FB2020_06, released Dec 22, 2020

Gene: Dmel\alph

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General Information
Symbol
Dmel\alph
Species
D. melanogaster
Name
alphabet
Annotation Symbol
CG1906
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086361
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Snapshot
alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling. [Date last reviewed: 2019-08-01]
Other Summaries
Also Known As

SK3-1, pp2c99B

Key Links
Genomic Location
Cytogenetic map
99B4-99B5
Sequence location
3R:29,591,831..29,617,157 [+]
Recombination map

3-99

RefSeq locus
NT_033777 REGION:29591831..29617157
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein serine/threonine phosphatase activity
inferred from direct assay
(Baril and Therrien, 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables magnesium ion binding
inferred from electronic annotation with InterPro:IPR012911
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables manganese ion binding
inferred from electronic annotation with InterPro:IPR012911
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (17 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
involved_in dephosphorylation
inferred from direct assay
(Baril and Therrien, 2006)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Baril et al., 2009)
involved_in dorsal closure
inferred from genetic interaction with FLYBASE:slpr; FB:FBgn0030018
(Baril et al., 2009)
involved_in imaginal disc fusion, thorax closure
inferred from genetic interaction with FLYBASE:slpr; FB:FBgn0030018
(Baril et al., 2009)
involved_in mitotic cell cycle
inferred from mutant phenotype
(Chen et al., 2007)
involved_in negative regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Baril and Therrien, 2006)
inferred from high throughput genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Ashton-Beaucage et al., 2014)
involved_in negative regulation of JNK cascade
inferred from mutant phenotype
(Baril et al., 2009)
inferred from genetic interaction with FLYBASE:hep; FB:FBgn0010303
(Baril et al., 2009)
involved_in negative regulation of photoreceptor cell differentiation
inferred from genetic interaction with FLYBASE:aop; FB:FBgn0000097
(Baril and Therrien, 2006)
involved_in negative regulation of R7 cell differentiation
inferred from genetic interaction with FLYBASE:aop; FB:FBgn0000097
(Baril and Therrien, 2006)
involved_in negative regulation of Ras protein signal transduction
inferred from high throughput genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Ashton-Beaucage et al., 2014)
involved_in negative regulation of sevenless signaling pathway
inferred from genetic interaction with FLYBASE:aop; FB:FBgn0000097
(Baril and Therrien, 2006)
involved_in negative regulation of stress-activated MAPK cascade
inferred from genetic interaction with FLYBASE:hep; FB:FBgn0010303
(Baril et al., 2009)
inferred from genetic interaction with FLYBASE:slpr; FB:FBgn0030018
(Baril et al., 2009)
inferred from genetic interaction with FLYBASE:lic; FB:FBgn0261524
(Baril et al., 2009)
involved_in negative regulation of stress-activated protein kinase signaling cascade
inferred from mutant phenotype
(Baril et al., 2009)
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333
(Baril et al., 2009)
involved_in regulation of p38MAPK cascade
inferred from genetic interaction with FLYBASE:lic; FB:FBgn0261524
(Baril et al., 2009)
involved_in response to oxidative stress
inferred from mutant phenotype
(Baril et al., 2009)
involved_in response to paraquat
inferred from mutant phenotype
(Baril et al., 2009)
involved_in response to UV-C
inferred from mutant phenotype
(Baril et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of stress-activated MAPK cascade
inferred from biological aspect of ancestor with PANTHER:PTN002675704
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN002302296
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002302296
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
PPM FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -
Metal-dependent protein phosphatase (PPM) are Mg2+- or Mn2+-dependent serine/threonine phosphatases. The phosphatase does not require regulatory subunits, but has additional domains that may determine substrate specificity. (Adapted from PMID:11230548 and PMID:19879837).
Pathway (FlyBase)
Negative Regulators of Sevenless Signaling Pathway -
Negative regulators of Sevenless signaling down-regulate the pathway, directing the presumptive R7 cell fate to that of a cone cell. (Adapted from FBrf0127283 and FBrf0221727).
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\alph for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.50

