RacGAP50C, RacGAP, acGAP, DRacGAP
cytoskeletal regulator required for cytokinesis - connects the contractile ring to cortical microtubules at the site of furrowing in dividing cells -negatively regulates the wingless pathway during Drosophila embryonic development - required for neuroblast proliferation and limits axon growth
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tum using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\tum in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: RacGAP50C tum
Source for identity of acGAP CG13345 was sequence comparison ( date:000721 ).
tum regulates microtubule organisation during myogenesis. tum is required for the change in localisation of the microtubule nucleator γ-tubulin, from a diffuse cytoplasmic location to discrete cytoplasmic puncta at the nuclear periphery, that normally occurs during myogenesis.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape and cytokinesis failure when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of tum results in supernumerary class I neurons and a range of arborization defects.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.
RacGAP50C alters the wg homozygous mutant cuticle pattern phenotype. The RacGAP50C mutation in a wild-type background reduces denticle diversity and produces a compression and lateral expansion of the denticle belts. In the first row of denticles in each belt, some or all of the denticles may be missing. RacGAP50C interacts genetically with the gene nkd, enhancing the nkd phenotype.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Expression of RacGAP50C is repressed by Egfr/Ras signalling in the prospective wing veins and accumulates at the vein/intervein boundaries.
Reduced RacGAP50C or increased Rac1 activity in the wing disc cause similar defects: widening of veins development of extra sensory organs, apoptosis and appearance of enlarged cells that differentiate multiple hairs with abnormal polarity.
The mutation was named "enhancer of naked" after the mutant phenotype.