FB2020_06, released Dec 22, 2020

Gene: Dmel\Akr1B

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General Information
Symbol
Dmel\Akr1B
Species
D. melanogaster
Name
Aldo-keto reductase 1B
Annotation Symbol
CG6084
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086254
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
68D-68C15
Sequence location
3L:11,620,535..11,624,381 [-]
Recombination map

3-36

RefSeq locus
NT_037436 REGION:11620535..11624381
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables alditol:NADP+ 1-oxidoreductase activity
inferred from biological aspect of ancestor with PANTHER:PTN000198921
(assigned by GO_Central )
(Gaudet et al., 2011)
enables indanol dehydrogenase activity
inferred from sequence or structural similarity with UniProtKB:O60218
(FlyBase Curators, 2008--)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in oxidation-reduction process
inferred from electronic annotation with InterPro:IPR018170, InterPro:IPR020471
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000198921
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ALDO-KETO REDUCTASES -
The aldo-keto reductases (NADP) are NAD(P)(H) dependent oxidoreductases that catalyze aldehyde or ketone reduction to yield primary and secondary alcohols. (Adapted from PMID:19706366 and PMID:18949601).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Akr1B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Akr1B-RA
FBtr0076139
NM_140227
1135
316
Akr1B-RB
FBtr0076138
NM_168467
1353
350
Akr1B-RC
FBtr0331546
NM_001274787
1172
350
Akr1B-RD
FBtr0331547
NM_001274788
1316
316
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Akr1B-PA
FBpp0075870
35.9
316
6.63
NP_648484
AAF50039
Akr1B-PB
FBpp0075869
40.1
350
8.03
NP_729726
AAN11878
Akr1B-PC
FBpp0303936
40.1
350
7.78
NP_001261716
AGB94410
Akr1B-PD
FBpp0303937
35.9
316
6.79
NP_001261717
AGB94411
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Akr1B using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism

