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Gene Dmel\lap

General Information
Symbol	Dmel\lap	Species	D. melanogaster
Name	like-AP180	Annotation symbol	CG2520
Feature type	protein_coding_gene	FlyBase ID	FBgn0086372
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	AP180, l(3)neo34, dAP-3
Genomic Location
Chromosome (arm)	3R	Recombination map	3-45.6 +/- 10.4
Cytogenetic map	84D1-84D2	Sequence location	3R:3,012,716..3,026,663 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene like-AP180 is referred to in FlyBase by the symbol Dmel\lap (CG2520, FBgn0086372). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: 1-phosphatidylinositol binding; clathrin binding. There is experimental evidence that it is involved in the biological process: phototaxis; synaptic transmission; neuron-neuron synaptic transmission; receptor-mediated endocytosis; synaptic vesicle endocytosis. 18 alleles are reported. The phenotypes of these alleles are annotated with: eye; ommatidium; synaptic vesicle. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: AP180 N-terminal homology (ANTH) domain; Clathrin adaptor, phosphoinositide-binding, GAT-like; ENTH/VHS; Epsin-like, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye. Comments on Affy2 ProbeSet: ProbeSet 1636846_at completely aligns to an exonic region of only a subset of 1 of the 3 FlyBase-annotated transcript isoforms of lap. Gene sequence location is 3R:3012716..3026663.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84D1-84D2   Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84C-84D   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000) 84C-84D     (Zhang, 1998.6.30) 84D1-84D14   (determined by in situ hybridisation)   (Spradling et al., 1999) 84C-84D   (determined by in situ hybridisation)   (Zhang et al., 1998) 84D1-84D14     (BDGP Project Members, 1994-1999) 84D-84D   (determined by in situ hybridisation)   (Cooley et al., 1988)
Experimentally Determined Recombination Data
Location	3-45.6 +/- 10.4 (Babcock et al., 2003)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lap for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lap-RA FBtr0081572  NM_079528   4341   468 lap-RC FBtr0302183  NM_001144547   5126   758 lap-RD FBtr0302184  NM_001170067   5216   788 lap-RE FBtr0305153  NM_001260029   2984   572 lap-RF FBtr0305154  NM_001260030   3249   685 lap-RG FBtr0305155  NM_001260031   4871   673 lap-RH FBtr0334886  NM_001275409   4964   704 lap-RI FBtr0334887  NM_001275410   5180   776 lap-RJ FBtr0334888  NM_001275411   4886   678
Additional Transcript Data & Comments
Reported size (kB)	4.2 (northern blot) (Zhang et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lap-PA   FBpp0081091   49.9   468   6.12     NP_524252   AAF54050 lap-PC   FBpp0291393   80.9   758   7.20     NP_001138019   ACL83478 lap-PD   FBpp0291394   84.2   788   7.28     NP_001163538   ACZ94835 lap-PE   FBpp0293683   61.7   572   6.68     NP_001246958   AFH06277 lap-PF   FBpp0293684   72.8   685   7.46     NP_001246959   AFH06278 lap-PG   FBpp0293685   71.8   673   7.70     NP_001246960   AFH06279 lap-PH   FBpp0306907   75.0   704   7.93     NP_001262338   AGB95721 lap-PI   FBpp0306908   83.2   776   7.49     NP_001262339   AGB95722 lap-PJ   FBpp0306909   72.4   678   8.15     NP_001262340   AGB95723
Additional Polypeptide Data & Comments
Reported size (kDa)	468 (aa) (Zhang et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • AP180 N-terminal homology (ANTH) domain (IPR011417) ENTH/VHS (IPR008942) Epsin-like, N-terminal (IPR013809) Clathrin adaptor, phosphoinositide-binding, GAT-like (IPR014712) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1HX8
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697658   AE014297 AAF54050   AC008029   AE014297 ACL83478   AE014297 ACZ94835   AF075247 AAD08669   AE014297 AFH06277   AE014297 AFH06278   AE014297 AFH06279   AE014297 AGB95721   AE014297 AGB95722   AE014297 AGB95723   AI062539   AI107068   AI110197   AI402607   AI517423   AI517546   AI517560   AI517949   AQ025244   AQ034102   AY070858   AY128498 AAM75091   BE976662   BF491614   BF497410   BG639567   BH840713   BI485635   BI485656   BI565852   BI565882   BI576958   BI585350   BI589529   BI593668   BI612003   BI612016   BI616023   BI616070   BI620086   BI621026   BI624142   BI628024   BI632020   BI632100   BI638020   BP548426   BT081403   CK132106   CK662100   CO155033   CO177283   CO177868   CO179721   CO187342   CO187885   CO188261   CO192330   CO195082   CO262049   CO266476   CO272112   