hydrolase - abdominal pigmentation - hydrolysis of N-β-alanyl dopamine to dopamine during cuticular melanization - hydrolysis of carcinine to histamine in the metabolism of photoreceptor neurotransmitter
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\t using the Feature Mapper tool.
t is expressed in the CNS but not the PNS in embryos. In adults, it is expressed in neurons but not glia in the adult brain, in the retina, and in the antennal lobes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\t in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: t CG12120
At temperatures ranging from 20oC to 37.5oC temperature sensitive mutants exhibit no effect on the heart rate of larvae.
The dopamine was detected only in late pupae that show some pigmentation and in adult flies. One of the enzymes involved in the formation of dopamine, β-alanyldopamine hydrolase (BAH), shows no activity in t/t and t/Y mutants and reduced activity in t/+ heterozygotes as compared to wild-type.
The mutant t is defective in courtship behaviors, the males showing aberrant visually-mediated responses to moving female flies.
The optomotor responses of mutants to horizontal and vertical movements are abnormal in that light intensity thresholds for responses are raised, the extent depending on the allele.
Mosaic studies indicate that the ERG phenotype of tan is cell autonomous.
No walking optomotor responses are detected, but there can be positive responses in flying optomotor tests if the rotating vertical stripes are relatively wide. The enzyme tyrosinase, which converts tyrosine to 3,4-dihydroxyphenylalanine (DOPA), is formed in tan adults.
In a Y-maze test for phototaxis tan mutants are sensitive to light.
Body color varies from light tan to almost wild-type. Easiest to identify by light tan antennae; male easier than female. Larval mouthparts in mutant alleles.