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Gene Dmel\Mer

General Information
Symbol	Dmel\Mer	Species	D. melanogaster
Name	Merlin	Annotation symbol	CG14228
Feature type	protein_coding_gene	FlyBase ID	FBgn0086384
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	Dmerlin
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	18E1-18E1	Sequence location	X:19,584,627..19,587,531 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Merlin is referred to in FlyBase by the symbol Dmel\Mer (CG14228, FBgn0086384). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 23 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; localization; sensory organ development; cell cycle; response to stimulus; regulation of developmental process; cell cycle process; compound eye morphogenesis; spermatid differentiation; endocytic recycling; regulation of cell proliferation; negative regulation of biological process; multicellular organism reproduction. 55 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; thoracic segment; imaginal precursor; external compound sense organ; spermatozoon; elongation stage spermatid; epithelial furrow; oocyte nucleus; integumentary plate. It has one annotated transcript and one annotated polypeptide. Protein features are: Band 4.1 domain; Band 4.1 family; Ezrin/radixin/moesin; Ezrin/radixin/moesin family; Ezrin/radixin/moesin, C-terminal; FERM central domain; FERM domain; FERM, C-terminal PH-like domain; FERM, N-terminal; FERM/acyl-CoA-binding protein, 3-helical bundle; Merlin; Moesin; Pleckstrin homology-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval/adult hindgut, larval Malpighian tubules, adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623379_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Mer. Gene sequence location is X:19584627..19587531.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	References Poon et al., 2011, Dev. Cell 21(5): 896--906 Benseñor et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(16): 7311--7316 Kopyl et al., 2010, Genetika, Moscow 46(3): 314--320 Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Lebedeva et al., 2010, Genetika, Moscow 46(2): 180--186 Dubatolova et al., 2010, Genetika, Moscow 46(2): 187--193 Carreira et al., 2011, BMC Dev. Biol. 11: 32 Sequence features HFA20259 BKN29361
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18E1-18E1   Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
Experimentally Determined Cytological Location
Cytogenetic map Notes References 18E-18E     (Fehon, 1996.2.21) 18D-18E   (determined by in situ hybridisation)   (Fehon et al., 1997)
Experimentally Determined Recombination Data
Location	1- (Fehon, 1996.2.21)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mer for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mer-RA FBtr0074754  NM_078689   2501   635
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mer-PA   FBpp0074523   74.5   635   6.39     NP_523413   AAF49005
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pleckstrin homology-type (IPR011993) Ezrin/radixin/moesin, C-terminal (IPR011259) Ezrin/radixin/moesin (IPR011174) Moesin (IPR008954) Ezrin/radixin/moesin family (IPR000798) FERM domain (IPR000299) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) Merlin (IPR015788) FERM, N-terminal (IPR018979) FERM, C-terminal PH-like domain (IPR018980) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201264   AA539080   AA735963   AA802325   AA803250   AE014298 AAF49005   AI062202   AI107499   AI238924   AI513277   AI513957   AW940037   AY094998 AAM11326   BI167880   BI368587   BI482891   BI486610   BI636485   BT099545   CO264068   CO265272   CO288512   EC064236   EC081571   EC198426   EC244350   EV583643   EV600779   U23799 AAA65060   U49724 AAB08449
UniProtKB/Swiss-Prot	Q24564
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086384    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086384 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086384 expression level Developmental Stage   Expression Level embryo 00-02hr    5280 embryo 02-04hr    4417 embryo 04-06hr    4293 embryo 06-08hr    3093 embryo 08-10hr    2394 embryo 10-12hr    1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6    1413 larva L3 puffstage 7-9    1567 white prepupae new    1494 white prepupae 12hr    1865 white prepupae 24hr    1856 pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day    2556 adult female 05day    3229 adult female 30day    3196 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5280) embryo 02-04hr  (4417) embryo 04-06hr  (4293) embryo 06-08hr  (3093) embryo 08-10hr  (2394) embryo 10-12hr  (1474) embryo 12-14hr  (1114) embryo 14-16hr  (1167) embryo 16-18hr  (869) embryo 18-20hr  (847) embryo 20-22hr  (745) embryo 22-24hr  (753) larva L1  (857) larva L2  (746) larva L3 12hr old  (838) larva L3 puffstage 1-2  (1124) larva L3 puffstage 3-6  (1413) larva L3 puffstage 7-9  (1567) white prepupae new  (1494) white prepupae 12hr  (1865) white prepupae 24hr  (1856) pupae 2d postWPP  (1241) pupae 3d postWPP  (1031) pupae 4d postWPP  (1347) adult male 01day  (1254) adult male 05day  (1204) adult male 30day  (1261) adult female 01day  (2556) adult female 05day  (3229) adult female 30day  (3196) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5280) embryo 02-04hr  (4417) embryo 04-06hr  (4293) embryo 06-08hr  (3093) embryo 08-10hr  (2394) embryo 10-12hr  1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6  1413 larva L3 puffstage 7-9  (1567) white prepupae new  1494 white prepupae 12hr  (1865) white prepupae 24hr  (1856) pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day  (2556) adult female 05day  (3229) adult female 30day  (3196) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5280 embryo 02-04hr    4417 embryo 04-06hr    4293 embryo 06-08hr    3093 embryo 08-10hr    2394 embryo 10-12hr    1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6    1413 larva L3 puffstage 7-9    1567 white prepupae new    1494 white prepupae 12hr    1865 white prepupae 24hr    1856 pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day    2556 adult female 05day    3229 adult female 30day    3196 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5280 embryo 02-04hr    4417 embryo 04-06hr    4293 embryo 06-08hr    3093 embryo 08-10hr    2394 embryo 10-12hr    1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6    1413 larva L3 puffstage 7-9    1567 white prepupae new    1494 white prepupae 12hr    1865 white prepupae 24hr    1856 pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day    2556 adult female 05day    3229 adult female 30day    3196 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086384 expression level Developmental Stage   Expression Level embryo 00-02hr    5280 embryo 02-04hr    4417 embryo 04-06hr    4293 embryo 06-08hr    3093 embryo 08-10hr    2394 embryo 10-12hr    1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6    1413 larva L3 puffstage 7-9    1567 white prepupae new    1494 white prepupae 12hr    1865 white prepupae 24hr    1856 pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day    2556 adult female 05day    3229 adult female 30day    3196 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5280) embryo 02-04hr  (4417) embryo 04-06hr  (4293) embryo 06-08hr  (3093) embryo 08-10hr  (2394) embryo 10-12hr  (1474) embryo 12-14hr  (1114) embryo 14-16hr  (1167) embryo 16-18hr  (869) embryo 18-20hr  (847) embryo 20-22hr  (745) embryo 22-24hr  (753) larva L1  (857) larva L2  (746) larva L3 12hr old  (838) larva L3 puffstage 1-2  (1124) larva L3 puffstage 3-6  (1413) larva L3 puffstage 7-9  (1567) white prepupae new  (1494) white prepupae 12hr  (1865) white prepupae 24hr  (1856) pupae 2d postWPP  (1241) pupae 3d postWPP  (1031) pupae 4d postWPP  (1347) adult male 01day  (1254) adult male 05day  (1204) adult male 30day  (1261) adult female 01day  (2556) adult female 05day  (3229) adult female 30day  (3196) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5280) embryo 02-04hr  (4417) embryo 04-06hr  (4293) embryo 06-08hr  (3093) embryo 08-10hr  2394 embryo 10-12hr  1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6  1413 larva L3 puffstage 7-9  1567 white prepupae new  1494 white prepupae 12hr  1865 white prepupae 24hr  1856 pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day  (2556) adult female 05day  (3229) adult female 30day  (3196) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5280 embryo 02-04hr    4417 embryo 04-06hr    4293 embryo 06-08hr    3093 embryo 08-10hr    2394 embryo 10-12hr    1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6    1413 larva L3 puffstage 7-9    1567 white prepupae new    1494 white prepupae 12hr    1865 white prepupae 24hr    1856 pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day    2556 adult female 05day    3229 adult female 30day    3196 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5280 embryo 02-04hr    4417 embryo 04-06hr    4293 embryo 06-08hr    3093 embryo 08-10hr    2394 embryo 10-12hr    1474 embryo 12-14hr    1114 embryo 14-16hr    1167 embryo 16-18hr    869 embryo 18-20hr    847 embryo 20-22hr    745 embryo 22-24hr    753 larva L1    857 larva L2    746 larva L3 12hr old    838 larva L3 puffstage 1-2    1124 larva