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Gene Dmel\sra

General Information
Symbol	Dmel\sra	Species	D. melanogaster
Name	sarah	Annotation symbol	CG6072
Feature type	protein_coding_gene	FlyBase ID	FBgn0086370
Gene Model Status	Current	Stock availability	27 publicly available
Also Known As	nla, 89B11
Genomic Location
Chromosome (arm)	3R	Recombination map	3-58.2
Cytogenetic map	89B7-89B7	Sequence location	3R:12,012,656..12,023,315 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene sarah is referred to in FlyBase by the symbol Dmel\sra (CG6072, FBgn0086370). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: olfactory learning; female meiosis; male pronucleus assembly; meiosis; long-term memory; sleep; mitochondrion organization; regulation of female receptivity, post-mating; egg activation; regulation of female receptivity. 89 alleles are reported. The phenotypes of these alleles are annotated with: meiotic anaphase I; egg; eye photoreceptor cell; meiosis II; mitochondrion; male pronucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: Calcipressin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639162_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of sra. Gene sequence location is 3R:12012656..12023315.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89B7-89B7   Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89B12-89B13   (determined by in situ hybridisation)   (Lukacsovich et al., 2001) 89B12-89B13     (McCormick, 1999.4.30) 89B12-89B13   (determined by in situ hybridisation)   (Spradling et al., 1999) 89B12-89B13   (determined by in situ hybridisation)   (Perrimon et al., 1996) 70D1-70D2   89B9--13   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-58.2 (Czank, 1997.5.14)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sra for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sra-RA FBtr0083255  NM_079654   1929   292
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sra-PA   FBpp0082709   31.4   292   4.82     NP_524378   AAF55285
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Calcipressin (IPR006931)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264722   AA391675   AA440575   AA540911   AA567400   AA735100   AA735361   AA941715   AA941854   AA979521   AA979551   AA990879   AE014297 AAF55285   AF147700 AAD33987   AI063590   AI064491   AI106901   AI113978   AI238144   AI239137   AI292492   AI387129   AI514532   AI514850   AI516541   AI518159   AI519533   AI946438   AQ026207   AQ254719   AW942353   AX093968   AX260048   AY061194 AAL28742   BE976497   BE976818   BF486088   BF486162   BF491173   BF501357   BG634018   BG635193   BH610055   BI162789   BI165899   BI165908   BI215668   BI216767   BI234170   BI235814   BI240002   BI356410   BI364056   BI370699   BI615165   BI618862   BI628333   BQ103247   CO266382   CO270668   CO283594   CO284707   CO306832   CO311869   CO324144   CO327545   CO341230   CZ466313   CZ475310   CZ485697   CZ487837   CZ490381   EC070189   EC084490   EC087845   EC088823   EC200732   EC201482   EC231807   EC233761   EC239544   EC252156   EC260239   EV576007   EV581014   EV586132   EV588782   GH749364   GH749673   GH749777   GH750398   GH750877   GH751615   GH752038   GH752089   GH752970   GH755830   GH755870   GH755897   GH756068   GH756531   GH758313   GH759161   GH760469   GH760892   GH760921   GH770140   GH770203   GH770888   GH770941   GH771420   GH771424   GH772078   GH772713   GH775065   GH775588   GH775815   GH776745   GH782525   GH783368   GH784722   GH785091   GH785372   GH785472   GH786784   GH786828   GH787272   GH787822   GH789069   GH789742   GH789906   GH790498   GH791981   GH793248   GH795397   GH795681   GH796325   GH796550   GH796888   GH797604   GH798335   GH798689   GH800645   GH802588   GH802806   GH803615   GH804855   GH806369   GH807031   GH807051   GH807503   GH807642   GH808473   GH808866   GH810180   GH811841   GH812520   GH812658   GH812770   GH813004   GH813270   GH816420   GH816992   GH817649   GH818052   GH819537   GH821330   GH821864   GH824377   GH825738   GH826366   GH828315   GH829222   GH830620   GH831103   GH831151   GH831381   GH831416   GH831651   GH833246   GH835230   GH835614   GH836086   GH836121   GH836174   GH836730   GH837284   GH838252   GH839459   GH839965   GH841184   GH841452   GH844498   GH846598   GH847034   GH847220   GH848751   GH849811   GH852725   GH853866   GH854848   GH856678   GH856823   GH858175   GH858270   GH858504   GH858748   GH863125   GH863499   GH864092   GH864408   GH865365   GH866471   GH867045   GH870366   GH870857   GH871252   GH871335   GH871777   GH871932   GH872629   GH873228   GH873795   GH875722   GH878435   GH879379   GH880341   GH881315   GH882829   GH882968   GH883411   GH883791   GH886200   GH886877   GH886911   GH888567   GH889235   GH889457   GH891209   GH891319   GH891963   GH893012   GH894133   GH894135   GH898394   GH898608   GH899146   GH900655   GH900690   GH900839   GH901089   GH901465   GH902326   GH902340   GH903488   GH904830   GH905312   GH905623   GH906200   GH906953   GH907478   GH907790   GH908747   GH910624   GH911065   GH911232   GH912112   GH912694   GH913717   GH914311   GH915801   GH918261   GH919070   GH919510   GH926178   GH927195   GH930157   GH930689   GH930690   GH931460   GH932369   GH932568   GH932798   GH932996   GH934539   GH934591   GH935623   GH937737   GH937894   GH938892   GH942461   GH942483
UniProtKB/Swiss-Prot	Q9XZL8
