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Gene Dmel\Orct2

General Information
Symbol	Dmel\Orct2	Species	D. melanogaster
Name	Organic cation transporter 2	Annotation symbol	CG13610
Feature type	protein_coding_gene	FlyBase ID	FBgn0086365
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95F8-95F8	Sequence location	3R:20,098,753..20,101,013 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Organic cation transporter 2 is referred to in FlyBase by the symbol Dmel\Orct2 (CG13610, FBgn0086365). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: organic cation transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: positive regulation of cell growth; germ-band shortening; positive regulation of multicellular organism growth. 13 alleles are reported. The phenotypes of these alleles are annotated with: eye; wing; germ band. It has one annotated transcript and one annotated polypeptide. Protein features are: General substrate transporter; Major facilitator superfamily domain; Major facilitator superfamily domain, general substrate transporter. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult salivary gland, larval trachea, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1636800_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Orct2. Gene sequence location is 3R:20098753..20101013.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN22207 HFA14613
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95F8-95F8   Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Orct2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Possible gene duplication of Orct:CG6331::DATE:2002-03-22 19:16:58::TS:1016842618000
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Orct2-RA FBtr0084598  NM_142981   2261   567
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Orct2-PA   FBpp0083982   63.2   567   6.40     NP_651238   AAF56270
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Major facilitator superfamily domain, general substrate transporter (IPR016196) General substrate transporter (IPR005828) Major facilitator superfamily domain (IPR020846)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56270   AI293257   AI532243   AI534625   AI541732   AI541734   AI542069   AI542274   AI543323   AI543426   AQ025167   AQ073022   AW944548   AY061615 AAL29163   BG635895   BG635964   BG636076   BG636862   BG640168   BG641409   BI233195   BI234793   BI356151   BI633342   BI639762   BI641267   BI641298   BI641584   CK659787   CO284409   CO305518   CO317568   CO317676   CZ474688   EC066651   EC071215   EC203433   EC238654   EC256042   EL878155   EL878156   EL883110   EL883111   EL883352   EL883353   GH740583   GH742521   GH762657   GH762748   GH767799
UniProtKB/Swiss-Prot	Q95R48
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086365    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086365 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086365 expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr    2057 embryo 06-08hr    3739 embryo 08-10hr    2372 embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr  (449) embryo 04-06hr  (2057) embryo 06-08hr  (3739) embryo 08-10hr  (2372) embryo 10-12hr  (1326) embryo 12-14hr  (677) embryo 14-16hr  (457) embryo 16-18hr  (359) embryo 18-20hr  (257) embryo 20-22hr  (201) embryo 22-24hr  (200) larva L1  (1011) larva L2  (1080) larva L3 12hr old  (312) larva L3 puffstage 1-2  (309) larva L3 puffstage 3-6  (509) larva L3 puffstage 7-9  (723) white prepupae new  (738) white prepupae 12hr  (227) white prepupae 24hr  (418) pupae 2d postWPP  (1155) pupae 3d postWPP  (291) pupae 4d postWPP  (217) adult male 01day  (450) adult male 05day  (506) adult male 30day  (571) adult female 01day  (257) adult female 05day  (307) adult female 30day  (318) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr  (2057) embryo 06-08hr  (3739) embryo 08-10hr  (2372) embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr    2057 embryo 06-08hr    3739 embryo 08-10hr    2372 embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr    2057 embryo 06-08hr    3739 embryo 08-10hr    2372 embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086365 expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr    2057 embryo 06-08hr    3739 embryo 08-10hr    2372 embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr  (449) embryo 04-06hr  (2057) embryo 06-08hr  (3739) embryo 08-10hr  (2372) embryo 10-12hr  (1326) embryo 12-14hr  (677) embryo 14-16hr  (457) embryo 16-18hr  (359) embryo 18-20hr  (257) embryo 20-22hr  (201) embryo 22-24hr  (200) larva L1  (1011) larva L2  (1080) larva L3 12hr old  (312) larva L3 puffstage 1-2  (309) larva L3 puffstage 3-6  (509) larva L3 puffstage 7-9  (723) white prepupae new  (738) white prepupae 12hr  (227) white prepupae 24hr  (418) pupae 2d postWPP  (1155) pupae 3d postWPP  (291) pupae 4d postWPP  (217) adult male 01day  (450) adult male 05day  (506) adult male 30day  (571) adult female 01day  (257) adult female 05day  (307) adult female 30day  (318) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr  2057 embryo 06-08hr  (3739) embryo 08-10hr  2372 embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr    2057 embryo 06-08hr    3739 embryo 08-10hr    2372 embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    449 embryo 04-06hr    2057 embryo 06-08hr    3739 embryo 08-10hr    2372 embryo 10-12hr    1326 embryo 12-14hr    677 embryo 14-16hr    457 embryo 16-18hr    359 embryo 18-20hr    257 embryo 20-22hr    201 embryo 22-24hr    200 larva L1    1011 larva L2    1080 larva L3 12hr old    312 larva L3 puffstage 1-2    309 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    723 white prepupae new    738 white prepupae 12hr    227 white prepupae 24hr    418 pupae 2d postWPP    1155 pupae 3d postWPP    291 pupae 4d postWPP    217 adult male 01day    450 adult male 05day    506 adult male 30day    571 adult female 01day    257 adult female 05day    307 adult female 30day    318 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086365    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086365 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult salivary gland, larval trachea, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086365 expression level Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086365 expression level Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    136.05 Larval Midgut    48.3 Larval Hindgut    124.5 Larval Malpighian Tubules    38 Larval Fat Body no informative data Larval Salivary Gland    81.5 Larval Trachea    106.9 Larval Carcass    47.75 Adult Head    34.7 Adult Eye    43.4 Adult Brain    38.6 Adult Thoracic-Abdominal Ganglion    46.6 Adult Crop no informative data Adult Midgut    45 Adult Hindgut    54.3 Adult Malpighian Tubules no informative data Adult Fat Body    73.4 Adult Salivary Gland    104.4 Adult Heart    74.95 Adult VirginFemale Spermatheca    56.7 Adult InseminatedFemale Spermatheca    64.1 Adult Ovary no informative data Adult Testis    29.8 Adult Male Accessory Gland    199.9 Adult Carcass    55.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary no informative data Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    34.7   NA  Eye    43.4   NA  Brain    38.6   136.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    46.6   NA  Crop    no informative data   48.3  Midgut    45   124.5  Hindgut    54.3   38  Malpighian Tubules    no informative data   no informative data  Fat Body    73.4   81.5  Salivary Gland    104.4   NA  Heart    74.95   106.9  Trachea    NA   NA  VirginFemale Spermatheca    56.7   NA  InseminatedFemale Spermatheca    64.1   NA  Ovary    no informative data   NA  Testis    29.8   NA  Male Accessory Gland    199.9   47.75  Carcass    55.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086365 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13610-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Orct2 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone Orct2R107 lethal | embryonic stage Orct2R106 Orct2R107 Orct2R165 lethal | embryonic stage, with Scer\GAL4[-]: Orct2EP1072 viable Orct2cald-GAL4 Orct2R161 viable, with Scer\GAL4pnr-MD237 Orct2GD225 Orct2GD16460 viable (with Orct2EP1072), with Scer\GAL4Orct2-R106 Orct2R106 viable (with Orct2EP1072), with Scer\GAL4Orct2-R107 Orct2R107 viable (with Orct2R106), with Scer\GAL4Orct2-R106 Orct2EP1072 viable (with Orct2R107), with Scer\GAL4Orct2-R107 Orct2EP1072 Other