FB2025_01 , released February 20, 2025
Gene: Dmel\Sec61α
Open Close
General Information
Symbol
Dmel\Sec61α
Species
D. melanogaster
Name
Sec61 α subunit
Annotation Symbol
CG9539
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086357
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
Sec61 α subunit (Sec61α) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Sec61, endd2, E(br)165, l(2)k04917, DSec61α

Key Links
Genomic Location
Cytogenetic map
26D7-26D8
Sequence location
Recombination map
2-20
RefSeq locus
NT_033779 REGION:6477182..6480575
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables protein transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000097217
(GO Reference Genome Project, 2011-)
enables ribosome binding
inferred from biological aspect of ancestor with PANTHER:PTN000097220
(GO Reference Genome Project, 2011-)
enables signal sequence binding
inferred from biological aspect of ancestor with PANTHER:PTN000097218
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in cellular response to virus
inferred from mutant phenotype
(Panda et al., 2013)
involved_in cuticle development
inferred from mutant phenotype
(Ward et al., 2003)
involved_in dorsal closure
inferred from mutant phenotype
(Wang and Ward, 2010, Ward et al., 2003)
involved_in head involution
inferred from mutant phenotype
(Ward et al., 2003)
involved_in negative regulation of autophagy
inferred from mutant phenotype
(Arsham and Neufeld, 2009)
involved_in positive regulation of iron ion transmembrane transport
inferred from mutant phenotype
(Panda et al., 2013)
involved_in positive regulation of viral entry into host cell
inferred from mutant phenotype
(Panda et al., 2013)
involved_in regulation of neuron apoptotic process
inferred from mutant phenotype
(Kanuka et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in post-translational protein targeting to membrane, translocation
inferred from biological aspect of ancestor with PANTHER:PTN000097220
(GO Reference Genome Project, 2011-)
involved_in protein transport
inferred from electronic annotation with InterPro:IPR002208
(InterPro Project Members, 2004-)
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation
inferred from biological aspect of ancestor with PANTHER:PTN000097217
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum
inferred from high throughput direct assay
(Lye et al., 2014)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008)
located_in rough endoplasmic reticulum
inferred from direct assay
(Roper, 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR002208
(InterPro Project Members, 2004-)
part_of Sec61 translocon complex
inferred from biological aspect of ancestor with PANTHER:PTN000097220
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Sec61 α subunit (Sec61α) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
SEC61 TRANSLOCON - CG8860 VARIANT -
The Sec61 translocon is a heterotrimeric complex comprising alpha, beta and gamma subunits localized to the membrane of the endoplasmic reticulum. Nascent polypeptides bound to the signal recognition particle (SRP) first interact with the SRP receptor and are then transferred to the Sec61 translocon, which either integrates the protein into the lipid bilayer or translocates it across the membrane to enter the secretory pathway. (Adapted from PMID:23414305.)
SEC61 TRANSLOCON - SEC61γ VARIANT -
The Sec61 translocon is a heterotrimeric complex comprising alpha, beta and gamma subunits localized to the membrane of the endoplasmic reticulum. Nascent polypeptides bound to the signal recognition particle (SRP) first interact with the SRP receptor and are then transferred to the Sec61 translocon, which either integrates the protein into the lipid bilayer or translocates it across the membrane to enter the secretory pathway. (Adapted from PMID:23414305.)
SEC61 TRANSLOCON - TESTIS-SPECIFIC VARIANT -
The Sec61 translocon is a heterotrimeric complex comprising alpha, beta and gamma subunits localized to the membrane of the endoplasmic reticulum. Nascent polypeptides bound to the signal recognition particle (SRP) first interact with the SRP receptor and are then transferred to the Sec61 translocon, which either integrates the protein into the lipid bilayer or translocates it across the membrane to enter the secretory pathway. (Adapted from PMID:23414305.)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sec61α for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8STG9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sec61α-RA
FBtr0079266
NM_135190
2019
476
Sec61α-RB
FBtr0345753
NM_001298745
2128
476
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sec61α-PA
FBpp0078896
52.2
476
8.35
Q8STG9
NP_609034
AAF52389
Sec61α-PB
FBpp0311774
52.2
476
8.35
Q8STG9
NP_001285674
AHN54189
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

476 aa isoforms: Sec61α-PA, Sec61α-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sec61α using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.91

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum
inferred from high throughput direct assay
(Lye et al., 2014)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008)
located_in rough endoplasmic reticulum
inferred from direct assay
(Roper, 2007)
Expression Deduced from Reporters
Reporter: P{PTT-GC}Sec61αCC00735
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
germarium
• fusome
(Lighthouse et al., 2008)
adult stage | male
male germline cyst
• fusome
(Lighthouse et al., 2008)
Reporter: P{PTT-un}Sec61αZCL0488
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
epidermis | ubiquitous
(Roper, 2007)
amnioserosa
(Roper, 2007)
oogenesis & adult stage | female
follicle cell
(Roper, 2007)
germarium | ubiquitous
(Roper, 2007)
nurse cell
(Roper, 2007)
oocyte
(Roper, 2007)
Reporter: PBac{754.P.FSVS-0}Sec61αCPTI002894
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult gnathal ganglion | restricted