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   pole plasm   (Fisher et al., 2012) Comment:maternally deposited organism   • pole plasm (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Chang and Min, 2005) mitochondrial matrix inferred from direct assay (Chang and Min, 2005) nucleus inferred from direct assay (Chang and Min, 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain    643.2 Adult Thoracic-Abdominal Ganglion    619.9 Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart    574.675 Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain  (643.2) Adult Thoracic-Abdominal Ganglion  (619.9) Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart  (574.675) Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain    643.2 Adult Thoracic-Abdominal Ganglion    619.9 Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart    574.675 Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain    643.2 Adult Thoracic-Abdominal Ganglion    619.9 Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart    574.675 Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain    643.2 Adult Thoracic-Abdominal Ganglion    619.9 Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart    574.675 Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain  643.2 Adult Thoracic-Abdominal Ganglion  619.9 Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart  574.675 Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain    643.2 Adult Thoracic-Abdominal Ganglion    619.9 Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart    574.675 Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    301.55 Larval Midgut    281.7 Larval Hindgut    218.7 Larval Malpighian Tubules    154.9 Larval Fat Body    92.9 Larval Salivary Gland    113.4 Larval Trachea    181.05 Larval Carcass    176.625 Adult Head    356.1 Adult Eye    284.825 Adult Brain    643.2 Adult Thoracic-Abdominal Ganglion    619.9 Adult Crop    271.5 Adult Midgut    188.8 Adult Hindgut    315.4 Adult Malpighian Tubules    209.8 Adult Fat Body    194 Adult Salivary Gland    298.1 Adult Heart    574.675 Adult VirginFemale Spermatheca    192 Adult InseminatedFemale Spermatheca    206.8 Adult Ovary    351.4 Adult Testis    230.2 Adult Male Accessory Gland    186.3 Adult Carcass    300.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    356.1   NA  Eye    284.825   NA  Brain    643.2   301.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    619.9   NA  Crop    271.5   281.7  Midgut    188.8   218.7  Hindgut    315.4   154.9  Malpighian Tubules    209.8   92.9  Fat Body    194   113.4  Salivary Gland    298.1   NA  Heart    574.675   181.05  Trachea    NA   NA  VirginFemale Spermatheca    192   NA  InseminatedFemale Spermatheca    206.8   NA  Ovary    351.4   NA  Testis    230.2   NA  Male Accessory Gland    186.3   176.625  Carcass    300.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    42 central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female    28 head, mated 4-day female    27 head, mated 20-day female    20 head, mated 1-day male    35 head, mated 4-day male    42 head, mated 20-day male    51 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    35 fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female    56 ovary, mated 4-day female    46 testis, mated 4-day male    129 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (42) central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female  (28) head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female  (28) head, mated 4-day female  (27) head, mated 20-day female    20 head, mated 1-day male  (35) head, mated 4-day male  (42) head, mated 20-day male  (51) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae  (35) fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female  (56) ovary, mated 4-day female  (46) testis, mated 4-day male  (129) accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    42 central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female    28 head, mated 4-day female    27 head, mated 20-day female    20 head, mated 1-day male    35 head, mated 4-day male    42 head, mated 20-day male    51 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    35 fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female    56 ovary, mated 4-day female    46 testis, mated 4-day male  (129) accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    42 central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female    28 head, mated 4-day female    27 head, mated 20-day female    20 head, mated 1-day male    35 head, mated 4-day male    42 head, mated 20-day male    51 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    35 fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female    56 ovary, mated 4-day female    46 testis, mated 4-day male    129 accessory gland, mated 4-day male    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    42 central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female    28 head, mated 4-day female    27 head, mated 20-day female    20 head, mated 1-day male    35 head, mated 4-day male    42 head, mated 20-day male    51 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    35 fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female    56 ovary, mated 4-day female    46 testis, mated 4-day male    129 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (42) central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female  28 head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female  28 head, mated 4-day female  27 head, mated 20-day female    20 head, mated 1-day male  (35) head, mated 4-day male  (42) head, mated 20-day male  (51) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae  (35) fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female  (56) ovary, mated 4-day female  (46) testis, mated 4-day male  (129) accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    42 central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female    28 head, mated 4-day female    27 head, mated 20-day female    20 head, mated 1-day male    35 head, mated 4-day male    42 head, mated 20-day male    51 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    35 fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female    56 ovary, mated 4-day female    46 testis, mated 4-day male  129 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    42 central nervous system, larvae L3    22 central nervous system, pupae P8    18 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    24 head, mated 1-day female    28 head, mated 4-day female    27 head, mated 20-day female    20 head, mated 1-day male    35 head, mated 4-day male    42 head, mated 20-day male    51 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    14 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    35 fat body, pupae P8    25 carcass, larvae L3 wandering    12 carcass, 1-day adult    21 carcass, 4-day adult    20 carcass, 20-day adult    21 ovary, virgin 4-day female    56 ovary, mated 4-day female    46 testis, mated 4-day male    129 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr    27 embryo 22-24hr    29 larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    27 white prepupae new    43 white prepupae 12hr    53 white prepupae 24hr    30 pupae 2d postWPP    30 pupae 3d postWPP    25 pupae 4d postWPP    34 adult male 01day    38 adult male 05day    49 adult male 30day    52 adult female 01day    30 adult female 05day    36 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (49) embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr  (27) embryo 22-24hr  (29) larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9  (27) white prepupae new  (43) white prepupae 12hr  (53) white prepupae 24hr  (30) pupae 2d postWPP  (30) pupae 3d postWPP    25 pupae 4d postWPP  (34) adult male 01day  (38) adult male 05day  (49) adult male 30day  (52) adult female 01day  (30) adult female 05day  (36) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr    27 embryo 22-24hr    29 larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    27 white prepupae new    43 white prepupae 12hr    53 white prepupae 24hr    30 pupae 2d postWPP    30 pupae 3d postWPP    25 pupae 4d postWPP    34 adult male 01day    38 adult male 05day    49 adult male 30day    52 adult female 01day    30 adult female 05day    36 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr    27 embryo 22-24hr    29 larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    27 white prepupae new    43 white prepupae 12hr    53 white prepupae 24hr    30 pupae 2d postWPP    30 pupae 3d postWPP    25 pupae 4d postWPP    34 adult male 01day    38 adult male 05day    49 adult male 30day    52 adult female 01day    30 adult female 05day    36 adult female 30day    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr    27 embryo 22-24hr    29 larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    27 white prepupae new    43 white prepupae 12hr    53 white prepupae 24hr    30 pupae 2d postWPP    30 pupae 3d postWPP    25 pupae 4d postWPP    34 adult male 01day    38 adult male 05day    49 adult male 30day    52 adult female 01day    30 adult female 05day    36 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (49) embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr  27 embryo 22-24hr  29 larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9  27 white prepupae new  (43) white prepupae 12hr  (53) white prepupae 24hr  30 pupae 2d postWPP  30 pupae 3d postWPP    25 pupae 4d postWPP  (34) adult male 01day  (38) adult male 05day  (49) adult male 30day  (52) adult female 01day  30 adult female 05day  (36) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr    27 embryo 22-24hr    29 larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    27 white prepupae new    43 white prepupae 12hr    53 white prepupae 24hr    30 pupae 2d postWPP    30 pupae 3d postWPP    25 pupae 4d postWPP    34 adult male 01day    38 adult male 05day    49 adult male 30day    52 adult female 01day    30 adult female 05day    36 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    15 embryo 06-08hr    16 embryo 08-10hr    21 embryo 10-12hr    21 embryo 12-14hr    17 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    19 embryo 20-22hr    27 embryo 22-24hr    29 larva L1    15 larva L2    10 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    27 white prepupae new    43 white prepupae 12hr    53 white prepupae 24hr    30 pupae 2d postWPP    30 pupae 3d postWPP    25 pupae 4d postWPP    34 adult male 01day    38 adult male 05day    49 adult male 30day    52 adult female 01day    30 adult female 05day    36 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    31 embryonic 1182-4H    59 embryonic GM2    36 embryonic Kc167    85 embryonic S1    93 embryonic S3    17 leg disc CME L1    32 wing disc CME-W2    44 wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    38 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    40 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    74 ovary fGS/OSS    38 ovary OSC    21 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  (31) embryonic 1182-4H  (59) embryonic GM2  (36) embryonic Kc167  (85) embryonic S1  (93) embryonic S3    17 leg disc CME L1  (32) wing disc CME-W2  (44) wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  (38) wing disc ML-DmD32  (47) haltere disc ML-DmD17-c3  (28) eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5  (40) mixed discs ML-DmD4-c1  (28) CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2  (103) tumorous blood cells mbn2  (74) ovary fGS/OSS  (38) ovary OSC    21 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    31 embryonic 1182-4H    59 embryonic GM2    36 embryonic Kc167    85 embryonic S1    93 embryonic S3    17 leg disc CME L1    32 wing disc CME-W2    44 wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    38 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    40 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2  103 tumorous blood cells mbn2    74 ovary fGS/OSS    38 ovary OSC    21 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    31 embryonic 1182-4H    59 embryonic GM2    36 embryonic Kc167    85 embryonic S1    93 embryonic S3    17 leg disc CME L1    32 wing disc CME-W2    44 wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    38 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    40 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    74 ovary fGS/OSS    38 ovary OSC    21 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    31 embryonic 1182-4H    59 embryonic GM2    36 embryonic Kc167    85 embryonic S1    93 embryonic S3    17 leg disc CME L1    32 wing disc CME-W2    44 wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    38 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    40 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    74 ovary fGS/OSS    38 ovary OSC    21 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  31 embryonic 1182-4H  (59) embryonic GM2  (36) embryonic Kc167  (85) embryonic S1  (93) embryonic S3    17 leg disc CME L1  32 wing disc CME-W2  (44) wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  (38) wing disc ML-DmD32  (47) haltere disc ML-DmD17-c3  28 eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5  (40) mixed discs ML-DmD4-c1  28 CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2  (103) tumorous blood cells mbn2  (74) ovary fGS/OSS  (38) ovary OSC    21 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    31 embryonic 1182-4H    59 embryonic GM2    36 embryonic Kc167    85 embryonic S1    93 embryonic S3    17 leg disc CME L1    32 wing disc CME-W2    44 wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    38 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    40 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2  103 tumorous blood cells mbn2    74 ovary fGS/OSS    38 ovary OSC    21 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    31 embryonic 1182-4H    59 embryonic GM2    36 embryonic Kc167    85 embryonic S1    93 embryonic S3    17 leg disc CME L1    32 wing disc CME-W2    44 wing disc ML-DmD8    24 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    38 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    40 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    74 ovary fGS/OSS    38 ovary OSC    21 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult  (50) Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult  (31) Cadmium 100 mM 48 hrs, 4-day adult  (64) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (27) Ethanol 2.5% 3 hrs, larvae L3  (68) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (57) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (56) Paraquat 10 mM 48 hrs, 4-day adult  (73) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult  (50) Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult  31 Cadmium 100 mM 48 hrs, 4-day adult  (64) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  27 Ethanol 2.5% 3 hrs, larvae L3  (68) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (57) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (56) Paraquat 10 mM 48 hrs, 4-day adult  (73) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    16 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    64 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    27 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD15403 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086370 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6072-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for sra Stages(s) 1-3 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sra62 sra05203 lethal | adult stage | female sraA108 lethal | embryonic stage | maternal effect sra05203 lethal | larval stage | recessive sra05203 lethal | recessive sra32 sra00934 sra05203 sra05702 sra07636 sra08235 sra08705 partially lethal - majority die | larval stage sraKO partially lethal - majority die | pupal stage sraKO viable sra619 sra687 sra05203 sraA108 sraA426 sraEP3462 sraGTD74-96 sraUM3 viable, with Scer\GAL4nos.UTR.T:Hsim\VP16 sraS215A.Scer\UAS.P\T.T:Zzzz\FLAG viable, with Scer\GAL4pnr-MD237 sraGD11808 Sterility Allele female sterile sra619 sra687 sraA108 sraA381 sraA426 sraKO sraUM3 female sterile (with Df(3R)sbd45) sra619 sra687 sra05203 sraA108 sraA426 sraUM3 female sterile | germline clone sra05203 female sterile | recessive sraA108 sraA381 female sterile | recessive, with Scer\GAL4[-]: sraGS3080 sraGS3168 fertile sraEP3462 Other Phenotypes Allele bang sensitive sra1 courtship behavior defective | female, with Scer\GAL4elav-C155 sraGS3080 sraScer\UAS.cEa courtship behavior defective | female, with Scer\GAL4sca-537.4 sraGS3168 