FB2021_06, released December 14, 2021

Gene: Dmel\stl

Open Close
General Information
Symbol
Dmel\stl
Species
D. melanogaster
Name
stall
Annotation Symbol
CG3622
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086408
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
stall (stl) encodes a protein involved in neuron migration inhibition and ovarian follicle development. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)
All Summaries
Also Known As

fs(2)A16

Key Links
Genomic Location
Cytogenetic map
59B2-59B2
Sequence location
Recombination map
2-101
RefSeq locus
NT_033778 REGION:22807860..22815993
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables metalloendopeptidase activity
inferred from sequence model
(Ozdowski et al., 2009)
inferred from biological aspect of ancestor with PANTHER:PTN000347317
(assigned by GO_Central )
(Gaudet et al., 2011)
enables zinc ion binding
inferred from sequence model
(Ozdowski et al., 2009)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in negative regulation of neuron migration
inferred from mutant phenotype
(Lhamo and Ismat, 2015)
involved_in oogenesis
inferred from high throughput mutant phenotype
(Schupbach and Wieschaus, 1991)
involved_in ovarian follicle cell development
inferred from mutant phenotype
(Ozdowski et al., 2009)
involved_in ovarian follicle cell stalk formation
inferred from mutant phenotype
(Willard et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in extracellular matrix organization
inferred from biological aspect of ancestor with PANTHER:PTN000347317
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001590
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular matrix
inferred from biological aspect of ancestor with PANTHER:PTN000347317
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
stall (stl) encodes a protein involved in neuron migration inhibition and ovarian follicle development. [Date last reviewed: 2019-08-01]
Gene Group (FlyBase)
ADAM WITH THROMBOSPONDIN MOTIF -
A Disintegrin And Metalloprotease Thrombospondin motif (ADAMTS) belongs to the metzincin superfamily of metalloproteases. ADAMTS is related to ADAM proteins, sharing in part their domain organisation. However, ADAMTS includes proteins that contain a variable number of thrombospondin-like repeats instead of disintegrin and cysteine rich domains. ADAMTS proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
fs(2)A16
Homozygous females have small (400-600 um long) abnormally organized ovaries. Ultrastructural studies by King and Buckles (1980, DIS 55: 74-75) reveal that oogonial cysts appear to be normal; surrounded by wedge-shaped follicle cells but not separated by interfollicular stalks so that the conventional moniliform vitellarium is not observed. Posterior end of ovariole filled with fusing follicles.
stl: stall (T. Schupbach)
Female-sterile; homozygous females often contain ovarian tumors; ovarioles filled with small undifferentiated cells, as well as egg chambers containing variable numbers of nurse cells and degenerating material. Occasional normal egg chambers take up yolk, but form abnormal, collapsing eggs which remain unfertilized.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\stl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.52

Additional transcripts may exist: alternative downstream 5' start sites postulated from RT-PCR data (FBrf0209377) are not annotated as they are not supported by RNA-Seq coverage, CAGE or other data types.

