Gene model reviewed during 5.45
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Akr1B using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Akr1B in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.
The existence of this gene is tentative, and is based on a match of an STS sequence from a European Drosophila Genome Mapping Project cosmid.
Designated as "dAR1" based on its sequence similarity to human aldose reductases akr1b10 and ark1b1. FlyBase curator comment: Named as 'Akr1B' in FlyBase because: (i) it is predicted to be an aldo-keto reductase; (ii) the human AKR1 family is divided into A, B, C, D and E subfamilies; and (iii) of the 11 AKR genes in D. melanogaster (FBgg0000920), CG6084 appears to be the single fly representative of the AKR1B subfamily.