L3 puffstage 3-6    1413 larva L3 puffstage 7-9    1567 white prepupae new    1494 white prepupae 12hr    1865 white prepupae 24hr    1856 pupae 2d postWPP    1241 pupae 3d postWPP    1031 pupae 4d postWPP    1347 adult male 01day    1254 adult male 05day    1204 adult male 30day    1261 adult female 01day    2556 adult female 05day    3229 adult female 30day    3196 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086384    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086384 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval/adult hindgut, larval Malpighian tubules, adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086384 expression level Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086384 expression level Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    57.825 Larval Midgut    87.6 Larval Hindgut    138.9 Larval Malpighian Tubules    136 Larval Fat Body    80 Larval Salivary Gland    91.5 Larval Trachea    122.625 Larval Carcass    181.4 Adult Head    87.9 Adult Eye    108.85 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    105.6 Adult Midgut    77.2 Adult Hindgut    110.8 Adult Malpighian Tubules    49.3 Adult Fat Body    74.4 Adult Salivary Gland    109.2 Adult Heart    66.35 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    64.4 Adult Ovary    191.4 Adult Testis    25.8 Adult Male Accessory Gland    131.2 Adult Carcass    114.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    87.9   NA  Eye    108.85   NA  Brain    54.9   57.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    69   NA  Crop    105.6   87.6  Midgut    77.2   138.9  Hindgut    110.8   136  Malpighian Tubules    49.3   80  Fat Body    74.4   91.5  Salivary Gland    109.2   NA  Heart    66.35   122.625  Trachea    NA   NA  VirginFemale Spermatheca    59   NA  InseminatedFemale Spermatheca    64.4   NA  Ovary    191.4   NA  Testis    25.8   NA  Male Accessory Gland    131.2   181.4  Carcass    114.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086384 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14228-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Mer4 lethal | heat sensitive (with Mer1) Merts1 lethal | heat sensitive (with Mer2) Merts1 lethal | heat sensitive (with Mer4) Merts1 lethal | heat sensitive (with Merts1) Mer1 Mer2 Mer4 lethal | male | partially | recessive Mer3 lethal | recessive Mer1 Mer2 Mer4 lethal | recessive | heat sensitive Merts1 viable Mer3 MerBG01543 viable, with Scer\GAL4pnr-MD237 MerGD1484 Sterility Allele male sterile Mer4 sterile Mer3 Other Phenotypes Allele cytokinesis defective Mer3 decreased cell size | recessive Mer3 increased cell number Mer4 meiotic cell cycle defective Mer3 mitotic cell cycle defective Mer4 smell perception defective MerBG01543 stress response defective MerBG01543 visible Mer3 visible, with Scer\GAL4ap-md52 MerΔBB.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4en-e16E MerBBA.Scer\UAS.T:Hsap\MYC MerΔBB.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4GMR.PF MerGD1484 visible | recessive Mer3 visible | somatic clone Mer4 MerB2 wild-type Merhs.PM Phenotype manifest in Allele adult cuticle & head Mer3 adult cuticle & head | posterior Mer3 adult cuticle & head | ventral Mer3 anterior crossvein, with Scer\GAL4en-e16E MerΔBB.Scer\UAS.T:Hsap\MYC egg chamber | posterior & follicle cell | somatic clone | rescuable maternal effect | cell non-autonomous Mer3 egg chamber | posterior & follicle cell | supernumerary | conditional ts Merts1 elongation stage spermatid Mer3 Mer4 embryonic/first instar larval cuticle & abdominal segment | conditional ts Merts1 eye Mer3 eye, with Scer\GAL4GMR.PF MerGD1484 eye | anterior | ventral Mer3 eye | somatic clone MerB2 Mer3 Mer4 eye-antennal disc | third instar larval stage Mer4 eye disc Mer3 eye disc | pupal stage | somatic clone MerB2 follicle cell & centrosome & egg chamber | posterior | conditional ts Merts1 follicle cell & egg chamber | posterior | conditional ts Merts1 individualization stage spermatid Mer3 Mer4 interommatidial bristle & eye disc & pupa Mer4 interommatidial bristle | pupal stage | somatic clone | supernumerary MerB2 interommatidial bristle | somatic clone Mer4 interommatidial bristle | supernumerary Mer4 morphogenetic furrow Mer3 morphogenetic furrow | ectopic Mer3 nucleus & elongation stage spermatid Mer3 ommatidium Mer3 ommatidium | somatic clone MerB2 oocyte & pericentriolar material | conditional ts Merts1 oocyte nucleus Mer3 oocyte nucleus | cell non-autonomous | rescuable maternal effect | somatic clone Mer3 oocyte nucleus | heat sensitive Merts1 photoreceptor cell | ectopic Mer3 pole cell | heat sensitive Merts1 posterior crossvein Mer3 posterior crossvein, with Scer\GAL4en-e16E MerΔBB.Scer\UAS.T:Hsap\MYC seminal vesicle Mer3 spermatocyte Mer3 spermatozoon Mer3 spindle & spermatocyte Mer3 vibrissae Mer3 vibrissae | ectopic Mer3 wing Mer3 wing, with Scer\GAL4ap-md52 MerΔBB.Scer\UAS.T:Hsap\MYC wing, with Scer\GAL4ap-md544 Mer1-600.Scer\UAS.T:Hsap\MYC wing, with Scer\GAL4en-e16E MerΔBB.Scer\UAS.T:Hsap\MYC MerBBA.Scer\UAS.T:Hsap\MYC wing | posterior compartment, with Scer\GAL4en-e16E MerΔBB.Scer\UAS.T:Hsap\MYC wing disc Mer4 wing vein Mer3 wing vein, with Scer\GAL4en-e16E MerΔBB.Scer\UAS.T:Hsap\MYC wing vein | ectopic, with Scer\GAL4en-e16E MerΔBB.Scer\UAS.T:Hsap\MYC wing vein L2 Mer3 wing vein L5, with Scer\GAL4en-e16E MerΔBB.Scer\UAS.T:Hsap\MYC
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Mer Class Mutagen Stocks Known lesion Mer3 ethyl methanesulfonate 1 Yes Mer4 loss of function allele ethyl methanesulfonate 1 Yes Merd03626 1 -- MerGG01771 P-element activity 1 -- MerMI02931 1 -- Mer1 ethyl methanesulfonate 0 Yes Mer2 ethyl methanesulfonate 0 Yes MerB2 ethyl methanesulfonate 0 Yes MerBG01543 0 Yes MerF705 ethyl methanesulfonate 0 Yes Merts1 loss of function allele ethyl methanesulfonate 0 Yes Merunspecified 0 --
Alleles Carried on Transgenic Constructs ( 43 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mer Class Mutagen Stocks Known lesion Mer+t36 in vitro construct - genomic fragment 3 Yes MerGD1484 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MerHMS00459 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MerJF02841 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mer1-169.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-169.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-330.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-330.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-349.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-350.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-350.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-375.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-375.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-600.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-600.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer1-600.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer3.hs.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Mer3.Scer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes Mer3.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Mer345-635.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer351-600.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer351-601.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer351-635.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer351-635.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer601-635.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mer601-635.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MerBBA.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Merhs.PM in vitro construct - regulatory fusion 0 Yes Merhs.T616A in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Merhs.T616D in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Merhs.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Merhs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MerMtnA.PM in vitro construct - regulatory fusion 0 Yes MerMtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MerScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes MerScer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes MerScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MerT616A.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes MerT616D.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes MerUbi-p63E.PM in vitro construct - regulatory fusion 0 Yes MerΔBB.hs.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MerΔBB.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MerΔBB.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6253 (Ryder, 2004.4.26)
Not disrupted in	Df(1)HF396 (Fehon et al., 1997) Df(1)JA27 (Fehon et al., 1997) Ts(1Rt;YLt)B50 (Fehon et al., 1997)
Duplicated in	Dp(1;3)DC365 (Popodi et al., 2010-) Dp(1;3)DC550 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1484} NA P{TRiP.HMS00459} NA P{TRiP.JF02841} NA P{UAS-Mer.H} NA P{UAS-Mer1-169.myc} NA P{UAS-Mer1-330.myc} NA P{UAS-Mer1-350.myc} NA P{UAS-Mer1-375.myc} NA P{UAS-Mer1-600.myc} NA P{UAS-Mer3.myc} NA P{UAS-Mer351-601.myc} NA P{UAS-Mer351-635.myc} NA P{UAS-Mer601-635.myc} NA P{UAS-Mer+.myc} NA P{UAS-MerBBA.myc} NA P{UAS-MerΔBB.myc} NA P{UAS-Myc-Mer.T616A} NA P{UASp-Mer3.myc} NA P{UASp-Mer+.myc} NA heat-shock construct P{Merhs.PM} NA characterization construct P{cosMer+} NA P{Ubi-p63E-Mer.M} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}MerMI02931 NA P{GT1}MerBG01543 NA P{SUPor-P}KG01034 NA insertion of mobile activating element P{EPg}HP11041 NA P{Mae-UAS.6.11}MerGG01771 NA P{XP}Merd03626 NA