CO282931   CO285907   CO289681   CO291523   CO296396   CO300718   CO301452   CO301920   CO304267   CO304343   CO307485   CO309659   CO310897   CO314770   CO317246   CO318977   CO319434   CO319619   CO321415   CO321626   CO323527   CO323966   CO326726   CO327000   CO327806   CO328150   CO333752   CO343380   CW848179   CZ469542   CZ480926   CZ480927   CZ481488   DN154105   EC058191   EC058444   EC066596   EC066852   EC069904   EC069950   EC072670   EC073988   EC075275   EC077549   EC081039   EC083241   EC085758   EC087598   EC088107   EC089804   EC089872   EC090325   EC195143   EC200437   EC201005   EC203040   EC204881   EC205425   EC211330   EC212102   EC213299   EC214223   EC217903   EC222890   EC227369   EC230736   EC235098   EC236222   EC237107   EC238342   EC239218   EC244901   EC246130   EC246343   EC251611   EC253129   EC255675   EC257882   EC259557   EC261049   ES689993
UniProtKB/Swiss-Prot	Q9VI75
UniProtKB/TrEMBL	B7Z0U7 E1JJ78
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   garland cell   (Zhang et al., 1998) presumptive embryonic/larval peripheral nervous system   (Zhang et al., 1998) presumptive embryonic/larval central nervous system   (Zhang et al., 1998)
Additional Descriptive Data
	lap transcripts are expressed mainly in the central and peripheral nervous systems and in garland cells in embryos. (Zhang et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage   bouton   (Zhang et al., 1998) immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   neuromuscular junction   (Zhang et al., 1998) neuromuscular junction | restricted   (Verstreken et al., 2009) Comment:Presynaptic third instar larval stage   embryonic/larval neuromuscular junction   • terminal bouton (Bronk et al., 2001) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	lap protein is enriched at synaptic boutons of neuromuscular junctions in larvae. lap protein and Clc protein co-localize at the synaptic boutons. The level of Clc protein is significantly reduced in lap mutants. (Zhang et al., 1998)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
coated pit inferred from direct assay (Zhang et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain    1073.6 Adult Thoracic-Abdominal Ganglion    1104.5 Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain  (1073.6) Adult Thoracic-Abdominal Ganglion  (1104.5) Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain  1073.6 Adult Thoracic-Abdominal Ganglion  (1104.5) Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain    1073.6 Adult Thoracic-Abdominal Ganglion    1104.5 Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain    1073.6 Adult Thoracic-Abdominal Ganglion    1104.5 Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain  (1073.6) Adult Thoracic-Abdominal Ganglion  (1104.5) Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain  1073.6 Adult Thoracic-Abdominal Ganglion  1104.5 Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    528.775 Larval Midgut    8.2 Larval Hindgut    19.6 Larval Malpighian Tubules    9.7 Larval Fat Body    8.8 Larval Salivary Gland    51.7 Larval Trachea    20.55 Larval Carcass    24.5 Adult Head    351.7 Adult Eye    451.325 Adult Brain    1073.6 Adult Thoracic-Abdominal Ganglion    1104.5 Adult Crop    8.1 Adult Midgut    5.4 Adult Hindgut    10.7 Adult Malpighian Tubules    4.1 Adult Fat Body    12.5 Adult Salivary Gland    22.5 Adult Heart    99.075 Adult VirginFemale Spermatheca    10.4 Adult InseminatedFemale Spermatheca    10.6 Adult Ovary    3.3 Adult Testis    1.7 Adult Male Accessory Gland    8.3 Adult Carcass    23.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    351.7   NA  Eye    451.325   NA  Brain    1073.6   528.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1104.5   NA  Crop    8.1   8.2  Midgut    5.4   19.6  Hindgut    10.7   9.7  Malpighian Tubules    4.1   8.8  Fat Body    12.5   51.7  Salivary Gland    22.5   NA  Heart    99.075   20.55  Trachea    NA   NA  VirginFemale Spermatheca    10.4   NA  InseminatedFemale Spermatheca    10.6   NA  Ovary    3.3   NA  Testis    1.7   NA  Male Accessory Gland    8.3   24.5  Carcass    23.