sraScer\UAS.cEa learning defective sra1 sra2 learning defective, with Scer\GAL4Act5C.PI sraScer\UAS.cCa learning defective, with Scer\GAL4c739 sraScer\UAS.cCa learning defective, with Scer\GAL4elav.PLu sraScer\UAS.cCa learning defective | RU486 conditional, with Scer\GAL4elav.Switch.PO sraScer\UAS.cCa locomotor behavior defective sraKO long lived, with Scer\GAL4hs.PB sraGS3080 meiotic cell cycle defective, with Scer\GAL4nos.UTR.T:Hsim\VP16 sraS215A.Scer\UAS.P\T meiotic cell cycle defective (with Df(3R)sbd45) sraA426 meiotic cell cycle defective (with sra619) sraA426 meiotic cell cycle defective (with sraA426) sra619 meiotic cell cycle defective | female sraKO meiotic cell cycle defective | female (with Df(3R)sbd45) sra687 sraA108 sraA426 meiotic cell cycle defective | female (with sra619) sra687 sraA108 sraA426 meiotic cell cycle defective | female (with sra687) sra619 meiotic cell cycle defective | female (with sraA108) sra619 meiotic cell cycle defective | female (with sraA426) sra619 meiotic cell cycle defective | female | germline clone sra05203 memory defective sra1 sra2 short lived sraKO sleep defective sraGS3080 sraKO sleep defective (with sraGS3080) sraKO sleep defective (with sraKO) sraGS3080 Phenotype manifest in Allele egg, with Scer\GAL4nos.UTR.T:Hsim\VP16 sraS215A.Scer\UAS.P\T egg, with Scer\GAL4nos.UTR.T:Hsim\VP16, sraKO sraS215A.Scer\UAS.P\T sraS219A.Scer\UAS.P\T egg, with Scer\GAL4nos.UTR.T:Hsim\VP16, sraS215A.Scer\UAS.P\T sraKO egg, with Scer\GAL4nos.UTR.T:Hsim\VP16, sraS219A.Scer\UAS.P\T sraKO egg & meiotic anaphase I sraKO egg & meiotic anaphase I | germ-line clone sraKO embryonic/first instar larval cuticle | maternal effect sra05203 eye photoreceptor cell sra1 eye photoreceptor cell, with Scer\GAL4elav.PLu sraScer\UAS.cCa eye photoreceptor cell (with sra1) sra62 eye photoreceptor cell (with sra62) sra1 male pronucleus sra687 male pronucleus (with Df(3R)sbd45) sraA108 male pronucleus (with sra619) sraA108 male pronucleus (with sraA108) sra619 meiosis II (with sra619) sraA426 meiosis II (with sraA426) sra619 meiotic anaphase I (with Df(3R)sbd45) sra687 sraA426 meiotic anaphase I (with sra619) sra687 sraA108 sraA426 meiotic anaphase I (with sra687) sraA108 sra619 meiotic anaphase I (with sraA108) sra687 sraA426 sra619 meiotic anaphase I (with sraA426) sraA108 sra619 meiotic anaphase I | female | germline clone sra05203 mitochondrion sra1 mitochondrion, with Scer\GAL4elav.PLu sraScer\UAS.cCa mitochondrion (with sra1) sra62 mitochondrion (with sra62) sra1
Classical Alleles ( 60 )
For All Classical Alleles Show
Allele of sra Class Mutagen Stocks Known lesion sraNP2564 2 -- sra05203 loss of function allele P-element activity 1 -- sra32 1 Yes sra5-HA-1860 1 -- sra5-SZ-3216 1 -- srac00247 piggyBac transposase 1 -- srac03110 1 -- sraCB-0728-3 1 -- sraCB-0918-3 1 -- sraCB-5085-3 1 -- sraCB-5350-3 1 -- sraCB-6064-3 1 -- srad06733 P-element activity 1 -- sraEP3462 P-element activity 1 Yes sraEY07182 P-element activity 1 -- sraf03150 piggyBac transposase 1 -- sraGS3080 P-element activity 1 Yes sraGS3168 1 Yes sraGTD74-96 P-element activity 1 Yes sraKG00335 P-element activity 1 -- sraMI06435 1 -- sraUM-8377-3 1 -- sra00934 P-element activity 0 -- sra05702 P-element activity 0 -- sra07636 P-element activity 0 -- sra08235 P-element activity 0 -- sra08705 P-element activity 0 -- sra117 0 Yes sra12 Delta2-3 0 Yes sra170 Delta2-3 0 Yes sra1 P-element activity 0 Yes sra2 Delta2-3 0 Yes sra3 P-element activity 0 Yes sra416 Delta2-3 0 Yes sra4 P-element activity 0 Yes sra619 loss of function allele P-element activity 0 Yes sra62 P-element activity 0 Yes sra687 loss of function allele Delta2-3 P-element activity 0 Yes sra75 Delta2-3 0 Yes sraA108 loss of function allele P-element activity 0 Yes sraA381 P-element activity 0 Yes sraA426 loss of function allele Delta2-3 0 Yes srac03600 0 -- sraCB-5163-3 0 -- sraDG10605 0 -- sraDG20509 0 -- sraf05211 piggyBac transposase 0 -- sraf07644 piggyBac transposase 0 -- sraGS10207 0 Yes sraGS10522 0 Yes sraGS10900 0 Yes sraGS12031 0 Yes sraGS9883 0 Yes srainvader4.1371 natural population 0 Yes sraKO loss of function allele recombination FLPase SCEI endonuclease gene targeting by homologous recombination 0 Yes sraP1 P-element activity 0 Yes sraP2 P-element activity 0 Yes sraPJ Delta2-3 0 Yes sraR7-18 Delta2-3 0 Yes sraUM3 loss of function allele P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sra Class Mutagen Stocks Known lesion sraGD11808 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sraGL01096 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sraJF02557 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sraKK107660 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sracHa in vitro construct - genomic fragment 0 Yes sraEndsOut.T in vitro construct 0 Yes srahs.PT in vitro construct - regulatory fusion 0 Yes sraS100A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sraS199A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS215A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS215A.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes sraS215D.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS215E.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS219A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS219A.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes sraS219D.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS219E.