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
stl-RC
FBtr0113110
NM_001103953
4051
1136
stl-RE
FBtr0309857
NM_001259540
4559
1136
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
stl-PC
FBpp0112023
128.9
1136
8.26
NP_001097423
AAF46905
stl-PE
FBpp0301591
128.9
1136
8.26
NP_001246469
AFH08222
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1136 aa isoforms: stl-PC, stl-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\stl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of stl
Transgenic constructs containing regulatory region of stl
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)BSC599
(Christensen et al., 2008.9.3)
Df(2R)d02208-f07572
(Ozdowski et al., 2009)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female sterile
female sterile | recessive
Other Phenotypes
Allele
abnormal cell migration | embryonic stage
abnormal cell migration | embryonic stage (with stl2)
abnormal cell migration | embryonic stage (with stl3)
abnormal cell migration | embryonic stage (with stl4)
decreased cell number | oogenesis | oogenesis
decreased cell number | oogenesis | oogenesis (with stl3)
decreased cell number | oogenesis | oogenesis (with stl8-1204)
Phenotype manifest in
Allele
abdominal lch1 neuron | embryonic stage
abdominal lch1 neuron | embryonic stage (with stl2)
abdominal lch1 neuron | embryonic stage (with stl3)
abdominal lch1 neuron | embryonic stage (with stl4)
basal stalk
female fusome
follicle cell
germarium
germline cyst
oocyte
ovariole
ovariole (with Df(2R)d02208-f07572)
ovariole (with stl3)
ovariole (with stl8-1204)
ovariole | somatic clone
ovary
ovary (with stl3)
ovary (with stl4)
spectrosome
stalk follicle cell
stalk follicle cell (with stl3)
stalk follicle cell (with stl8-1204)
stalk follicle cell | P-stage
vitellarium
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADAMTS2
2 of 15
Yes
No
Hsap\ADAMTS3
2 of 15
Yes
No
Hsap\ADAMTS5
2 of 15
Yes
No
Hsap\ADAMTS6
2 of 15
Yes
No
Hsap\ADAMTS7
2 of 15
Yes
No
Hsap\ADAMTS10
2 of 15
Yes
No
Hsap\ADAMTS12
2 of 15
Yes
No
Hsap\ADAMTS13
2 of 15
Yes
No
Hsap\ADAMTS14
2 of 15
Yes
No
Hsap\ADAMTS16
2 of 15
Yes
No
Hsap\ADAMTS17
2 of 15
Yes
No
Hsap\ADAMTS18
2 of 15
Yes
No
Hsap\ADAMTS19
2 of 15
Yes
No
Hsap\ADAMTSL2
2 of 15
Yes
No
Hsap\ADAMTSL4
2 of 15
Yes
No
Hsap\ADAMTSL5
2 of 15
Yes
No
Hsap\PAPLN
2 of 15
Yes
No
Hsap\THSD4
2 of 15
Yes
No
Hsap\ADAMTS1
1 of 15
No
No
1  
Hsap\ADAMTS4
1 of 15
No
No
Hsap\ADAMTS8
1 of 15
No
No
Hsap\ADAMTS9
1 of 15
No
No
Hsap\ADAMTS15
1 of 15
No
No
1  
Hsap\ADAMTS20
1 of 15
No
No
Hsap\ADAMTSL1
1 of 15
No
No
Hsap\ADAMTSL3
1 of 15
No
No
Hsap\ADGRB1
1 of 15
No
Yes
Hsap\CFP
1 of 15
No
Yes
Hsap\THSD7A
1 of 15
No
Yes
Hsap\THSD7B
1 of 15
No
Yes
Hsap\WFIKKN1
1 of 15
No
No
Hsap\WFIKKN2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adamts2
2 of 15
Yes
No
Mmus\Adamts3
2 of 15
Yes
No
Mmus\Adamts5
2 of 15
Yes
No
Mmus\Adamts6
2 of 15
Yes
No
Mmus\Adamts7
2 of 15
Yes
No
Mmus\Adamts10
2 of 15
Yes
No
Mmus\Adamts12
2 of 15
Yes
No
Mmus\Adamts13
2 of 15
Yes
No
Mmus\Adamts14
2 of 15
Yes
No
Mmus\Adamts16
2 of 15
Yes
No
Mmus\Adamts17
2 of 15
Yes
No
Mmus\Adamts18
2 of 15
Yes
No
Mmus\Adamts19
2 of 15
Yes
No
Mmus\Adamtsl2
2 of 15
Yes
No
Mmus\Adamtsl4
2 of 15
Yes
No
Mmus\Adamtsl5
2 of 15
Yes
No
Mmus\Papln
2 of 15
Yes
No
Mmus\Thsd4
2 of 15
Yes
No
Mmus\Adamts1
1 of 15
No
No
Mmus\Adamts4
1 of 15
No
No
Mmus\Adamts8
1 of 15
No
No
Mmus\Adamts9
1 of 15
No
No
Mmus\Adamts15
1 of 15
No
No
Mmus\Adamts20
1 of 15
No
No
Mmus\Adamtsl1
1 of 15
No
No
Mmus\Adamtsl3
1 of 15
No
No
Mmus\Adgrb1
1 of 15
No
Yes
Mmus\Cfp
1 of 15
No
Yes
Mmus\Sspo
1 of 15
No
No
Mmus\Thsd7a