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    36 head, virgin 1-day female    32 head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male    37 head, mated 4-day male    39 head, mated 20-day male    27 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8  (36) head, virgin 1-day female  (32) head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male  (37) head, mated 4-day male  (39) head, mated 20-day male  (27) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    36 head, virgin 1-day female    32 head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male    37 head, mated 4-day male    39 head, mated 20-day male    27 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    36 head, virgin 1-day female    32 head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male    37 head, mated 4-day male    39 head, mated 20-day male    27 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    36 head, virgin 1-day female    32 head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male    37 head, mated 4-day male    39 head, mated 20-day male    27 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8  (36) head, virgin 1-day female  32 head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male  (37) head, mated 4-day male  (39) head, mated 20-day male  27 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    36 head, virgin 1-day female    32 head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male    37 head, mated 4-day male    39 head, mated 20-day male    27 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    36 head, virgin 1-day female    32 head, virgin 4-day female    23 head, virgin 20-day female    15 head, mated 1-day female    21 head, mated 4-day female    21 head, mated 20-day female    14 head, mated 1-day male    37 head, mated 4-day male    39 head, mated 20-day male    27 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    7 fat body, white prepupae    20 fat body, pupae P8    9 carcass, larvae L3 wandering    9 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new    26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new  26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day  26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new    26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new    26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day    26 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new    26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new  26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day  26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new    26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    13 embryo 10-12hr    11 embryo 12-14hr    17 embryo 14-16hr    11 embryo 16-18hr    15 embryo 18-20hr    13 embryo 20-22hr    12 embryo 22-24hr    17 larva L1    13 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    21 white prepupae new    26 white prepupae 12hr    17 white prepupae 24hr    17 pupae 2d postWPP    16 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    13 adult male 05day    14 adult male 30day    11 adult female 01day    16 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    7 embryonic 1182-4H    8 embryonic GM2    11 embryonic Kc167    6 embryonic S1    5 embryonic S3    14 leg disc CME L1    6 wing disc CME-W2    10 wing disc ML-DmD8    21 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    6 ovary fGS/OSS    4 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086372 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2520-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with lapKG06751) lapsd-3 lethal (with lapsd-3) lapKG06751 lethal | larval stage | recessive lap1 lapsd-3 lethal | pupal stage | recessive lapsd-3 lethal | recessive lap1 partially lethal - majority die | recessive lap1 viable lapEY11719 laprv1 viable, with Scer\GAL4pnr-MD237 lapGD4725 Sterility Allele fertile lapEY11719 Other Phenotypes Allele hypoactive | recessive lap1 locomotor behavior defective | recessive lap1 neuroanatomy defective lap1 neuroanatomy defective | third instar larval stage lap1 neurophysiology defective | larval stage | recessive lap1 neurophysiology defective | somatic clone lapsd-3 neurophysiology defective | third instar larval stage lap1 phototaxis defective | somatic clone lapsd-3 uncoordinated | larval stage | recessive lap1 visible, with Scer\GAL4GMR.PF lapEP3060 Phenotype manifest in Allele eye, with Scer\GAL4GMR.PF lapEP3060 NMJ bouton | supernumerary lap1 ommatidium, with Scer\GAL4GMR.PF lapEP3060 synaptic vesicle lap1 type I bouton & synaptic vesicle & third instar larva lap1