Gene Ontology: Function, Process & Cellular Component ( 35 unique terms )
Terms Based on Experimental Evidence ( 32 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with ex (McCartney et al., 2000) inferred from physical interaction with Moe AND inferred from physical interaction with arm (McCartney and Fehon, 1996) inferred from physical interaction with sav (Yu et al., 2010)
Biological Process
CV term Evidence References
axis specification inferred from mutant phenotype (MacDougall et al., 2001) cell-cell signaling inferred from expression pattern (McCartney and Fehon, 1996) cell cycle arrest inferred from genetic interaction with ex (Hamaratoglu et al., 2006) compound eye morphogenesis inferred from genetic interaction with crb (Ling et al., 2010) compound eye photoreceptor cell differentiation inferred from genetic interaction with ex (Maitra et al., 2006) decapentaplegic signaling pathway inferred from genetic interaction with dpp (McCartney et al., 2000) endocytic recycling inferred from genetic interaction with ex (Maitra et al., 2006) endocytosis inferred from expression pattern (McCartney and Fehon, 1996) hippo signaling cascade inferred from genetic interaction with hpo, ex (Hamaratoglu et al., 2006) male meiosis cytokinesis inferred from mutant phenotype (Dorogova et al., 2008) negative regulation of cell proliferation inferred from genetic interaction with ex (McCartney et al., 2000, Hamaratoglu et al., 2006) inferred from mutant phenotype (McCartney et al., 2000, Pellock et al., 2007, Willecke et al., 2006) negative regulation of organ growth inferred from genetic interaction with ex (Hamaratoglu et al., 2006) inferred from mutant phenotype (Pellock et al., 2007) olfactory behavior inferred from mutant phenotype (Sambandan et al., 2006) pole plasm mRNA localization inferred from mutant phenotype (Herpers and Rabouille, 2004) positive regulation of phosphorylation inferred from genetic interaction with ex (Hamaratoglu et al., 2006) regulation of apoptosis inferred from genetic interaction with ex (Hamaratoglu et al., 2006) regulation of cell differentiation inferred from genetic interaction with ex (McCartney et al., 2000) regulation of cell growth inferred from expression pattern (McCartney and Fehon, 1996) regulation of cell proliferation inferred from mutant phenotype (LaJeunesse et al., 1998) regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Pellock et al., 2007) regulation of signal transduction inferred from genetic interaction with ex (Maitra et al., 2006) spermatogenesis inferred from mutant phenotype (Dorogova et al., 2008) sperm individualization inferred from mutant phenotype (Dorogova et al., 2008)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (McCartney and Fehon, 1996) apical plasma membrane inferred from direct assay (McCartney et al., 2000) cell cortex inferred from direct assay (Dorogova et al., 2008) cytoplasm inferred from direct assay (McCartney and Fehon, 1996, de Cuevas et al., 1996, LaJeunesse et al., 1998) NOT fusome inferred from direct assay (de Cuevas et al., 1996) membrane inferred from direct assay (LaJeunesse et al., 1998) Nebenkern inferred from direct assay (Dorogova et al., 2008) plasma membrane inferred from direct assay (de Cuevas et al., 1996)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cytoskeletal protein binding inferred from electronic annotation with InterPro:IPR000798, InterPro:IPR008954, InterPro:IPR011174, InterPro:IPR011259, InterPro:IPR015788 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoskeleton inferred from electronic annotation with InterPro:IPR000299 (FlyBase Curators et al., 2004-) extrinsic to membrane inferred from electronic annotation with InterPro:IPR000798, InterPro:IPR008954, InterPro:IPR011174, InterPro:IPR011259 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mer allele Gene References Mer1 ex (McCartney et al., 2000) Mer3 bs (LaJeunesse et al., 2001) dpp (McCartney et al., 2000) E(Mer)IIb (LaJeunesse et al., 2001) E(Mer)IIIa (LaJeunesse et al., 2001) ex (McCartney et al., 2000) net (LaJeunesse et al., 2001) sbb (LaJeunesse et al., 2001) Mer4 ex (McCartney et al., 2000) Merts1 grk (MacDougall et al., 2001) MerΔBB.Scer\UAS.T:Hsap\MYC bs (LaJeunesse et al., 2001) E(Mer)IIb (LaJeunesse et al., 2001) E(Mer)IIIa (LaJeunesse et al., 2001) net (LaJeunesse et al., 2001) sbb (LaJeunesse et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59275 DroID - A comprehensive database of gene and protein interactions. • FBgn0086384 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32979