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS67A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraS72A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes sraScer\UAS.cEa in vitro construct - regulatory fusion 0 Yes sraScer\UAS.P\T.cTa in vitro construct - regulatory fusion 0 Yes sraScer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sraScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sraT102A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraT196A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes sraT246A.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes srat4 in vitro construct - genomic fragment 0 Yes sraΔ212-221.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)bxd100 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)Exel6268 (Ryder, 2004.4.26) Df(3R)sbd26 (Czank and Kubli, 2001, Czank, 1997.5.14) Df(3R)sbd45 (Czank and Kubli, 2001, Horner, 2006) Df(3R)sbd104 (Czank and Kubli, 2001, Czank, 1997.5.14, BDGP Project Members, 1994-1999) Df(3R)sbd105 (Spradling et al., 1999) Df(3R)sra-l1 (Czank and Kubli, 2001) Df(3R)sra-l2 (Czank and Kubli, 2001) Tp(3;3)sbd104 (Czank, 1997.5.14)
Partially disrupted in	Df(3R)Bin112 (Singh et al., 2005) Df(3R)Bin1170 (Singh et al., 2005) Df(3R)Bin1R7-18 (Singh et al., 2005)
Not disrupted in	Df(3R)P10 (BDGP Project Members, 1994-1999) Df(3R)P115 (BDGP Project Members, 1994-1999) Df(3R)sbd104 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11808} NA P{KK107660} NA P{TRiP.GL01096} NA P{TRiP.JF02557} NA P{UASp-sra.FLAG} NA P{UASp-sra.S67A.FLAG} NA P{UASp-sra.S72A.FLAG} NA P{UASp-sra.S100A.FLAG} NA P{UASp-sra.S199A.FLAG} NA P{UASp-sra.S215A.FLAG} NA P{UASp-sra.S215A} NA P{UASp-sra.S215D.FLAG} NA P{UASp-sra.S215E.FLAG} NA P{UASp-sra.S219A.FLAG} NA P{UASp-sra.S219A} NA P{UASp-sra.S219D.FLAG} NA P{UASp-sra.S219E.FLAG} NA P{UASp-sra.T102A.FLAG} NA P{UASp-sra.T196A.FLAG} NA P{UASp-sra.T246A.FLAG} NA P{UASp-sra.T} NA P{UASp-sra.Δ212-221} NA P{UAS-sra.C} NA P{UAS-sra.E} NA heat-shock construct P{hs-sra.T} NA characterization construct P{Bin1+t4} NA P{EndsOut-sra.T} NA P{sracHa} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}sraEP3462 NA P{EPgy2}sraEY07182 NA P{GSV1}sraGS3080 NA P{GSV1}sraGS3168 NA P{GSV6}sraGS9883 NA P{GSV6}sraGS10207 NA P{GSV6}sraGS10522 NA P{GSV6}sraGS10900 NA P{GSV6}sraGS12031 NA P{XP}srad06733 NA miscellaneous insertions Mi{MIC}sraMI06435 NA P{?EP}Bin1R7-18 NA P{?EP}sra75 NA P{?lacZ}sra62 NA P{}sraP1 NA P{}sraP2 NA P{Acp70Ag.Yp1.hs}sraA108 NA P{GTD-b}sraGTD74-96 NA P{RS3}sraCB-0728-3 NA P{RS3}sraCB-0918-3 NA P{RS3}sraCB-5085-3 NA P{RS3}sraCB-5163-3 NA P{RS3}sraCB-5350-3 NA P{RS3}sraCB-6064-3 NA P{RS3}sraUM-8377-3 NA P{RS5}sra5-HA-1860 NA P{RS5}sra5-SZ-3216 NA P{SUPor-P}sraKG00335 NA P{UASp-YFP.Rab11}sra32 NA P{wHy}sraDG10605 NA P{wHy}sraDG20509 NA PBac{PB}srac00247 NA PBac{PB}srac03110 NA PBac{PB}srac03600 NA PBac{WH}sraf03150 NA PBac{WH}sraf05211 NA PBac{WH}sraf07644 NA insertion of enhancer trap binary system P{GawB}sraNP2564 No PBac{IT.GAL4}1.1 No insertion of enhancer trap P{lacW}sra619 No P{lacW}sraA381 No P{lacW}sraA426 No P{lacZ}sra1 No P{PZ}sra00934 No P{PZ}sra05203 No P{PZ}sra05702 No P{PZ}sra07636 No P{PZ}sra08235 No P{PZ}sra08705 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with CanB2 (Takeo et al., 2006) inferred from physical interaction with Pp2B-14D (Takeo et al., 2006)
Biological Process
CV term Evidence References
egg activation inferred from mutant phenotype (Horner et al., 2006) female meiosis inferred from mutant phenotype (Takeo et al., 2006, Horner et al., 2006, Takeo et al., 2012) long-term memory inferred from mutant phenotype (Chang et al., 2003) male pronucleus assembly inferred from mutant phenotype (Horner et al., 2006) meiosis inferred from genetic interaction with Pp2B-14D (Takeo et al., 2010) mitochondrion organization inferred from mutant phenotype (Chang and Min, 2005) olfactory learning inferred from mutant phenotype (Chang et al., 2003) regulation of female receptivity inferred from mutant phenotype (Ejima et al., 2004) regulation of female receptivity, post-mating inferred from mutant phenotype (Ejima et al., 2004) sleep inferred from direct assay (Nakai et al., 2011)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Chang and Min, 2005) mitochondrial matrix inferred from direct assay (Chang and Min, 2005) nucleus inferred from direct assay (Chang and Min, 2005)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
calcium-mediated signaling inferred from electronic annotation with InterPro:IPR006931 (FlyBase Curators et al., 2004-) meiosis I non-traceable author statement (Swiss-Prot Project Members, 2000.2.15)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sra - Pp2B-14D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sra allele Gene References unspecified Pp2B-14D (Takeo et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0086370 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47384
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6R7VX0 Dipteran inclusive ortholog search EOG6ZS9C3 Insect inclusive ortholog search EOG6B2RT8 Arthropod inclusive ortholog search EOG6S1RQ6 Metazoa inclusive ortholog search EOG69SK1Q
Orthologs in Drosophila Species (EOG6R7VX0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sra     Drosophila simulans   Dsim\GD19080     Drosophila sechellia   Dsec\GM24291     Drosophila erecta   Dere\GG16986     Drosophila yakuba   Dyak\GE24376     Drosophila ananassae   Dana\GF23052     Drosophila pseudoobscura pseudoobscura   Dpse\GA19337     Drosophila persimilis   Dper\GL12228     Drosophila willistoni   Dwil\GK13268     Drosophila virilis   Dvir\GJ23390     Drosophila mojavensis   Dmoj\GI22663     Drosophila grimshawi   Dgri\GH18771