1 of 15
No
No
Mmus\Thsd7b
1 of 15
No
Yes
Mmus\Wfikkn1
1 of 15
No
Yes
Mmus\Wfikkn2
1 of 15
No
No
Rattus norvegicus (Norway rat) (29)
Rnor\Adamts3
2 of 13
Yes
No
Rnor\Adamts6
2 of 13
Yes
No
Rnor\Adamts7
2 of 13
Yes
No
Rnor\Adamts12
2 of 13
Yes
No
Rnor\Adamts13
2 of 13
Yes
No
Rnor\Adamts14
2 of 13
Yes
No
Rnor\Adamts16
2 of 13
Yes
No
Rnor\Adamts17
2 of 13
Yes
No
Rnor\Adamts18
2 of 13
Yes
No
Rnor\Adamtsl2
2 of 13
Yes
No
Rnor\Adamtsl4
2 of 13
Yes
No
Rnor\Adamtsl5
2 of 13
Yes
No
Rnor\Adamts1
1 of 13
No
No
Rnor\Adamts2
1 of 13
No
No
Rnor\Adamts4
1 of 13
No
No
Rnor\Adamts8
1 of 13
No
No
Rnor\Adamts9
1 of 13
No
No
Rnor\Adamts10
1 of 13
No
No
Rnor\Adamts15
1 of 13
No
No
Rnor\Adamts19
1 of 13
No
No
Rnor\Adamts20
1 of 13
No
No
Rnor\Adamtsl3
1 of 13
No
No
Rnor\Cfp
1 of 13
No
Yes
Rnor\Papln
1 of 13
No
No
Rnor\Sspo
1 of 13
No
No
Rnor\Thsd7a
1 of 13
No
Yes
Rnor\Thsd7b
1 of 13
No
Yes
Rnor\Wfikkn1
1 of 13
No
Yes
Rnor\Wfikkn2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (28)
Xtro\adamts2
2 of 12
Yes
No
Xtro\adamts3
2 of 12
Yes
No
Xtro\adamts6
2 of 12
Yes
No
Xtro\adamts7
2 of 12
Yes
No
Xtro\adamts10
2 of 12
Yes
No
Xtro\adamts12
2 of 12
Yes
No
Xtro\adamts13
2 of 12
Yes
No
Xtro\adamts14
2 of 12
Yes
No
Xtro\adamts16
2 of 12
Yes
No
Xtro\adamts17
2 of 12
Yes
No
Xtro\adamts18
2 of 12
Yes
No
Xtro\adamtsl4
2 of 12
Yes
No
Xtro\adamtsl5
2 of 12
Yes
No
Xtro\LOC100487633
2 of 12
Yes
No
Xtro\papln
2 of 12
Yes
No
Xtro\adamts1
1 of 12
No
No
Xtro\adamts4
1 of 12
No
No
Xtro\adamts5
1 of 12
No
No
Xtro\adamts8
1 of 12
No
No
Xtro\adamts9
1 of 12
No
No
Xtro\adamts15
1 of 12
No
No
Xtro\adamts20
1 of 12
No
No
Xtro\adamtsl3
1 of 12
No
No
Xtro\adgrb1
1 of 12
No
Yes
Xtro\thsd7a
1 of 12
No
Yes
Xtro\thsd7b
1 of 12
No
Yes
Xtro\wfikkn1
1 of 12
No
Yes
Xtro\wfikkn2
1 of 12
No
Yes
Danio rerio (Zebrafish) (36)
Drer\adamts2
2 of 15
Yes
No
Drer\adamts3
2 of 15
Yes
No
Drer\adamts6
2 of 15
Yes
No
Drer\adamts7
2 of 15
Yes
No
Drer\adamts10
2 of 15
Yes
No
Drer\adamts12
2 of 15
Yes
No
Drer\adamts13
2 of 15
Yes
No
Drer\adamts17
2 of 15
Yes
No
Drer\adamts18
2 of 15
Yes
No
Drer\adamtsl2
2 of 15
Yes
No
Drer\adamtsl5
2 of 15
Yes
No
Drer\LOC568792
2 of 15
Yes
No
Drer\paplna
2 of 15
Yes
No
Drer\si:ch211-267e7.3
2 of 15
Yes
No
Drer\adamts1
1 of 15
No
No
Drer\adamts8a
1 of 15
No
No
Drer\adamts15a
1 of 15
No
No
Drer\adamtsl3
1 of 15
No
No
Drer\adamtsl7
1 of 15
No
No
Drer\adgrb1a
1 of 15
No
Yes
Drer\cfp
1 of 15
No
Yes
Drer\col28a1a
1 of 15
No
No
Drer\LOC100001991
1 of 15
No
No
Drer\LOC100002059
1 of 15
No
No
Drer\LOC100331635
1 of 15
No
Yes
Drer\lrp11
1 of 15
No
No
Drer\paplnb
1 of 15
No
No
Drer\scospondin
1 of 15
No
No
Drer\si:ch73-237c6.1
1 of 15
No
Yes
Drer\si:dkeyp-73b11.8
1 of 15
No
No
Drer\thsd7aa
1 of 15
No
No
Drer\thsd7ba
1 of 15
No
No
Drer\thsd7bb
1 of 15
No
Yes
Drer\wfikkn2a
1 of 15
No
Yes
Drer\wfikkn2b
1 of 15
No
No
Drer\wu:fb59d01
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\adt-3
10 of 15
Yes
Yes
Cele\adt-1
9 of 15
No
Yes
Cele\adt-2
5 of 15
No
Yes
Cele\mig-17
2 of 15
No
No
Cele\C36B7.5
1 of 15
No
No
Cele\gon-1
1 of 15
No
No
Cele\madd-4
1 of 15
No
No
Cele\T21B6.3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919017E )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002143
Drosophila simulans
Dsim\GD11705
Drosophila sechellia
Dsec\GM15952
Drosophila erecta
Dere\GG22794
Drosophila yakuba
Dyak\GE14024
Drosophila ananassae
Dana\GF13538
Drosophila pseudoobscura pseudoobscura
Dpse\GA17566
Drosophila persimilis
Dper\GL11380
Drosophila willistoni
Dwil\GK21456
Drosophila virilis
Dvir\GJ22051
Drosophila mojavensis
Dmoj\GI20327
Drosophila grimshawi
Dgri\GH19787
