FB2022_03, released June 9, 2022

Gene: Dmel\Tab2

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General Information
Symbol
Dmel\Tab2
Species
D. melanogaster
Name
TAK1-associated binding protein 2
Annotation Symbol
CG7417
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086358
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
TAK1-associated binding protein 2 (Tab2) encodes a protein with an ubiquitin binding domain. It interacts with the product of Tak1, a MAP kinase kinase kinase involved the activation of the immune deficiency, JNK and Grindelwald-Eiger pathways. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dTAB2, TAB, galere, ORF1

Key Links
Genomic Location
Cytogenetic map
56C8-56C9
Sequence location
Recombination map
2-88
RefSeq locus
NT_033778 REGION:19292529..19304508
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables signaling adaptor activity
inferred from direct assay
(Geuking et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables ubiquitin binding
inferred from electronic annotation with InterPro:IPR003892
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Ertürk-Hasdemir et al., 2009, Valanne et al., 2007, Kleino et al., 2005)
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
inferred from mutant phenotype
(Kleino et al., 2005)
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
acts_upstream_of positive regulation of cell death
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Geuking et al., 2005)
involved_in positive regulation of defense response to virus by host
inferred from mutant phenotype
(Avadhanula et al., 2009)
involved_in tumor necrosis factor-mediated signaling pathway
inferred from mutant phenotype
(Zhang et al., 2010)
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Geuking et al., 2005)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
TAK1-associated binding protein 2 (Tab2) encodes a protein with an ubiquitin binding domain. It interacts with the product of Tak1, a MAP kinase kinase kinase involved the activation of the immune deficiency, JNK and Grindelwald-Eiger pathways. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Imd Signaling Pathway Core Components -
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
TNFα-Eiger Signaling Pathway Core Components -
The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Tab2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q6NQZ7)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tab2-RA
FBtr0086516
NM_137564
3249
831
Tab2-RB
FBtr0305333
NM_001259488
3305
831
Tab2-RC
FBtr0331925
NM_001274157
3081
820
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Tab2-PA
FBpp0085704
91.0
831
7.45
Q6NQZ7
NP_611408
AAF57580
Tab2-PB
FBpp0293876
91.0
831
7.45
Q6NQZ7
NP_001246417
AFH08170
Tab2-PC
FBpp0304258
90.3
820
7.35
A0A0B4KG87
NP_001261086
AGB93618
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

831 aa isoforms: Tab2-PA, Tab2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tab2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}cb30
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 17
embryonic/larval midgut
(Ward et al., 2002)
third instar larval stage
embryonic/larval central nervous system
(Ward et al., 2002)
embryonic/larval brain
(Ward et al., 2002)
ventral thoracic disc
(Ward et al., 2002)
circular visceral muscle fiber
(Lajeunesse et al., 2010)
larval enteroendocrine cell | subset
(Lajeunesse et al., 2010)
embryonic/larval midgut enterocyte
(Lajeunesse et al., 2010)
larval enteroendocrine cell
(Lajeunesse et al., 2010)
adult stage | male
testis | faint
(Ward et al., 2002)
oogenesis & adult stage | female
terminal filament
(Ward et al., 2002)
female germline stem cell
(Ward et al., 2002)
oogenesis stage S1 -- S6 & adult stage | female
nurse cell | faint
(Ward et al., 2002)
oogenesis stage S10 -- S14 & adult stage | female
oocyte | faint
(Ward et al., 2002)
Reporter: P{GawB}Tab2201Y
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
Kenyon cell
(O'Dell et al., 1995)
adult mushroom body | restricted
(Yang et al., 1995)
embryonic stage 4
yolk
(Kim et al., 2007)
embryonic brain
(Kim et al., 2007)
larval stage
adult mushroom body alpha-lobe | restricted
(Tettamanti et al., 1997)
mushroom body calyx
(Tettamanti et al., 1997)
Kenyon cell | subset
(Tettamanti et al., 1997)
adult mushroom body gamma-lobe | restricted
(Marin et al., 2005, Tettamanti et al., 1997)
adult mushroom body alpha'-lobe | restricted
(Tettamanti et al., 1997)
mushroom body pedunculus | restricted
(Tettamanti et al., 1997)
adult mushroom body beta-lobe | restricted
(Tettamanti et al., 1997)
embryonic/larval mushroom body | restricted
(Suster et al., 2003)
ring gland
(Pauls et al., 2010)
neuron of larval ventral nerve cord
(Pauls et al., 2010)
neuron of brain
(Pauls et al., 2010)
larval stage -- adult stage
gamma Kenyon cell
(Wong et al., 2013)
alpha/beta Kenyon cell | subset
(Wong et al., 2013)
first instar larval stage -- second instar larval stage
Kenyon cell | subset
(Kurusu et al., 2002)
mushroom body pedunculus | restricted
(Kurusu et al., 2002)
lobe system of mushroom body | restricted
(Kurusu et al., 2002)
third instar larval stage
Kenyon cell
(Kurusu et al., 2002)
mushroom body pedunculus
(Kurusu et al., 2002)
lobe system of mushroom body
(Kurusu et al., 2002)
embryonic/larval mushroom body
(Moran and Kyriacou, 2009, Armstrong et al., 1998)
mushroom body pedunculus | restricted
(Zhan et al., 2004)
lobe system of mushroom body | restricted
(Zhan et al., 2004)
embryonic/larval mushroom body | restricted
(Honjo and Furukubo-Tokunaga, 2009)
surface layer of the larval mushroom body
(Pauls et al., 2010)
outer layer of the larval mushroom body
(Pauls et al., 2010)
inner layer of the larval mushroom body
(Pauls et al., 2010)
third instar larval stage -- pupal stage P6
adult mushroom body gamma-lobe
(Watts et al., 2003)
pupal stage P5
adult mushroom body alpha-lobe
(Armstrong et al., 1998)
adult mushroom body beta-lobe
(Armstrong et al., 1998)
pupal stage P5 -- P7
mushroom body
(Armstrong et al., 1998)
pupal stage P6 -- P7
adult mushroom body gamma-lobe
(Armstrong et al., 1998)
pupal stage P7
adult mushroom body alpha-lobe
(Armstrong et al., 1998)
adult mushroom body beta-lobe
(Armstrong et al., 1998)
adult stage
adult mushroom body alpha-lobe | restricted
(Armstrong et al., 1998)
adult mushroom body beta-lobe | restricted
(Armstrong et al., 1998)
gamma Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28, Marchetti et al., 2014, Tanaka et al., 2008, Strausfeld et al., 2003, Zhu et al., 2003)
alpha/beta Kenyon cell | subset