EST data suggest additional 3' exon(s)

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
alph-RA
FBtr0085442
NM_170416
2576
368
alph-RB
FBtr0085443
NM_170419
2712
371
alph-RC
FBtr0085446
NM_170417
2341
368
alph-RD
FBtr0085445
NM_170418
2417
368
alph-RE
FBtr0085444
NM_143444
1683
374
alph-RF
FBtr0309241
NM_001260427
2504
332
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
alph-PA
FBpp0084808
41.0
368
4.95
NP_733295
AAF56905
alph-PB
FBpp0084809
41.4
371
4.77
NP_733298
AAN14179
alph-PC
FBpp0084812
41.0
368
4.95
NP_733296
AAN14177
alph-PD
FBpp0084811
41.0
368
4.95
NP_733297
AAN14178
alph-PE
FBpp0084810
41.6
374
4.88
NP_651701
AAN14176
alph-PF
FBpp0301180
36.9
332
5.47
NP_001247356
AFH06673
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

368 aa isoforms: alph-PA, alph-PC, alph-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\alph using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\alph in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of alph
Transgenic constructs containing regulatory region of alph
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
partially lethal - majority live (with alphS-331)
partially lethal - majority live (with alphS-355)
partially lethal - majority live (with alphXS-88)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile
Other Phenotypes
Allele
exocytosis defective | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
long lived
oxidative stress response defective
radiation sensitive
radiation sensitive, with Scer\GAL4Tub.PU
visible (with alphS-331)
visible (with alphS-355)
visible (with alphXS-88)
wild-type
Phenotype manifest in
Allele
cone cell
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
eye (with alphS-331)
eye (with alphS-355)
eye (with alphXS-88)
photoreceptor cell R7 | supernumerary
primary pigment cell
secondary pigment cell | supernumerary
tertiary pigment cell | supernumerary
wing (with alphS-331)
wing (with alphS-355)
wing (with alphXS-88)
wing vein (with alphS-331)
wing vein (with alphS-355)
wing vein (with alphXS-88)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PPM1A
13 of 15
Yes
Yes
Hsap\PPM1B
12 of 15
No
Yes
1  
Hsap\PPM1N
7 of 15
No
Yes
Hsap\PPM1F
3 of 15
No
No
1  
Hsap\PPM1G
3 of 15
No
No
Hsap\PDP2
2 of 15
No
No
Hsap\PP2D1
2 of 15
No
Yes
Hsap\PPM1E
2 of 15
No
No
Hsap\ILKAP
1 of 15
No
No
Hsap\PDP1
1 of 15
No
No
Hsap\PPM1D
1 of 15
No
No
Hsap\PPM1H
1 of 15
No
No
Hsap\PPM1J
1 of 15
No
No
Hsap\PPM1K
1 of 15
No
No
Hsap\PPM1L
1 of 15
No
No
Hsap\PPM1M
1 of 15
No
No
1  
Hsap\PPTC7
1 of 15
No
No
Hsap\TAB1
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ppm1a
13 of 15
Yes
Yes
Mmus\Ppm1b
13 of 15
Yes
Yes
Mmus\Ppm1n
7 of 15
No
Yes
Mmus\Ppm1f
3 of 15
No
No
Mmus\Pdp2
2 of 15
No
No
Mmus\Pp2d1
2 of 15
No
Yes
Mmus\Ppm1e
2 of 15
No
No
Mmus\Ppm1g
2 of 15
No
No
Mmus\Ilkap
1 of 15
No
No
Mmus\Pdp1
1 of 15
No
No
Mmus\Ppm1d
1 of 15
No
No
Mmus\Ppm1h
1 of 15
No
No
