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Gene Dmel\tw

General Information
Symbol	Dmel\tw	Species	D. melanogaster
Name	Protein O-mannosyltransferase 2	Annotation symbol	CG12311
Feature type	protein_coding_gene	FlyBase ID	FBgn0086368
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Pomt2, DPOMT2, EG:34F3.7
Genomic Location
Chromosome (arm)	X	Recombination map	1-0.4
Cytogenetic map	1C4-1D4	Sequence location	X:678,824..682,077 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein O-mannosyltransferase 2 is referred to in FlyBase by the symbol Dmel\tw (CG12311, FBgn0086368). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: dolichyl-phosphate-mannose-protein mannosyltransferase activity. There is experimental evidence that it is involved in the biological process: somatic muscle development; protein O-linked mannosylation; sarcomere organization; muscle attachment. 20 alleles are reported. The phenotypes of these alleles are annotated with: cytoplasmic part; multicellular structure; sarcomere; organelle; organ system; adult; anatomical structure; thoracic segment; organ system subdivision; proteinaceous extracellular matrix. It has one annotated transcript and one annotated polypeptide. Protein features are: Glycosyl transferase, family 39; MIR; MIR motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1639933_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of tw. Gene sequence location is X:678824..682077.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	tw: twisted Abdomens of males and females twisted about 30 clockwise, as viewed from the posterior. Body tends to be dwarfed. Viability reduced; hatching delayed. Males usually fertile. 1% nondisjunction for homologs in males (Davis, 1975, 1980). tw2 Abdomens of males and females twisted 30-60 clockwise, as viewed from the posterior; more extreme than tw. Male genitalia often twisted counter-clockwise. Viability reduced. Males usually fertile. tw2/tw flies resemble tw2/tw2. tw3 Abdomens of males and females twisted up to 90, as viewed from the posterior. Male genitalia and anal plate often twisted clockwise or counter-clockwise (misalignment up to 180). Males and females often sterile, although male genitalia appear normal and sperm are motile. 1% nondisjunction for homologues in males (Davis, 1975, 1980).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN22587 HFA18537
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1C4-1D4   Limits computationally determined from genome sequence between P{EP}sdkEP369 and P{EP}EP1600&P{EP}EP1498; Left limit from complementation mapping against T(1;2)Bld (citation unavailable) Right limit from inclusion within Df(1)su(s)83 (FBrf0049919)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-0.4
Left of (cM)
Right of (cM)
Notes	Mapping based on tw1; 1-0.1 based on tw3.
Gene Model & Products
Please see the GBrowse view of Dmel\tw for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tw-RA FBtr0070139  NM_130502   2624   765
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tw-PA   FBpp0070134   86.2   765   9.50     NP_569858   AAF45548
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • MIR (IPR003608) Glycosyl transferase, family 39 (IPR003342) MIR motif (IPR016093)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45548   AB176551 BAD54755   AI257485   AI257648   AI258474   AL031583 CAA20897   AW943980   AY095525 AAM12256   CO182685   GH945846   GH946220   GH947873   GH951545   GH952994   GH955670   GH957892   GH961375   GH964500   GH964780   GH965378   GH966517   GH973349   GH974867   GH977511   GH981667   GH983919
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W5D4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10   organism | faint   (Ichimiya et al., 2004) germ band | intense   (Ichimiya et al., 2004) early stomodeal invagination | intense   (Ichimiya et al., 2004) hindgut proper primordium | intense   (Ichimiya et al., 2004) posterior midgut primordium | intense   (Ichimiya et al., 2004)
