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Gene Dmel\stl

General Information
Symbol	Dmel\stl	Species	D. melanogaster
Name	stall	Annotation symbol	CG3622
Feature type	protein_coding_gene	FlyBase ID	FBgn0086408
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-102
Cytogenetic map	59B2-59B2	Sequence location	2R:18,695,365..18,703,498 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene stall is referred to in FlyBase by the symbol Dmel\stl (CG3622, FBgn0086408). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: metalloendopeptidase activity. There is experimental evidence that it is involved in the biological process: ovarian follicle cell stalk formation; oogenesis. 9 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; anatomical structure; ovariole; portion of tissue; multi-tissue structure; epithelial cell; cytoplasmic part; vitellarium; organelle; female organism. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Metallopeptidase, catalytic domain; Peptidase M12B, ADAM/reprolysin; Thrombospondin, type 1 repeat. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1634620_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of stl. Gene sequence location is 2R:18695365..18703498.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	fs(2)A16 Homozygous females have small (400-600 um long) abnormally organized ovaries. Ultrastructural studies by King and Buckles (1980, DIS 55: 74-75) reveal that oogonial cysts appear to be normal; surrounded by wedge-shaped follicle cells but not separated by interfollicular stalks so that the conventional moniliform vitellarium is not observed. Posterior end of ovariole filled with fusing follicles. stl: stall (T. Schupbach) Female-sterile; homozygous females often contain ovarian tumors; ovarioles filled with small undifferentiated cells, as well as egg chambers containing variable numbers of nurse cells and degenerating material. Occasional normal egg chambers take up yolk, but form abnormal, collapsing eggs which remain unfertilized.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA04396 BKN23966
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59B2-59B2   Limits computationally determined from genome sequence between P{PZ}blw03972 and P{EP}EP627
Experimentally Determined Cytological Location
Cytogenetic map Notes References   FlyBase curator comment: Cytological location stated to be 60B8--C5, however this is at odds with mapped genomic location.   (Jones et al., 1999)   Cytological location of stl at 60B8--C5 was reported in FBrf0108820 and was based on the breakpoints of a deficiency that failed to complement stl. However, subsequently the deficiency chromosome was shown to include a second mutation at the (not-deleted) stl locus.   (Ozdowski, 2007.2.26)
Experimentally Determined Recombination Data
Location	2-102   2- (Bakken, 1973) 2-100.5--101 (Ozdowski, 2007.2.26) 2-100.5--100.8 (Ozdowski et al., 2009)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\stl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 DGC clone GM08694 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) stl-RA FBtr0071885  NM_166559   3093   790 stl-RC FBtr0113110  NM_001103953   4115   1136 stl-RD FBtr0303512  NM_001202056   3505   1091 stl-RE FBtr0309857     4559   1136
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein stl-PA   FBpp0071796   89.3   790   8.24     NP_726248   AAM71125 stl-PC   FBpp0112023   128.9   1136   8.26     NP_001097423   AAF46905 stl-PD   FBpp0292546   124.1   1091   7.99     NP_001188985   ADV37231 stl-PE   FBpp0301591   128.9   1136   8.26
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M12B, ADAM/reprolysin (IPR001590) Thrombospondin, type 1 repeat (IPR000884) Metallopeptidase, catalytic domain (IPR024079)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696915   AE013599 AAF46905   AE013599 AAM71125   AE013599 ADV37231   AW941324   AY089340 AAL90078   AY094759 AAM11112   BF492249   BF500726   BF502496   BF502501   BI565913   BI583468   BI585467   BI617029   BI629901   BP554543   CK135448   CO308388   EC051719   EC051720   EC052666   EC053642   EC054128   EC054644   EC055802   EC055885   EC055932   EC198330   EC215037
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W1Z6 Q8T458 Q8T3M5 Q8MME1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0086408    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0086408 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0086408 expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr  (183) embryo 04-06hr  (139) embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr  105 embryo 14-16hr  (412) embryo 16-18hr  (162) embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr  (243) white prepupae 24hr  (268) pupae 2d postWPP  (671) pupae 3d postWPP  (313) pupae 4d postWPP  (237) adult male 01day  (173) adult male 05day    91 adult male 30day    71 adult female 01day  (531) adult female 05day  (490) adult female 30day  (479) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0086408 expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr  (183) embryo 04-06hr  139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr  105 embryo 14-16hr  (412) embryo 16-18hr  (162) embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr  (243) white prepupae 24hr  (268) pupae 2d postWPP  (671) pupae 3d postWPP  (313) pupae 4d postWPP  (237) adult male 01day  (173) adult male 05day    91 adult male 30day    71 adult female 01day  (531) adult female 05day  (490) adult female 30day  (479) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    183 embryo 04-06hr    139 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    64 embryo 12-14hr    105 embryo 14-16hr    412 embryo 16-18hr    162 embryo 18-20hr    85 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    42 larva L2    75 larva L3 12hr old    22 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    31 white prepupae new    61 white prepupae 12hr    243 white prepupae 24hr    268 pupae 2d postWPP    671 pupae 3d postWPP    313 pupae 4d postWPP    237 adult male 01day    173 adult male 05day    91 adult male 30day    71 adult female 01day    531 adult female 05day    490 adult female 30day    479 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0086408    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0086408 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0086408 expression level Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0086408 expression level Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.825 Larval Midgut    16.9 Larval Hindgut no informative data Larval Malpighian Tubules    6.2 Larval Fat Body    7.6 Larval Salivary Gland no informative data Larval Trachea    9.025 Larval Carcass no informative data Adult Head    24.2 Adult Eye    24.475 Adult Brain    54.9 Adult Thoracic-Abdominal Ganglion    28.9 Adult Crop no informative data Adult Midgut    47 Adult Hindgut no informative data Adult Malpighian Tubules    8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.025 Adult VirginFemale Spermatheca    25.8 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    35.8 Adult Testis    21.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    24.2   NA  Eye    24.475   NA  Brain    54.9   7.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    28.9   NA  Crop    no informative data   16.9  Midgut    47   no informative data  Hindgut    no informative data   6.2  Malpighian Tubules    8   7.6  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    4.025   9.025  Trachea    NA   NA  VirginFemale Spermatheca    25.8   NA  InseminatedFemale Spermatheca    25.8   NA  Ovary    35.8   NA  Testis    21.4   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086408 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3622-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 stlGD2160 Sterility Allele female sterile stl1 stl2 stl3 stl4 stl8-1204 female sterile | recessive stl8-1204 Phenotype manifest in Allele basal stalk stl2 stl4 female fusome stlunspecified follicle cell stl8-1204 germarium stl3 stl4 germline cyst stl3 stl4 interfollicle cell stl1 stl2 stl3 stl4 stl8-1204 interfollicle cell (with stl3) stl8-1204 interfollicle cell (with stl8-1204) stl3 interfollicle cell | P-stage stlunspecified oocyte stl8-1204 stlunspecified ovariole stl1 stl2 stl3 stl4 stl8-1204 ovariole (with Df(2R)d02208-f07572) stl8-1204 ovariole (with stl3) stl8-1204 ovariole (with stl8-1204) stl3 ovariole | somatic clone stl3 stl8-1204 ovary stl8-1204 ovary (with stl3) stl4 ovary (with stl4) stl3 spectrosome stlunspecified vitellarium stl8-1204
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of stl Class Mutagen Stocks Known lesion stl1 ethyl methanesulfonate 2 Yes stlMI03108 1 -- stl8-1204 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes stl2 ethyl methanesulfonate 0 Yes stl3 ethyl methanesulfonate 0 Yes stl4 ethyl methanesulfonate 0 Yes stlunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of stl Class Mutagen Stocks Known lesion stlGD2160 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes stlKK103774 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC599 (Christensen et al., 2008.9.3) Df(2R)d02208-f07572 (Ozdowski et al., 2009, Ozdowski et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2160} NA P{KK103774} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}stlMI03108 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
oogenesis inferred from mutant phenotype (Schupbach and Wieschaus, 1991) ovarian follicle cell stalk formation inferred from mutant phenotype (Willard et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase activity inferred from sequence or structural similarity with UniProtKB:Q8TE57 (FlyBase, 1992-)
Biological Process
CV term Evidence References
ovarian follicle cell stalk formation traceable author statement (Dobens and Raftery, 2000) proteolysis inferred from electronic annotation with InterPro:IPR001590 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions stl allele Gene References stl8-1204 da (Smith and Cronmiller, 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63231 DroID - A comprehensive database of gene and protein interactions. • FBgn0086408 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37619