Mmus\Ppm1j
1 of 15
No
No
Mmus\Ppm1k
1 of 15
No
No
Mmus\Ppm1l
1 of 15
No
No
Mmus\Ppm1m
1 of 15
No
No
Mmus\Pptc7
1 of 15
No
No
Mmus\Tab1
1 of 15
No
No
Rattus norvegicus (Norway rat) (17)
Rnor\Ppm1a
11 of 13
Yes
Yes
Rnor\Ppm1b
10 of 13
No
Yes
Rnor\Ppm1n
5 of 13
No
Yes
Rnor\Ppm1g
3 of 13
No
No
Rnor\Pdp2
2 of 13
No
No
Rnor\Pp2d1
2 of 13
No
Yes
Rnor\Ppm1f
2 of 13
No
No
Rnor\Ilkap
1 of 13
No
No
Rnor\Pdp1
1 of 13
No
No
Rnor\Ppm1d
1 of 13
No
No
Rnor\Ppm1e
1 of 13
No
No
Rnor\Ppm1h
1 of 13
No
No
Rnor\Ppm1j
1 of 13
No
No
Rnor\Ppm1k
1 of 13
No
No
Rnor\Ppm1l
1 of 13
No
No
Rnor\Pptc7
1 of 13
No
No
Rnor\Tab1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\ppm1b
12 of 12
Yes
Yes
Xtro\ppm1a
11 of 12
No
Yes
Xtro\pdp2
2 of 12
No
No
Xtro\ppm1f
2 of 12
No
No
Xtro\ppm1g
2 of 12
No
No
Xtro\ilkap
1 of 12
No
No
Xtro\pdp1
1 of 12
No
No
Xtro\ppm1d
1 of 12
No
No
Xtro\ppm1e
1 of 12
No
No
Xtro\ppm1h
1 of 12
No
No
Xtro\ppm1j
1 of 12
No
No
Xtro\ppm1k
1 of 12
No
No
Xtro\ppm1l
1 of 12
No
No
Xtro\pptc7
1 of 12
No
No
Xtro\tab1
1 of 12
No
No
Danio rerio (Zebrafish) (23)
Drer\ppm1ab
12 of 15
Yes
Yes
Drer\ppm1ba
12 of 15
Yes
Yes
Drer\ppm1bb
12 of 15
Yes
Yes
Drer\ppm1aa
10 of 15
No
Yes
Drer\ppm1na
7 of 15
No
Yes
Drer\ppm1nb
7 of 15
No
Yes
Drer\ppm1f
3 of 15
No
No
Drer\ppm1g
3 of 15
No
No
Drer\ilkap
1 of 15
No
No
Drer\pdp1
1 of 15
No
No
Drer\pdp2
1 of 15
No
No
Drer\ppm1da
1 of 15
No
No
Drer\ppm1db
1 of 15
No
No
Drer\ppm1e
1 of 15
No
No
Drer\ppm1j
1 of 15
No
No
Drer\ppm1k
1 of 15
No
No
Drer\ppm1la
1 of 15
No
No
Drer\ppm1lb
1 of 15
No
No
Drer\pptc7a
1 of 15
No
No
Drer\pptc7b
1 of 15
No
No
Drer\si:ch211-15p9.2
1 of 15
No
No
Drer\si:ch211-149b19.3
1 of 15
No
No
Drer\tab1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\ppm-1.A
15 of 15
Yes
Yes
Cele\ppm-2
4 of 15
No
No
Cele\ppm-1.G
3 of 15
No
No
Cele\fem-2
2 of 15
No
No
Cele\tap-1
2 of 15
No
No
Cele\ilkp-1
1 of 15
No
No
Cele\pdp-1
1 of 15
No
No
Cele\ppm-1.D
1 of 15
No
No
Cele\W09D10.4
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\AT2G25070
3 of 9
Yes
No
Atha\AT4G31860
3 of 9
Yes
No
Atha\ABI1
1 of 9
No
Yes
Atha\ABI2
1 of 9
No
Yes
Atha\AHG1
1 of 9
No
Yes
Atha\AT4G11040
1 of 9
No
Yes
Atha\DBP1
1 of 9
No
Yes
Atha\HAB1
1 of 9
No
Yes
Atha\HAB2
1 of 9
No
Yes
Atha\HAI1
1 of 9
No
Yes
Atha\HAI2
1 of 9
No
Yes
Atha\HAI3
1 of 9
No
Yes
Atha\PP2CA
1 of 9
No
Yes
Atha\PP2CG1
1 of 9
No
Yes
Atha\TAP38
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\PTC2
5 of 15
Yes
No
Scer\PTC1
3 of 15
No
Yes
Scer\PTC3
3 of 15
No
No
Scer\PTC4
1 of 15
No
No
Scer\PTC5
1 of 15
No
No
Scer\PTC6
1 of 15
No
No
Scer\PTC7
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\ptc2
3 of 12
Yes
No
Spom\ptc3
3 of 12
Yes
No
Spom\ptc1
1 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AT3 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012969
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012751
Drosophila simulans
Dsim\GD21442
Drosophila sechellia
