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Gene Dmel\tef

General Information
Symbol	Dmel\tef	Species	D. melanogaster
Name	teflon	Annotation symbol	CG8961
Feature type	protein_coding_gene	FlyBase ID	FBgn0086350
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-80.0
Cytogenetic map	53F2-53F5	Sequence location	2R:12,942,048..12,944,329 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene teflon is referred to in FlyBase by the symbol Dmel\tef (CG8961, FBgn0086350). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. There is experimental evidence that it is involved in the biological process: male meiosis I; male meiosis chromosome segregation. 14 alleles are reported. The phenotypes of these alleles are annotated with: meiosis I; spermatocyte. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1638779_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of tef. Gene sequence location is 2R:12942048..12944329.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN23290 HFA07301
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 53F2-53F5   Limits computationally determined from genome sequence between P{lacW}l(2)k11405k11405&P{EP}EP641 and P{lacW}l(2)k10815k10815; Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 53F-53F   Localisation based on recombination and deletion mapping.   (Tomkiel and Briscoe, 2001) 53F1-53F5   (determined by in situ hybridisation)   (Spradling et al., 1999) 53F1-53F5   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-80.0 (Tomkiel et al., 2001)
Left of (cM)	P{lacW}l(2)k09202k09202 (Tomkiel et al., 2001)
Right of (cM)	P{lacW}GstS1k08805 (Tomkiel et al., 2001)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tef for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tef-RA FBtr0087014  NM_079042   2160   649
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tef-PA   FBpp0086165   73.4   649   8.92     NP_523766   AAF57911
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201129   AA202530   AA202545   AA202704   AA263747   AA390692   AA439422   AA439493   AA441249   AA536372   AA816423   AA941377   AA978662   AA979469   AE013599 AAF57911   AQ026096   AW943141   AY051818 AAK93242   AY840216 AAV90631   AY840217 AAV90632   AY840218 AAV90633   AY840219 AAV90634   AY840220 AAV90635   BI164300   BI165215   BI167619   BI170254   BI170520   BI212896   BI214348   BI216208   BI227890   BI228461   BI239718   BI239818   BI242385   BI362562   BI363845   BI364427   BI365398   BI365723   BI366266   BI368381   BI370675   BI481885   BI486194   BI580106   BI580463   CO266376   CO311369   CO312553   CO315754   CO331851   EC076235   EC089287   EC213800   EC216547   EV597948   GH754560   GH771824   GH772638   GH774719   GH776565   GH798112   GH809486   GH810472   GH812900   GH819084   GH827804   GH831904   GH836578   GH849922   GH851201   GH853738   GH857756   GH859033   GH861578   GH867132   GH870403   GH879044   GH879133   GH892574   GH896344   GH898018   GH898672   GH904361   GH904483   GH904776   GH907496   GH914367   GH916608   GH923497   GH924264   GH927082   GH931982   GH936447
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K4M4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086350    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086350 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086350 expression level Developmental Stage   Expression Level embryo 00-02hr    2385 embryo 02-04hr    1933 embryo 04-06hr    1676 embryo 06-08hr    1266 embryo 08-10hr    1598 embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day    1619 adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2385) embryo 02-04hr  (1933) embryo 04-06hr  (1676) embryo 06-08hr  (1266) embryo 08-10hr  (1598) embryo 10-12hr  (669) embryo 12-14hr  (1133) embryo 14-16hr  (436) embryo 16-18hr  (687) embryo 18-20hr  (247) embryo 20-22hr  (822) embryo 22-24hr  (1208) larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2  104 larva L3 puffstage 3-6  (194) larva L3 puffstage 7-9  (320) white prepupae new  (322) white prepupae 12hr  (453) white prepupae 24hr  (384) pupae 2d postWPP  (198) pupae 3d postWPP  107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day  (385) adult female 05day  (1619) adult female 30day  (1368) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2385) embryo 02-04hr  (1933) embryo 04-06hr  (1676) embryo 06-08hr    1266 embryo 08-10hr  (1598) embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day  (1619) adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2385 embryo 02-04hr    1933 embryo 04-06hr    1676 embryo 06-08hr    1266 embryo 08-10hr    1598 embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day    1619 adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2385 embryo 02-04hr    1933 embryo 04-06hr    1676 embryo 06-08hr    1266 embryo 08-10hr    1598 embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day    1619 adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086350 expression level Developmental Stage   Expression Level embryo 00-02hr    2385 embryo 02-04hr    1933 embryo 04-06hr    1676 embryo 06-08hr    1266 embryo 08-10hr    1598 embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day    1619 adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2385) embryo 02-04hr  (1933) embryo 04-06hr  (1676) embryo 06-08hr  (1266) embryo 08-10hr  (1598) embryo 10-12hr  (669) embryo 12-14hr  (1133) embryo 14-16hr  (436) embryo 16-18hr  (687) embryo 18-20hr  (247) embryo 20-22hr  (822) embryo 22-24hr  (1208) larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2  104 larva L3 puffstage 3-6  (194) larva L3 puffstage 7-9  (320) white prepupae new  (322) white prepupae 12hr  (453) white prepupae 24hr  (384) pupae 2d postWPP  (198) pupae 3d postWPP  107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day  (385) adult female 05day  (1619) adult female 30day  (1368) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2385 embryo 02-04hr  1933 embryo 04-06hr  1676 embryo 06-08hr    1266 embryo 08-10hr  1598 embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day  1619 adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2385 embryo 02-04hr    1933 embryo 04-06hr    1676 embryo 06-08hr    1266 embryo 08-10hr    1598 embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day    1619 adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2385 embryo 02-04hr    1933 embryo 04-06hr    1676 embryo 06-08hr    1266 embryo 08-10hr    1598 embryo 10-12hr    669 embryo 12-14hr    1133 embryo 14-16hr    436 embryo 16-18hr    687 embryo 18-20hr    247 embryo 20-22hr    822 embryo 22-24hr    1208 larva L1    62 larva L2    53 larva L3 12hr old    62 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    194 larva L3 puffstage 7-9    320 white prepupae new    322 white prepupae 12hr    453 white prepupae 24hr    384 pupae 2d postWPP    198 pupae 3d postWPP    107 pupae 4d postWPP    42 adult male 01day    76 adult male 05day    64 adult male 30day    52 adult female 01day    385 adult female 05day    1619 adult female 30day    1368 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086350    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086350 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086350 expression level Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary    649.2 Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary  (649.2) Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary    649.2 Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary    649.2 Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086350 expression level Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary    649.2 Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary  649.2 Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary    649.2 Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    286.475 Larval Midgut    15.3 Larval Hindgut    29.8 Larval Malpighian Tubules no informative data Larval Fat Body    9.4 Larval Salivary Gland    11 Larval Trachea    34.75 Larval Carcass    20.075 Adult Head    21 Adult Eye    9.25 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    53.9 Adult Crop    25.2 Adult Midgut    25.6 Adult Hindgut    19.7 Adult Malpighian Tubules no informative data Adult Fat Body    5.6 Adult Salivary Gland no informative data Adult Heart    6.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17 Adult Ovary    649.2 Adult Testis    32.7 Adult Male Accessory Gland    15.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    21   NA  Eye    9.25   NA  Brain    63.6   286.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    53.9   NA  Crop    25.2   15.3  Midgut    25.6   29.8  Hindgut    19.7   no informative data  Malpighian Tubules    no informative data   9.4  Fat Body    5.6   11  Salivary Gland    no informative data   NA  Heart    6.175   34.75  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    17   NA  Ovary    649.2   NA  Testis    32.7   NA  Male Accessory Gland    15.9   20.075  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086350 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8961-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive tefk15914 tefk15915 viable tefk15914 tefZ1869 tefZ3455 tefZ4169 tefZ5549 tefZ5864 viable, with Scer\GAL4pnr-MD237 tefGD14081 Sterility Allele female fertile (with Df(2R)P803-Δ15) tefyh137 male fertile tefZ1869 tefZ3455 tefZ4169 tefZ5549 tefZ5864 Other Phenotypes Allele meiotic cell cycle defective | male (with Df(2R)P803-Δ15) tefyh137 meiotic cell cycle defective | male (with tefyh137) tefZ5549 meiotic cell cycle defective | male (with tefZ5549) tefyh137 meiotic cell cycle defective | male | recessive tefyh137 tefZ1869 tefZ4169 tefZ5549 tefZ5864 Phenotype manifest in Allele meiosis I tefZ1869 tefZ4169 tefZ5549 tefZ5864 spermatocyte tefZ5864
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of tef Class Mutagen Stocks Known lesion tefk15914 hypomorphic allele - genetic evidence P-element activity 2 Yes tefk15915 P-element activity 0 -- tefP1150 hypomorphic allele - genetic evidence 0 -- tefyh137 natural population 0 -- tefZ1869 ethyl methanesulfonate 0 Yes tefZ3455 ethyl methanesulfonate 0 Yes tefZ4169 ethyl methanesulfonate 0 Yes tefZ5549 ethyl methanesulfonate 0 Yes tefZ5864 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tef Class Mutagen Stocks Known lesion tefGD14081 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tefJF01285 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tefJF01493 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tefKK103098 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tefScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)Jp8 (Tomkiel et al., 2001) Df(2R)Pcl7B (Tomkiel et al., 2001)