Additional Descriptive Data
	At embryonic stage 10, intense expression of tw is observed in the germ band and in the invaginating gut. Faint but steady expression is observed in all cells of the stage 10 embryo. (Ichimiya et al., 2004)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086368    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086368 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086368 expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr    3363 embryo 12-14hr    4306 embryo 14-16hr    5491 embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2    2609 larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new    1741 white prepupae 12hr    1193 white prepupae 24hr    2245 pupae 2d postWPP    4503 pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr  (137) embryo 06-08hr  (452) embryo 08-10hr  (715) embryo 10-12hr  (3363) embryo 12-14hr  (4306) embryo 14-16hr  (5491) embryo 16-18hr  (847) embryo 18-20hr  (239) embryo 20-22hr  (127) embryo 22-24hr  (131) larva L1  (444) larva L2  (2609) larva L3 12hr old  (470) larva L3 puffstage 1-2  (542) larva L3 puffstage 3-6  (891) larva L3 puffstage 7-9  (1296) white prepupae new  (1741) white prepupae 12hr  (1193) white prepupae 24hr  (2245) pupae 2d postWPP  (4503) pupae 3d postWPP  (510) pupae 4d postWPP  (234) adult male 01day  (226) adult male 05day  (157) adult male 30day  (195) adult female 01day  (172) adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr  (3363) embryo 12-14hr  (4306) embryo 14-16hr  (5491) embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2  (2609) larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new  (1741) white prepupae 12hr    1193 white prepupae 24hr  (2245) pupae 2d postWPP  (4503) pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr    3363 embryo 12-14hr    4306 embryo 14-16hr    5491 embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2    2609 larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new    1741 white prepupae 12hr    1193 white prepupae 24hr    2245 pupae 2d postWPP    4503 pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr    3363 embryo 12-14hr    4306 embryo 14-16hr    5491 embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2    2609 larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new    1741 white prepupae 12hr    1193 white prepupae 24hr    2245 pupae 2d postWPP    4503 pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086368 expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr    3363 embryo 12-14hr    4306 embryo 14-16hr    5491 embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2    2609 larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new    1741 white prepupae 12hr    1193 white prepupae 24hr    2245 pupae 2d postWPP    4503 pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr  137 embryo 06-08hr  (452) embryo 08-10hr  (715) embryo 10-12hr  (3363) embryo 12-14hr  (4306) embryo 14-16hr  (5491) embryo 16-18hr  (847) embryo 18-20hr  (239) embryo 20-22hr  127 embryo 22-24hr  131 larva L1  (444) larva L2  (2609) larva L3 12hr old  (470) larva L3 puffstage 1-2  (542) larva L3 puffstage 3-6  (891) larva L3 puffstage 7-9  (1296) white prepupae new  (1741) white prepupae 12hr  (1193) white prepupae 24hr  (2245) pupae 2d postWPP  (4503) pupae 3d postWPP  (510) pupae 4d postWPP  (234) adult male 01day  (226) adult male 05day  (157) adult male 30day  (195) adult female 01day  (172) adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr  (3363) embryo 12-14hr  (4306) embryo 14-16hr  (5491) embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2  (2609) larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new  