Phenotypes Allele decreased cell size Orct2R161 decreased cell size | cell autonomous | somatic clone Orct2R107 developmental rate defective | larval stage Orct2R161 developmental rate defective | pupal stage Orct2R161 small body | adult stage Orct2R161 small body | cold sensitive (with Orct2EP1072), with Scer\GAL4Orct2-R106 Orct2R106 small body | cold sensitive (with Orct2R106), with Scer\GAL4Orct2-R106 Orct2EP1072 Phenotype manifest in Allele chaeta & mesothoracic tergum | somatic clone Orct2R107 eye Orct2R161 germ band Orct2R106 Orct2R107 Orct2R165 germ band, with Scer\GAL4[-]: Orct2EP1072 wing Orct2R161 wing margin bristle | somatic clone Orct2R107
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of Orct2 Class Mutagen Stocks Known lesion Orct2MB12221 1 -- Orct2cald-GAL4 0 Yes Orct2d05723 P-element activity 0 -- Orct2EP1072 P-element activity 0 -- Orct2EP3569 0 Yes Orct2EY06405 P-element activity 0 -- Orct2R106 Delta2-3 0 Yes Orct2R107 Delta2-3 0 Yes Orct2R161 Delta2-3 0 Yes Orct2R165 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Orct2 Class Mutagen Stocks Known lesion Orct2GD225 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Orct2GD16460 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Orct2KK102141 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6199 (Ryder, 2004.4.26) Df(3R)Exel8178 (Ryder, 2004.4.26)
Not disrupted in	Df(3R)jar322 (Petritsch et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD225} NA P{GD16460} NA P{KK102141} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP3425 NA P{EP}jarEP3569 NA P{EP}Orct2EP1072 NA P{EPgy2}Orct2EY06405 NA P{XP}Orct2d05723 NA miscellaneous insertions P{?GawB}Orct2R106 NA P{?GawB}Orct2R107 NA P{?GawB}Orct2R161 NA P{?GawB}Orct2R165 NA P{SUPor-P}jarKG07413 NA P{SUPor-P}KG00150 NA insertion of enhancer trap binary system Mi{ET1}Orct2MB12221 No P{GawB}Orct2cald-GAL4 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
germ-band shortening inferred from mutant phenotype (Herranz et al., 2006) positive regulation of cell growth inferred from mutant phenotype (Herranz et al., 2006) positive regulation of multicellular organism growth inferred from mutant phenotype (Herranz et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
cation transmembrane transporter activity non-traceable author statement (Shirras, 2000.1.5) organic cation transmembrane transporter activity inferred from sequence or structural similarity with EMBL:AB018436 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q9U539 (Swiss-Prot Project Members, 2004.10.25)
Biological Process
CV term Evidence References
organic cation transport inferred from sequence or structural similarity with UniProtKB:Q9U539 (Swiss-Prot Project Members, 2004.10.25) non-traceable author statement (Shirras, 2000.1.5) transmembrane transport inferred from electronic annotation with InterPro:IPR005828 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR005828 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2004.10.25)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Orct2 allele Gene References EP1072EP1072 pnr (Pena-Rangel et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67818 DroID - A comprehensive database of gene and protein interactions. • FBgn0086365 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42890
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA12403
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • ENSMMUP00000009291 Macaca mulatta (rhesus monkey) ENSMMUP00000010724 Macaca mulatta (rhesus monkey) LOC_Os04g53930.1 Oryza sativa (asian rice) 213049 Physcomitrella patens (moss) ENSPTRP00000025451 Pan troglodytes (chimpanzee) ENSPTRP00000031591 Pan troglodytes (chimpanzee) 4889205 Sorghum bicolor (sorghum) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10380 LH14192 FBgn0240646 FBgn0240645 FBgn0213747 FBgn0213746 FBgn0213745 FBgn0211292 FBgn0211291 FBgn0192537 FBgn0192536 FBgn0181434 FBgn0181433 FBgn0079513 FBgn0072449 FBgn0160952 FBgn0160951 FBgn0144823 FBgn0144822 FBgn0019952 FBgn0121661 FBgn0103573 FBgn0103572 FBgn0093142 FBgn0093141 CPIJ001657 ACYPI20158 ACYPI003152 GB13312 AGAP004309 AAEL012443 PB20945 PHUM284880 GLEAN_02947
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	29284 w1118; Mi{ET1}Orct2MB12221