Disrupted in	Df(2R)Exel6065 (Ryder, 2004.4.26) Df(2R)P803-Δ15 (Tomkiel, 2001.12.6, Arya et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14081} NA P{KK103098} NA P{TRiP.JF01285} NA P{TRiP.JF01493} NA P{UAS-tef.EGFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}tefk15914 No P{lacW}tefk15915 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
male meiosis chromosome segregation inferred from mutant phenotype (Hirai et al., 2004, Arya et al., 2006) male meiosis I inferred from mutant phenotype (Tomkiel et al., 2001)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
synapsis non-traceable author statement (Tomkiel and Briscoe, 2001)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tef allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086350 DroID - A comprehensive database of gene and protein interactions. • FBgn0086350
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA21437 (Arya et al., 2006) Dsim\tef (Arya et al., 2006) Dyak\tef (Arya et al., 2006)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231839 FBgn0208640 FBgn0196790 FBgn0174895 FBgn0081424 FBgn0148165 FBgn0141174 FBgn0130401 FBgn0114395 FBgn0090460
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	31046 y1 v1; P{TRiP.JF01493}attP2 31328 y1 v1; P{TRiP.JF01285}attP2 11150 y1 w67c23; P{lacW}tefk15914 fat-spondink15914/CyO
Kyoto	111350 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}tefk15914 /CyO y+
VDRC	v107091 P{KK103098}VIE-260B v23660 w1118; P{GD14081}v23660
Genomic Clones ( 1 )
	BACR32P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 88 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32631
Other clones	DPiM_LD32631
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01495 LD01962 LD02170 LD03195 LD03801 LD07073 LD09762 LD13992 LD14077 LD16118 LD16955 LD25495 LD34058 RE03952 RE05055 RE08041 RE11647 RE12010 RE18163 RE20125 RE23150 RE25274 RE26012 RE36287 RE36413 RE39691 RE47157 RE48807 RE49530 RE50707 RE51090 RE51767 RE54346 RE57388 RE64495 RE69584 RE74243 RE74659
Other clones	102070 104504 159032 274371 Dmel_neb_012070_0851_2887 EK146207 EK224313 EK229249 EK262362 EK301840 RP003001103 RP003040945 RP003051778 RP003074987 RP003082756 RP003082935 RP003088019 RP003090584 RP003095173 RP003097107 RP003100564 RP003123127 RP003126704 RP003130572 RP003135951 RP003140171 RP003192256 RP003205104 RP003218019 RP003223268 RP003228746 RP003253604 RP003264551 RP003268808 RP003320203 RP003340246 RP003345388 RP003385805 RP003401643 RP003405304 RP003472492 RP003483703 RP003549995 RP003604564 RP003607525 RP003661512 RP003671409 RP003677248
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086350 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36920
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tef CG8961 (Tomkiel, 2001.3.5)
Source for database merge of	Source for merge of: tef l(2)k15914 (Arya et al., 2006)
Additional comments	It is possible that "mei-S8" and "tef" identify the same complementation group, but lack of extant "mei-S8" mutant stocks precludes complementation tests. (Tomkiel, 2001.3.5)
Other Comments
	tef expression is required in the male germline prior to spermatocyte stage S4 for the proper segregation of the autosomes during meiosis. (Arya et al., 2006) Mutations in tef cause meiosis-I specific nondisjunction of the autosomes in males. (Tomkiel et al., 2001) tef is required for maintenance of pairing between autosomal bivalents until their separation at anaphase I. (Tomkiel and Briscoe, 2001) Mutations cause high rates of fourth chromosome nondisjunction and also nondisjunction of the major autosomes in male meiosis. The mutant phenotype is male-specific. (Tomkiel, 2001.3.5)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079042 RefSeq (Proteins) • NP_523766 DDBJ / EMBL / GenBank • AA978662 AA979469 AAF57911 AAK93242 AAV90631 AAV90632 AAV90633 AAV90634 AAV90635 AQ026096 AW943141 AY051818 AY840216 AY840217 AY840218 AY840219 AY840220 Entrez Gene - A searchable database of RefSeq genes. • 36920 UniProtKB/TrEMBL • Q7K4M4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086350 DroID - A comprehensive database of gene and protein interactions. • FBgn0086350 DRSC - Results from RNAi screens. • FBgn0086350 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086350 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8961-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086350 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36920 modMine - Data generated by the modENCODE project. • FBgn0086350 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231839 FBgn0208640 FBgn0196790 FBgn0174895 FBgn0081424 FBgn0148165 FBgn0141174 FBgn0130401 FBgn0114395 FBgn0090460
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG8961 (Arya et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2008) l(2)k15914 (Arya et al., 2006, ) tef (Arya et al., 2006, Thomas et al., 2005, Thomas and Tomkiel, 2007, Hartl et al., 2008)
Name Synonym	lethal (2) k15914   teflon (Matsui et al., 2007, Thomas and Tomkiel, 2007, Tomkiel and Briscoe, 2001, Tomkiel et al., 2001, Arya et al., 2006, Hartl et al., 2008, Anderson et al., 2009, Reis et al., 2011) Teflon (McKim, 2005)
Secondary FlyBase IDs
	FBgn0021831 FBgn0034185 FBgn0043472
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 2 ) Review  ( 3 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...