Comment: rapidly degraded

(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval fat body
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Akr1B in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Akr1B
Transgenic constructs containing regulatory region of Akr1B
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\AKR1B1
13 of 15
Yes
Yes
Hsap\AKR1B10
13 of 15
Yes
Yes
1  
Hsap\AKR1B15
10 of 15
No
Yes
Hsap\AKR1D1
8 of 15
No
Yes
Hsap\AKR1E2
8 of 15
No
Yes
Hsap\AKR1A1
5 of 15
No
No
Hsap\AKR1C1
5 of 15
No
Yes
Hsap\AKR1C2
5 of 15
No
Yes
Hsap\AKR1C3
5 of 15
No
Yes
Hsap\AKR1C4
5 of 15
No
Yes
Hsap\AKR1C8P
1 of 15
No
Yes
Hsap\GCLM
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Akr1b3
13 of 15
Yes
Yes
Mmus\Akr1b7
13 of 15
Yes
Yes
Mmus\Akr1b8
12 of 15
No
Yes
Mmus\Akr1b10
10 of 15
No
Yes
Mmus\Akr1e1
9 of 15
No
Yes
Mmus\Akr1d1
7 of 15
No
Yes
Mmus\Akr1c19
6 of 15
No
Yes
Mmus\Akr1c21
6 of 15
No
Yes
Mmus\Akr1a1
5 of 15
No
No
Mmus\Akr1c6
5 of 15
No
Yes
Mmus\Akr1c12
5 of 15
No
Yes
Mmus\Akr1c13
5 of 15
No
No
Mmus\Akr1c14
5 of 15
No
Yes
Mmus\Akr1c18
5 of 15
No
Yes
Mmus\Akr1c20
5 of 15
No
Yes
Mmus\Akr1cl
5 of 15
No
Yes
Mmus\Gclm
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Akr1b1
12 of 13
Yes
Yes
Rnor\Akr1b7
11 of 13
No
Yes
Rnor\Akr1e2
10 of 13
No
Yes
Rnor\Akr1b8
9 of 13
No
Yes
Rnor\Akr1d1
7 of 13
No
Yes
Rnor\Akr1b10
6 of 13
No
Yes
Rnor\Akr1c15
6 of 13
No
Yes
Rnor\Akr1c19
6 of 13
No
No
Rnor\Akr1c2
5 of 13
No
Yes
Rnor\Akr1c3
5 of 13
No
No
Rnor\Akr1c12l1
5 of 13
No
No
Rnor\Akr1c12
5 of 13
No
No
Rnor\Akr1c13
5 of 13
No
No
Rnor\Akr1c14
5 of 13
No
No
Rnor\RGD1564865
5 of 13
No
Yes
Rnor\Akr1a1
4 of 13
No
No
Rnor\Akr1c1
4 of 13
No
No
Rnor\LOC100910708
2 of 13
No
Yes
Rnor\Gclm
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\akr1b1
8 of 12
Yes
Yes
Xtro\akr1a1
5 of 12
No
Yes
Xtro\akr1c1
3 of 12
No
No
Xtro\akr1c2
3 of 12
No
Yes
Xtro\akr1c8p
3 of 12
No
Yes
Xtro\akr1d1
3 of 12
No
Yes
Xtro\akr1c3
2 of 12
No
Yes
Xtro\akr1c4
2 of 12
No
Yes
Xtro\LOC734139
2 of 12
No
Yes
Xtro\LOC100490956
2 of 12
No
Yes
Xtro\LOC100494522
2 of 12
No
Yes
Xtro\LOC105946859
2 of 12
No
Yes
Xtro\9030611n15rik
1 of 12
No
Yes
Xtro\gclm
1 of 12
No
No
Xtro\LOC548351
1 of 12
No
Yes
Xtro\LOC101733893
1 of 12
No
Yes
Danio rerio (Zebrafish) (9)
Drer\akr1b1.2
13 of 15
Yes
Yes
Drer\akr1b1.1
11 of 15
No
Yes
Drer\akr1a1a
6 of 15
No
No
Drer\akr1a1b
5 of 15
No
No
Drer\zgc:56622
5 of 15
No
No
Drer\zgc:101765
3 of 15
No
No
Drer\zgc:110366
2 of 15
No
Yes
Drer\gclm
1 of 15
No
No
Drer\zgc:110782
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\Y39G8B.1
11 of 15
Yes
Yes
Cele\C07D8.6
6 of 15
No
No
Cele\Y39G8B.2
6 of 15
No
No
Cele\ZC443.1
6 of 15
No
No
Cele\T08H10.1
5 of 15
No
No
Cele\F53F1.2
4 of 15
No
Yes
Cele\C01G5.5
3 of 15
No
Yes
Cele\C07D8.5
2 of 15
No
No
Cele\C35D10.6
2 of 15
No
Yes
Cele\C56G3.2
2 of 15
No
No
Cele\F53F1.3
2 of 15
No
Yes
Cele\ZK1290.5
2 of 15
No
Yes
Cele\E01A2.1
1 of 15
No
No
Cele\K07C5.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (10)
Atha\AKR4C10
7 of 9
Yes
Yes
Atha\AKR4C11
7 of 9
Yes
Yes
Atha\AT2G21250
7 of 9
Yes
Yes
Atha\AT2G21260
7 of 9
Yes
Yes
Atha\ChlAKR
7 of 9
Yes
Yes
Atha\AKR4C8
6 of 9
No
Yes
Atha\AT5G01670
4 of 9
No
Yes
Atha\AT5G62420
3 of 9
No
Yes
Atha\AT1G59950
2 of 9
No
Yes
Atha\AT1G59960
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\GRE3
10 of 15
Yes
Yes
Scer\GCY1
9 of 15
No
Yes
Scer\YPR1
8 of 15
No
Yes
Scer\YJR096W
6 of 15
No
Yes
Scer\ARA1
2 of 15
No
No
Scer\AAD3
1 of 15
No
No
Scer\AAD4
1 of 15
No
No
Scer\AAD10
1 of 15
No
No
Scer\AAD14
1 of 15
No
No
Scer\AAD15
1 of 15
No
Yes
Scer\YDL124W
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\SPAC26F1.07
9 of 12
Yes
Yes
Spom\SPBC8E4.04
9 of 12
Yes
Yes
Spom\SPAC2F3.05c
4 of 12
No
Yes
Spom\SPAC19G12.09
1 of 12
No
Yes
Spom\SPAP32A8.02
1 of 12
No
Yes
Spom\SPBC28F2.05c
1 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190B7B )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011441
Drosophila simulans
Dsim\GD12789
Drosophila sechellia
Dsec\GM24729
Drosophila erecta
Dere\GG13904
Drosophila yakuba
Dyak\GE20195
Drosophila ananassae
Dana\GF24531
Drosophila pseudoobscura pseudoobscura
Dpse\GA19342
Drosophila persimilis
Dper\GL22808
Drosophila willistoni
Dwil\GK14636
Drosophila willistoni
Dwil\GK17015
Drosophila virilis
Dvir\GJ11267
Drosophila mojavensis
Dmoj\GI11589
Drosophila grimshawi
Dgri\GH16631
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506X1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010558
Glossina morsitans
Tsetse fly
Gmor\GMOY009603
Glossina morsitans
Tsetse fly
Gmor\GMOY002110
Glossina morsitans
Tsetse fly
Gmor\GMOY006191
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05882
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12926
Mayetiola destructor
Hessian fly
Mdes\Mdes003985
Mayetiola destructor
Hessian fly
Mdes\Mdes003768
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004088
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004102
Anopheles darlingi
American malaria mosquito
Adar\ADAC006882
Anopheles darlingi
American malaria mosquito
Adar\ADAC000145
Anopheles darlingi
American malaria mosquito
Adar\ADAC006888
Anopheles gambiae
Malaria mosquito
Agam\AGAP011050
Anopheles gambiae
Malaria mosquito
Agam\AGAP011066
Anopheles gambiae
Malaria mosquito
Agam\AGAP011068
Anopheles gambiae
Malaria mosquito
Agam\AGAP011051
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003393
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003391
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003392
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W070S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012152
Bombyx mori
Silkmoth
Bmor\BGIBMGA014453
Danaus plexippus
Monarch butterfly
Dple\DPOGS214986-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215024-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207021-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014821
Heliconius melpomene
Postman butterfly
Hmel\HMEL010629
Apis florea
Little honeybee
Aflo\3313534308
Apis florea
Little honeybee
Aflo\3313534756
Apis florea
Little honeybee
Aflo\2525065492
Apis mellifera
Western honey bee
Amel\LOC551968
Apis mellifera
Western honey bee
Amel\LOC552018
Apis mellifera
Western honey bee
Amel\Ame.2761
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15622
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15625
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15626
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15623
Bombus terrestris
Buff-tailed bumblebee
Bter\15210781
Bombus terrestris
Buff-tailed bumblebee
Bter\15210779
Bombus terrestris
Buff-tailed bumblebee
Bter\15210782
Bombus terrestris
Buff-tailed bumblebee
Bter\15210785
Linepithema humile
Argentine ant
Lhum\LH10685
Linepithema humile
Argentine ant
Lhum\LH10683
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c73
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c74
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c76
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008120
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008124
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008122
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008121
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008123
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008116
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008118
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02827
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_13017
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02981
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06841
Tribolium castaneum
Red flour beetle
Tcas\TC004951
Tribolium castaneum
Red flour beetle
Tcas\TC004878
Tribolium castaneum
Red flour beetle
Tcas\TC004950
Tribolium castaneum
Red flour beetle
Tcas\TC005686
Tribolium castaneum
Red flour beetle
Tcas\TC004879
Tribolium castaneum
Red flour beetle
Tcas\TC004510
Tribolium castaneum
Red flour beetle
Tcas\TC004877
Tribolium castaneum
Red flour beetle
Tcas\TC004881
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07811
Pediculus humanus
Human body louse
Phum\PHUM282300
Pediculus humanus
Human body louse
Phum\PHUM335220
Pediculus humanus
Human body louse
Phum\PHUM335210
Rhodnius prolixus
Kissing bug
Rpro\RPRC003141
Rhodnius prolixus
Kissing bug
Rpro\RPRC011290
Cimex lectularius
Bed bug
Clec\CLEC010943
Cimex lectularius
Bed bug
Clec\CLEC010944
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002745
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002128
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000225
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005685
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006694
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01417
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16831
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01418
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09734
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01419
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09735
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0AE2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007354
Ixodes scapularis
Black-legged tick
Isca\ISCW002128
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72168.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g11330
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g11410
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g11390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g11530
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g11340
Tetranychus urticae
Two-spotted spider mite
Turt\tetur30g00660
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_230297
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_208580
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_45302
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_191566
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_127555
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0D69 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-AkrL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-AkrL_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-AkrL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Akrf_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-AkrL_2
Ciona intestinalis
Vase tunicate
Cint\LOC100187155
Ciona intestinalis
Vase tunicate
Cint\LOC100176557
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007642
Ciona intestinalis
Vase tunicate
Cint\LOC100176226
Gallus gallus
Domestic chicken
Ggal\AKR1A1
Gallus gallus
Domestic chicken
Ggal\AKR1B10
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013058
Gallus gallus
Domestic chicken
Ggal\AKR1D1
Gallus gallus
Domestic chicken
Ggal\AKR1B1
Gallus gallus
Domestic chicken
Ggal\LOC418170
Gallus gallus
Domestic chicken
Ggal\akr
Gallus gallus
Domestic chicken
Ggal\LOC425137
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG10863
8 of 10
CG12766
8 of 10
CG9436
7 of 10
CG10638
7 of 10
ARY
6 of 10
CG6083
6 of 10
CG2767
5 of 10
CG3397
1 of 10
CG12224
1 of 10
CG18547
1 of 10
Gclm
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AKR1B1; aldo-keto reductase family 1 member B
    13 of 15
    103880
        AKR1B10; aldo-keto reductase family 1 member B10
        13 of 15
        604707
             