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of lap Class Mutagen Stocks Known lesion lap1 loss of function allele P-element activity 1 Yes lapc04836 piggyBac transposase 1 -- lapd09643 1 -- lape03163 piggyBac transposase 1 -- lape03734 piggyBac transposase 1 -- lapKG06751 P-element activity 1 -- lapMB09294 1 -- lapNP3025 1 -- lapDG06808 0 -- lapEP3060 P-element activity 0 -- lapEY11719 P-element activity 0 -- laprv1 P-element activity 0 Yes lapsd-3 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lap Class Mutagen Stocks Known lesion lapGD4725 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes lapHMS01939 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lapJF02994 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lapKK109279 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lapNIG.2520R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Antp1 (Zhang et al., 1998, Babcock et al., 2003) Df(3R)Antp17 (Spradling et al., 1999, Babcock et al., 2003, BDGP Project Members, 1994-1999) Df(3R)BSC221 (Gresens and Cook, 2006.12.5) Df(3R)dsx2M (Babcock et al., 2003) Df(3R)Exel6146 (Ryder, 2004.4.26) Df(3R)Scx4 (Babcock et al., 2003)
Not disrupted in	Df(3R)BSC548 (Christensen et al., 2008.6.11)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4725} NA P{KK109279} NA P{NIG.2520R} NA P{TRiP.HMS01939} NA P{TRiP.JF02994} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{hsneo}lap1 NA P{SUPor-P}lapKG06751 NA P{wHy}lapDG06808 NA PBac{PB}lapc04836 NA PBac{RB}lape03163 NA PBac{RB}lape03734 NA insertion of mobile activating element P{EP}lapEP3060 NA P{EPgy2}lapEY11719 NA P{XP}lapd09643 NA insertion of enhancer trap binary system Mi{ET1}lapMB09294 No P{GawB}lapNP3025 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neuron-neuron synaptic transmission inferred from mutant phenotype (Babcock et al., 2003) phototaxis inferred from mutant phenotype (Babcock et al., 2003) receptor-mediated endocytosis inferred from direct assay (Zhang et al., 1998) synaptic transmission inferred from mutant phenotype (Karunanithi et al., 2002) synaptic vesicle endocytosis inferred from mutant phenotype (Zhang et al., 1998)
Cellular Component
CV term Evidence References
coated pit inferred from direct assay (Zhang et al., 1998)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
1-phosphatidylinositol binding inferred from sequence or structural similarity with UniProtKB:O55012 (Swiss-Prot Project Members, 2004.3.29) clathrin binding inferred from sequence or structural similarity with UniProtKB:Q13492 (Swiss-Prot Project Members, 2004.3.29) non-traceable author statement (Narayanan and Ramaswami, 2001)
Biological Process
CV term Evidence References
clathrin coat assembly inferred from electronic annotation with InterPro:IPR014712 (FlyBase Curators et al., 2004-) neurotransmitter secretion non-traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle coating traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle transport traceable author statement (Narayanan and Ramaswami, 2001)
Cellular Component
CV term Evidence References
clathrin adaptor complex inferred from sequence or structural similarity (Zhang and Ganetzky, 1997) non-traceable author statement (Zhang, 1998.6.30) clathrin coat inferred from electronic annotation with InterPro:IPR014712 (FlyBase Curators et al., 2004-) synaptic vesicle traceable author statement (Stimson and Ramaswami, 1999)
Sequence Ontology: Class of Gene
	gene   gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lap allele Gene References EP3060EP3060 pnr (Pena-Rangel et al., 2002) unspecified Atx2 (Sun et al., 2006) CG32137 (Sun et al., 2006) cnc (Sun et al., 2006) D1 (Sun et al., 2006) EP3303 (Sun et al., 2006) EP3377 (Sun et al., 2006) H (Mueller et al., 2005) jigr1 (Sun et al., 2006) jing (Sun et al., 2006) nuf (Sun et al., 2006) XNP (Sun et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66058 DroID - A comprehensive database of gene and protein interactions. • FBgn0086372 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40863
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG670V3H Dipteran inclusive ortholog search EOG69ZXZ5 Insect inclusive ortholog search EOG6ZPCR4 Arthropod inclusive ortholog search EOG6ZCRMB Metazoa inclusive ortholog search EOG6HB9GQ
Orthologs in Drosophila Species (EOG670V3H)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\lap     Drosophila simulans   Dsim\GD19919     Drosophila sechellia   Dsec\GM10940     Drosophila erecta   Dere\GG13908     Drosophila yakuba   Dyak\GE24911     Drosophila ananassae   Dana\GF17660     Drosophila pseudoobscura pseudoobscura   Dpse\GA15384     Drosophila persimilis   Dper\GL12427     Drosophila willistoni   Dwil\GK14525     Drosophila virilis   Dvir\GJ10920     Drosophila mojavensis   Dmoj\GI24100     Drosophila grimshawi   Dgri\GH18291