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA12841
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006018-PB Aedes aegypti (mosquito) AGAP010346-PA Anopheles gambiae (mosquito) XP_001949236.1 Acyrthosiphon pisum (pea aphid) 84263 Branchiostoma floridae (lancelet) XP_001895150.1 Brugia malayi (roundworm nematode) BGIBMGA014502-PA Bombyx mori (silk worm) ENSBTAP00000017489 Bos taurus (bovine) ENSCAFP00000031455 Canis familiaris (dog) CPIJ007590 Culex pipens (mosquito) ENSCPOP00000013070 Cavia porcellus (guinea pig) 18813 Capitella spl (polychaete worm) 128926 Daphnia pulex (daphnia) ENSDARP00000035057 Danio rerio (zebra fish) ENSECAP00000020708 Equus caballus (horse) ENSGACP00000027115 Gymnopilus aculeatus (mushroom) ENSGALP00000034386 Gallus gallus (chicken) ENSP00000344666 Homo sapiens (human) 103995 Lottia gigantea (owl limpet) ENSMODP00000011100 Monodelphis domestica (gray opossum) ENSMMUP00000013509 Macaca mulatta (rhesus monkey) ENSMUSP00000105536 Mus musculus (house mouse) 234576 Nematostella vectensis (starlet anemone) XP_001601599.1 Nasonia vitripennis (wasp) ENSOANP00000012225 Ornithorynchus anatinus (platypus) ENSORLP00000001097 Oryzias latipes (japanese killifish) PHUM002926-PA Pediculus humanus (human body louse) ENSPPYP00000013045 Pongo pygmaeus (orangutan) ENSPTRP00000040707 Pan troglodytes (chimpanzee) ENSRNOP00000050582 Rattus norvegicus (norway rat) XP_001196408.1 Strongylocentrotus purpuratus (purple sea urchin) XP_972226.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018677 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000042030 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000053343 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17642 NV13230 LH17866 FBgn0234830 FBgn0227825 FBgn0202808 FBgn0177586 JGI_V11_128926 FBgn0072886 FBgn0155909 FBgn0133782 FBgn0119737 FBgn0110249 FBgn0097276 CPIJ019642 CPIJ007590 BGIBMGA014502 ACYPI004883 GB15815 AGAP010346 AAEL014907 AAEL006018 PHUM322080 GLEAN_14860
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	9103 w* Mer3 P{neoFRT}19A/FM6 36167 y1 w* Mi{MIC}MerMI02931 34958 y1 sc* v1; P{TRiP.HMS00459}attP2 20224 y1 w67c23 P{Mae-UAS.6.11}MerGG01771 28007 y1 v1; P{TRiP.JF02841}attP2/TM3, Sb1 9104 y1 w* Mer4 P{neoFRT}19A/FM7i, P{ActGFP}JMR3 9101 w* sn3 l(1)18DEb3 P{neoFRT}19A; P{cosMer+}3/+ 9100 w* sn3 l(1)18DEa2 P{neoFRT}19A/C(1)A, y1; P{cosMer+}3/+ 9102 w* sn3 l(1)18DEc1 P{neoFRT}19A/C(1)A, y1; P{cosMer+}3/+
Harvard	- P{XP}Merd03626
VDRC	v7161 w1118; P{GD1484}v7161
Genomic Clones ( 1 )
	BACR33M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 25 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01330
Other clones	FI03665
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05215 GH13844 GH15064 GH26985 GM04205 GM10209 GM10459 LD04288 LD18781 RE08369 RE54581 RE65696 RE70060 SD18173
Other clones	29313 31386 80162 CK01.87A.F2 Dmel_dig_015514_0658_0287 Dmel_neb_014468_0876_1836 EK068653 EK137320 EK142102
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086384 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32979
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Mer BG01543 (Sambandan et al., 2006)
Additional comments	The gene referred to in FlyBase as "mer" (FBgn0041733) is not the same gene as that referred to in FlyBase as "Mer" (FBgn0086384) - they are on different chromosomes. (FlyBase, 1992-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Mer is specifically required only in the posterior follicle cells to initiate axis formation in the oocyte. It is not required to specify posterior follicle cell identity in response to the grk signal from the oocyte, but is required for the unknown polarising signal back to the oocyte. Mer is also required non-autonomously to maintain cell polarity and limit proliferation in the posterior follicle cells (that have received the grk signal), but is not required in embryos and larvae. (MacDougall et al., 2001) Mer and ex function cooperatively in regulating cell proliferation and differentiation in developing epithelial cells. (McCartney et al., 2000) Mer is not allelic to btdl. (Fehon et al., 1997) The Mer gene product is not a component of fusomes. (de Cuevas et al., 1996) Mer and Moe are frequently coexpressed in developing tissues, but their subcellular localisations are distinct. Moe shows continuous plasma membrane association and Mer is localised in punctate structures that are associated with both the plasma membrane and the cytoplasm. Mer is associated with endocytic compartments in cultured cells. (McCartney and Fehon, 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078689 RefSeq (Proteins) • NP_523413 DDBJ / EMBL / GenBank • AAA65060 AAB08449 AAF49005 AAM11326 AI062202 AW940037 AY094998 U23799 U49724 Entrez Gene - A searchable database of RefSeq genes. • 32979 UniProtKB/Swiss-Prot • Q24564
