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FB2025_02
,
released April 17, 2025
RacGAP50C, RacGAP, acGAP, DRacGAP
cytoskeletal regulator required for cytokinesis - connects the contractile ring to cortical microtubules at the site of furrowing in dividing cells - negatively regulates the wingless pathway during Drosophila embryonic development - required for neuroblast proliferation and limits axon growth
Please see the JBrowse view of Dmel\tum for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tum using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
tum protein is localized throughout muscle fibers and in discrete cytoplasmic puncta in body wall muscles in late embryos.
JBrowse - Visual display of RNA-Seq signals
View Dmel\tum in JBrowse2-68
2-73.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2-unspecified : S2 cells stably expressing GFP-tagged pav or tum under the control of the Act5C promoter were generated. In addition lines containing GFP-tagged tum with human CD8 attached or just CD8-GFP under the control of the metallothionein promoter were generated.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape and cytokinesis failure when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of tum results in supernumerary class I neurons and a range of arborization defects.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.
RacGAP50C alters the wg homozygous mutant cuticle pattern phenotype. The RacGAP50C mutation in a wild-type background reduces denticle diversity and produces a compression and lateral expansion of the denticle belts. In the first row of denticles in each belt, some or all of the denticles may be missing. RacGAP50C interacts genetically with the gene nkd, enhancing the nkd phenotype.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Expression of RacGAP50C is repressed by Egfr/Ras signalling in the prospective wing veins and accumulates at the vein/intervein boundaries.
tum has a function in dendritic development.
"49C--50D" was stated as revision.
Source for merge of: RacGAP50C tum
Source for identity of acGAP CG13345 was sequence comparison ( date:000721 ).
Source for identity of: RacGAP50C eon
Source for identity of: acGAP CG13345
The mutation was named "enhancer of naked" after the mutant phenotype.