Comment: Only a small number of late-born neurons are labelled.

(Zhu et al., 2003)
adult ventral nerve cord
(Connolly et al., 1996)
adult brain | restricted
(Crocker et al., 2010, Connolly et al., 1996)
calyx of adult mushroom body
(Tanaka et al., 2008)
adult mushroom body dorsal accessory calyx
(Tanaka et al., 2008)
mushroom body alpha lobe posterior layer
(Aso et al., 2009, Tanaka et al., 2008)
mushroom body alpha lobe surface layer
(Aso et al., 2009, Tanaka et al., 2008)
mushroom body alpha lobe core layer
(Tanaka et al., 2008)
mushroom body beta lobe posterior layer
(Aso et al., 2009, Tanaka et al., 2008)
mushroom body beta lobe surface layer
(Aso et al., 2009, Tanaka et al., 2008)
mushroom body beta lobe core layer
(Tanaka et al., 2008)
adult mushroom body | restricted
(Bushey et al., 2009, Strausfeld et al., 2003, Tettamanti et al., 1997)
adult mushroom body
(Moran and Kyriacou, 2009, Mehren and Griffith, 2004, Connolly et al., 1996)
adult mushroom body gamma-lobe
(Pauls et al., 2010, Aso et al., 2009, Strausfeld et al., 2003, Armstrong et al., 1998)
adult pars intercerebralis | restricted
(Crocker et al., 2010)
mushroom body beta lobe core layer | intense
(Aso et al., 2009)
mushroom body alpha lobe core layer | intense
(Aso et al., 2009)
adult antennal lobe | faint
(Aso et al., 2009)
adult tritocerebrum
(Aso et al., 2009)
adult gnathal ganglion | faint
(Aso et al., 2009)
adult pars intercerebralis
(Aso et al., 2009, Connolly et al., 1996)
alpha/beta core Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28, Marchetti et al., 2014)
alpha/beta surface Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28)
alpha/beta posterior Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28)
Kenyon cell
(Flybrain Neuron Database et al., 2018.6.28)
adult mushroom body alpha-lobe
(Pauls et al., 2010)
adult mushroom body beta-lobe
(Pauls et al., 2010)
adult Malpighian tubule | restricted
(Wang et al., 2004)
adult midgut
(Wang et al., 2004)
adult stage | male
adult mushroom body alpha-lobe
(Blum et al., 2009)
adult mushroom body beta-lobe
(Blum et al., 2009)
adult mushroom body gamma-lobe
(Blum et al., 2009)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tab2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 47 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tab2
Transgenic constructs containing regulatory region of Tab2
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6069
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TAB2
4 of 15
Yes
Yes
Hsap\TAB3
4 of 15
Yes
Yes
Hsap\TNFRSF1A
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tab2
4 of 15
Yes
Yes
Mmus\Tab3
4 of 15
Yes
Yes
Mmus\Tnfrsf1a
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Tab2
4 of 13
Yes
Yes
Rnor\Tab3
4 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\tab2
4 of 12
Yes
Yes
Xtro\tab3
1 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\tab2
4 of 15
Yes
Yes
Drer\tab3
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
    4 of 15
    605101
      TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
      4 of 15
      300480
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Tab2
          suppressible
          POSH
          (Zhang et al., 2010)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          egr
          suppressible
          Tab2
          (Geuking et al., 2005)
          HUWE1
          suppressible
          Tab2
          (Yanku et al., 2018)
          Syx7
          suppressible
          Tab2
          (Andersen et al., 2015)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Imd Signaling Pathway Core Components -
          The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
          TNFα-Eiger Signaling Pathway Core Components -
          The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-88
          Cytogenetic map
          56C8-56C9
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          56C8-56C9
          Limits computationally determined from genome sequence between P{PZ}ena02029&P{lacW}corak08713 and P{lacW}htsk06121
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          56D-56D
          (Yang, 2000.4.19)
          Experimentally Determined Recombination Data
          Location