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pleckstrin homology-type (IPR011993) Ezrin/radixin/moesin, C-terminal (IPR011259) Ezrin/radixin/moesin (IPR011174) Moesin (IPR008954) Ezrin/radixin/moesin family (IPR000798) FERM domain (IPR000299) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) Merlin (IPR015788) FERM, N-terminal (IPR018979) FERM, C-terminal PH-like domain (IPR018980) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59275 DroID - A comprehensive database of gene and protein interactions. • FBgn0086384 DRSC - Results from RNAi screens. • FBgn0086384 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086384 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14228-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086384 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32979 InParanoid A subset of ortholog calls from InParanoid. • AAEL006018-PB Aedes aegypti (mosquito) AGAP010346-PA Anopheles gambiae (mosquito) XP_001949236.1 Acyrthosiphon pisum (pea aphid) 84263 Branchiostoma floridae (lancelet) XP_001895150.1 Brugia malayi (roundworm nematode) BGIBMGA014502-PA Bombyx mori (silk worm) ENSBTAP00000017489 Bos taurus (bovine) ENSCAFP00000031455 Canis familiaris (dog) CPIJ007590 Culex pipens (mosquito) ENSCPOP00000013070 Cavia porcellus (guinea pig) 18813 Capitella spl (polychaete worm) 128926 Daphnia pulex (daphnia) ENSDARP00000035057 Danio rerio (zebra fish) ENSECAP00000020708 Equus caballus (horse) ENSGACP00000027115 Gymnopilus aculeatus (mushroom) ENSGALP00000034386 Gallus gallus (chicken) ENSP00000344666 Homo sapiens (human) 103995 Lottia gigantea (owl limpet) ENSMODP00000011100 Monodelphis domestica (gray opossum) ENSMMUP00000013509 Macaca mulatta (rhesus monkey) ENSMUSP00000105536 Mus musculus (house mouse) 234576 Nematostella vectensis (starlet anemone) XP_001601599.1 Nasonia vitripennis (wasp) ENSOANP00000012225 Ornithorynchus anatinus (platypus) ENSORLP00000001097 Oryzias latipes (japanese killifish) PHUM002926-PA Pediculus humanus (human body louse) ENSPPYP00000013045 Pongo pygmaeus (orangutan) ENSPTRP00000040707 Pan troglodytes (chimpanzee) ENSRNOP00000050582 Rattus norvegicus (norway rat) XP_001196408.1 Strongylocentrotus purpuratus (purple sea urchin) XP_972226.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018677 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000042030 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000053343 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/merlin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32979 modMine - Data generated by the modENCODE project. • FBgn0086384 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17642 NV13230 LH17866 FBgn0234830 FBgn0227825 FBgn0202808 FBgn0177586 JGI_V11_128926 FBgn0072886 FBgn0155909 FBgn0133782 FBgn0119737 FBgn0110249 FBgn0097276 CPIJ019642 CPIJ007590 BGIBMGA014502 ACYPI004883 GB15815 AGAP010346 AAEL014907 AAEL006018 PHUM322080 GLEAN_14860
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BG01543 (Sambandan et al., 2006, ) CG14228 (Rogers et al., 2003, Goldstein and Gunawardena, 2000, Perkins et al., 2009, Ni et al., 2011.7.19) D-Mer (Dorogova et al., 2008) Dmerlin (Cereijido et al., 2003, Muller, 2000, Fehon, 1996.2.21, de Cuevas et al., 1996, McCartney and Fehon, 1996, McCartney and Fehon, 1995, McCartney and Fehon, 1994, McCartney and Fehon, 1995) EMR2 (Winge, 1995.3.30) Emr2   mer (Zhao et al., 2008, Pellock et al., 2007, Edgar, 2006, Silva et al., 2006, Ling et al., 2010, Polesello and Tapon, 2007, Hamaratoglu et al., 2006, Hamaratoglu et al., 2009, Willecke et al., 2006, Sun et al., 2008, Genevet et al., 2009, Classen et al., 2009, Yu et al., 2008, Yu et al., 2010, Genevet et al., 2010, Chen et al., 2010, Thomson and Johnson, 2010) Mer (Zhao et al., 2008, Maitra et al., 2006, Maitra et al., 2006, Hamaratoglu et al., 2007, Richter et al., 2011, Rasmussen and Kellis, 2007, Johnston and Gallant, 2002, McCartney et al., 2000, Edgar, 2006, Silva et al., 2006, Fernández et al., 2011, Silva, 2006, Hughes and Fehon, 2006, Bakal et al., 2007, Hariharan, 2006, Oh and Irvine, 2008, Mensch et al., 2008, Hamaratoglu et al., 2009, Willecke et al., 2008, Cho et al., 2006, Hamaratoglu et al., 2006, Robinson et al., 2010, Genevet et al., 2009, Yu et al., 2010, Baumgartner et al., 2010, Genevet et al., 2010, Yu et al., 2010, Baumgartner et al., 2010, Milton et al., 2010, Reddy et al., 2010, Popodi et al., 2010-, Lebedeva et al., 2010, Dubatolova et al., 2010, Kopyl et al., 2010, Benseñor et al., 2010, Lebedeva et al., 2010, Dubatolova et al., 2010, Kopyl et al., 2010)