1741 white prepupae 12hr    1193 white prepupae 24hr  2245 pupae 2d postWPP  (4503) pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr    3363 embryo 12-14hr    4306 embryo 14-16hr    5491 embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2    2609 larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new    1741 white prepupae 12hr    1193 white prepupae 24hr    2245 pupae 2d postWPP    4503 pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    53 embryo 04-06hr    137 embryo 06-08hr    452 embryo 08-10hr    715 embryo 10-12hr    3363 embryo 12-14hr    4306 embryo 14-16hr    5491 embryo 16-18hr    847 embryo 18-20hr    239 embryo 20-22hr    127 embryo 22-24hr    131 larva L1    444 larva L2    2609 larva L3 12hr old    470 larva L3 puffstage 1-2    542 larva L3 puffstage 3-6    891 larva L3 puffstage 7-9    1296 white prepupae new    1741 white prepupae 12hr    1193 white prepupae 24hr    2245 pupae 2d postWPP    4503 pupae 3d postWPP    510 pupae 4d postWPP    234 adult male 01day    226 adult male 05day    157 adult male 30day    195 adult female 01day    172 adult female 05day    42 adult female 30day    44 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086368    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086368 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086368 expression level Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086368 expression level Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.875 Larval Midgut no informative data Larval Hindgut    80 Larval Malpighian Tubules    9.4 Larval Fat Body    9.8 Larval Salivary Gland no informative data Larval Trachea    143.775 Larval Carcass    110.85 Adult Head no informative data Adult Eye    17.95 Adult Brain    3 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    58.4 Adult Midgut    9.9 Adult Hindgut    53.7 Adult Malpighian Tubules    9.9 Adult Fat Body    7.6 Adult Salivary Gland    8.5 Adult Heart    6.025 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.5 Adult Testis    7.8 Adult Male Accessory Gland    76.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    17.95   NA  Brain    3   6.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.1   NA  Crop    58.4   no informative data  Midgut    9.9   80  Hindgut    53.7   9.4  Malpighian Tubules    9.9   9.8  Fat Body    7.6   no informative data  Salivary Gland    8.5   NA  Heart    6.025   143.775  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    2.5   NA  Testis    7.8   NA  Male Accessory Gland    76.6   110.85  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086368 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12311-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for tw Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | partially | heat sensitive, with Scer\GAL4Act5C.PHb twdsRNA.Scer\UAS.cIa lethal | partially | recessive twunspecified semi-viable tw1 tw2 viable, with Scer\GAL4pnr-MD237 twGD1160 viable | reduced tw4 tw5 tw6 tw7 tw8 tw9 tw10 tw11 tw12 tw13 Sterility Allele sterile tw3 Other Phenotypes Allele developmental rate defective tw1 flight defective twunspecified flight defective (with Df(1)Exel6223) twunspecified increased cell death twunspecified locomotor behavior defective | adult stage (with Df(1)Exel6223) twunspecified locomotor behavior defective | adult stage | recessive twunspecified small body tw1 Phenotype manifest in Allele abdomen tw1 tw2 tw3 adult abdomen tw1 adult abdomen, with Scer\GAL4Act5C.PHb twdsRNA.Scer\UAS.cIa adult abdomen | female (with Df(1)su(s)83) tw1 adult myoblast twunspecified basement membrane twunspecified embryonic/larval somatic muscle twunspecified male genitalia tw2 tw3 muscle attachment site | third instar larval stage tw1 sarcomere twunspecified sarcomere | third instar larval stage tw1 sarcoplasmic reticulum twunspecified striated muscle myosin thick filament twunspecified striated muscle thin filament twunspecified wing disc twunspecified Z disc twunspecified