          2-88

          (FlyBase, 2016)

          2-94.1

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (16)
          Genomic Clones (19)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (59)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Tsapras et al., 2022)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: ORF1 CG7417

          (FlyBase, 1996-)
          Source for database merge of

          Source for merge of: Tab2 galere

          (Ferrandon et al., 2007)
          Additional comments

          Source for identity of ORF1 CG7417 was sequence comparison ( date:000501 ).

          (FlyBase, 1996-)
          Other Comments

          Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

          (Liu and Lehmann, 2008)

          dsRNA has been made from templates generated with primers directed against this gene. RNAi of Tab2 results in inappropriate anterior arborization of ddaE neurons as well as inappropriate posterior arborization of ddaD neurons. RNAi also causes defects in dendrite morphogenesis.

          (Parrish et al., 2006)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a specific decrease in AttA activity in response to heat-killed E.coli when assayed in S2 cells. This effect is independent of ecdysone. Tab2 RNAi also decreases Drs activity via the Tl pathway. Tab2 RNAi fails to prevent AttA activation by Iap2, indicating that Tab2 is upstream of Iap2 in the imd signalling pathway.

          (Kleino et al., 2005)

          Tab2 may be involved in Rel nuclear localization.

          (Kleino et al., 2005)

          galere regulates the antibacterial response.

          (Ferrandon et al., 2001)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 54 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (15)
          Reported As
          Symbol Synonym
          7417
          (Shim et al., 2001)
          CG7417
          (Valanne, 2014, Douglas et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Carrera et al., 2008, Wu and Silverman, 2007, Parrish et al., 2006, Pilot et al., 2006, Rehwinkel et al., 2006, Gesellchen et al., 2005, Geuking et al., 2005, Kleino et al., 2005, Ringrose et al., 2004, Wang et al., 2004, Ringrose et al., 2003, Yang, 2000.10.10, FlyBase, 1996-)
          ORF1
          (Yang, 2000.4.19)
          TAB
          (Younes et al., 2020, Nelson et al., 2013, Douglas et al., 2011, Kuranaga and Miura, 2007, Wu and Silverman, 2007, Kleino et al., 2005)
          TAB2
          (Sciambra and Chtarbanova, 2021, Galenza and Foley, 2019, Mussabekova et al., 2017, Imler, 2014, Kleino and Silverman, 2014, Myllymäki et al., 2014, Aparicio et al., 2013, Fukuyama et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Eleftherianos and Castillo, 2012, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Vandenabeele and Bertrand, 2012, Ertürk-Hasdemir et al., 2009, Ferrandon et al., 2007, Wu and Silverman, 2007)
          Tab2
          (Havula et al., 2022, Rosendo Machado et al., 2021, Zhu et al., 2021, Krautz et al., 2020, La Marca and Richardson, 2020, Li et al., 2020, Goto et al., 2018, Yanku et al., 2018, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Andersen et al., 2015, Ashwal-Fluss et al., 2014, Valanne, 2014, Katzenberger et al., 2013, Mizrak et al., 2012, Abruzzi et al., 2011, Bates et al., 2010, Valanne et al., 2010, Ayroles et al., 2009, Moran and Kyriacou, 2009, Zsindely et al., 2009, Carrera et al., 2008, Liu and Lehmann, 2008, Riedl et al., 2007, Valanne et al., 2007)
          cg7417
          (Parrish et al., 2007)
          dTAB2
          (Mishra et al., 2021, Arora and Ligoxygakis, 2020, Palmer et al., 2018, Fernando et al., 2014, Kingsolver et al., 2013, Merkling and van Rij, 2013, Meinander et al., 2012, Zhang et al., 2010, Bond and Foley, 2009, Geuking et al., 2005)
          dTab2
          (Richardson and Portela, 2018, Bangi et al., 2012)
          galere
          tab-2
          (Aparicio et al., 2013)
          tab2
          (Moulton and Letsou, 2016, Avadhanula et al., 2009)
          Name Synonyms
          TAK1-associated Binding Protein2
          (Ferrandon et al., 2007)
          TAK1-associated binding protein 2
          (Bates et al., 2010)
          TGF-β–activated kinase 1/MAP3K7 binding protein 2
          (Fukuyama et al., 2013)
          Tab2
          galere
          (Wu and Silverman, 2007, Ferrandon et al., 2001)
          Secondary FlyBase IDs
          • FBgn0034431
          • FBgn0043901
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          References (117)