Orthologs in non-Drosophila Dipterans (EOG6ZS9C3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015066   Anopheles gambiae Malaria mosquito  Agam\AGAP006685   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014788
Orthologs in non-Dipteran Insects (EOG6B2RT8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55542   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014610   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17868   Atta cephalotes Leafcutter ant  Acep\ACEP21555   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13521   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19779   Linepithema humile Argentine ant  Lhum\LH15802   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20621   Solenopsis invicta Red fire ant  Sinv\SINV16721   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002870   Bombyx mori Silkmoth  Bmor\BGIBMGA011095   Pediculus humanus Human body louse  Phum\PHUM106420   Tribolium castaneum Red flour beetle  Tcas\sra
Orthologs in non-Insect Arthropods (EOG6S1RQ6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Psd4   Ixodes scapularis Deer tick  Isca\ISCW005875
Orthologs in non-Arthropod Metazoa (EOG69SK1Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rcn-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024656gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019071gn   Danio rerio Zebrafish  Drer\rcan1   Danio rerio Zebrafish  Drer\DKEY-67C22.1   Danio rerio Zebrafish  Drer\rcan3   Danio rerio Zebrafish  Drer\OTTDARG00000006877   Xenopus tropicalis Western clawed frog  Xtro\rcan2   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034070   Xenopus tropicalis Western clawed frog  Xtro\rcan1   Gallus gallus Domestic chicken  Ggal\RCAN2   Gallus gallus Domestic chicken  Ggal\ENSGALG00000004282   Gallus gallus Domestic chicken  Ggal\RCAN1   Mus musculus House mouse  Mmus\Rcan2   Mus musculus House mouse  Mmus\Rcan1   Mus musculus House mouse  Mmus\Rcan3   Rattus norvegicus Norway rat  Rnor\Rcan3   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000010350   Rattus norvegicus Norway rat  Rnor\Rcan1   Homo sapiens Human  Hsap\RCAN2   Homo sapiens Human  Hsap\ENSG00000159200   Homo sapiens Human  Hsap\RCAN3
Human Orthologs (3)
Gene OMIM HGNC Hsap\RCAN2     Hsap\ENSG00000159200     Hsap\RCAN3
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 27 )
Harvard	- P{XP}srad06733 - PBac{PB}srac00247 - PBac{PB}srac03110 - PBac{WH}sraf03150
Kyoto	109063 w*; P{GTD-b}sraGTD74-96 123299 w1118; P{RS3}sraCB-0728-3 123376 w1118; P{RS3}sraCB-0918-3 123450 w1118; P{RS3}sraCB-5085-3 123577 w1118; P{RS3}sraCB-5350-3 123902 w1118; P{RS3}sraCB-6064-3
VDRC	v107573 P{KK107660}VIE-260B v27546 w1118; P{GD11808}v27546/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR37I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 278 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15403
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16650 AT20266 AT20371 AT27852 AT30047 AT31703 GH03488 GH04936 GH06155 GH10552 GH14145 GH15412 GH17571 GM03051 HL01131 LD01009 LD08658 LD11608 LD20790 LD21180 LD27082 LD27165 LD34137 LD34168 LD34271 LD37591 LD39157 LD41069 LD41275 LD42438 RE02023 RE05890 RE05908 RE22250 RE24040 RE29826 RE31749 RE36642 RE42552 RE49092 RE57420 RH44723 RH49791 RH56703
Other clones	35519 39513 64640 76989 103857 146156 194122 214349.24 214505.21 bs25g12 bs52c05 bs56c11 CK01.88A.C11 CK01.128D.H11 Dmel_dig_008432_0661_3521 Dmel_dig_010456_0661_1174 Dmel_dig_020994_0721_0881 Dmel_neb_012299_0192_1746 EK099732 EK146215 EK163733 EK166609 EK192762 EK227111 EK252529 EP07451 EP12062 RP003001242 RP003001622 RP003001884 RP003009147 RP003020837 RP003024315 RP003027003 RP003027571 RP003028695 RP003033369 RP003036221 RP003037225 RP003037629 RP003038377 RP003041698 RP003043460 RP003044349 RP003047075 RP003047903 RP003047962 RP003048447 RP003050618 RP003052013 RP003053988 RP003059065 RP003060561 RP003067600 RP003068116 RP003069484 RP003073041 RP003077746 RP003084647 RP003090472 RP003091076 RP003094084 RP003097585 RP003099617 RP003102870 RP003105961 RP003108251 RP003112311 RP003114074 RP003116021 RP003117841 RP003118664 RP003120691 RP003123758 RP003125040 RP003125049 RP003126364 RP003127161 RP003135048 RP003135737 RP003135959 RP003136749 RP003148984 RP003154743 RP003157036 RP003158129 RP003170007 RP003171021 RP003174590 RP003175041 RP003175378 RP003176830 RP003180163 RP003181516 RP003183031 RP003185794 RP003188699 RP003188793 RP003190458 RP003194822 RP003195221 RP003195638 RP003198354 RP003200968 RP003214724 RP003215150 RP003220413 RP003221074 RP003224008 RP003224091 RP003225788 RP003228668 RP003233238 RP003238408 RP003240461 RP003249196 RP003251022 RP003263711 RP003273578 RP003274074 RP003274662 RP003282232 RP003285491 RP003285990 RP003286388 RP003289736 RP003290501 RP003293042 RP003295219 RP003298912 RP003299090 RP003300252 RP003313232 RP003313926 RP003314141 RP003323826 RP003329294 RP003335946 RP003345496 RP003354145 RP003357088 RP003357451 RP003360271 RP003360358 RP003366670 RP003368345 RP003368931 RP003378071 RP003378327 RP003382843 RP003391309 RP003392851 RP003399299 RP003399365 RP003401017 RP003406006 RP003410572 RP003411706 RP003417837 RP003422260 RP003426683 RP003430823 RP003439573 RP003444932 RP003448619 RP003448792 RP003450963 RP003453819 RP003454610 RP003455252 RP003455976 RP003455984 RP003459930 RP003460046 RP003461737 RP003462372 RP003464068 RP003472363 RP003473880 RP003475168 RP003477311 RP003477815 RP003479754 RP003479838 RP003482723 RP003491602 RP003494894 RP003501864 RP003504810 RP003508707 RP003511090 RP003511167 RP003514445 RP003519548 RP003519698 RP003520613 RP003526980 RP003527900 RP003533866 RP003537773 RP003541773 RP003542175 RP003549005 RP003558836 RP003559386 RP003560366 RP003561387 RP003565763 RP003572058 RP003575828 RP003581010 RP003581290 RP003581735 RP003581888 RP003582927 RP003585252 RP003585661 RP003595447 RP003597671 RP003607812 RP003609976 RP003626573 RP003628697 RP003636087 RP003636253 RP003636301 RP003637289 RP003657244 RP003665192 RP003667044 RP003676616 RP003679165 UUGC0649