VDRC	v106681 P{KK102141}VIE-260B v1176 w1118; P{GD225}v1176 v1177 w1118; P{GD225}v1177 v48870 w1118; P{GD16460}v48870/CyO
Genomic Clones ( 2 )
	BACR04E17 BACR29F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD08136
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16405 LP17793 RE29484 RE30550 RE42224 SD03666 SD06823 SD06835 SD07543 SD08513 SD10044 SD10170 SD11131 SD12741 SD13408 SD13510 SD13666 SD14659 SD22432 SD24489 SD24526 SD24982 SD27412
Other clones	146173 164034 164049 CK01.126A.E1 EC256042 EK166006 EK248855 EK268526 EK268753 IP08054 IP12838 IP13038 RP001003569 RP001007846 RP001024840 RP001035353 RP001056030
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086365 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42890
Antibody Information
Other Information
Discoverer
Etymology
	The embryonic expression pattern of the gene resembles a "calderon", the Spanish name for the symbol that increases the length of a musical note, hence the name. (Herranz et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Orct2 CG13610 (Shirras, 2005.5.31) Source for merge of: Orct2 EP1072 (Herranz et al., 2006)
Additional comments	FlyBase curator comment: "EP1072" phenotype of modifying the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is stated to be due to its effect on Orct2 but orientation of the P{EP} element suggests otherwise. (Shulman and Feany, 2003)
Other Comments
	The InR pathway regulates Orct2 expression. (Herranz et al., 2006) Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Showed cycling in Canton S and low expression in Clk mutants in microarray experiments. Identified in S2/cycloheximide assay as a direct target of Clk mediated transcriptional regulation. (McDonald and Rosbash, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142981 RefSeq (Proteins) • NP_651238 DDBJ / EMBL / GenBank • AAF56270 AAL29163 AI542069 AQ025167 AQ073022 AW944548 AY061615 CZ474688 Entrez Gene - A searchable database of RefSeq genes. • 42890 UniProtKB/Swiss-Prot • Q95R48
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Major facilitator superfamily domain, general substrate transporter (IPR016196) General substrate transporter (IPR005828) Major facilitator superfamily domain (IPR020846)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67818 DroID - A comprehensive database of gene and protein interactions. • FBgn0086365 DRSC - Results from RNAi screens. • FBgn0086365 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086365 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13610-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086365 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42890 InParanoid A subset of ortholog calls from InParanoid. • ENSMMUP00000009291 Macaca mulatta (rhesus monkey) ENSMMUP00000010724 Macaca mulatta (rhesus monkey) LOC_Os04g53930.1 Oryza sativa (asian rice) 213049 Physcomitrella patens (moss) ENSPTRP00000025451 Pan troglodytes (chimpanzee) ENSPTRP00000031591 Pan troglodytes (chimpanzee) 4889205 Sorghum bicolor (sorghum) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42890 modMine - Data generated by the modENCODE project. • FBgn0086365 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10380 LH14192 FBgn0240646 FBgn0240645 FBgn0213747 FBgn0213746 FBgn0213745 FBgn0211292 FBgn0211291 FBgn0192537 FBgn0192536 FBgn0181434 FBgn0181433 FBgn0079513 FBgn0072449 FBgn0160952 FBgn0160951 FBgn0144823 FBgn0144822 FBgn0019952 FBgn0121661 FBgn0103573 FBgn0103572 FBgn0093142 FBgn0093141 CPIJ001657 ACYPI20158 ACYPI003152 GB13312 AGAP004309 AAEL012443 PB20945 PHUM284880 GLEAN_02947
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	cald (Herranz et al., 2006) CG13610 (Herranz et al., 2006, Ni et al., 2006, Shirras, 2005.5.31, Shulman and Feany, 2003, McDonald and Rosbash, 2001, Stuart et al., 2007, Keleman et al., 2009.8.5, Petritsch et al., 2003) EP1072   EP(3)1072 (Pena-Rangel et al., 2002) orct2 (Herranz et al., 2006) Orct2 (Spresser et al., 2008, Cook et al., 2010.2.12)
Name Synonym	calderon (Herranz et al., 2006) EP1072   Organic cation transporter 2 (Shirras, 2000.1.5)
Secondary FlyBase IDs
	FBgn0029146 FBgn0039176 FBgn0062704
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...