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500Q5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024621
Glossina morsitans
Tsetse fly
Gmor\GMOY007653
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01710
Mayetiola destructor
Hessian fly
Mdes\Mdes004489
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010084
Anopheles gambiae
Malaria mosquito
Agam\AGAP004961
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010894
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01CU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001969
Danaus plexippus
Monarch butterfly
Dple\DPOGS200771-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011060
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12659
Tribolium castaneum
Red flour beetle
Tcas\TC009506
Pediculus humanus
Human body louse
Phum\PHUM043240
Rhodnius prolixus
Kissing bug
Rpro\RPRC014897
Cimex lectularius
Bed bug
Clec\CLEC004846
Cimex lectularius
Bed bug
Clec\CLEC004848
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003694
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06007
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0A6W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010464
Ixodes scapularis
Black-legged tick
Isca\ISCW000910
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76431.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01760
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309664
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
sona
3 of 10
AdamTS-A
2 of 10
AdamTS-B
2 of 10
loh
2 of 10
nolo
2 of 10
Ppn
2 of 10
CG31609
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-101
    Cytogenetic map
    59B2-59B2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    59B2-59B2
    Limits computationally determined from genome sequence between P{PZ}blw03972 and P{EP}EP627
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    FlyBase curator comment: Cytological location stated to be 60B8--C5, however this is at odds with mapped genomic location.
    (Jones et al., 1999)
    Cytological location of stl at 60B8--C5 was reported in FBrf0108820 and was based on the breakpoints of a deficiency that failed to complement stl. However, subsequently the deficiency chromosome was shown to include a second mutation at the (not-deleted) stl locus.
    (Ozdowski, 2007.2.26)
    Experimentally Determined Recombination Data
    Location

    2-101

    (FlyBase, 2016)

    2-105.8

    (Comeron et al., 2012)

    2-100.5--100.8

    (Ozdowski et al., 2009)

    2-100.5--101

    (Ozdowski, 2007.2.26)

    2-

    (Bakken, 1973)

    2-102

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (19)
    cDNA Clones (17)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: stl fs(2)A16

      (Smith and Cronmiller, 2001)

      Source for merge of: stl CG3622

      (Ozdowski, 2007.2.26, Ozdowski and Cronmiller, 2007)

      Source for merge of: CG3622 BcDNA:GM08694

      (FlyBase, 1996-)
      Additional comments

      Source for merge of CG3622 BcDNA:GM08694 was a shared cDNA ( date:020730 ).

      (FlyBase, 1996-)
      Other Comments

      Long-range control of follicle individualisation during oogenesis requires stl gene function in cells outside of the ovary.

      (Willard et al., 2004)

      The stl locus affects early oogenesis: mutations cause the production of few, defective germ cells.

      (Schupbach and Wieschaus, 1991)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 45 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (7)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (55)