn13 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - Rpn2 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - Rpn6 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Rpn7 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - Rpn8 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Rpt2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα2 - Rpt3 experimental knowledge based (Guruharsha et al., 2011) Prosα2 - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα2 - Smn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Syx17 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Tgt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Traf4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Tsc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Uch-L5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Vha100-4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - Vps28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - boly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - ens anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - ine anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - levy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - mRpL15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - morgue anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - ninaE anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - p53 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - pigeon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - regucalcin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - rpr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - santa-maria anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - shf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - spi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - stet anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα2 - zpg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prosα2 allele Gene References Su(DTS)-11 Prosβ2 (Smyth and Belote, 1999) Prosβ6 (Smyth and Belote, 1999) unspecified Prosβ2 (Neuburger et al., 2006) Prosβ6 (Neuburger et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66629 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086134 DroID - A comprehensive database of gene and protein interactions. • FBgn0086134 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41531
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W6PG9 Dipteran inclusive ortholog search EOG6FN4SP Insect inclusive ortholog search EOG66M9FN Arthropod inclusive ortholog search EOG6HT786 Metazoa inclusive ortholog search EOG6N67R8
Orthologs in Drosophila Species (EOG6W6PG9)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Prosα2     Drosophila simulans   Dsim\GD18834     Drosophila sechellia   Dsec\GM24033     Drosophila erecta   Dere\GG18927     Drosophila yakuba   Dyak\GE26194     Drosophila ananassae   Dana\GF17957     Drosophila pseudoobscura pseudoobscura   Dpse\GA18772     Drosophila persimilis   Dper\GL27312     Drosophila willistoni   Dwil\GK14404     Drosophila virilis   Dvir\GJ24473     Drosophila mojavensis   Dmoj\GI24829     Drosophila grimshawi   Dgri\GH13898
Orthologs in non-Drosophila Dipterans (EOG6FN4SP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006061   Anopheles gambiae Malaria mosquito  Agam\AGAP001995   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006946
Orthologs in non-Dipteran Insects (EOG66M9FN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Pros25   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002206   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16598   Atta cephalotes Leafcutter ant  Acep\ACEP22760   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15573   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14099   Linepithema humile Argentine ant  Lhum\LH18131   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25298   Solenopsis invicta Red fire ant  Sinv\SINV22989   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001003   Bombyx mori Silkmoth  Bmor\BGIBMGA009562   Pediculus humanus Human body louse  Phum\PHUM361340   Tribolium castaneum Red flour beetle  Tcas\TC004868
Orthologs in non-Insect Arthropods (EOG6HT786)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\RBCS
Orthologs in non-Arthropod Metazoa (EOG6N67R8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pas-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026430gn   Danio rerio Zebrafish  Drer\psma2   Danio rerio Zebrafish  Drer\si:rp71-45k5.4   Xenopus tropicalis Western clawed frog  Xtro\psma2   Gallus gallus Domestic chicken  Ggal\PSMA2   Mus musculus House mouse  Mmus\Psma2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000015824   Homo sapiens Human  Hsap\PSMA2   Homo sapiens Human  Hsap\PSMA2
Human Orthologs (2)
Gene OMIM HGNC Hsap\PSMA2     Hsap\PSMA2
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	32621 w1118; P{EP}Prosα2G8948/TM6C, Sb1 36898 y1 sc* v1; P{TRiP.GL01088}attP2/TM3, Sb1
Kyoto	122030 w1118; P{EP}Prosα2EP931