Name Synonym	BG01543   D Merlin (Lopez-Schier, 2003) Dmerlin (Cereijido et al., 2003) Ezrin-moesin-radixin-2   Merlin (Sambandan et al., 2008, Hawley and Gilliland, 2006, Rogers et al., 2003, Willecke et al., 2007, Jukam and Desplan, 2007, Hamaratoglu et al., 2007, Fehon et al., 1997, Bassett et al., 1997, Sambandan et al., 2006, Dorogova et al., 2007, Riechmann and Ephrussi, 2001, Maitra and Fehon, 2002, Silva et al., 2006, Johnston and Gallant, 2002, McCartney et al., 2000, Maitra et al., 2006, Edgar, 2006, Ling et al., 2010, Bakal et al., 2007, Hughes and Fehon, 2006, Li and Baker, 2007, Hariharan, 2006, Oh and Irvine, 2008, Polesello and Tapon, 2007, Dorogova et al., 2008, Mensch et al., 2008, Hamaratoglu et al., 2009, Cho et al., 2006, Willecke et al., 2006, Hamaratoglu et al., 2006, Yu et al., 2010, Baumgartner et al., 2010, Genevet et al., 2010, Milton et al., 2010, Reddy et al., 2010, Pertceva et al., 2010, Yan et al., 2011) merlin (Turunen et al., 1998, McCartney and Fehon, 1996, Herpers and Rabouille, 2004, Rogers et al., 2003, Pellock et al., 2007, Edgar, 2006, Jukam and Claude, 2008, Golovnina et al., 2005, Sun et al., 2008, Yu et al., 2008, Chen et al., 2010) Merlin/Neurofibromin 2 (Thomson and Johnson, 2010)
Secondary FlyBase IDs
	FBgn0013951 FBgn0014341 FBgn0070004
References ( 136 )
Generate a list of	All references relating to this gene ( 136 )
List References by type	Research paper  ( 61 ) Supplementary material  ( 13 ) Review  ( 16 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 25 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 24 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Yan et al., 2011, Development 138(9): 1697--1703 Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling. [FBrf0213488] Baumgartner et al., 2010, Dev. Cell 18(2): 309--316 The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila. [FBrf0210061] Benseñor et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(16): 7311--7316 Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. [FBrf0214876] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15810--15815 The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. [FBrf0211766] Dubatolova et al., 2010, Russ. J. Genet. 46(2): 164--169 Effect of mutations in Drosophila melanogaster tumor suppressor Merlin on proliferation and differentiation of wing cells. [FBrf0215198] Dubatolova et al., 2010, Genetika, Moscow 46(2): 187--193 [Effect of mutations in Drosophila melanogaster tumor suppressor Merlin on proliferation and differentiation of wing cells] [FBrf0210296] Genevet et al., 2010, Dev. Cell 18(2): 300--308 Kibra is a regulator of the Salvador/Warts/Hippo signaling network. [FBrf0211094] Karpowicz et al., 2010, Development 137(24): 4135--4145 The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. [FBrf0212383] Kopyl et al., 2010, Russ. J. Genet. 46(3): 276--282 Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap. [FBrf0215199] Kopyl et al., 2010, Genetika, Moscow 46(3): 314--320 [Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap] [FBrf0210615] Lebedeva et al., 2010, Russ. J. Genet. 46(2): 157--163 Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin. [FBrf0215197] Lebedeva et al., 2010, Genetika, Moscow 46(2): 180--186 [Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin] [FBrf0210293] Ling et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10532--10537 The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. [FBrf0211036] Milton et al., 2010, Development 137(5): 735--743 Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. [FBrf0209966] Pertceva et al., 2010, Cell Biol. Int. 34(10): 991--996 The role of Drosophila hyperplastic discs gene in spermatogenesis. [FBrf0211767] Reddy et al., 2010, Development 137(14): 2397--2408 Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Thomson and Johnson, 2010, Cell Death Differ. 17(11): 1717--1727 Inducible somatic oocyte destruction in response to rapamycin requires wild-type regulation of follicle cell epithelial polarity. [FBrf0211996] Yu et al., 2010, Dev. Cell 18(2): 288--299 Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded. [FBrf0210017] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...