            AKR1B15; aldo-keto reductase family 1 member B15
            10 of 15
            616336
                AKR1D1; aldo-keto reductase family 1 member D1
                8 of 15
                604741
                AKR1E2; aldo-keto reductase family 1 member E2
                8 of 15
                617451
                    AKR1A1; aldo-keto reductase family 1 member A1
                    5 of 15
                    103830
                        AKR1C1; aldo-keto reductase family 1 member C1
                        5 of 15
                        600449
                            AKR1C2; aldo-keto reductase family 1 member C2
                            5 of 15
                            600450
                            AKR1C3; aldo-keto reductase family 1 member C3
                            5 of 15
                            603966
                                AKR1C4; aldo-keto reductase family 1 member C4
                                5 of 15
                                600451
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                esyN Network Diagram
                                Show neighbor-neighbor interactions:
                                Select Layout:
                                Legend:
                                Protein
                                RNA
                                Selected Interactor(s)
                                Interactions Browser
                                View in Interactions Browser
                                Please see the Physical Interaction reports below for full details
                                protein-protein
                                Physical Interaction
                                Assay
                                References
                                Akr1B - ATPsynCF6
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Akap200
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - AnxB10
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - AnxB9
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Bacc
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG10638
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG10863
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG11267
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG14715
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG2767
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG2852
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG8036
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - CG9705
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Calr
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Chd64
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Df31
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - EndoGI
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Eno
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Fkbp12
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Fkbp14
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Gdi
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - GstE6
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - GstO3
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - HINT1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Inos
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Mdh2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Moe
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Nacα
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Nlp
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Ntf-2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - PCNA
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - PHGPx
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Pdi
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Pgd
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Pglym78
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Prosα4
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Prx2540-2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - RhoGDI
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Sh3β
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Sod2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Stip1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Trx-2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Trxr-1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - Uch
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - awd
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - capt
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - chic
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - cib
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - eEF1δ
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - eEF5
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - fabp
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - p23
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - regucalcin
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - scf
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - scu
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Akr1B - smt3
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Summary of Genetic Interactions
                                esyN Network Diagram
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                External Data
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3L
                                Recombination map