VDRC	v101409 P{KK109089}VIE-260B v29686 w1118; P{GD15087}v29686
Genomic Clones ( 1 )
	BACR28I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 115 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM13604
Other clones	DPiM_GM13604
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18725 GH21388 GM04302 LP01456 LP20744 RE13374 RE22680 RE59435 RH24704 RH25789 RH28226 RH28677 RH29430 RH46883 RH49133 RH55675 SD07136 SD17878 SD19087 SD22634
Other clones	40191 60654 60872 123085 163354 191517 192243 bs48e09 bs63h11 CK01.146B.C4 Dmel_dig_011150_0704_2414 Dmel_dig_014023_0705_2336 EC28882 EC31253 EC34066 EC38453 EK057805 EK120242 EK186837 EK186852 EK244103 EK267740 EK295014 EK295223 FGC025H09 FGM212A06 FGM313A05 RP003015324 RP003044490 RP003046392 RP003070122 RP003072311 RP003077641 RP003082260 RP003089645 RP003104771 RP003108788 RP003130591 RP003131410 RP003150026 RP003170660 RP003181116 RP003181971 RP003182754 RP003193911 RP003195784 RP003198365 RP003206543 RP003208797 RP003209875 RP003212229 RP003216640 RP003230094 RP003236170 RP003240728 RP003242819 RP003259197 RP003271063 RP003278663 RP003284609 RP003304562 RP003305765 RP003316387 RP003337543 RP003349094 RP003355191 RP003356844 RP003385288 RP003396978 RP003416048 RP003433852 RP003436526 RP003440892 RP003445092 RP003456898 RP003458602 RP003473497 RP003476979 RP003479626 RP003487199 RP003525107 RP003533858 RP003545732 RP003550324 RP003559097 RP003568083 RP003592282 RP003592493 RP003610317 RP003623788 RP003638626 RP003663174 RP003676063
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086134 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41531
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Prosα2 Pros25 (FlyBase, 2009-)
Source for database merge of	Source for merge of: Pros25 Su(DTS)-1 (Neuburger et al., 2006)
Additional comments	The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms. (FlyBase, 2009-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of short, monastral spindles and severe proliferation defects when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) The sequence and genomic organisation of the Pros25 locus has been determined. (Seelig et al., 1993) Pros25 has been cloned and sequenced. (Seelig et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079604 RefSeq (Proteins) • NP_524328 DDBJ / EMBL / GenBank • AA803599 AAF54814 AAL39425 AI518972 AQ254676 AY069280 CAA49783 X70304 Entrez Gene - A searchable database of RefSeq genes. • 41531 UniProtKB/Swiss-Prot • P40301
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome, subunit alpha/beta (IPR001353) Proteasome, alpha-subunit, N-terminal domain (IPR000426) Proteasome A-type subunit (IPR023332) MEROPS - An information resource for peptidases and the proteins that inhibit them • T01.972 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM13604
Linkouts
	BioGRID - A database of protein and genetic interactions • 66629 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086134 DroID - A comprehensive database of gene and protein interactions. • FBgn0086134 DRSC - Results from RNAi screens. • FBgn0086134 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086134 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086134 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 99000 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41531 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41531 modMine - Data generated by the modENCODE project. • FBgn0086134
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	153303_at (Kristensen et al., 2005) Alpha-2 (Lundgren et al., 2005) alpha2 (Yano et al., 2012) CG5266 (Pile et al., 2003, Goshima et al., 2007, Ni et al., 2011.7.19, Barbash and Lorigan, 2007, Keleman et al., 2009.8.5, Ma et al., 2002, Cammarato et al., 2011, Lundgren et al., 2005, Puri et al., 2008, Belote and Zhong, 2009, Yano et al., 2012) dα2 (Wojcik and DeMartino, 2002) PRC3 (Mushegian et al., 1998) Pros25 (Stuart et al., 2007, Carbone et al., 2009, Barbash and Lorigan, 2007, Puri et al., 2008, Neuburger et al., 2006, Goshima et al., 2007, Geng and MacDonald, 2007, Ma et al., 2002, Lundgren et al., 2005) PROS Dm25 (Seelig et al., 1993, Seelig et al., 1993) PROS-Dm25g (Seelig, 1993.2.5) Prosα2 (Ma et al., 2002, Belote and Zhong, 2009) PSA2_DROME (Storm and Sonnhammer, 2003) Su(DTS) (Neuburger et al., 2006) Su(DTS)-1   α2 (Belote and Zhong, 2009) α2_dm (Zaiss and Belote, 1997)
Name Synonym	20s proteasome (Speese et al., 2003) 20S proteasome (Bohm et al., 2000) Pros25 (Cammarato et al., 2011) Proteasome 25kD subunit   Proteasome subunit α-type 2 (Adrain et al., 2004) Proteasome α2 subunit   Proteosome (Takahashi et al., 2001) Su(DTS)-1   α2 (Nickell et al., 2009) α-subunit of 20S proteasome (Fredriksson et al., 2012)
Secondary FlyBase IDs
	FBgn0010405 FBgn0024727
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Fredriksson et al., 2012, Aging Cell 11(4): 634--643 Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster. [FBrf0218923] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...