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of tw Class Mutagen Stocks Known lesion tw1 hypomorphic allele - genetic evidence 2 Yes tw10 ethyl nitrosourea 0 -- tw11 ethyl nitrosourea 0 -- tw12 ethyl nitrosourea 0 -- tw13 ethyl methanesulfonate 0 -- tw2 spontaneous 0 -- tw3 ethyl methanesulfonate 0 -- tw4 ethyl methanesulfonate 0 -- tw5 ethyl methanesulfonate 0 -- tw6 ethyl nitrosourea 0 -- tw7 ethyl nitrosourea 0 -- tw8 ethyl nitrosourea 0 -- tw9 ethyl nitrosourea 0 -- twunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tw Class Mutagen Stocks Known lesion twGD1160 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes twdsRNA.Scer\UAS.cIa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes twdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes twMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes twScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes twScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;f)3 (Rayle and Hoar, 1969) Dp(1;f)18 (Rayle and Hoar, 1969) Dp(1;f)101 (Rayle and Hoar, 1969) Dp(1;f)1337 (Rayle and Hoar, 1969) Dp(1;Y)59k9-1 (Rayle and Hoar, 1969) Dp(1;Y)59k9-4 (Kramers et al., 1983, Kramers et al., 1991) Dp(1;Y)60e17.4-3 (Rayle and Hoar, 1969) Dp(1;Y)68h20 (Rayle and Hoar, 1969) Dp(1;Y)y267g19.1 (Lefevre, 1981, Schalet, 1986)
Not duplicated in	Dp(1;3)sta (Kramers et al., 1983, Kramers et al., 1991) Dp(1;3)wvco (Rayle and Hoar, 1969) Dp(1;Y)2E-C (Rayle and Hoar, 1969)
Not disrupted in	Df(1)403 (Kramers et al., 1991) Df(1)A94 (Craymer and Roy, 1980, Kramers et al., 1983, Kramers et al., 1991) Df(1)cin-arth (Kramers et al., 1991) Df(1)HA18 (Schalet, 1986) Df(1)S39 (Craymer and Roy, 1980, Kramers et al., 1983, Kramers et al., 1991) Df(1)Sp(br-dor) (Schalet, 1986) Df(1)Sp(J1a) (Schalet, 1986) Df(1)Sp(J1b) (Schalet, 1986) Df(1)Sp(J1c) (Schalet, 1986) Df(1)sta (Kramers et al., 1983, Kramers et al., 1991) Df(1)svr (Kramers et al., 1983, Kramers et al., 1991) Df(1)y74k10.1 (Voelker et al., 1989) Df(1)y74k24.1 (Kramers et al., 1983, Voelker et al., 1989, Kramers et al., 1991) Df(1)yT8-206 (Voelker et al., 1989) Df(1)yT9-7 (Voelker et al., 1989) Df(1)yT9-21 (Voelker et al., 1989) Df(1)yT9-220 (Voelker et al., 1989) Df(1)yT9-275 (Voelker et al., 1989) Df(1)yT10-102 (Voelker et al., 1989) Df(1)yT10-106 (Voelker et al., 1989) Df(1)yT10-581 (Voelker et al., 1989) Df(1)yT10-665 (Voelker et al., 1989) Df(1)yT10-673 (Voelker et al., 1989) Df(1)yT10-677 (Voelker et al., 1989) Df(1)yT12-173 (Voelker et al., 1989) Df(1)yT12-187 (Voelker et al., 1989) Df(1)yT12-200 (Voelker et al., 1989) Df(1)yT12-246 (Voelker et al., 1989) Df(1)yT12-667 (Voelker et al., 1989) Df(1)yT13-423 (Voelker et al., 1989) Df(1)yT13-464 (Voelker et al., 1989) Df(1)yT14-546 (Voelker et al., 1989) Df(1)yT14-576 (Voelker et al., 1989) Df(1)yT15-5 (Voelker et al., 1989) Df(1)yT15-6 (Voelker et al., 1989) Df(1)yT15-28 (Voelker et al., 1989) Df(1)yT15-56 (Voelker et al., 1989) Df(1)yT15-105 (Voelker et al., 1989) Df(1)yT15-158b (Voelker et al., 1989) Df(1)yT15-161 (Voelker et al., 1989) Df(1)yT15-171 (Voelker et al., 1989) Df(1)yT15-177 (Voelker et al., 1989) Df(1)yT15-183 (Voelker et al., 1989) Df(1)yT15-189 (Voelker et al., 1989) Df(1)yT15-219 (Voelker et al., 1989) Df(1)yT15-222 (Voelker et al., 1989) Df(1)yT15-270 (Voelker et al., 1989) Df(1)yT15-274 (Voelker et al., 1989) Df(1)yT15-286 (Voelker et al., 1989) Df(1)yT15-300 (Voelker et al., 1989) Df(1)yT15-318 (Voelker et al., 1989) Df(1)yT15-325 (Voelker et al., 1989) Df(1)yT15-327 (Voelker et al., 1989) Df(1)yT15-334 (Voelker et al., 1989) Df(1)yT15-364 (Voelker et al., 1989) Df(1)yT15-365 (Voelker et al., 1989) Df(1)yT15-383 (Voelker et al., 1989) Df(1)yT15-390 (Voelker et al., 1989) Df(1)yT15-392 (Voelker et al., 1989) Df(1)yT15-405 (Voelker et al., 1989) Df(1)yT15-408 (Voelker et al., 1989) Df(1)yT15-410 (Voelker et al., 1989) Df(1)yT15-412 (Voelker et al., 1989) Df(1)yT15-433 (Voelker et al., 1989) Df(1)yT15-449 (Voelker et al., 1989) Df(1)yT15-460 (Voelker et al., 1989) Df(1)yT15-468 (Voelker et al., 1989) Df(1)yT15-502 (Voelker et al., 1989) Df(1)yT15-509 (Voelker et al., 1989) Df(1)yT15-511 (Voelker et al., 1989) Df(1)yT15-517 (Voelker et al., 1989) Df(1)yT15-533 (Voelker et al., 1989) Df(1)yT15-543 (Voelker et al., 1989) Df(1)yT15-548 (Voelker et al., 1989) Df(1)yT15-552 (Voelker et al., 1989) Df(1)yT15-564 (Voelker et al., 1989) Df(1)yT15-568 (Voelker et al., 1989) Df(1)yT15-575 (Voelker et al., 1989) Df(1)yT15-586 (Voelker et al., 1989) Df(1)yT15-597 (Voelker et al., 1989) Df(1)yT15-599 (Voelker et al., 1989) Df(1)yT16-14 (Voelker et al., 1989) Df(1)yT16-411 (Voelker et al., 1989) Df(1)yT16-499 (Voelker et al., 1989) Df(1)yT16-534 (Voelker et al., 1989) Df(1)yT16-554 (Voelker et al., 1989) Dp(1;3)su(s)E2 (Voelker et al., 1989)
Disrupted in	Df(1)Exel6223 (Ryder, 2004.4.26) Df(1)su(s)2 (Voelker et al., 1989) Df(1)su(s)3 (Voelker et al., 1989) Df(1)su(s)83 (Voelker et al., 1989) Df(1)yT17-570 (Voelker et al., 1989) Df(1)yT17-600 (Voelker et al., 1989) Df(1)yT18-319 (Voelker et al., 1989) Df(1)yT19-16 (Voelker et al., 1989) Df(1)yT19-253 (Voelker et al., 1989)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1160} NA P{UAS-tw.dsRNA} NA P{UAS-tw.U} NA P{UAS-twi.HA} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
dolichyl-phosphate-mannose-protein mannosyltransferase activity inferred from direct assay (Ichimiya et al., 2004) contributes_to dolichyl-phosphate-mannose-protein mannosyltransferase activity inferred from direct assay (Ueyama et al., 2010)
Biological Process
CV term Evidence References
muscle attachment inferred from genetic interaction with Dg (Haines et al., 2007) protein O-linked mannosylation inferred from direct assay (Ichimiya et al., 2004) sarcomere organization inferred from genetic interaction with Dg (Haines et al., 2007) somatic muscle development inferred from mutant phenotype (Ueyama et al., 2010)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from direct assay (Lyalin et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
dolichyl-phosphate-mannose-protein mannosyltransferase activity inferred from sequence or structural similarity (EDGP Project Members, 1994-) inferred from sequence or structural similarity with Saccharomyces PMT3 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Ichimiya et al., 2004) membrane inferred from electronic annotation with InterPro:IPR003342, InterPro:IPR003608, InterPro:IPR016093 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tw allele Gene References Pomt2dsRNA.Scer\UAS rt (Ichimiya et al., 2004) unspecified rt (Lyalin et al., 2006)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086368 DroID - A comprehensive database of gene and protein interactions. • FBgn0086368 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31024
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA11548
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013732-PA Aedes aegypti (mosquito) AGAP002674-PA Anopheles gambiae (mosquito) XP_623973.1 Apis mellifera (honey bee) XP_001946715.1 Acyrthosiphon pisum (pea aphid) 20500 Batrachochytrium dendrobatidis (chytrid fungus) 212992 Branchiostoma floridae (lancelet) ENSBTAP00000003502 Bos taurus (bovine) CAL0005653 Candida albicans (a form of yeast) ENSCAFP00000025298 Canis familiaris (dog) CAGL0J08734g Candida glabrata (haploid yeast) ENSCINP00000026045 Ciona intestinalis (sea squirt) cn10155 Cryptococcus neoformans (yeast-like fungus) CPIJ014461 Culex pipens (mosquito) ENSCPOP00000006389 Cavia porcellus (guinea pig) ENSCSAVP00000015810 Ciona savignyi (sedentary tunicate) 152537 Capitella spl (polychaete worm) DEHA2F04840g Debaryomyces Hansenii (yeast) 300808 Daphnia pulex (daphnia) ENSDARP00000071774 Danio rerio (zebra fish) ENSECAP00000016525 Equus caballus (horse) ENSGACP00000007728 Gymnopilus aculeatus (mushroom) ENSGALP00000016954 Gallus gallus (chicken) ENSP00000261534 Homo sapiens (human) ISCW023197-PA Ixodes scapularis (deer tick) KLLA0E01343g Kluyveromyces lactis (yeast) 129702 Lottia gigantea (owl limpet) 29409 Monocosta brevicollis (choanoflagellate) ENSMODP00000006753 Monodelphis domestica (gray opossum) ENSMMUP00000001459 Macaca mulatta (rhesus monkey) ENSMUSP00000035260 Mus musculus (house mouse) 99284 Nematostella vectensis (starlet anemone) XP_001600041.1 Nasonia vitripennis (wasp) ENSOANP00000016791 Ornithorynchus anatinus (platypus) PHUM000882-PA Pediculus humanus (human body louse) ENSPPYP00000006848 Pongo pygmaeus (orangutan) ENSPTRP00000011170 Pan troglodytes (chimpanzee) ENSRNOP00000016242 Rattus norvegicus (norway rat) YAL023C Saccharomyces cerevisiae (budding yeast) SPAPB1E7.09 Schizosaccharomyces pombe (fission yeast) XP_001197646.1 Strongylocentrotus purpuratus (purple sea urchin) 30184 Trichoplax adhaerens (metazoa) XP_973439.1 Tribolium castaneum (red flour beetle) ENSTRUP00000039160 Takifugu rubripes (pufferfish Takifugu) 86088.m00429 Trichomonas vaginalis (parasitic flagellated protozoan) 86245.m00059 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0C23364g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18475 NV11275 LH20114 ISCW023197 FBgn0234137 FBgn0222063 FBgn0206199 FBgn0188134 FBgn0173992 JGI_V11_300808 JGI_V11_314503 JGI_V11_300810 FBgn0071599 FBgn0164339 FBgn0133890 FBgn0125133 FBgn0105087 FBgn0098200 CPIJ014461 BGIBMGA005070 ACYPI007134 GB11823 AGAP002674 AAEL013732 AAEL006100 PHUM238630 GLEAN_09840
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	134 tw1/C(1)DX, y1 f1
Kyoto	105753 tw1/C(1)DX, y1 f1
VDRC	v5583 w1118; P{GD1160}v5583 v5584 w1118; P{GD1160}v5584
Genomic Clones ( 1 )
	BACR19J01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 22 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP01681
Other clones	DPiM_LP01681
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP05869 LP06067
Other clones	EC23661 RP004048281 RP004092568 RP004137364 RP004160612 RP004203627 RP004204738 RP004221851 RP004225744 RP004228826 RP004289173 RP004355373 RP004383097 RP004478349 RP004492791 RP004500728 RP004503336 RP004536009
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086368 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31024 44303
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pomt2 CG12311 (Ichimiya et al., 2004)
Source for database merge of	Source for merge of: tw Pomt2 (Lyalin et al., 2006)
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_130502 RefSeq (Proteins) • NP_569858 DDBJ / EMBL / GenBank • AAF45548 AAM12256 AB176551 AI258474 AL031583 AW943980 AY095525 BAD54755 CAA20897 Entrez Gene - A searchable database of RefSeq genes. • 31024 UniProtKB/TrEMBL • Q9W5D4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • MIR (IPR003608) Glycosyl transferase, family 39 (IPR003342) MIR motif (IPR016093)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0086368 DroID - A comprehensive database of gene and protein interactions. • FBgn0086368 DRSC - Results from RNAi screens. • FBgn0086368 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086368 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12311-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086368 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31024 44303 InParanoid A subset of ortholog calls from InParanoid. • AAEL013732-PA Aedes aegypti (mosquito) AGAP002674-PA Anopheles