                                3-36

                                Cytogenetic map
                                68D-68C15
                                Sequence location
                                3L:11,620,535..11,624,381 [-]
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                68D-68C15
                                Left limit from in situ hybridisation (FBrf0071734) Right limit from in situ hybridisation (FBrf0071734); Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                68D-68D
                                (determined by in situ hybridisation)
                                (Louis et al., 1997, EDGP Project Members, 1994-)
                                Experimentally Determined Recombination Data
                                Location

                                3-36

                                (FlyBase, 2016)

                                3-30.1

                                (Comeron et al., 2012)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (11)
                                Genomic Clones (16)
                                 

                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                cDNA Clones (233)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                  Drosophila Genomics Resource Center cDNA clones

                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                  cDNA Clones, End Sequenced (ESTs)
                                  BDGP DGC clones
                                  Other clones
                                  RNAi and Array Information
                                  Linkouts
                                  DRSC - Results frm RNAi screens
                                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                  Antibody Information
                                  Laboratory Generated Antibodies
                                   
                                  Commercially Available Antibodies
                                   
                                  Other Information
                                  Relationship to Other Genes
                                  Source for database identify of

                                  Source for identity of: Akr1B CG6084

                                  (Yang et al., 2019)
                                  Source for database merge of

                                  Source for merge of: CG6084 ESTS:34F4T

                                  (FlyBase, 1996-)
                                  Additional comments
                                  Other Comments

                                  Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

                                  (Hansen et al., 2009)

                                  The existence of this gene is tentative, and is based on a match of an STS sequence from a European Drosophila Genome Mapping Project cosmid.

                                  Origin and Etymology
                                  Discoverer
                                  Etymology

                                  Designated as "dAR1" based on its sequence similarity to human aldose reductases akr1b10 and ark1b1. FlyBase curator comment: Named as 'Akr1B' in FlyBase because: (i) it is predicted to be an aldo-keto reductase; (ii) the human AKR1 family is divided into A, B, C, D and E subfamilies; and (iii) of the 11 AKR genes in D. melanogaster (FBgg0000920), CG6084 appears to be the single fly representative of the AKR1B subfamily.

                                  (Yang et al., 2019)
                                  Identification
                                  External Crossreferences and Linkouts ( 75 )
                                  Sequence Crossreferences
                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                  Other crossreferences
                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                  Flygut - An atlas of the Drosophila adult midgut
                                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                  InterPro - A database of protein families, domains and functional sites
                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                  modMine - A data warehouse for the modENCODE project
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  DroID - A comprehensive database of gene and protein interactions.
                                  DRSC - Results frm RNAi screens
                                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                  FlyMine - An integrated database for Drosophila genomics
                                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Synonyms and Secondary IDs (9)
                                  Datasets (0)
                                  Study focus (0)
                                  Experimental Role
                                  Project
                                  Project Type
                                  Title
                                  References (80)