Orthologs in non-Drosophila Dipterans (EOG69ZXZ5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013863   Anopheles gambiae Malaria mosquito  Agam\AGAP010087   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012112
Orthologs in non-Dipteran Insects (EOG6ZPCR4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43906   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014628   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24035   Atta cephalotes Leafcutter ant  Acep\ACEP18158   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21261   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18488   Linepithema humile Argentine ant  Lhum\LH17233   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21030   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21033   Solenopsis invicta Red fire ant  Sinv\SINV16928   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005124   Bombyx mori Silkmoth  Bmor\BGIBMGA010066   Pediculus humanus Human body louse  Phum\PHUM491870   Pediculus humanus Human body louse  Phum\PHUM618570   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07906   Tribolium castaneum Red flour beetle  Tcas\TC002717
Orthologs in non-Insect Arthropods (EOG6ZCRMB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_192459   Ixodes scapularis Deer tick  Isca\ISCW003738   Ixodes scapularis Deer tick  Isca\ISCW006457
Orthologs in non-Arthropod Metazoa (EOG6HB9GQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\unc-11   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002714gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018719gn   Danio rerio Zebrafish  Drer\si:ch211-200p22.4   Danio rerio Zebrafish  Drer\CT025910.1   Danio rerio Zebrafish  Drer\si:ch211-214j24.9   Danio rerio Zebrafish  Drer\picalml   Danio rerio Zebrafish  Drer\snap91   Danio rerio Zebrafish  Drer\picalm   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032563   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000001528   Xenopus tropicalis Western clawed frog  Xtro\snap91   Gallus gallus Domestic chicken  Ggal\SNAP91   Gallus gallus Domestic chicken  Ggal\LOC772071   Gallus gallus Domestic chicken  Ggal\PICALM   Mus musculus House mouse  Mmus\Snap91   Mus musculus House mouse  Mmus\ENSMUSG00000039361   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023861   Rattus norvegicus Norway rat  Rnor\Picalm   Homo sapiens Human  Hsap\ENSG00000073921   Homo sapiens Human  Hsap\SNAP91
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000073921     Hsap\SNAP91
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	26463 w1118; Mi{ET1}lapMB09294 28358 y1 v1; P{TRiP.JF02994}attP2 39021 y1 v1; P{TRiP.HMS01939}attP40 14314 y1; P{SUPor-P}lapKG06751 ry506/TM3, Sb1 Ser1
Harvard	- P{XP}lapd09643 - PBac{PB}lapc04836 - PBac{RB}lape03163 - PBac{RB}lape03734
Kyoto	104345 y* w*; P{GawB}lapNP3025 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v105767 P{KK109279}VIE-260B v12732 w1118; P{GD4725}v12732 v12731 w1118; P{GD4725}v12731/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR01C11 BACR03E11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 83 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM10787 RH47395
Other clones	MIP05850
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11572 AT28405 GH01766 GH09740 GH21856 GH28358 GH28549 GH28565 HL02944 LP13366 LP22070 RE64217 RE68692 RH09572 RH14491 RH15318 RH22468 RH31534 RH33655 RH38904 RH41757 RH44039 RH52307 RH55616 RH57848 RH61554 RH61802 RH63482 RH63958 SD02595
Other clones	54921 158173 214375.73 bs54d05 CK01.65A.G2 CK01.79D.D5 EC33538 EC39681 EK028351 EK034620 EK038807 EK053057 EK054541 EK060413 EK061141 EK071758 EK084019 EK105915 EK146530 EK161807 EK179244 EK180129 EK181015 EK182715 EK185631 EK186042 EK190713 EK192048 EK197551 EK213544 EK218742 EK222927 EK237743 EK244229 EK244416 EK254655 EK267426 EK275660 EK278118 EK279359 EK307860 EN05237 EP04520 EP05429 EP08053 EP08646 EP16663 FGH127F08 GH06360 RC0-DA0003-130700-022-A03
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086372 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40863
Antibody Information
Other Information
Discoverer
	A. Spradling.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: lap CG2520 (Milshina, 1999.11)
Source for database merge of	Source for merge of: lap BcDNA:GM10787 (FlyBase, 1996-) Source for merge of: lap EP3060 (Sun et al., 2006)