Comment: part of adult subesophageal ganglion

(Knowles-Barley, 2011.8.24)
adult brain cell body rind

Comment: adult brain cortex, higher around central brain

(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sec61α in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sec61α
Transgenic constructs containing regulatory region of Sec61α
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL429BD
lethal, with Scer\GAL4c355
lethal, with Scer\GAL4dpp.blk1
lethal, with Scer\GAL4hs.2sev
lethal (with Df(2L)BSC296)
lethal | embryonic stage
lethal | embryonic stage (with Sec61α1)
lethal | embryonic stage (with Sec61αk04917)
lethal | first instar larval stage
lethal | first instar larval stage (with Sec61α1)
lethal | first instar larval stage (with Sec61αk04917)
lethal | recessive
lethal - all die during embryonic stage (with Df(2L)BSC6)
lethal - all die during embryonic stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal stress response, with Scer\GAL4hs.PU
some die during embryonic stage (with Df(2L)BSC6)
some die during embryonic stage | recessive
Phenotype manifest in
Allele
autophagic vacuole & larval fat body | somatic clone | cell autonomous
autophagic vacuole & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP
cephalopharyngeal skeleton
cephalopharyngeal skeleton (with Df(2L)BSC6)
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle (with Df(2L)BSC6)
embryonic/first instar larval cuticle | dorsal
embryonic/larval crystal cell
embryonic/larval midgut primordium
embryonic leading edge cell
embryonic midgut constriction 2
larval tracheal system
lysosome & larval fat body | somatic clone | cell autonomous
lysosome & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP
organism | dorsal closure stage
rhabdomere R7, with Scer\GAL4Rh3.PP
tracheal metamere
ventral denticle belt
ventral denticle belt (with Df(2L)BSC6)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\SEC61A2
14 of 14
Yes
Yes
1  
Hsap\SEC61A1
13 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Sec61a2
14 of 14
Yes
Yes
Rnor\Sec61a1
13 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Sec61a1
13 of 14
Yes
Yes
Mmus\Sec61a2
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\sec61a1
6 of 13
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\sec61a1
13 of 14
Yes
Yes
Drer\sec61a1l
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\sec-61.A
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP009182
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (5)
Atha\AT1G78720
13 of 13
Yes
Yes
Atha\AT1G29310
12 of 13
No
Yes
Atha\AT2G34250
12 of 13
No
Yes
Atha\SCY1
1 of 13
No
Yes
Atha\SCY2
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\SEC61
12 of 13
Yes
Yes
Scer\SSH1
4 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\sec61
11 of 12
Yes
Yes
Spom\SPBC19G7.17
3 of 12
No
Yes
Escherichia coli (enterobacterium) (1)
Ecol\secY
2 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sec61α. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SEC61A2; SEC61 translocon subunit alpha 2
    14 of 14
    618271
         
        SEC61A1; SEC61 translocon subunit alpha 1
        13 of 14
        609213
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Show/hide secondary interactors 
          (data from AllianceMine provided by esyN)
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Other Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Sec61α - Agpat3
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Atpα
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - CCT8
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - CG13220
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - CG3164
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - CG31729
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - CG33303
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - CG8195
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - CG8475
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Cds
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Cnx99A
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Cyp12d1-p
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Fatp1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - GluProRS
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Gp93
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Idh3a
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Ipo9
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Kap-α3
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Karyβ3
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - KdelR
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Kdsr
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Kr-h2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - MRP
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Mcad
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Mec2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Mpcp2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Ost48
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - OstΔ
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Ostγ
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Past1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - PhKγ
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Pp2A-29B
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Rab5
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Rdh1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Rer1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - SERCA
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Scamp
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Spindly
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Surf4
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Tango9
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Tapδ
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Tecr
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - TrpRS
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - UQCR-C2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - Vps4
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - ZnT63C
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - emb
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - fax
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - jagn
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - spidey
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - sun
          experimental knowledge based
          (Guruharsha et al., 2011)
          Sec61α - wal
          experimental knowledge based
          (Guruharsha et al., 2011)
          Summary of Genetic Interactions
          esyN Network Diagram
          Show/hide secondary interactors 
          (data from AllianceMine provided by esyN)
          esyN Network Key:
          Suppression
          Enhancement
          Other Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          br
          enhanceable
          Sec61α
          (Ward et al., 2003)
          H
          enhanceable
          Sec61α
          (Müller et al., 2005)
          peb
          suppressible
          Sec61α
          (Wilk et al., 2004)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-20
          Cytogenetic map
          26D7-26D8
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          26D7-26D8
          Limits computationally determined from genome sequence between P{lacW}l(2)k09923k09923&P{lacW}CG9523k07502b and P{EP}Sec61αEP2180
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          26D6-26D8
          (determined by in situ hybridisation)
          (Spradling et al., 1999)
          26D6-26D8
          26D6--9 26D7--8
          (BDGP Project Members, 1994-1999)
          Experimentally Determined Recombination Data
          Location

          2-20

          (FlyBase, 2016)

          2-20.8

          (Comeron et al., 2012)

          2-17--31

          (Ward et al., 2003)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (16)
          Genomic Clones (20)
          cDNA Clones (161)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release.