Dsec\GM13564
Drosophila sechellia
Dsec\GM12795
Drosophila erecta
Dere\GG11671
Drosophila yakuba
Dyak\GE23859
Drosophila ananassae
Dana\GF23353
Drosophila pseudoobscura pseudoobscura
Dpse\GA15122
Drosophila persimilis
Dper\GL13894
Drosophila willistoni
Dwil\GK11903
Drosophila virilis
Dvir\GJ10608
Drosophila mojavensis
Dmoj\GI23119
Drosophila grimshawi
Dgri\GH18902
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507O1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012971
Glossina morsitans
Tsetse fly
Gmor\GMOY007008
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11666
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003326
Anopheles darlingi
American malaria mosquito
Adar\ADAC007994
Anopheles gambiae
Malaria mosquito
Agam\AGAP008149
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004872
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W082D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004743
Danaus plexippus
Monarch butterfly
Dple\DPOGS214749-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006010
Apis florea
Little honeybee
Aflo\3170936452
Apis mellifera
Western honey bee
Amel\GB52229
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11405
Bombus terrestris
Buff-tailed bumblebee
Bter\15216253
Linepithema humile
Argentine ant
Lhum\LH14091
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003524
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05285
Tribolium castaneum
Red flour beetle
Tcas\TC015925
Pediculus humanus
Human body louse
Phum\PHUM335180
Rhodnius prolixus
Kissing bug
Rpro\RPRC009605
Cimex lectularius
Bed bug
Clec\CLEC003309
Cimex lectularius
Bed bug
Clec\CLEC005985
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07159
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07Y6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003078
Ixodes scapularis
Black-legged tick
Isca\ISCW008982
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77742.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur24g01750
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307949
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AJQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ppm1a/b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ppm1g
Ciona intestinalis
Vase tunicate
Cint\LOC100178049
Ciona intestinalis
Vase tunicate
Cint\LOC100183363
Gallus gallus
Domestic chicken
Ggal\PPM1A
Gallus gallus
Domestic chicken
Ggal\PPM1B
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (12)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG6036
7 of 10
CG17746
7 of 10
Ppm1
7 of 10
CG10417
5 of 10
CG10376
4 of 10
CG7115
3 of 10
Pdp
3 of 10
Pp2C1
3 of 10
CG17598
2 of 10
CG12091
1 of 10
CG15035
1 of 10
fig
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A
    13 of 15
    606108
        PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B
        12 of 15
        603770
             