Additional comments	FlyBase curator comment: "EP3060" overexpression phenotype stated to be due to its effect on EST RE52393 (which corresponds to CG10055) but orientation of the P{EP} element suggests otherwise. (Pena-Rangel et al., 2002) Source for merge of lap BcDNA:GM10787 was a shared cDNA (date:020730). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) A mutation in lap severely impairs the efficiency of synaptic vesicle endocytosis. (Zhang et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079528 NM_001144547 NM_001170067 NM_001260029 NM_001260030 NM_001260031 NM_001275409 NM_001275410 NM_001275411 RefSeq (Proteins) • NP_524252 NP_001138019 NP_001163538 NP_001246958 NP_001246959 NP_001246960 NP_001262338 NP_001262339 NP_001262340 DDBJ / EMBL / GenBank • AAD08669 AAF54050 AAM75091 AC008029 ACL83478 ACZ94835 AF075247 AFH06277 AFH06278 AFH06279 AGB95721 AGB95722 AGB95723 AI107068 AI517949 AQ025244 AQ034102 AY128498 BH840713 BI620086 CW848179 CZ469542 CZ480926 CZ480927 CZ481488 Entrez Gene - A searchable database of RefSeq genes. • 40863 UniProtKB/Swiss-Prot • Q9VI75 UniProtKB/TrEMBL • B7Z0U7 E1JJ78
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • AP180 N-terminal homology (ANTH) domain (IPR011417) ENTH/VHS (IPR008942) Epsin-like, N-terminal (IPR013809) Clathrin adaptor, phosphoinositide-binding, GAT-like (IPR014712) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1HX8
Linkouts
	BioGRID - A database of protein and genetic interactions • 66058 DroID - A comprehensive database of gene and protein interactions. • FBgn0086372 DRSC - Results from RNAi screens. • FBgn0086372 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086372 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2520-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086372 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40863 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40863 modMine - Data generated by the modENCODE project. • FBgn0086372
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	AP180 (Dickman et al., 2006, Broadie, 2004, Marie et al., 2004, Narayanan and Ramaswami, 2001, Zhang et al., 1998, Verstreken and Bellen, 2006, Korolchuk et al., 2007, Pack-Chung et al., 2007, Verstreken et al., 2009) BcDNA:GM10787   CG2520 (Provost et al., 2006, Robertson, 2001.7.7, Verstreken and Bellen, 2000.9.4, Stuart et al., 2007, Toledano-Katchalski et al., 2007, Casillas et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Cammarato et al., 2011, Ni et al., 2010.12.1) dAP-3 (Zhang and Ganetzky, 1997, Zhang and Ganetzky, 1997) EP3060   EP(3)3060 (Pena-Rangel et al., 2002) l(3)neo34 (Provost et al., 2006, Cooley et al., 1988, ) lap (FlyBase Curators, 2008, Provost et al., 2006, Sun et al., 2006, Dickman, 2006, Gresens and Cook, 2006.12.5, Stuart et al., 2007, Izutsu et al., 2012, Christensen et al., 2008.4.15, Christensen et al., 2008.6.11, Guan et al., 2011, Toledano-Katchalski et al., 2007, Bhogal et al., 2011, Dickman and Davis, 2009, Cherry and Perrimon, 2004, Liebl and Featherstone, 2005, Bao et al., 2005, Tsurudome et al., 2010, Jepson and Reenan, 2009, Wasbrough et al., 2010, Kopyl et al., 2010, Kopyl et al., 2010, Kaplow et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Savva et al., 2012) Lap (Chen et al., 2002, Korolchuk et al., 2007, Majumdar et al., 2006) LAP (Bronk et al., 2001, Lloyd et al., 2000, Spradling et al., 1999, McMahon, 1999, Bao et al., 2007, Pack-Chung et al., 2007) lap/AP180 (Koh et al., 2004) sig (Gruber and Buening, 1999)
Name Synonym	complementation group 12 (Babcock et al., 2003) EP3060   like-AP180 (Zhang, 1998.6.30, Zhang et al., 1998, Cammarato et al., 2011, Kaplow et al., 2007) like AP180 (Cherry and Perrimon, 2004) Like-AP180 (Bao et al., 2005) saisoog (Gruber and Buening, 1999)
Secondary FlyBase IDs
	FBgn0011467 FBgn0026062 FBgn0026210 FBgn0047251 FBgn0062670
References ( 85 )
Generate a list of	All references relating to this gene ( 85 )
List References by type	Research paper  ( 37 ) Supplementary material  ( 11 ) Review  ( 5 ) Personal communication to FlyBase  ( 19 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 )
Recent research papers ( 4 )
	Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Savva et al., 2012, Nat. Commun. 3: 790 Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. [FBrf0218141] Bhogal et al., 2011, Nat. Neurosci. 14(12): 1517--1524 Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. [FBrf0216747] Guan et al., 2011, Learn. Mem. 18(4): 191--206 Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. [FBrf0213277] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...