                (Zhang et al., 2006)

                Area matching Drosophila EST AA391135. This EST has sequence similarity to human SEC61. Probable intron in gene represented by EST AA391135.

                (Davies, 2001.3.15)

                Area matching Drosophila ESTs A!295205 and AA141054. These ESTs show evidence of alternative splicing.

                (Davies, 2001.3.15)

                Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

                (Harvie et al., 1998)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: BEST:LD29847 CG9539

                (Bayraktaroglu, 2000.11.2)

                Source for merge of: l(2)k04917 Sec61α

                (Kanuka et al., 2003)

                Source for merge of: Sec61α E(br)165

                (Wang et al., 2007)

                Source for merge of: Sec61α BcDNA:LD29847

                (FlyBase, 1996-)

                Source for merge of: Sec61α anon-WO0118547.195 anon-WO0118547.277

                (FlyBase, 1996-)
                Additional comments

                Source for merge of Sec61α BcDNA:LD29847 was a shared cDNA ( date:020730 ).

                (FlyBase, 1996-)

                Source for merge of Sec61α anon-WO0118547.195 anon-WO0118547.277 was sequence comparison ( date:051113 ).

                (FlyBase, 1996-)

                Source for identity of Sec61α BEST:LD29847 was sequence comparison ( date:011219 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of

                Source for identity of: Sec61α endd2

                (Kanuka, 2002.3.19)

                Source for identity of: Sec61α BEST:LD29847

                (FlyBase, 1996-)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (25)
                Reported As
                Symbol Synonym
                0455
                (Harvie et al., 1998)
                BEST:LD29847
                BcDNA:LD29847
                CG9539
                (National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Çiçek et al., 2016, McEachern et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Li et al., 2010, Keleman et al., 2009.8.5, Sepp et al., 2008, Quinones-Coello, 2007, Dorer et al., 2006, Kanuka et al., 2005)
                DSec61alpha
                (Kanuka, 2001.6.1)
                DSec61α
                (Kanuka et al., 2005, Kanuka et al., 2003)
                E(br)165
                (Wang et al., 2007)
                LD29847
                (Toba et al., 1999)
                SEC61-alpha
                (Dorer et al., 2006)
                SEC61ALPHA
                (Vinci et al., 2008)
                Sec61
                (Arsham and Neufeld, 2008, Pokrywka et al., 2008, Milchanowski et al., 2004, Wilk et al., 2004)
                Sec61-α
                (Roper, 2007)
                Sec61a
                (Wang et al., 2007)
                Sec61alpha
                (National Institute of Genetics Fly Stocks, 2022-, Sarov et al., 2016, Aradska et al., 2015, Zirin et al., 2015, Kwon et al., 2013, Fox et al., 2010, Sims et al., 2009, Tan et al., 2009, Lighthouse et al., 2008, Sepp et al., 2008, Buszczak et al., 2007, Quinones-Coello, 2007, Giot et al., 2003)
                Sec61α
                (Muita and Baxter, 2023, Wang et al., 2023, Okuda et al., 2022, Gupta and Stocker, 2020, Lerner et al., 2013, O'Sullivan et al., 2013, Maynard et al., 2010, Wang and Ward, 2010, Zhang et al., 2010, Sepp et al., 2008, Roper, 2007, Zhang et al., 2006, Kanuka et al., 2005)
                anon-WO0118547.195
                anon-WO0118547.277
                dSEC61A
                (Panda et al., 2013)
                dSec61α
                (Arsham and Neufeld, 2009)
                endd2
                (Kanuka et al., 2005, Kanuka et al., 2003, Kanuka et al., 2002)
                l(2)k04917
                (Spradling et al., 1999, Beaton, 1997.3.4)
                sec61
                (Clyne et al., 2003)
                sec61α
                (Wang et al., 2008)
                Name Synonyms
                E(br)165
                Sec61 α subunit
                Sec61alpha
                (McEachern et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011, Sepp et al., 2008)
                Sec61α
                (Sepp et al., 2008)
                effector for neural death and degeneration 2
                (Kanuka et al., 2005)
                Secondary FlyBase IDs
                • FBgn0026571
                • FBgn0069450
                • FBgn0019697
                • FBgn0031819
                • FBgn0047201
                • FBgn0062125
                • FBgn0062178
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 48 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                References (107)