gambiae (mosquito) XP_623973.1 Apis mellifera (honey bee) XP_001946715.1 Acyrthosiphon pisum (pea aphid) 20500 Batrachochytrium dendrobatidis (chytrid fungus) 212992 Branchiostoma floridae (lancelet) ENSBTAP00000003502 Bos taurus (bovine) CAL0005653 Candida albicans (a form of yeast) ENSCAFP00000025298 Canis familiaris (dog) CAGL0J08734g Candida glabrata (haploid yeast) ENSCINP00000026045 Ciona intestinalis (sea squirt) cn10155 Cryptococcus neoformans (yeast-like fungus) CPIJ014461 Culex pipens (mosquito) ENSCPOP00000006389 Cavia porcellus (guinea pig) ENSCSAVP00000015810 Ciona savignyi (sedentary tunicate) 152537 Capitella spl (polychaete worm) DEHA2F04840g Debaryomyces Hansenii (yeast) 300808 Daphnia pulex (daphnia) ENSDARP00000071774 Danio rerio (zebra fish) ENSECAP00000016525 Equus caballus (horse) ENSGACP00000007728 Gymnopilus aculeatus (mushroom) ENSGALP00000016954 Gallus gallus (chicken) ENSP00000261534 Homo sapiens (human) ISCW023197-PA Ixodes scapularis (deer tick) KLLA0E01343g Kluyveromyces lactis (yeast) 129702 Lottia gigantea (owl limpet) 29409 Monocosta brevicollis (choanoflagellate) ENSMODP00000006753 Monodelphis domestica (gray opossum) ENSMMUP00000001459 Macaca mulatta (rhesus monkey) ENSMUSP00000035260 Mus musculus (house mouse) 99284 Nematostella vectensis (starlet anemone) XP_001600041.1 Nasonia vitripennis (wasp) ENSOANP00000016791 Ornithorynchus anatinus (platypus) PHUM000882-PA Pediculus humanus (human body louse) ENSPPYP00000006848 Pongo pygmaeus (orangutan) ENSPTRP00000011170 Pan troglodytes (chimpanzee) ENSRNOP00000016242 Rattus norvegicus (norway rat) YAL023C Saccharomyces cerevisiae (budding yeast) SPAPB1E7.09 Schizosaccharomyces pombe (fission yeast) XP_001197646.1 Strongylocentrotus purpuratus (purple sea urchin) 30184 Trichoplax adhaerens (metazoa) XP_973439.1 Tribolium castaneum (red flour beetle) ENSTRUP00000039160 Takifugu rubripes (pufferfish Takifugu) 86088.m00429 Trichomonas vaginalis (parasitic flagellated protozoan) 86245.m00059 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0C23364g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31024 modMine - Data generated by the modENCODE project. • FBgn0086368 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18475 NV11275 LH20114 ISCW023197 FBgn0234137 FBgn0222063 FBgn0206199 FBgn0188134 FBgn0173992 JGI_V11_300808 JGI_V11_314503 JGI_V11_300810 FBgn0071599 FBgn0164339 FBgn0133890 FBgn0125133 FBgn0105087 FBgn0098200 CPIJ014461 BGIBMGA005070 ACYPI007134 GB11823 AGAP002674 AAEL013732 AAEL006100 PHUM238630 GLEAN_09840
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG12311 (Alekseyenko et al., 2006, Ichimiya et al., 2004, Benos, 2000.12.13, ) DmPOMT2 (Willer et al., 2002) DPOMT2 (Lyalin et al., 2007, Lyalin et al., 2006) dPOMT2 (Ichimiya et al., 2004) EG:34F3.7 (Claridge-Chang et al., 2001, Benos et al., 2001, ) Pomt2 (Lyalin et al., 2006, ) POMT2 (Nakamura et al., 2007, Ichimiya and Nishihara, 2004.4.6, Haines et al., 2007, Ueyama et al., 2010) tw (Lyalin et al., 2006, Lyalin et al., 2007, Lyalin et al., 2008, Haines et al., 2007, Nakamura et al., 2010, Ueyama et al., 2010)
Name Synonym	Protein O-mannosyltransferase 2 (Ichimiya et al., 2004) tricky-dickey   twisted (Nakamura et al., 2007, Ueyama et al., 2010) Twisted (Nakamura et al., 2010)
Secondary FlyBase IDs
	FBgn0003898 FBgn0025618
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Book  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Nakamura et al., 2010, Glycobiology 20(3): 381--394 Drosophila Dystroglycan is a target of O-mannosyltransferase activity of two protein O-mannosyltransferases, Rotated Abdomen and Twisted. [FBrf0209880] Ueyama et al., 2010, PLoS ONE 5(7): e11557 Increased apoptosis of myoblasts in Drosophila model for the walker-warburg syndrome. [FBrf0211260] Show all research papers ...