            PPM1N; protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
            7 of 15
                PPM1F; protein phosphatase, Mg2+/Mn2+ dependent 1F
                3 of 15
                     
                    PPM1G; protein phosphatase, Mg2+/Mn2+ dependent 1G
                    3 of 15
                    605119
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        esyN Network Diagram
                        Show neighbor-neighbor interactions:
                        Select Layout:
                        Legend:
                        Protein
                        RNA
                        Selected Interactor(s)
                        Interactions Browser
                        View in Interactions Browser
                        Please see the Physical Interaction reports below for full details
                        protein-protein
                        Physical Interaction
                        Assay
                        References
                        alph - Tak1
                        anti tag coimmunoprecipitation, western blot
                        (Baril et al., 2009)
                        alph - slpr
                        anti tag coimmunoprecipitation, western blot
                        (Baril et al., 2009)
                        alph - wnd
                        anti tag coimmunoprecipitation, western blot
                        (Baril et al., 2009)
                        Summary of Genetic Interactions
                        esyN Network Diagram
                        esyN Network Key:
                        Suppression
                        Enhancement
                        View in Interactions Browser
                        Please look at the allele data for full details of the genetic interactions
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        alph
                        suppressible
                        hep
                        (Baril et al., 2009)
                        alph
                        enhanceable
                        PTP-ER
                        (Baril and Therrien, 2006)
                        alph
                        enhanceable
                        RasGAP1
                        (Baril and Therrien, 2006)
                        alph
                        enhanceable
                        rl
                        (Baril and Therrien, 2006)
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        aop
                        enhanceable
                        alph
                        (Baril and Therrien, 2006)
                        hep
                        suppressible
                        alph
                        (Baril et al., 2009)
                        ksr::tor
                        suppressible
                        alph
                        (Baril and Therrien, 2006, Therrien et al., 2000)
                        lic
                        suppressible
                        alph
                        (Baril et al., 2009)
                        PTP-ER
                        enhanceable
                        alph
                        (Baril and Therrien, 2006)
                        Rac1
                        suppressible
                        alph
                        (Baril et al., 2009)
                        Rac1
                        enhanceable
                        alph
                        (Baril et al., 2009)
                        Raf
                        suppressible
                        alph
                        (Therrien et al., 2000)
                        Ras85D
                        enhanceable
                        alph
                        (Baril and Therrien, 2006, Therrien et al., 2000)
                        rl
                        enhanceable
                        alph
                        (Baril and Therrien, 2006)
                        slpr
                        suppressible
                        alph
                        (Baril et al., 2009)
                        slpr
                        enhanceable
                        alph
                        (Baril et al., 2009)
                        External Data
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DroID - A comprehensive database of gene and protein interactions.
                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                        MIST (genetic) - An integrated Molecular Interaction Database
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        Negative Regulators of Sevenless Signaling Pathway -
                        Negative regulators of Sevenless signaling down-regulate the pathway, directing the presumptive R7 cell fate to that of a cone cell. (Adapted from FBrf0127283 and FBrf0221727).
                        Metabolic Pathways
                        External Data
                        Linkouts
                        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        3R
                        Recombination map

                        3-99

                        Cytogenetic map
                        99B4-99B5
                        Sequence location
                        3R:29,591,831..29,617,157 [+]
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        99B4-99B5
                        Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        99A-99B
                        (Therrien et al., 2000)
                        Experimentally Determined Recombination Data
                        Location

                        3-99

                        (FlyBase, 2016)

                        3-96.6

                        (Comeron et al., 2012)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (12)
                        Genomic Clones (35)
                        cDNA Clones (169)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequenced
                        BDGP DGC clones
                        Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                        Other clones
                        RNAi and Array Information
                        Linkouts
                        DRSC - Results frm RNAi screens
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        Antibody Information
                        Laboratory Generated Antibodies
                         
                        Commercially Available Antibodies
                         
                        Other Information
                        Relationship to Other Genes
                        Source for database identify of

                        Source for identity of: SK3-1 pp2c99B

                        (Baril and Therrien, 2004)
                        Source for database merge of

                        Source for merge of: alph pp2c99B

                        (Baril and Therrien, 2006)

                        Source for merge of: alph CG1906

                        (Baril and Therrien, 2006)
                        Additional comments
                        Other Comments

                        Encodes a Ser/Thr phosphatase that is highly homologous to mammalian PP2C.

                        (Baril and Therrien, 2006)

                        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                        (Kiger et al., 2003)
                        Origin and Etymology
                        Discoverer
                        Etymology
                        Identification
                        External Crossreferences and Linkouts ( 59 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                        Flygut - An atlas of the Drosophila adult midgut
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        modMine - A data warehouse for the modENCODE project
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DPiM - Drosophila Protein interaction map
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        FlyMine - An integrated database for Drosophila genomics
                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                        MIST (genetic) - An integrated Molecular Interaction Database
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                        Synonyms and Secondary IDs (7)
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        References (66)