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA17566
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010084-PA Aedes aegypti (mosquito) AGAP004961-PA Anopheles gambiae (mosquito) XP_001946413.1 Acyrthosiphon pisum (pea aphid) BGIBMGA001969-PA Bombyx mori (silk worm) CN05563 Caenorhabditis brenneri (small nematode) CBP32793 Caenorhabditis briggsae (nematode) CE30185 Caenorhabditis elegans (worm) JA18331 Caenorhabditis japonica (nematode) CPIJ010894 Culex pipens (mosquito) RP35600 Caenorhabditis remanei (nematode) 228725 Capitella spl (polychaete worm) 316025 Daphnia pulex (daphnia) 89720 Hypsipyla robusta (cedar shoot borer) PHUM006310-PA Pediculus humanus (human body louse) XP_975032.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW000910 FBgn0231654 FBgn0223448 FBgn0209165 FBgn0183445 FBgn0170868 JGI_V11_309664 FBgn0077577 FBgn0148989 FBgn0143063 FBgn0127251 FBgn0114959 FBgn0090567 CPIJ010894 BGIBMGA001969 ACYPI003694 AGAP004961 AAEL010084 PHUM043240 GLEAN_09506
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	35922 y1 w*; Mi{MIC}stlMI03108 5115 cn1 stl1 bw1 sp1/CyO, l(2)DTS5131
Kyoto	108049 cn1 stl1 bw1 sp1/CyO, l(2)DTS5131
VDRC	v104737 P{KK103774}VIE-260B v16906 w1118; P{GD2160}v16906
Genomic Clones ( 1 )
	BACR09K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT15733 GM08694
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT18333 AT18345 AT29153 RH22085 RH25058 RH34734 RH58839
Other clones	21218 153928 EC051719 EC051720 EC052666 EC053642 EC054128 EC054644 EC055802 EC055885 EC055932 EK257760 FGM230D10 RH47230
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0086408 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37619 45362
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG3622 BcDNA:GM08694 (FlyBase, 1996-) Source for merge of: stl CG3622 (Ozdowski and Cronmiller, 2007, Ozdowski, 2007.2.26) Source for merge of: stl fs(2)A16 (Smith and Cronmiller, 2001)
Additional comments	Source for merge of CG3622 BcDNA:GM08694 was a shared cDNA (date:020730). (FlyBase, 1996-)
Other Comments
	Long-range control of follicle individualisation during oogenesis requires stl gene function in cells outside of the ovary. (Willard et al., 2004) The stl locus affects early oogenesis: mutations cause the production of few, defective germ cells. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166559 NM_001103953 NM_001202056 RefSeq (Proteins) • NP_726248 NP_001097423 NP_001188985 DDBJ / EMBL / GenBank • AA696915 AAF46905 AAL90078 AAM11112 AAM71125 ADV37231 AW941324 AY089340 AY094759 BF500726 BI617029 Entrez Gene - A searchable database of RefSeq genes. • 37619 UniProtKB/TrEMBL • Q8MME1 Q8T3M5 Q8T458 Q9W1Z6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M12B, ADAM/reprolysin (IPR001590) Thrombospondin, type 1 repeat (IPR000884) Metallopeptidase, catalytic domain (IPR024079)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63231 DroID - A comprehensive database of gene and protein interactions. • FBgn0086408 DRSC - Results from RNAi screens. • FBgn0086408 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086408 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3622-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0086408 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37619 45362 InParanoid A subset of ortholog calls from InParanoid. • AAEL010084-PA Aedes aegypti (mosquito) AGAP004961-PA Anopheles gambiae (mosquito) XP_001946413.1 Acyrthosiphon pisum (pea aphid) BGIBMGA001969-PA Bombyx mori (silk worm) CN05563 Caenorhabditis brenneri (small nematode) CBP32793 Caenorhabditis briggsae (nematode) CE30185 Caenorhabditis elegans (worm) JA18331 Caenorhabditis japonica (nematode) CPIJ010894 Culex pipens (mosquito) RP35600 Caenorhabditis remanei (nematode) 228725 Capitella spl (polychaete worm) 316025 Daphnia pulex (daphnia) 89720 Hypsipyla robusta (cedar shoot borer) PHUM006310-PA Pediculus humanus (human body louse) XP_975032.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37619 modMine - Data generated by the modENCODE project. • FBgn0086408 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW000910 FBgn0231654 FBgn0223448 FBgn0209165 FBgn0183445 FBgn0170868 JGI_V11_309664 FBgn0077577 FBgn0148989 FBgn0143063 FBgn0127251 FBgn0114959 FBgn0090567 CPIJ010894 BGIBMGA001969 ACYPI003694 AGAP004961 AAEL010084 PHUM043240 GLEAN_09506
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BcDNA:GM08694   CG3622 (Ozdowski, 2007.2.26, Ozdowski and Cronmiller, 2007, Keleman et al., 2009.8.5, Ozdowski et al., 2009) fs(2)A16 (Bakken, 1973, ) stl (Ozdowski, 2007.2.26, Ozdowski and Cronmiller, 2007, Jones et al., 1999, Christensen et al., 2008.9.3, Ozdowski et al., 2009, Wasbrough et al., 2010)
Name Synonym	CG3622   female sterile(2)A16   stall (Ozdowski, 2007.2.26, Tworoger et al., 1999, Tworoger et al., 1998, Ozdowski and Cronmiller, 2007, Ozdowski et al., 2009)
Secondary FlyBase IDs
	FBgn0000946 FBgn0003529 FBgn0034778 FBgn0062482
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 8 ) FlyBase analysis  ( 2 ) Computer file  ( 1 ) Book  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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