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086370 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47384
Antibody Information
Other Information
Discoverer
Etymology
	Gene name is "Sarah" because Sarah, Abraham's wife, was infertile for many years but eventually had a child. This is also the fate of homozygous sra[A381] females. (Czank, 1997.5.14)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: sra anon-WO0118547.92 anon-WO0172774.10 (FlyBase, 1996-) Source for merge of: sra l(3)05203 (Horner, 2006) Source for merge of: sra nla (Czank, 2002.4.24)
Additional comments	The relationship between "fey" and "sra" is unclear. It is possible that "fey" is a lethal "sra" allele. (Czank and Kubli, 2001) "sra" is a distinct gene from "Sb". (Czank, 1997.5.14) Source for merge of sra anon-WO0118547.92 anon-WO0172774.10 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	bcd mRNA is not translated in eggs laid by sra mutant females. (Horner et al., 2006) Double heterozygous progeny from crosses using sra and Bin1 mutant alleles are viable and fertile at 22oC and 25oC. (Singh et al., 2005) Mutant females show spontaneous ovulation as virgins, sterility with impaired meiotic progression and compromised postmating responses, with a lower ovulation level, higher remating rate and shorter period for restoration of receptivity. (Ejima et al., 2004) Area matching Drosophila EST AA979551. This EST overlaps EST AA567400. (Davies, 2001.3.15) Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation. (Braun et al., 1997) Mutations of sra affect oviposition. (Czank et al., 1997) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. l(3)05203 gene expression during oogenesis is not critical to embryonic development, but the gene function may be essential for fertilisation and/or completion of meiosis. (Perrimon et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079654 RefSeq (Proteins) • NP_524378 DDBJ / EMBL / GenBank • AA440575 AA979551 AAD33987 AAF55285 AAL28742 AF147700 AQ026207 AQ254719 AW942353 AX093968 AX260048 AY061194 BH610055 CZ466313 CZ475310 CZ485697 CZ487837 CZ490381 Entrez Gene - A searchable database of RefSeq genes. • 47384 UniProtKB/Swiss-Prot • Q9XZL8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Calcipressin (IPR006931) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD15403
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0086370 DRSC - Results from RNAi screens. • FBgn0086370 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086370 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6072-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086370 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47384 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/sarah1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47384 modMine - Data generated by the modENCODE project. • FBgn0086370
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	89B (Czank, 1997.5.14) 89B11 (Czank, 1997.5.14, Czank et al., 1997) anon-WO0118547.92   anon-WO0172774.10   CG6072 (Seong et al., 2001, Ni et al., 2011.7.19, González et al., 2008, Keleman et al., 2009.8.5, Curtis et al., 2007) l(3)05203 (McClure and Schubiger, 2008) nebula (Chang and Min, 2005) nla (Aigaki et al., 2002, Seong et al., 2001, Zhu et al., 2001, Lukacsovich et al., 2001, Chang and Min, 2009) sra (Cui et al., 2008, Bonnefoy et al., 2007, Horner, 2006, Takeo et al., 2006, Takeo et al., 2006, FlyBase Curators, 2008, Zhang et al., 2007, Chang and Min, 2005, Akdemir et al., 2007, Sakai and Aigaki, 2010, González et al., 2008, Weil et al., 2008, Rangan et al., 2009, Perkins et al., 2009.8.10, Takeo et al., 2010, González et al., 2010, Gohl et al., 2011, Nakai et al., 2011, Rangan et al., 2008, Takeo et al., 2012) Sra (Huang et al., 2008, Takeo et al., 2012)
Name Synonym	lethal (3) 05203   nebula (Rebeiz et al., 2002, Chang et al., 2003, Chang and Min, 2005, Chang and Min, 2009) sara (Li and White, 2003) sarah (Horner et al., 2006, Takeo et al., 2006, Czank, 1997.5.14, Chang and Min, 2005, Sackton et al., 2007, Weil et al., 2008, Curtis et al., 2007, Gohl et al., 2011, Bonnefoy et al., 2007, Nakai et al., 2011) Sarah (Sakai and Aigaki, 2010, Takeo et al., 2010)
Secondary FlyBase IDs
	FBgn0010860 FBgn0020250 FBgn0026629 FBgn0046492 FBgn0061526
References ( 76 )
Generate a list of	All references relating to this gene ( 76 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 8 ) Review  ( 2 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) Patent  ( 2 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Thesis  ( 1 )
Recent research papers ( 3 )
	Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Takeo et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(17): 6382--6389 Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. [FBrf0218117] Nakai et al., 2011, J. Neurosci. 31(36): 12759--12766 Calcineurin and Its Regulator Sra/DSCR1 Are Essential for Sleep in Drosophila. [FBrf0215272] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...